Chem Rec 2021 Nov 28;21(11):2958-2979. Epub 2021 Oct 28.
School of Biological and Chemical Sciences, NUI Galway, University Road, Galway, H91 TK33, Ireland.
This personal account focuses on synthesis of polyhydroxylated piperidines, a subset of compounds within the iminosugar family. Cyclisations to form the piperidine ring include reductive amination, substitution via amines, iminium ions and cyclic nitrones, transamidification (N-acyl transfer), addition to alkenes, ring contraction and expansion, photoinduced electron transfer, multicomponent Ugi reaction and ring closing metathesis. Enantiomerically pure piperidines are obtained from chiral pool precursors (e. Read More