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Multiple sclerosis incidence and prevalence in Poland: Data from administrative health claims.

Mult Scler Relat Disord 2021 Jul 22;55:103162. Epub 2021 Jul 22.

Department of Neurology, Jagiellonian University Medical College, Krakow, Poland; Department of Neurology, University Hospital in Krakow, Krakow, Poland.

Background: The detailed data concerning multiple sclerosis (MS) epidemiology in Poland are based on studies from few and less populated provinces. Therefore, we evaluated MS incidence and prevalence in Poland using electronic administrative health claims (AHCs) from the National Health Fund.

Methods: We retrospectively analyzed the AHC financial database collected from 2009 to 2019, encompassing all patients using public health resources. Read More

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Enhancing stress reactivity and wellbeing in early schizophrenia: A randomized controlled trial of Integrated Coping Awareness Therapy (I-CAT).

Schizophr Res 2021 Jul 28;235:91-101. Epub 2021 Jul 28.

Department of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, United States of America; School of Behavioural and Health Sciences, Australian Catholic University, Australia.

Individuals with schizophrenia spectrum disorders (SSD) are at heightened risk for exposure to stressful life events which can lead to increased sensitivity to stress and a dysregulated stress response, which are in turn associated with poor long-term functioning. Stress reactivity is thus a promising treatment target in the early stages of SSD. Integrated-Coping Awareness Therapy (I-CAT) is a manualized intervention integrating mindfulness and positive psychology to target a dysregulated stress response in SSD. Read More

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Stress management versus cognitive restructuring in trauma-affected refugees - A follow-up study on a pragmatic randomised trial.

J Affect Disord 2021 Jul 16;294:628-637. Epub 2021 Jul 16.

Competence Centre for Transcultural Psychiatry, Mental Health Centre Ballerup, Mental Health Services of the Capital Region, Ballerup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Background: There is a lack of research and consensus with respect to long-term effective treatments for trauma-affected refugees. The purpose of this follow-up study of a randomised clinical trial was to investigate the effectiveness of Stress Management (SM) versus Cognitive Restructuring (CR) in treating trauma-affected refugees, six and 18 months post-treatment, respectively.

Methods: From a total of 126 refugees with PTSD, the intention-to-treat sample in the original trial, 74 patients were present at the six-month follow-up (SM; n = 37, CR; n = 37) and 34 patients at the 18-month follow-up (SM; n = 14, CR; n = 20). Read More

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Predicting probable eating disorder case-status in men using the Clinical Impairment Assessment: Evidence for a gender-specific threshold.

Eat Behav 2021 Jul 20;42:101541. Epub 2021 Jul 20.

Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.

The Clinical Impairment Assessment (CIA) is a widely used self-report measure of the psychosocial impairment associated with eating-disorder symptoms. Past studies recommended a global CIA score of 16 to identify clinically significant impairment associated with a probable eating disorder (ED). However, to date, research on the properties of the CIA has been conducted in majority-women samples. Read More

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Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease.

Phytomedicine 2021 Jul 12;91:153648. Epub 2021 Jul 12.

Mr. & Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. Electronic address:

Background: Alzheimer's disease (AD) is the most common neurodegenerative disease. Deposition of amyloid β plaques (Aβ) and neurofibrillary tangles (NFTs) is the key pathological hallmark of AD. Accumulating evidence suggest that impairment of autophagy-lysosomal pathway (ALP) plays key roles in AD pathology. Read More

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Identification of plant-based multitargeted leads for Alzheimer's disease: In-vitro and in-vivo validation of Woodfordia fruticosa (L.) Kurz.

Phytomedicine 2021 Jul 21;91:153659. Epub 2021 Jul 21.

Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India. Electronic address:

Background: Alzheimer's disease (AD) is a complex neurodegenerative disease with no availability of disease-modifying therapeutics. The complex etiology and recent failures in clinical trials indicate the need for multitargeted agents.

Purpose: The present study aims to discover new plant-based multitargeted anti-AD leads. Read More

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Xin-Ji-Er-Kang protects myocardial and renal injury in hypertensive heart failure in mice.

Phytomedicine 2021 Jul 18;91:153675. Epub 2021 Jul 18.

Department of Pharmacology, Basic Medical College, Anhui Medical University, Hefei 230032, China. Electronic address:

Background: Xin-Ji-Er-Kang (XJEK) as a herbal formula of traditional Chinese medicine (TCM) has shown the protective effects on myocardial function as well as renal function in mouse models of myocardial infarction.

Hypothesis/purpose: We investigated the effects of XJEK on cardiovascular- and renal-function in a heart failure mouse model induced by high salt (HS) and the associated mechanisms.

Study Design: For the purpose of assessing the effects of XJEK on a hypertensive heart failure model, mice were fed with 8% high salt diet. Read More

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Topical treatment with mastic (resin from Pistacia lentiscus) elicits anti-inflammatory and anti-pruritic responses by modulating keratinocyte activation in a mouse model of allergic dermatitis.

Phytomedicine 2021 Jul 19;91:153679. Epub 2021 Jul 19.

Laboratory of Veterinary Pharmacology, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa, Japan. Electronic address:

Background: As the number of patients with skin allergies, including atopic dermatitis, has increased rapidly, therapeutic options such as anti-IL-31 antibody and Janus kinase inhibitor have been developed recently. However, many concerns remain regarding the adverse effects and cost of these drugs; therefore, development of supplements that could support the effect of therapeutic agents is always required.

Purpose: The aim of this study was to develop preventive and supportive options for skin allergies by focusing on a natural product called "Mastic". Read More

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Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action.

Phytomedicine 2021 Jul 9;91:153650. Epub 2021 Jul 9.

Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangzhou 510006, China; Institute of Chinese Medicine, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China. Electronic address:

Background: Diabetic nephropathy (DN) is associated with renal interstitial injury and fibrosis. Our previous study showed that andrographolide protected against the progression of DN and high glucose (HG)-induced mesangial dysfunction. However, the protective effects of andrographolide on renal tubular epithelial cells have not been fully elucidated. Read More

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PCR-based rapid diagnostic tools for the authentication of medicinal mistletoe species.

Phytomedicine 2021 Jul 16;91:153667. Epub 2021 Jul 16.

Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju, Jeollanam-do 58245, Republic of Korea. Electronic address:

Background: Taxilli Herba (TH) and Visci Herba (VH), defined as the leaves and branches of the mistletoe species Taxillus chinensis and Viscum coloratum, respectively, are popular herbal medicines in East Asia. However, commercial TH and VH products are frequently adulterated with related inauthentic mistletoe species, posing efficacy and safety concerns. Accurate species identification of herbal medicinal products is a prerequisite for quality control, but traditional morphological identification methods are hampered by difficulties in discriminating among closely related species and in identifying the source materials in processed products. Read More

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Mindfulness-based interventions for medication adherence: A systematic review and narrative synthesis.

J Psychosom Res 2021 Jul 26;149:110585. Epub 2021 Jul 26.

Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, United States. Electronic address:

Objective: Inadequate medication adherence is a significant limitation for achieving optimal health outcomes across chronic health conditions. Mindfulness-based interventions (MBIs) have been increasingly applied to promote medical regimen adherence as MBIs have been shown to improve patient-level barriers to adherence (i.e. Read More

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A novel phantom with dia- and paramagnetic substructure for quantitative susceptibility mapping and relaxometry.

Phys Med 2021 Jul 28;88:278-284. Epub 2021 Jul 28.

Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Purpose: A phantom is presented in this study that allows for an experimental evaluation of QSM reconstruction algorithms. The phantom contains susceptibility producing particles with dia- and paramagnetic properties embedded in an MRI visible medium and is suitable to assess the performance of algorithms that attempt to separate isotropic dia- and paramagnetic susceptibility at the sub-voxel level.

Methods: The phantom was built from calcium carbonate (diamagnetic) and tungsten carbide particles (paramagnetic) embedded in gelatin and surrounded by agarose gel. Read More

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Bilingual phonological development across generations: Segmental accuracy and error patterns in second- and third-generation British Bengali children.

J Commun Disord 2021 Jul 4;93:106140. Epub 2021 Jul 4.

Department of Child and Family Studies, Rongxiang Xu College of Health and Human Services, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, United States of America. Electronic address:

Introduction: While developmental norms for speech sound development have been widely reported for monolingual children, and increasingly for bilingual children, little is known about speech sound development across different generations of children growing up in heritage language settings. The purpose of the present study was to gain a better understanding of inter-generational differences in the phonological development of British Bengali children.

Methods: Typically-developing second-generation and third-generation Bengali heritage children living in Wales (n=19), aged between 4 and 5 years, participated in a picture-naming task in Sylheti and English. Read More

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Effects of Ankle Continuous Passive Motion on Soleus Hypertonia in Individuals with Cerebral Palsy: A Case Series.

Biomed J 2021 Jul 28. Epub 2021 Jul 28.

School of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, No.259, Wen-hua 1st Rd., Guishan Dist., Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, No.5, Fuhsing Str., Guishan Dist., Taoyuan, Taiwan. Electronic address:

Background: Continuous passive motion device (CPM) provides repetitive movement over extended periods of time for those who have low functional ability. The purpose of this research was to evaluate the effects of a four-week program of continuous passive motion of the ankle joint on the changes in soleus hypertonia in individuals with cerebral palsy who suffered from life-long hypertonia.

Material And Methods: A single group, repeated-measures study was conducted. Read More

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Human tear fluid modulates the Pseudomonas aeruginosa transcriptome to alter antibiotic susceptibility.

Ocul Surf 2021 Jul 28. Epub 2021 Jul 28.

School of Optometry, University of California, Berkeley, CA, USA; Graduate Groups in Vision Science, Microbiology, and Infectious Diseases & Immunity, University of California, Berkeley, CA, USA. Electronic address:

Purpose: Previously, we showed that tear fluid protects corneal epithelial cells against Pseudomonas aeruginosa without suppressing bacterial viability. Here, we studied how tear fluid affects bacterial gene expression.

Methods: RNA-sequencing was used to study the P. Read More

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Tear metabolomics highlights new potential biomarkers for differentiating between Sjögren's syndrome and other causes of dry eye.

Ocul Surf 2021 Jul 28. Epub 2021 Jul 28.

Mitolab, MitoVasc Institute, CNRS, 6015, INSERM U1083, University of Angers, France; Department of Biochemistry and Molecular Biology, University Hospital, Angers, France.

Purpose: The lacrimal exocrinopathy of primary Sjögren's syndrome (pSS) is one of the main causes of severe dry eye syndrome and a burden for patients. Early recognition and treatment could prevent irreversible damage to lacrimal glands. The aim of this study was to find biomarkers in tears, using metabolomics and data mining approaches, in patients with newly-diagnosed pSS compared to other causes of dry eye syndrome. Read More

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Comparison of Surgical Invasiveness and Morbidity of Adult Spinal Deformity Surgery to Other Major Operations.

Spine J 2021 Jul 28. Epub 2021 Jul 28.

Department of Orthopaedic Surgery, Och Spine Hospital, Columbia University Medical Center, New York, NY; Department of Neurological Surgery, Vanderbilt University, Nashville, TN. Electronic address:

Background Context: Adult spinal deformity (ASD) surgeries are complex, involving long operative times and surgical morbidity. It is currently unclear how the invasiveness of ASD surgery compares to other major operations.

Purpose: To: a) develop a quantitative metric of surgical morbidity and invasiveness, and b) compare this score between ASD surgery and other major operations. Read More

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Analysis of factors associated with sagittal alignment deterioration after correction of degenerative scoliosis by in situ contouring.

Orthop Traumatol Surg Res 2021 Jul 28:103023. Epub 2021 Jul 28.

Service de Chirurgie du Rachis, Hôpitaux Universitaires de Strasbourg, Fédération de Médecine Translationnelle (FMTS), Université de Strasbourg, 1 Avenue Molière, 67200 Strasbourg, France.

Introduction: In situ contouring is one of the surgical techniques used for scoliosis reduction. The initial correction could change over time, with deterioration of the sagittal balance. The purpose of this study was to analyze the loss of correction after degenerative lumbar scoliosis surgery using in situ contouring. Read More

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A comparative study on chemical compositions and biological activities of four essential oils: Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L.) Presl, Salvia japonica Thunb. and Rosa rugosa Thumb.

J Ethnopharmacol 2021 Jul 28:114472. Epub 2021 Jul 28.

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China. Electronic address:

Ethnopharmacological Relevance: Essential oils (EOs) are important active ingredients in Chinese herbal medicine. Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L. Read More

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Gender-linked determinants for utilization of long2 term care in community-dwelling adults 65+ in 3 Germany: Results from the population-based 4 KORA-Age study.

Exp Gerontol 2021 Jul 28:111500. Epub 2021 Jul 28.

Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, Germany; Quality Management and Gender Medicine, München Klinik Schwabing, Kölner Platz 1, 80804 Munich, Germany. Electronic address:

Background: The number of people using long-term care (LTC) is increasing steadily, hence, demand for adequate services is rising. The purpose of this exploratory study was to identify relevant gender-linked determinants for utilization of LTC in community-dwelling older adults.

Methods: We examined 4077 females (52. Read More

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Anterior Shoulder Instability Part I - Diagnosis, Non-Operative Management, and Bankart Repair - An International Consensus Statement.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Purpose: The purpose of this study was to establish consensus statements via a modified Delphi process on the diagnosis, non-operative management, and Bankart repair for anterior shoulder instability.

Methods: A consensus process on the treatment utilizing a modified Delphi technique was conducted, with 65 shoulder surgeons from 14 countries across 5 continents participating. Experts were assigned to one of 9 working groups defined by specific subtopics of interest within anterior shoulder instability. Read More

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Anterior Shoulder Instability Part II - Latarjet, Remplissage, and Glenoid Bone-Grafting - An International Consensus Statement.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Purpose: The purpose of this study was to establish consensus statements via a modified Delphi process on the Latarjet procedure, Remplissage, and glenoid-bone grafting for anterior shoulder instability.

Methods: A consensus process on the treatment utilizing a modified Delphi technique was conducted, with 65 shoulder surgeons from 14 countries across 5 continents participating. Experts were assigned to one of 9 working groups defined by specific subtopics of interest within anterior shoulder instability. Read More

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Anterior Shoulder Instability Part III - Revision Surgery, Rehabilitation and Return to Play, and Clinical Follow-Up - An International Consensus Statement.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Purpose: The purpose of this study was to establish consensus statements via a modified Delphi process on revision surgery, rehabilitation and return to play, and clinical follow-up for anterior shoulder instability.

Methods: A consensus process on the treatment utilizing a modified Delphi technique was conducted, with 65 shoulder surgeons from 14 countries across 5 continents participating. Experts were assigned to one of 9 working groups defined by specific subtopics of interest within anterior shoulder instability. Read More

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All-Suture Anchor Versus Intramedullary Unicortical Button for Onlay Distal Biceps Repair: A Biomechanical Comparison.

Arthroscopy 2021 Jul 28. Epub 2021 Jul 28.

Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; Department of Orthopaedic Surgery, Inova Health System, Fairfax, VA, USA.

Purpose: To evaluate the biomechanical profile of onlay distal biceps repair with an intramedullary unicortical button versus all-suture anchors under cyclic loading and maximal load to failure.

Methods: Twenty paired fresh-frozen human cadaveric elbows were randomized to onlay distal biceps repair with either a single intramedullary button or with two 1.35 mm all-suture anchors. Read More

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The neural substrate of speech act recognition.

Neuroscience 2021 Jul 28. Epub 2021 Jul 28.

Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología UNAM Campus Juriquilla, Querétaro, México. Electronic address:

Pragmatic competence demands linguistic, but also communicative, social and cognitive competence. Successful use of language in social interaction requires mutual understanding of the speaker's intentions; without it, a conversation cannot proceed. The term speech act refers to what a speaker intends to accomplish when saying something. Read More

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Seroprevalence and risk factors of toxoplasmosis among University of Kirkuk female students.

Ann Parasitol 2021 ;67(2):175-186

Department of Biology, College of Education/ Al-Hawija, University of Kirkuk, Iraq.

The study was conducted in the College of Education/Hawija, University of Kirkuk from September 1st, 2018 until the period February 28th, 2019. The first part included determine the prevalence of Toxoplasma gondii, which involved collecting blood from the female students from different stages in the different colleges of the University of Kirkuk, Kirkuk province (northeastern Iraq), ranged ˂20-24 years old. All necessary information was recorded using a questionnaire prepared for this purpose. Read More

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January 2021

Sialendoscopy: A 4-Year Single Center Experience.

J Oral Maxillofac Surg 2021 Jun 22. Epub 2021 Jun 22.

OMFS IMPATH research group, Faculty of Medicine, Clinical intern, Department of Imaging & Pathology, KU Leuven, Leuven, Belgium; Professor and Chairperson, Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Belgium.

Purpose: Sialendoscopy is a relatively new technique designed to diagnose and treat benign obstructive salivary gland disease using a minimally invasive approach. The purpose of this study is to present our experiences regarding the use of sialendoscopy in the form of a 4-year, single center experience and to demonstrate its usefulness in oral and maxillofacial practice.

Methods: We collected data on patients who underwent sialendoscopy at the Oral-Maxillofacial Surgery Department of UZ Leuven between November 2015 and August 2019, including age, gender, sex, initial clinical presentation and symptoms, gland involvement, type of diagnostic investigations, diagnosis, localization of the obstruction, therapeutic intervention, surgeon, type of anesthesia, materials used, complications, secondary treatment, duration of follow-up, and outcome. Read More

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Novel Prediction Models for Patients With Oral Squamous Cell Carcinoma at Different Anatomical Sites.

J Oral Maxillofac Surg 2021 Jun 22. Epub 2021 Jun 22.

Professor, Department of Orthodontics, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China; Professor, Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China. Electronic address:

Purpose: The individualized prediction of oral cavity squamous cell carcinoma (OC-SCC) is essential and should be as comprehensive as possible. The aim of this study was to identify new risk factors and develop nomograms comparing all anatomic sites of the oral cavity.

Materials And Methods: We performed a retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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An investigation into the effects of ocular nebulization combined with meibomian gland massage on ocular surface status and corneal higher-order aberrations for the treatment of meibomian gland dysfunction.

Acta Ophthalmol 2021 Jul 31. Epub 2021 Jul 31.

Department of Ophthalmology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Purpose: To evaluate ocular surface status and corneal higher-order aberrations after a new ocular nebulization therapy combined with meibomian gland massage for the treatment of meibomian gland dysfunction (MGD).

Patients And Methods: This prospective randomized study involved 38 patients diagnosed with MGD. Subjects were classified into two groups: the nebulization and meibomian gland massage group (or NB group, 14 patients, 28 eyes) and the eye drop group (or ED group, 24 patients, 48 eyes). Read More

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Synthesis, characterization, and evaluation of curcumin-loaded endodontic reparative material.

J Biochem Mol Toxicol 2021 Jul 31:e22854. Epub 2021 Jul 31.

Stem Cell Research Center and Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Curcumin (CUR) is an ancient therapeutic agent with remarkable antimicrobial and anti-inflammatory properties. The purpose of the current study was to synthesize and evaluate a curcumin-based reparative endodontic material to reduce infection and inflammation besides the induction of mineralization during the healing of the dentin-pulp complex. Poly-ɛ-caprolactone (PCL)/gelatin (Gel)/CUR scaffold was synthesized and assessed by scanning electron microscopy, Fourier transform infrared spectroscopy, and thermo-gravimetric analysis (TGA). Read More

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