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Utilization of spectral domain optical coherence tomography to identify posterior vitreous detachment in patients with a retinal detachment.

Retina 2021 May 5. Epub 2021 May 5.

VitreoRetinal Surgery, PA, 3601 West 76 Street Suite 300, Edina, MN 55435.

Purpose: To compare posterior vitreous detachment (PVD) identification rate between clinical examination vs. spectral domain optical coherence tomography (SD-OCT) in patients with retinal detachment (RD).

Methods: Data from the Primary Retinal detachment Outcomes (PRO) study was utilized for this retrospective cross-sectional study of 506 patients. Read More

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Evaluation of a patient-specific algorithm for predicting distribution for convection-enhanced drug delivery into the brainstem of patients with diffuse intrinsic pontine glioma.

J Neurosurg Pediatr 2021 May 14:1-9. Epub 2021 May 14.

2Department of Neurological Surgery, Weill Medical College of Cornell University, New York, New York.

Objective: With increasing use of convection-enhanced delivery (CED) of drugs, the need for software that can predict infusion distribution has grown. In the context of a phase I clinical trial for pediatric diffuse intrinsic pontine glioma (DIPG), CED was used to administer an anti-B7H3 radiolabeled monoclonal antibody, iodine-124-labeled omburtamab. In this study, the authors retrospectively evaluated a software algorithm (iPlan Flow) for the estimation of infusate distribution based on the planned catheter trajectory, infusion parameters, and patient-specific MRI. Read More

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Circulating angiogenic profiles and histo-morphological placental characteristics of uncomplicated post-date pregnancies.

Placenta 2021 May 5;109:55-63. Epub 2021 May 5.

Division of Obstetrics and Gynaecology, Department of Obstetrics, Oslo University Hospital, Oslo, Norway; University of Oslo, Faculty of Medicine, Oslo, Norway. Electronic address:

Introduction: The objectives of this study were to describe the histo-morphology of post-date placentas in clinically uncomplicated pregnancies without adverse delivery outcomes and the association with maternal circulating pre-delivery Placental Growth Factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1), as well as the sFlt-1/PlGF ratio.

Methods: Post-date placentas (gestational week ≥40, n = 87) were macroscopically and histo-morphologically assessed according to the international, standardized Amsterdam Workshop Consensus Group criteria. Inter-rater agreement was evaluated by percentage of agreement. Read More

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Energy system transformations and carbon emission mitigation for China to achieve global 2 °C climate target.

J Environ Manage 2021 May 11;292:112721. Epub 2021 May 11.

Center for Energy and Environmental Policy Research, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing, 100081, China; School of Management and Economics, Beijing Institute of Technology, Beijing, 100081, China; Beijing Key Lab of Energy Economics and Environmental Management, Beijing, 100081, China.

The Paris Agreement calls for countries to pursue efforts to limit global-mean temperature rise to 2 °C compared to the pre-industrial level. To achieve this, it is essential to accelerate the low-carbon transition of energy system. China is the largest carbon emitter and plays a decisive role in mitigating global climate change. Read More

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An optoelectronic flow-through detectors for active ingredients determination in the pharmaceutical formulations.

J Pharm Biomed Anal 2021 May 6;201:114128. Epub 2021 May 6.

University of Baghdad, College of Science, Department of Chemistry, Baghdad, Al-Jadriya, Iraq. Electronic address:

An optoelectronic flow-through detector for active ingredients determination in pharmaceutical formulations is explained. Two consecutive compact photodetector's devices operating according to light-emitting diodes-solar cells concept where the LEDs acting as a light source and solar cells for measuring the attenuated light of the incident light at 180˚ have been developed. The turbidimetric detector, fabricated of ten light-emitting diodes and five solar cells only, integrated with a glass flow cell has been easily adapted in flow injection analysis manifold system. Read More

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Assistance from Automated ASPECTS Software Improves Reader Performance.

J Stroke Cerebrovasc Dis 2021 May 10;30(7):105829. Epub 2021 May 10.

Department of Radiology, Neuroimaging and Neurointervention Division, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, United States.

Purpose: To compare physicians' ability to read Alberta Stroke Program Early CT Score (ASPECTS) in patients with a large vessel occlusion within 6 hours of symptom onset when assisted by a machine learning-based automatic software tool, compared with their unassisted score.

Materials And Methods: 50 baseline CT scans selected from two prior studies (CRISP and GAMES-RP) were read by 3 experienced neuroradiologists who were provided access to a follow-up MRI. The average ASPECT score of these reads was used as the reference standard. Read More

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Differentiation of inflammatory from degenerative changes in the sacroiliac joints by machine learning supported texture analysis.

Eur J Radiol 2021 May 11;140:109755. Epub 2021 May 11.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland; Faculty of Medicine, University of Zurich, Switzerland.

Purpose: To compare the diagnostic performance of texture analysis (TA) against visual qualitative assessment in the differentiation of spondyloarthritis (SpA) from degenerative changes in the sacroiliac joints (SIJ).

Method: Ninety patients referred for suspected inflammatory lower back pain from the rheumatology department were retrospectively included at our university hospital institution. MRI at 3 T of the lumbar spine and SIJ was performed with oblique coronal T1-weighted (w), fluid-sensitive fat-saturated (fs) TIRM and fsT1w intravenously contrast-enhanced (CE) images. Read More

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The association between ERK inhibitor sensitivity and molecular characteristics in colorectal cancer.

Biochem Biophys Res Commun 2021 May 11;560:59-65. Epub 2021 May 11.

Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

The mitogen-activated protein kinase (MAPK) pathway plays an important role in the colorectal cancer (CRC) progression, being supposed to be activated by the gene mutations, such as BRAF or KRAS. Although the inhibitors of extracellular signal-regulated kinase (ERK) have demonstrated efficacy in the cells with the BRAF or KRAS mutations, a clinical response is not always associated with the molecular signature. The patient-derived organoids (PDO) have emerged as a powerful in vitro model system to study cancer, and it has been widely applied for the drug screening. Read More

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When less is more: The perception of psychotherapy techniques as a function of patient personality disorder.

Psychol Psychother 2021 May 14. Epub 2021 May 14.

The Department of Psychology, University of Haifa, Israel.

Objective: Psychopathology research suggests that individuals with higher levels of personality disorder (PD) traits, especially those with a comorbid major depressive disorder (MDD), tend to be highly aroused in interpersonal contexts, manifested by an intensified perception of interpersonal interactions. Little is known about the way this tendency manifests in the process of psychotherapy. The current study explored the patient's perception of techniques in psychotherapy among patients with higher vs. Read More

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Adherence to cardiovascular pharmacotherapy by patients in Iraq: A mixed methods assessment using quantitative dried blood spot analysis and the 8-item Morisky Medication Adherence Scale.

PLoS One 2021 14;16(5):e0251115. Epub 2021 May 14.

Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort University, Leicester, United Kingdom.

This study evaluated the adherence to prescribed cardiovascular therapy medications among cardiovascular disease patients attending clinics in Misan, Amara, Iraq. Mixed methods were used to assess medication adherence comprising the Arabic version of the eight-item Morisky Medication Adherence Scale (MMAS-8) and determination of drug concentrations in patient dried blood spot (DBS) samples by liquid chromatography-high resolution mass spectrometry. Three hundred and three Iraqi patients (median age 53 years, 50. Read More

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Artificial intelligence for classifying uncertain images by humans in determining choroidal vascular running pattern and comparisons with automated classification between artificial intelligence.

PLoS One 2021 14;16(5):e0251553. Epub 2021 May 14.

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Purpose: Abnormalities of the running pattern of choroidal vessel have been reported in eyes with pachychoroid diseases. However, it is difficult for clinicians to judge the running pattern with high reproducibility. Thus, the purpose of this study was to compare the degree of concordance of the running pattern of the choroidal vessels between that determined by artificial intelligence (AI) to that determined by experienced clinicians. Read More

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Is the HPV-test more cost-effective than cytology in cervical cancer screening? An economic analysis from a middle-income country.

PLoS One 2021 14;16(5):e0251688. Epub 2021 May 14.

Obstetrics and Gynecology Department, State University of Campinas, Campinas, Brazil.

Objective: To report a modelling study using local health care costs and epidemiological inputs from a population-based program to access the cost-effectiveness of adopting hrHPV test.

Methods: A cost-effectiveness analysis based on a microsimulation dynamic Markov model. Data and costs were based on data from the local setting and literature review. Read More

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Preferentially Expressed Antigen in Melanoma Immunostaining in a Series of Melanocytic Neoplasms.

Am J Dermatopathol 2021 May 11. Epub 2021 May 11.

Departments of Dermatology, and Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; and AU/UGA Medical Partnership, Medical College of Georgia, Athens, GA.

Abstract: In their 2018 article, Lezcano et al [AJSP 2018(11):1456] show that diffuse tumor cell nuclear reactivity for Preferentially expressed Antigen in Melanoma (PRAME) is a feature of melanoma and that benign and atypical melanocytic tumors are PRAME negative or show only focal positivity for PRAME. We report our observations of PRAME staining in 253 melanocytic tumors. Tumors were classified by hematoxylin and eosin sections. Read More

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Use of Bone Marrow Concentrate to Treat Pain and Musculoskeletal Disorders: An Academic Delphi Investigation.

Pain Physician 2021 May;24(3):263-273

Research & Development, Regenexx, LLC.

Background: Acute and degenerative musculoskeletal disorders are among the most common etiologies of disability worldwide. Recently, there has been interest in the field of regenerative medicine to bridge the gap between conservative and surgical management of these conditions. Autologous bone marrow concentrate is one type of injectate that has increased in popularity over the last few decades. Read More

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Interobserver variability in the classification of childhood maculopapular cutaneous mastocytosis.

J Eur Acad Dermatol Venereol 2021 May 14. Epub 2021 May 14.

Hospital Virgen del Valle, Complejo Hospitalario Universitario de Toledo, Toledo, Spain.

Background: Maculopapular cutaneous mastocytosis (MPCM) in children is classified in two variants: 1) monomorphic variant, presenting with the small macules or papules typically seen in adult patients; and 2) polymorphic variant with larger lesions of variable size and shape, typically seen in children. The definition of polymorphic and monomorphic variants is mostly intuitive, and a validation of this classification has not been done.

Objective: To study interobserver variability in the classification of MPCM in two groups of observers: mastocytosis experts and general dermatologists. Read More

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Water quality assessment of a river using deep learning Bi-LSTM methodology: forecasting and validation.

Environ Sci Pollut Res Int 2021 May 14. Epub 2021 May 14.

CSE, GGSIPU, AIACTR, Krishna Nagar Road Chacha Nahru Bal Chikitsalaya, Geeta Colony, Delhi, New Delhi, 110031, India.

Water is a prime necessity for the survival and sustenance of all living beings. Over the past few years, the water quality of rivers is adversely affected due to harmful wastes and pollutants. This ever-increasing water pollution is a big matter of concern as it deteriorating the water quality, making it unfit for any type of use. Read More

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Comparison of Cadmium Zinc Telluride ECG-gated SPECT equilibrium radionuclide angiocardiography to magnetic resonance imaging to measure right ventricular volumes and ejection fraction in patients with cardiomyopathy.

J Nucl Cardiol 2021 May 14. Epub 2021 May 14.

Department of Cardiology, University Hospital, Grenoble Alpes, France.

Aims: The objective of this study was to determine the accuracy of right ventricular function (RVF) assessed by Cadmium Zinc Telluride ECG-gated SPECT equilibrium radionuclide angiocardiography (CZT-ERNA).

Methods And Results: Twenty-one consecutive patients with cardiomyopathy (aged 54 ± 19 years; 62% male) were included. RV ejection fraction (EF) and volumes were analyzed by CZT-ERNA and compared with values obtained by cardiac magnetic resonance imaging (CMR). Read More

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Evaluation of ELISA and PCR in parallel to single intradermal cervical tuberculin test (SICT) for diagnosis of tuberculosis in buffaloes.

Trop Anim Health Prod 2021 May 14;53(2):322. Epub 2021 May 14.

Division of Animal Health, ICAR-Central Sheep and Wool Research Institute, Avikanagar, Rajasthan, India.

Bovine tuberculosis is an economically important disease with very high zoonotic potential. Single intradermal cervical tuberculin test (SICT) is considered a gold standard assay for the diagnosis of bovine tuberculosis. However, bovines especially buffaloes may produce a false negative result when the animal becomes cell-mediated immune (CMI) anergic in the advanced stage of the disease. Read More

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Knowledge, Attitudes, and Beliefs Regarding the COVID-19 Pandemic Among Women in Kansas.

J Community Health 2021 May 14. Epub 2021 May 14.

Department of Obstetrics and Gynecology, The University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.

The COVID-19 pandemic brought forward the challenge of dispersing accurate medical information to the public rapidly. Credible and non-credible sources may impact public reactions to the virus. The purpose of this study is to assess those reactions of women located in or near Kansas. Read More

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Scattering of light by ZnO nanorod arrays.

Opt Lett 2021 May;46(10):2360-2363

The optical properties of ZnO nanorod (NR) arrays were investigated by optical total transmittance (TT) and diffuse reflectance (DR) spectroscopy in the visible region. The NRs were grown electrochemically in a three-electrode cell over a glass/fluorine-doped tin oxide (FTO) substrate. The mean length, radius, and density of NR samples were characterized by scanning electron microscopy. Read More

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Optical frequency-to-time mapping using a phase-modulated frequency-shifting loop.

Opt Lett 2021 May;46(10):2336-2339

A real-time spectral analysis is demonstrated experimentally with a frequency-shifting loop that includes an electro-optic phase modulator. When a single-frequency laser seeds the loop, pulse doublets are emitted if the integer Talbot condition is satisfied. With a polychromatic seed, frequency-to-time mapping is demonstrated, namely the temporal output of the loop maps the spectral power of the seed, with a resolution of 400 kHz. Read More

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Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration.

Elife 2021 May 14;10. Epub 2021 May 14.

Center for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany.

Axolotls are uniquely able to resolve spinal cord injuries, but little is known about the mechanisms underlying spinal cord regeneration. We previously found that tail amputation leads to reactivation of a developmental-like program in spinal cord ependymal cells (Rodrigo Albors ., 2015), characterized by a high-proliferation zone emerging 4 days post-amputation (Rost , 2016). Read More

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Leptomeningeal enhancement on post-contrast FLAIR images for early diagnosis of Susac syndrome.

Mult Scler 2021 May 14:13524585211012349. Epub 2021 May 14.

Department of Neuroradiology, Hôpital Purpan, Toulouse, France.

Background: Leptomeningeal enhancement (LME) is a key feature of Susac syndrome (SuS) but is only occasionally depicted on post-contrast T1-weighted images (T1-WI).

Objective: As post-contrast fluid-attenuated inversion recovery (FLAIR) may be more sensitive, our aim was to assess LME in SuS on this sequence.

Methods: From 2010 to 2020, 20 patients with definite SuS diagnosis were retrospectively enrolled in this multicentre study. Read More

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Scattering Amplitudes and Conservative Binary Dynamics at O(G^{4}).

Phys Rev Lett 2021 Apr;126(17):171601

Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Parks Road, Oxford OX1 3PU, United Kingdom.

Using scattering amplitudes, we obtain the potential contributions to conservative binary dynamics in general relativity at fourth post-Minkowskian order O(G^{4}). As in previous lower-order calculations, we harness powerful tools from the modern scattering amplitudes program including generalized unitarity, the double copy, and advanced multiloop integration methods, in combination with effective field theory. The classical amplitude involves polylogarithms with up to transcendental weight two and elliptic integrals. Read More

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Deep-Learning Approach to First-Principles Transport Simulations.

Phys Rev Lett 2021 Apr;126(17):177701

National Institute of Advanced Industrial Science and Technology (AIST), Central 2, Umezono 1-1-1, Tsukuba 305-8568, Japan.

Large-scale first-principles transport calculations, while essential for device modeling, remain computationally demanding. To overcome this bottle neck, we combine first-principles transport calculations with machine learning-based nonlinear regression. We calculate the electronic conductance through first-principles based nonequilibrium Green's function techniques for small systems and map the transport properties onto local properties using local descriptors. Read More

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Measurement of the 2νββ Decay Half-Life of ^{130}Te with CUORE.

Phys Rev Lett 2021 Apr;126(17):171801

INFN-Sezione di Roma, Roma I-00185, Italy.

We measured two-neutrino double beta decay of ^{130}Te using an exposure of 300.7 kg yr accumulated with the CUORE detector. Using a Bayesian analysis to fit simulated spectra to experimental data, it was possible to disentangle all the major background sources and precisely measure the two-neutrino contribution. Read More

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Modeling and Observation of Nonlinear Damping in Dissipation-Diluted Nanomechanical Resonators.

Phys Rev Lett 2021 Apr;126(17):174101

Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, 2100 Copenhagen, Denmark and Center for Hybrid Quantum Networks (Hy-Q), Niels Bohr Institute, University of Copenhagen, 2100 Copenhagen, Denmark.

Dissipation dilution enables extremely low linear loss in stressed, high aspect ratio nanomechanical resonators, such as strings or membranes. Here, we report on the observation and theoretical modeling of nonlinear dissipation in such structures. We introduce an analytical model based on von Kármán theory, which can be numerically evaluated using finite-element models for arbitrary geometries. Read More

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Imaging Trapped Ion Structures via Fluorescence Cross-Correlation Detection.

Phys Rev Lett 2021 Apr;126(17):173602

QUANTUM, Institut für Physik, Johannes Gutenberg-Universität Mainz, Staudingerweg 7, 55128 Mainz, Germany.

Cross-correlation signals are recorded from fluorescence photons scattered in free space off a trapped ion structure. The analysis of the signal allows for unambiguously revealing the spatial frequency, thus the distance, as well as the spatial alignment of the ions. For the case of two ions we obtain from the cross-correlations a spatial frequency f_{spatial}=1490±2_{stat}±8_{syst}  rad^{-1}, where the statistical uncertainty improves with the integrated number of correlation events as N^{-0. Read More

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Relative Entropy of Random States and Black Holes.

Phys Rev Lett 2021 Apr;126(17):171603

Kadanoff Center for Theoretical Physics, University of Chicago, Chicago, Illinois 60637, USA.

We study the relative entropy of highly excited quantum states. First, we sample states from the Wishart ensemble and develop a large-N diagrammatic technique for the relative entropy. The solution is exactly expressed in terms of elementary functions. Read More

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Retraction.

Authors:

J Cell Biochem 2021 Jul 16;122(7):770. Epub 2021 Mar 16.

"Suppression of basic fibroblast growth factor expression by antisense oligonucleotides inhibits neural stem cell proliferation and differentiation in rat models with focal cerebral infarction," by Chao Li, Li-He Che, Lei Shi, and Jin-Lu Yu, J Cell Biochem. 2017; 3875-3882: The above article, published online on April 8, 2017 in Wiley Online Library (https://onlinelibrary.wiley. Read More

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