1,808 results match your criteria pustular psoriasis

Psoriasis beyond the skin: Ophthalmological changes (Review).

Exp Ther Med 2021 Sep 12;22(3):981. Epub 2021 Jul 12.

Third Department, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Psoriasis is a chronic, immune-mediated inflammatory disease of unknown etiology that may be associated with abnormal T-lymphocyte function. Ocular manifestations associated with psoriasis, particularly artropathic or pustular psoriasis, usually affect men, often during exacerbations of the disease. It has been reported that eye damage tends to occur later compared with cutaneous or joint manifestations, blindness being the most disabling complication. Read More

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September 2021

Rapid response to secukinumab in a 5-year-old with deficiency of the interleukin-36 receptor antagonist (DITRA) with severe scalp and nail involvement.

Pediatr Dermatol 2021 Aug 2. Epub 2021 Aug 2.

Department of Dermatology, University of Hong Kong Shenzhen Hospital, Shenzhen, China.

Deficiency of the interleukin-36 receptor antagonist (DITRA) is an autosomal recessive disease caused by mutations of the IL36RN gene. DITRA is characterized by acute generalized pustular psoriasis (GPP), fever, systemic inflammation, and leukocytosis. We report the case of a 5-year-old girl with severe scalp and nail involvement with a rapid response to secukinumab. Read More

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A randomized prospective study of different dose regimens using the 308-nm excimer laser in the treatment of palmoplantar pustulosis.

Dermatol Ther 2021 Aug 1. Epub 2021 Aug 1.

Department of Dermatology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.

The objective of this study was to evaluate optimal treatment regimen of 308-nm excimer laser for palmoplantar pustulosis (PPP). 77 patients with PPP were randomly assigned to receive low dose (2-fold of MED as initial dose), medium dose (4-fold of MED as initial dose) and high dose group (6-fold of MED as initial dose) and the MED of each patient depended on the ultraviolet light sensitivity of individual's skin which ranged from 0.1 J/cm -0. Read More

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Pustular psoriasis of pregnancy in early first trimester: A case report.

Clin Case Rep 2021 Jul 21;9(7):e04438. Epub 2021 Jul 21.

School of Medicine Isfahan University of Medical Sciences Isfahan Iran.

Pustular psoriasis of pregnancy is a rare skin condition which mostly affects women in the third trimester and is sometimes followed by adverse outcomes for the mother and the fetus. Read More

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Differential impacts of TNFα inhibitors on the transcriptome of Th cells.

Arthritis Res Ther 2021 Jul 23;23(1):199. Epub 2021 Jul 23.

Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA, 02115, USA.

Background: Targeting TNFα is beneficial in many autoimmune and inflammatory diseases, including rheumatoid arthritis. However, the response to each of the existing TNFα inhibitors (TNFis) can be patient- and/or disease-dependent. In addition, TNFis can induce the production of type 1 interferons (IFNs), which contribute to their non-infection side effects, such as pustular psoriasis. Read More

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Characteristics of hospitalizations and emergency department visits due to generalized pustular psoriasis in the United States.

Curr Med Res Opin 2021 Jul 24:1-7. Epub 2021 Jul 24.

Department of Dermatology, Dermatology Research and Education Foundation, Irvine, CA, USA.

Objectives: Generalized pustular psoriasis (GPP) is a rare and severe, inflammatory skin disease. GPP is characterized by recurrent flares that consist of disseminated erythematous skin rash with sterile neutrophil-filled pustules that can result in an emergency department (ED) visit or hospital stay due to systemic complications. This study characterizes hospitalizations, ED visits, and inpatient treatment due to GPP in the United States (US). Read More

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Patient characteristics and burden of disease in Japanese patients with generalized pustular psoriasis: Results from the Medical Data Vision claims database.

J Dermatol 2021 Jul 1. Epub 2021 Jul 1.

Department of Dermatology, Tokyo Medical University Hospital, Tokyo, Japan.

Generalized pustular psoriasis (GPP) is a rare and severe systemic, neutrophilic skin disease. To date, accurate clinical profiling of patients with GPP remains poorly understood. In this study, we present the characteristics and estimate the burden of disease in patients with GPP compared with those with plaque psoriasis, in Japan. Read More

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Recurrence of secukinumab-induced eczematous eruptions after guselkumab treatment for pustular psoriasis.

J Dermatol 2021 Jul 1. Epub 2021 Jul 1.

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan.

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Histologic Patterns and Clues to Autoinflammatory Diseases in Children: What a Cutaneous Biopsy Can Tell Us.

Dermatopathology (Basel) 2021 Jun 8;8(2):202-220. Epub 2021 Jun 8.

Department of Dermatology, Oregon Health and Sciences University, Portland, OR 97239, USA.

Autoinflammation is defined by aberrant, antigen-independent activation of the innate immune signaling pathways. This leads to increased, pro-inflammatory cytokine expression and subsequent inflammation. In contrast, autoimmune and allergic diseases are antigen-directed immune responses from activation of the adaptive immune system. Read More

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Characteristics of Pruritus in Various Clinical Variants of Psoriasis: Results of the Multinational, Multicenter, Cross-Sectional Study.

Life (Basel) 2021 Jun 27;11(7). Epub 2021 Jun 27.

Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszów, Poland.

Psoriasis is a chronic, inflammatory skin disease present in about 3% of the world's population. The clinical symptoms manifest diversely, therefore one can distinguish several subtypes of psoriasis. The majority of patients with psoriasis experience pruritus, which is an unpleasant sensation that decreases patients' quality of life. Read More

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A generalized pustular psoriasis flare after CoronaVac COVID-19 vaccination: Case report.

Health Promot Perspect 2021 19;11(2):261-262. Epub 2021 May 19.

Department of Dermatology and Venereology, Bezmialem Vakif University, Istanbul, Turkey.

CoronoVac is a non-viable vaccine for severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). Nowadays, there has been vaccination program for at-risk groups and older adults in Turkey. We here present 72-year-old male psoriasis patient who developed generalized pustular psoriasis flare after administration of CoronoVac. Read More

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Autoinflammatory keratinitzation diseases (AIKDs.

Actas Dermosifiliogr 2021 Jun 9. Epub 2021 Jun 9.

Servicio de Dermatología, Consorci Corporació Sanitària Parc Taulí, Universidad Autónoma de Barcelona, Spain.

Autoinflammatory keratinization disease (AiKD) is a novel clinical concept encompassing diseases with a genetic background and mixed pathogenic mechanisms of autoinflammation and autoimmunity, leading to an aberrant keratinization of the skin. Recent advances in medical genetics have revealed genetic causes and/or predisposing factors for a number of AiKD's, such as mutations in IL36RN related with pustular psoriasis, acrodermatitis continua and hidradenitis suppurativa, in CARD14 in pityriasis rubra pilaris type V and some forms of pustular psoriasis, and in NLRP1 related with familial keratosis lichenoides chronica (KLC). It is suspected that AiKD pathophysiology would also be involved in non-monogenic disorders. Read More

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Treatments and outcomes of generalized pustular psoriasis: A cohort of 1516 patients in a nationwide inpatient database in Japan.

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Background: Because generalized pustular psoriasis (GPP) is rare, there are few studies reporting treatments and outcomes for large numbers of patients.

Objective: To report treatments and outcomes in a large cohort of patients hospitalized with GPP.

Methods: Using a Japanese national inpatient database, we identified 1516 patients with GPP who required hospitalization between July 2010 and March 2019. Read More

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Use of brodalumab for the treatment of chronic plaque psoriasis: a one-year real-life study in the Lazio region, Italy.

Expert Opin Biol Ther 2021 Jun 28:1-11. Epub 2021 Jun 28.

Dipartimento Scienze Mediche E Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Dermatologia, Rome, Italy.

: Information is limited from real-life studies evaluating the efficacy and safety of brodalumab.: In this real-life study, we retrospectively examined a database of 90 patients with moderate-to-severe psoriasis treated with brodalumab (210 mg, s.c. Read More

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Tinea Incognito Mimicking Pustular Psoriasis in a Patient With Psoriasis and Cushing Syndrome.

Gerhard Eichhoff

Cutis 2021 Apr;107(4):E30-E32

Dermatology Service Capital and Coast District Health Board, Wellington Regional Hospital, New Zealand.

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Management of Vipadika with Mahisha Gritha Padanimajjana - a case report.

J Complement Integr Med 2021 Jun 4. Epub 2021 Jun 4.

Department of Panchakarma, Amrita School of Ayurveda, Amrita Vishwa Vidyapeetham, Amritapuri, Kerala, India.

Objectives: Vipadika (Palmo plantar Psoriasis) is a Kshudra Kushta (minor skin disorder) of Vatakapha origin (body humors like vata and kapha) characterized by Sphutana (cracks) and Teevra Vedana (severe pain) in Pani (palm) and Pada (sole). Based on the symptoms it can be correlated to Palmo Plantar Psoriasis which is a variant of psoriasis which affects the skin of the palms and soles with the features of hyperkeratotic, pustular, or mixed morphologies. The treatment methods for Palmo plantor psoriasis causes severe side effects due to which an evident shift from modern treatments to ayurvedic treatment line. Read More

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Pustular Psoriasis and Associated Musculoskeletal Disorders.

J Rheumatol Suppl 2021 Jun;97:34-38

P.S. Helliwell, MD, PhD, Professor of Clinical Rheumatology, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Harehills Lane, Leeds, and NIHR Leeds Biomedical Research Centre, Leeds, UK.

Pustular psoriasis (PsO) is an uncommon variant of PsO that may present in a generalized or localized fashion with or without musculoskeletal or systemic inflammatory involvement.Generalized pustular PsO (GPP) presents as a widespread acute or subacute pustular eruption that may be familial and is often associated with severe flares and systemic inflammation. The palmoplantar pustulosis variant is localized to palms and soles, whereas acrodermatitis continua of Hallopeau is localized to the nail apparatus. Read More

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Prologue: 2020 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).

J Rheumatol Suppl 2021 Jun;97:1-3

L.V. McFarland, MS, PhD, Consultant, Public Health Reserves Corps, Seattle, Washington, USA.

The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) held its annual meeting in 2020 in an online format due to travel restrictions during the coronavirus disease 2019 (COVID-19; caused by SARS-CoV-2) pandemic. The virtual meeting was attended by 351 rheumatologists, dermatologists, representatives of biopharmaceutical companies, and patient research partners. Similar to previous years, GRAPPA's annual meeting focused on the 3 overlapping missions of education, research, and clinical care of psoriatic disease. Read More

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Recalcitrant paradoxical pustular psoriasis induced by infliximab: Two case reports.

World J Clin Cases 2021 May;9(15):3655-3661

Department of Dermatology, Midwest Center for Dermatology and Cosmetic Surgery, Clinton Township, MI 48038, United States.

Background: Paradoxical psoriasis induced by tumor necrosis factor alpha antagonists is a rare side effect of those drugs and has similarities with and differences from classical psoriasis in clinical and pathological characteristics. Treating severe paradoxical psoriasis is challenging because the reported cases are rare, with treatment experience being only anecdotal.

Case Summary: We report 2 cases of paradoxical psoriasis caused by infliximab. Read More

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Clinical analysis of generalized pustular psoriasis in Chinese patients: A retrospective study of 110 patients.

J Dermatol 2021 May 21. Epub 2021 May 21.

Department of Dermatology, Shanghai Skin Disease Hospital, Institute of Psoriasis, Tongji University School of Medicine, Shanghai, China.

Generalized pustular psoriasis is an immune-mediated dermatologic condition characterized by widespread, sterile, subcorneal pustules. However, limited information exists regarding the clinical course of generalized pustular psoriasis. This study aimed to examine the precipitating factors, clinical manifestations, laboratory data, relapse patterns, and prognosis of generalized pustular psoriasis at our hospital and to improve the diagnosis and treatment. Read More

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Psoriasis: a brief overview.

Clin Med (Lond) 2021 05;21(3):170-173

St John's Institute of Dermatology, London, UK

Psoriasis is a clinically heterogeneous lifelong skin disease that presents in multiple forms such as plaque, flexural, guttate, pustular or erythrodermic. An estimated 60 million people have psoriasis worldwide, with 1.52% of the general population affected in the UK. Read More

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Infantile pustular psoriasis: Case report of successful treatment with acitretin in a 4-week-old infant.

JAAD Case Rep 2021 May 1;11:121-123. Epub 2021 Apr 1.

UCSF Dermatopathology and Oral Pathology Service, San Francisco, California.

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Clinical and trichoscopic features in various forms of scalp psoriasis.

J Eur Acad Dermatol Venereol 2021 May 15. Epub 2021 May 15.

Dermatology -IRCCS Policlinico di Sant'Orsola - Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy.

Background: Scalp psoriasis is often undiagnosed or inadequately treated. The patient himself underestimates the seriousness of this hair disease and consults too late to a dermatologist.

Objectives: The aim of our study was to create a correlation between the clinical patterns and trichoscopy of scalp psoriasis such in a way to help the clinician to make the diagnosis and select the appropriate therapy. Read More

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Treatment of Generalized Pustular Psoriasis of Pregnancy With Infliximab.

Cutis 2021 Mar;107(3):E2-E5

Dr. Beksac is from the Department of Dermatology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey. Dr. Adisen is from and Dr. Gurer was from the Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.

Generalized pustular psoriasis of pregnancy (GPPP) is a rare and severe condition that may impair the health of the mother and fetus. Effective treatment is essential, as treatment options for GPPP are limited due to concerns about unfavorable pregnancy outcomes. We report the case of a 22-year-old woman with GPPP that was unresponsive to systemic corticosteroids. Read More

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An update on genetic basis of generalized pustular psoriasis (Review).

Int J Mol Med 2021 Jun 6;47(6). Epub 2021 May 6.

Department of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Generalized pustular psoriasis (GPP) is a rare and severe auto‑inflammatory skin disease that is characterized by recurrent, acute onset, and generalized pustular eruptions on erythematous, inflamed skin. GPP is traditionally classified as a variant of psoriasis vulgaris, even though recent clinical, histological and genetic evidence suggests that it is a heterogeneous disease and requires a separate diagnosis. In recent years, variants of , , and genes have been identified as causative or contributing to genetic defects in a proportion of patients affected by GPP. Read More

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