3,598 results match your criteria pulse separation

Assessment of multi-energy inter-pixel coincidence counters for photon counting detectors at the presence of charge sharing and pulse pileup: a simulation study.

Med Phys 2021 Jul 20. Epub 2021 Jul 20.

Independent consultant, Los Angeles, California, 90049, USA.

Purpose: Spectral distortion due to charge sharing (CS) and pulse pileup (PP) in photon counting detectors (PCDs) degrades the quality of PCD data. We recently proposed multi-energy inter-pixel coincidence counters (MEICC) that provided spectral cross-talk information related to CS. When PP was absent, the normalized Cramér-Rao lower bounds (nCRLBs) of 225-µm pixel PCDs with MEICC was comparable to those of 450-µm pixel PCD without MEICC. Read More

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Improved Voltammetric Determination of Kynurenine at the Nafion Covered Glassy Carbon Electrode - Application in Samples Delivered from Human Cancer Cells.

Int J Tryptophan Res 2021 30;14:11786469211023468. Epub 2021 Jun 30.

Laboratory of Separation and Spectroscopic Method Applications, Centre for Interdisciplinary Research, Faculty of Science and Health, The John Paul II Catholic University of Lublin, Lublin, Poland.

Nowadays, development of analytical methods responding to a need for rapid and accurate determination of human metabolites is highly desirable. Herein, an electrochemical method employing a Nafion-coated glassy carbon electrode (Nafion/GCE) has been developed for reliable determination of kynurenine (a key tryptophan metabolite) using a differential pulse adsorptive stripping voltammetry. To our knowledge, this is the first analytical method to allow for kynurenine determination at the Nafion-coated electrode. Read More

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Clinical impact of MultiPoint pacing in responders to cardiac resynchronization therapy.

Pacing Clin Electrophysiol 2021 Jul 13. Epub 2021 Jul 13.

Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.

Background: Cardiac resynchronization therapy demonstrated benefits in heart failure. However, only 60-70% are responders and only 22% are super-responders. MultiPoint pacing (MPP) improves structural remodeling, but data in responder patients is scarce. Read More

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Xenon diffusion in ionic liquids with blurred nanodomain separation.

Chemphyschem 2021 Jul 12. Epub 2021 Jul 12.

Politecnico di Milano, Department of Chemistry, Materials and Chemical Engineering, p.za L. da Vinci, 32, Milano, ITALY.

The dynamics of xenon gas, loaded in in a series of 1-alkyl-3-methylimidazolium  based  ionic liquids,  probes the formation of increasingly blurred polar/apolar nanodomains as function of the anion type and cations' chain length. Exploiting 129Xe NMR spectroscopy techniques, like Pulse Gradient Spin Echo (PGSE) and inversion recovery (IR), the diffusion motion and relaxation times are determined for 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [CnC1im][TFSI]. A correlation between the ILs nano-structure and both xenon diffusivity and relaxation times, as well as chemical shifts,  is outlined. Read More

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A dual high-energy radiography platform with 15 μm resolution at the National Ignition Facility.

Rev Sci Instrum 2021 Apr;92(4):043712

Lawrence Livermore National Laboratory, Livermore, California 94550, USA.

To study matter at extreme densities and pressures, we need mega laser facilities such as the National Ignition Facility as well as creative methods to make observations during timescales of a billionth of a second. To facilitate this, we developed a platform and diagnostic to characterize a new point-projection radiography configuration using two micro-wires irradiated by a short pulse laser system that provides a large field of view with up to 3.6 ns separation between images. Read More

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Real-time signal processing system based on FPGA for motional Stark effect diagnostic on EAST.

Rev Sci Instrum 2021 May;92(5):055105

Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031, Anhui, China.

The plasma current density profile plays a key role in the development of a high poloidal beta scenario, which is essential for long-pulse and high-performance plasma operation on a tokamak. Based on the polarimetry technique, a Motional Stark Effect (MSE) diagnostic has been built on the Experimental Advanced Superconducting Tokamak. To be prepared for real-time (RT) feedback control of the plasma current density profile in the future, a RT signal processing system has been developed. Read More

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An UPLC - Q - Orbitrap method for pharmacokinetics and tissue distribution of four triterpenoids in rats after oral administration of Poria cocos ethanol extracts.

J Pharm Biomed Anal 2021 Sep 2;203:114237. Epub 2021 Jul 2.

School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Education Office of Anhui Province, Hefei, 230012, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, 230012, China; Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei, 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, 230012, China. Electronic address:

Poria cocos (Schw.) Wolf, is a fungus that is widely used as medicine and dietary supplement in China. But its action mechanism is still not very clear. Read More

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September 2021

[Integrated multi-column two-dimensional liquid chromatographic system for determination of amisulpride in serum].

Se Pu 2021 Feb;39(2):197-202

Dalian Elite Analytical Instruments Co., Ltd., Dalian 116023, China.

Amisulpride is a clinically effective antipsychotic drug. It has been recommended for therapeutic drug monitoring in . An integrated multicolumn two-dimensional liquid chromatography system was constructed. Read More

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February 2021

[Mass transport properties and applications of nanochannels].

Se Pu 2020 Oct;38(10):1189-1196

School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

With the development of materials science, micro/nano processing technologies, and mass transport theories at the micro/nano scale, nanochannel-based technology has been receiving increasing attention. Nanochannels can be classified as biological and artificial. The size of a nanochannel is typically 1-100 nm, which greatly enhances the interaction between the channel surface and substances inside the channel, inducing several special mass transport properties such as ion selectivity, ionic current rectification, and resistive current pulse. Read More

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October 2020

[Research progress on analysis of human papillomavirus by microchip capillary electrophoresis].

Se Pu 2020 Oct;38(10):1179-1188

Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084, China.

Human papillomavirus (HPV), is a common spherical DNA virus that can lead to six types of cancers later in life, which has recently garnered human's attention. Microchip capillary electrophoresis (MCE) has provided simple, fast, portable, and sensitive HPV typing assay assisted by a variety of signal amplification technologies. This review presents the latest research progress of MCE in routine HPV typing assays, including both of the MCE techniques and MCE combined with the nucleic acid amplification techniques for HPV assay. Read More

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October 2020

Dedicated Algorithm for Unobtrusive Fetal Heart Rate Monitoring Using Multiple Dry Electrodes.

Sensors (Basel) 2021 Jun 23;21(13). Epub 2021 Jun 23.

Department of Electrical Engineering, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.

Multi-channel measurements from the maternal abdomen acquired by means of dry electrodes can be employed to promote long-term monitoring of fetal heart rate (fHR). The signals acquired with this type of electrode have a lower signal-to-noise ratio and different artifacts compared to signals acquired with conventional wet electrodes. Therefore, starting from the benchmark algorithm with the best performance for fHR estimation proposed by Varanini et al. Read More

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Ratiometric photon reassignment based on fluorescence lifetime to improve resolution in pulse STED microscopy.

Opt Lett 2021 Jul;46(13):3304-3307

Depletion beams with long pulse durations (∼600) have recently been applied in stimulated emission depletion (STED) microscopy to reduce photobleaching and phototoxicity. Therefore, improving the resolution of pulse STED at lower depletion power for the super-resolution imaging of live biological specimens has attracted increasing interest. Herein, we present a simple method termed ratiometric photon reassignment based on the fluorescence lifetime, in which highly spatially resolved long-lifetime fluorophore components in the center are extracted, and short-lifetime fluorophore components in the periphery are discarded to improve resolution without increasing the depletion power. Read More

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Infants' stress responses and protest behaviors at childcare entry and the role of care providers.

Dev Psychobiol 2021 Jul 1. Epub 2021 Jul 1.

University of Cambridge, Cambridge, UK.

During the transition from home to childcare, 70 15-month-old infants were videotaped, and their negative emotions were rated. Infants' attachments to mothers were assessed prior to child care entry and to care providers five months later using the Strange Situation Procedure (SSP). Infant heart rate was monitored at home, during adaptation to childcare (mothers present), and during subsequent separations. Read More

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Optically Induced Coherent Phonons in Bismuth Oxyiodide (BiOI) Nanoplatelets.

Nano Lett 2021 Jun 30. Epub 2021 Jun 30.

Chair for Photonics and Optoelectronics, Nano-Institute Munich, Department of Physics, Ludwig-Maximilians-Universität (LMU), Königinstraße 10, 80539 Munich, Germany.

Bismuth oxyiodide (BiOI) is a promising material for photocatalysis combining intriguing optical and structural properties. We show that excitation by a femtosecond laser pulse creates coherent phonons inducing a time-variant oscillating modulation of the optical density. We find that the two underlying frequencies originate from lattice vibrations along the [001] crystallographic axis, the stacking direction of oppositely charged layers in BiOI. Read More

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Pharmacokinetic and tissue distribution study of ZCY-15, a novel compound against Alzheimer's disease, in rats by liquid chromatography-tandem mass spectrometry.

Eur J Pharm Sci 2021 Sep 24;164:105917. Epub 2021 Jun 24.

Department of Pharmacy, The First Hospital of China Medical University, Nanjing Street No.155, Heping District, Shenyang City 110001, Liaoning, China. Electronic address:

ZCY-15, N-(3,5-dimethyladamatan-1-yl)-N-(3-methylphenyl) urea, is a candidate compound synthesized from the memantine structure and has been shown to be remarkably effective in treating Alzheimer's disease. To elucidate the pharmacokinetics and tissue distribution of ZCY-15 in rats after oral and intravenous administration, a rapid and selective LC-MS/MS method was established for the determination of ZCY-15 in rat plasma and tissues. According to the dissolution characteristics, the plasma samples were prepared by acetonitrile protein precipitation and carbamazepine was selected as the internal standard (IS). Read More

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September 2021

ResNet and CycleGAN for pulse shape discrimination of He-4 detector pulses: Recovering pulses conventional algorithms fail to label unanimously.

Appl Radiat Isot 2021 Jun 9;176:109819. Epub 2021 Jun 9.

Nuclear Engineering Program, University of Florida, Gainesville, FL, 32611, USA.

Pulse shape discrimination (PSD) capable detectors, such as He-4, that respond to neutron and gamma-ray interactions have a threshold deposited energy value below which n/γ discrimination vanishes when using conventional PSD algorithms. Recent attempts in applying supervised learning based artificial neural networks for PSD use the pulses in the separated regions to train the networks so they can be used to classify another set of separated pulses. In doing so, pulses previously indistinguishable are not recovered for classification, which would have increased the number of neutron and gamma-ray pulses that could be used for further analysis. Read More

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Evolution of the Laser-Induced Spallation Technique in Film Adhesion Measurement.

Appl Mech Rev 2021 May 28;73(3):030802. Epub 2021 Apr 28.

Department of Mechanical Engineering, University of Kentucky, Lexington, KY 40506.

Laser-induced spallation is a process in which a stress wave generated from a rapid, high-energy laser pulse initiates the ejection of surface material opposite the surface of laser impingement. Through knowledge of the stress-wave amplitude that causes film separation, the adhesion and interfacial properties of a film-on-substrate system are determined. Some advantages of the laser spallation technique are the noncontact loading, development of large stresses (on the order of GPa), and high strain rates, up to 10/s. Read More

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Nonlinear polarization interferometer for enhancement of laser pulse contrast and power.

Efim Khazanov

Opt Express 2021 May;29(11):17277-17285

A method for enhancing the temporal contrast of high-power femtosecond laser pulses is proposed. The suppression of low-intensity radiation and the simultaneous 100% transmission of a pulse peak are attained due to the nonlinear phase difference π between the orthogonally polarized waves, leading to a 90-degree rotation of polarization. The polarization interferometer has an in-line geometry that does not demand spatial beam separation. Read More

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Correcting physiological noise in whole-head functional near-infrared spectroscopy.

J Neurosci Methods 2021 Jun 17;360:109262. Epub 2021 Jun 17.

Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA; Institute for Biomedical Engineering, Science and Technology, University of Oklahoma, Norman, OK, USA. Electronic address:

Background: Functional near-infrared spectroscopy (fNIRS) has been increasingly employed to monitor cerebral hemodynamics in normal and diseased conditions. However, fNIRS suffers from its susceptibility to superficial activity and systemic physiological noise. The objective of the study was to establish a noise reduction method for fNIRS in a whole-head montage. Read More

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Magnetic Array Assisted Triboelectric Nanogenerator Sensor for Real-Time Gesture Interaction.

Nanomicro Lett 2021 Jan 5;13(1):51. Epub 2021 Jan 5.

Department of Applied Physics, State Key Laboratory of Power Transmission Equipment & System Security and New Technology, Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, Chongqing University, Chongqing, 400044, People's Republic of China.

In human-machine interaction, robotic hands are useful in many scenarios. To operate robotic hands via gestures instead of handles will greatly improve the convenience and intuition of human-machine interaction. Here, we present a magnetic array assisted sliding triboelectric sensor for achieving a real-time gesture interaction between a human hand and robotic hand. Read More

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January 2021

One-Step Preparation of Robust Superhydrophobic Foam for Oil/Water Separation by Pulse Electrodeposition.

Langmuir 2021 Jun 3;37(23):7043-7054. Epub 2021 Jun 3.

College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.

Frequent leakage and pollution of oily wastewater seriously affect the world's ecosystem safety and economic development, which prompts us to urgently develop a highly effective, low-cost, wear-resistant, chemically stable, and environmentally friendly new functional material for oil/water separation. In this paper, a robust superhydrophobic material was successfully electrodeposited on the porous copper foam substrates in myristic acid (CH(CH)COOH) and lanthanum chloride (LaCl·6HO) electrodeposition solution under a continuous pumping circulation and rotation condition. Moreover, SEM, EDS, XRD, FTIR, and XPS technologies were utilized to characterize the surface morphology and chemical composition information. Read More

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A screen printed electrode modified with [email protected] core-shell nanoparticles for electrochemical detection of 6-mercaptopurine and 6-thioguanine.

Talanta 2021 Sep 20;232:122379. Epub 2021 Apr 20.

Department of Materials Science and Engineering, Research Institute of Advanced Materials, Seoul National University, Seoul, 08826, Republic of Korea. Electronic address:

In this paper, [email protected] core-shell nanoparticles (NPs) could be produced and utilized for the development of a novel electrochemical sensor to detect 6-mercaptopurine (6-MP). 6-MP determination was examined by cyclic voltammetry (CV), chronoamperometry (CHA), linear sweep voltammetry (LSV), and differential pulse voltammetry (DPV) at [email protected] core-shell NPs modified screen printed electrode ([email protected]/SPE) in phosphate buffered solution (PBS). The outcomes obtained from DPV demonstrated that the [email protected]/SPE proved a linear concentration range among 0. Read More

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September 2021

Graphene Nanoribbon Gap Waveguides for Dispersionless and Low-Loss Propagation with Deep-Subwavelength Confinement.

Nanomaterials (Basel) 2021 May 14;11(5). Epub 2021 May 14.

Shenzhen Key Laboratory of Laser Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

Surface plasmon polaritons (SPPs) have been attracting considerable attention owing to their unique capabilities of manipulating light. However, the intractable dispersion and high loss are two major obstacles for attaining high-performance plasmonic devices. Here, a graphene nanoribbon gap waveguide (GNRGW) is proposed for guiding dispersionless gap SPPs (GSPPs) with deep-subwavelength confinement and low loss. Read More

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Phototherapy Using a Light-Emitting Fabric (BUBOLight) Device in the Treatment of Newborn Jaundice: Protocol for an Interventional Feasibility and Safety Study.

JMIR Res Protoc 2021 May 25;10(5):e24808. Epub 2021 May 25.

EA4489, Perinatal Growth and Health, Jeanne de Flandre Hospital, Department of Obstetrics, Univ- Lille, CHU Lille, F-59000 Lille, France.

Background: Neonatal jaundice is a common condition occurring in 60%-80% of all healthy-term and late-preterm neonates. In the majority of cases, neonatal jaundice resolves spontaneously and causes no harm; however, in some neonates, significant hyperbilirubinemia can develop and lead to kernicterus jaundice, a serious neurological disease. Phototherapy (PT) is the preferred treatment for jaundice; however, to be effective, PT devices need to have a broad light emission surface to generate no or little heat and to provide an optimal wavelength and light intensity (420-490 nm and ≥30 µW/cm²/nm, respectively). Read More

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Enzyme pre-milling treatments improved milling performance of chickpeas by targeting mechanisms of seed coat and cotyledon adhesion with various effects on dhal quality.

J Sci Food Agric 2021 May 25. Epub 2021 May 25.

University of New England, Armidale, NSW, Australia.

Background: Dehulling and splitting are important elements of the milling process to produce dhal from pulses. However, grain that is difficult-to-mill because of tightly adhered seed coats or cotyledons that resist separation makes it difficult to achieve high quality dhal. Milling yields are reduced, energy inputs into the milling process are increased, and the resulting dhal can be of poorer quality, chipped or abraded. Read More

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1-Year Results From the RANGER II SFA Randomized Trial of the Ranger Drug-Coated Balloon.

JACC Cardiovasc Interv 2021 May;14(10):1123-1133

Department of Angiology, Universitäts-Herzzentrum Freiberg-Bad Krozingen, Bad Krozingen, Germany.

Objectives: This study sought to evaluate the safety and effectiveness of the Ranger drug-coated balloon (DCB) (paclitaxel dose density 2 μg/mm) for treating superficial femoral artery or proximal popliteal artery lesions.

Background: Paclitaxel-coated balloon treatment prevents reinterventions, but dose and coating characteristics differ among balloons and necessitate discrete confirmation of safety and effectiveness.

Methods: Patients with symptomatic lower limb ischemia (Rutherford classification 2 to 4) were randomized 3:1 to treatment with the Ranger DCB or standard percutaneous transluminal angioplasty (PTA). Read More

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Ginsenoside Contents in Ginseng: Quality by Design-Coupled Two-Dimensional Liquid Chromatography Technique.

J Chromatogr Sci 2021 May 19. Epub 2021 May 19.

The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Red ginseng and white ginseng, with different chemical constituents, exhibit different antioxidative, anticancer, antiasthmatic and immunomodulatory properties. The aim of this study was to determine the amount of ginsenoside contents (Rg1, Re, Rb1, Rb2, Rc, Rd and Ro) in red and white ginseng. A rapid and comprehensive method was developed using the quality-by-design (QbD) and heart-cutting two-dimensional liquid chromatography (2D-LC) techniques. Read More

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Exploring physiological stability of infants in Kangaroo Mother Care position versus placed in transport incubator during neonatal ground ambulance transport in Sweden.

Scand J Caring Sci 2021 May 18. Epub 2021 May 18.

Department of Health Sciences, Lund University, Lund, Sweden.

Background: The positive effects of Kangaroo mother care in NICU's are well documented but, to a lesser extent, explored during inter-hospital neonatal transport. Inter-hospital transport, with the infant placed in a transport incubator, increases the risk of separation while infants in Kangaroo mother care position implies that the parents accompany the transport. There exists limited knowledge if physiological stability differs when transported in Kangaroo mother care position compared to transport in a transport incubator. Read More

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Lower-body dynamic exercise reduces wave reflection in healthy young adults.

Exp Physiol 2021 May 17. Epub 2021 May 17.

Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, USA.

New Findings: What is the central question of this study? There is a paradoxical reduction in augmentation index during lower-body dynamic (LBD) exercise in the face of an increase in central pressure. To determine causality, the amplitudes of forward and backward pressure waves were assessed separately using wave separation analysis. What is the main finding and its importance? Reflection magnitude decreased during LBD exercise in healthy young adults and was attributable to an increased forward pressure wave amplitude and decreased backward pressure wave amplitude. Read More

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