Neurology 2021 May 4. Epub 2021 May 4.
Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA.
Objective: To test the hypothesis that fundamental relationships along the amyloid, tau, and neurodegeneration (A/T/N) cascade depend on synaptic integrity in older adults and postmortem.
Methods: Two independent observational, cross-sectional cohorts: 1) community-dwelling, clinically normal adults from the UCSF Memory and Aging Center completed lumbar puncture and MRI (exclusion criteria, CDR>0), and 2) postmortem decedents from the Rush Memory and Aging Project (exclusion criteria, inability to sign informed consent). measures included cerebrospinal fluid (CSF) synaptic proteins (synaptotagmin-1, SNAP-25, neurogranin, and GAP-43), Aβ, ptau and MRI gray matter volume (GMV). Read More