20,186 results match your criteria pulse complex

Rationale and Design of a Randomized Study Comparing the Agent Drug Coated Balloon to Plain Old Balloon Angioplasty in Patients with In-Stent Restenosis.

Am Heart J 2021 Jul 24. Epub 2021 Jul 24.

Columbia University Irving Medical Center/NewYork-Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY, USA.

Background: Drug-coated balloon (DCB) technology was developed as an alternative treatment for obstructive coronary artery disease (CAD) and in-stent restenosis (ISR). Management of coronary ISR is clinically challenging and frequently encountered in practice. The Agent DCB uses an inactive excipient to effectively deliver a targeted, therapeutic dose of paclitaxel to the vessel wall. Read More

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Defect-Driven Oxide Transformations and the Electrochemical Interphase.

Acc Chem Res 2021 Jul 23. Epub 2021 Jul 23.

ConspectusThe redox reaction pathway is crucial to the sustainable production of the fuels and chemicals required for a carbon-neutral society. Our society is becoming increasingly dependent on devices using batteries and electrolyzers, all of which rely on a series of redox reactions. The overall properties of oxide materials make them very well suited for such electrochemical and catalytic applications due to their associated cationic redox properties and the static site-adsorbate interactions. Read More

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Intranasal dexmedetomidine: the ideal drug for sedation in the pediatric echo lab?

Cardiol Young 2021 Jul 23:1-5. Epub 2021 Jul 23.

Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Background: Intranasal dexmedetomidine is an attractive option for procedural sedation in pediatrics due to ease of administration and its relatively short half-life. This study sought to compare the safety and efficacy of intranasal dexmedetomidine to a historical cohort of pediatric patients sedated using chloral hydrate in a pediatric echo lab.

Methods: Chart review was performed to compare patients sedated between September, 2017 and October, 2019 using chloral hydrate and intranasal dexmedetomidine. Read More

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LncRNA HCP5 in hBMSC-derived exosomes alleviates myocardial ischemia reperfusion injury by sponging miR-497 to activate IGF1/PI3K/AKT pathway.

Int J Cardiol 2021 Jul 23. Epub 2021 Jul 23.

Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210000, Jiangsu Province, PR China. Electronic address:

Ischemia/reperfusion (I/R) injury is an inevitable process during heart transplant and suppressing I/R injury could greatly improve the survival rate of recipients. Mesenchymal stem cells (MSCs) have positive effects on I/R. We aimed to investigate the mechanisms underlying the protective roles of MSCs in I/R. Read More

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Micro-RNA 133a-3p induces repolarization abnormalities in atrial myocardium and modulates ventricular electrophysiology affecting I and Ito currents.

Eur J Pharmacol 2021 Jul 23:174369. Epub 2021 Jul 23.

Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Heart Embryology and Anatomy Research Team, Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland.

Mir-133a-3p is the most abundant myocardial microRNA. The impact of mir-133a-3p on cardiac electrophysiology is poorly explored. In this study, we investigated the effects of mir-133a-3p on the main ionic currents critical for action potential (AP) generation and electrical activity of the heart. Read More

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The association between sleep quality, health status, and disability due to breathlessness in COPD patients.

Clin Respir J 2021 Jul 26. Epub 2021 Jul 26.

MD, Department of Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Chronic obstructive pulmonary disease (COPD) increases susceptibility to sleep disturbances. This study aimed to evaluate the association between COPD severity criteria with sleep quality.

Methods: 158 patients in Rasul Akram Hospital of Iran university of medical sciences, Tehran, Iran, from April 2019 to March 2021 diagnosed with COPD were examined using the Pittsburgh Sleep Quality Index (PSQI), COPD assessment test (CAT), modified Medical Research Council (mMRC) dyspnea scale, spirometry, and pulse oximetry. Read More

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Coherent Excitation and Control of Plasmons on Gold Using Two-Dimensional Transition Metal Dichalcogenides.

ACS Photonics 2021 Jun 26;8(6):1607-1615. Epub 2021 May 26.

Department of Physics, Lund University, Box 118, 22100 Lund, Sweden.

The hybrid combination of two-dimensional (2D) transition metal dichalcogenides (TMDs) and plasmonic materials open up novel means of (ultrafast) optoelectronic applications and manipulation of nanoscale light-matter interaction. However, control of the plasmonic excitations by TMDs themselves has not been investigated. Here, we show that the ultrathin 2D WSe crystallites permit nanoscale spatially controlled coherent excitation of surface plasmon polaritons (SPPs) on smooth Au films. Read More

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Catheter ablation of complex cardiac arrhythmias: Single-centre experience in Armed Forces.

Med J Armed Forces India 2021 Jul 24;77(3):312-321. Epub 2021 Mar 24.

Director General Armed Forces Medical Services & Senior Colonel Commandant, O/o DGAFMS, MOD, 'M' Block, New Delhi, India.

Background: Complex arrhythmia ablation remains a technical challenge despite advances in hardware and mapping techniques. The aim of the study was to analyse the efficacy of radiofrequency ablation of arrhythmias requiring complex electrophysiological procedures at a tertiary-care centre.

Methods: A retrospective study was done for catheter ablation of arrhythmias performed at a single centre from Aug 2012 to Nov 2016 (4 years 4 months). Read More

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Rat model of smoke inhalation-induced acute lung injury.

BMJ Open Respir Res 2021 Jul;8(1)

Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA

Background: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a lethal disease with limited therapeutic options and an unacceptably high mortality rate. Understanding the complex pathophysiological processes involved in the development of ALI/ARDS is critical for developing novel therapeutic strategies. Smoke inhalation (SI) injury is the leading cause of morbidity and mortality in patients with burn-associated ALI/ARDS; however, to our knowledge few reliable, reproducible models are available for pure SI animal model to investigate therapeutic options for ALI/ARDS without the confounding variables introduced by cutaneous burn or other pathology. Read More

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[Effect of high-flow nasal cannula oxygen on patients with chronic obstructive pulmonary disease and mild hypercapnia: a retrospective cohort study based on the Medical Information Mart for Intensive Care-IV database].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jun;33(6):686-691

Department of Medical ICU, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China. Corresponding author: Du Bin, Email:

Objective: To observe the effect of high-flow nasal cannula oxygen therapy (HFNC) in patients with chronic obstructive pulmonary disease (COPD) and mild hypercapnia, and to evaluate the early predictive ability of physiological parameters in these patients.

Methods: A retrospective cohort study was conducted based on Medical Information Mart for Intensive Care-IV (MIMIC-IV) updated in September 2020 and the data of adult patients with COPD and mild hypercapnia [45 mmHg (1 mmHg = 0.133 kPa) < arterial partial pressure of carbon dioxide (PaCO) ≤ 60 mmHg] from 2008 to 2019 were collected. Read More

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Low-Power Laser Ignition of an Antenna-Type Secondary Energetic Copper Complex: Synthesis, Characterization, Evaluation, and Ignition Mechanism Studies.

Inorg Chem 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry, Ludwig Maximilian University Munich, München 81377, Germany.

In recent years, development of new energetic compounds and formulations, suitable for ignition with relatively low-power lasers, is a highly active and competitive field of research. The main goal of these efforts is focused on achieving and providing much safer solutions for various detonator and initiator systems. In this work, we prepared, characterized, and studied thermal and ignition properties of a new laser-ignitable compound, based on the 5,6-bis(ethylnitroamino)-'2,'3-dihydroxypyrazine-2,3-bis(carboximidamide) (DS3) proligand. Read More

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Elucidating the Role of Halides and Iron during Radiolysis-Driven Oxidative Etching of Gold Nanocrystals Using Liquid Cell Transmission Electron Microscopy and Pulse Radiolysis.

J Am Chem Soc 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry, University of California-Berkeley, Berkeley, California 94720, United States.

Graphene liquid cell transmission electron microscopy (TEM) has enabled the observation of a variety of nanoscale transformations. Yet understanding the chemistry of the liquid cell solution and its impact on the observed transformations remains an important step toward translating insights from liquid cell TEM to benchtop chemistry. Gold nanocrystal etching can be used as a model system to probe the reactivity of the solution. Read More

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Discriminationof PHIP signals through their evolution in multipulse sequences.

Chemphyschem 2021 Jul 21. Epub 2021 Jul 21.


The antiphase character of the PHIP associated signals after a hydrogenation reaction is particularly sensitive to line broadening introduced by magnetic field inhomogeneities and interferences by the presence resonance lines steaming from a large amount of thermally polarized spins. These obstacles impose a limitation in the detection of reaction products as well as in the experimental setups. A simple way to overcome these impediments consists of acquiring the signal with a train of refocusing pulses instead of a single r. Read More

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The diagnostic challenge of acute Q fever endocarditis.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Internal Medicine Department, Hospital de Santa Marta - Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal.

A 79-year-old man was admitted to our ward with symptomatic heart failure 2 months after aortic valve replacement due to severe aortic stenosis. On the third day following admission, he became febrile (>38°C) while manifesting an increase in inflammatory markers. Endocarditis was suspected despite negative blood cultures. Read More

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First-in-Human Clinical Application of the Medyria TrackCath System in Endovascular Repair of Complex Aortic Aneurysms (ACCESS Trial): A Prospective Multicenter Single-Arm Clinical Trial.

J Endovasc Ther 2021 Jul 21:15266028211030536. Epub 2021 Jul 21.

Department of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Germany.

Purpose: The Medyria TrackCath Catheter (MedTCC) is an innovative, thermal convection-based blood flow velocity (BFV) tracking catheter that may be used during complex aortic endovascular procedures for identification and catheterization of target orifices. The ACCESS Trial analyzes the safety and performance of the MedTCC for targeted vessel catheterization to generally evaluate the feasibility of thermal convection-based BFV.

Materials And Methods: We performed a first-in-human, proof-of-concept, prospective single-arm multicenter clinical trial between March 2018 and February 2019 in patients who underwent endovascular aortic procedures at 4 high-volume centers. Read More

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CTP and coordinate ParB partition complex dynamics and ParA-ATPase activation for ParABS-mediated DNA partitioning.

Elife 2021 Jul 21;10. Epub 2021 Jul 21.

NIDDK/NIH, Bethesda, United States.

ParABS partition systems, comprising the centromere-like DNA sequence the -binding ParB-CTPase and the nucleoid-binding ParA-ATPase, ensure faithful segregation of bacterial chromosomes and low-copy-number plasmids. F-plasmid partition complexes containing ParB and move by generating and following a local concentration gradient of nucleoid-bound ParA. However, the process through which ParB activates ParA-ATPase has not been defined. Read More

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Elastic and Stretchable Double Network Hydrogel as Printable Ink for High-Resolution Fabrication of Ionic Skin.

Int J Bioprint 2021 25;7(3):377. Epub 2021 Jun 25.

Key State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian, 116024, P.R. China.

A hydrogel that combines both printability and adaptability, high elasticity, and stretchability can provide ideal mechanical properties, and also render complex and accurate construction for ionic skin. However, it is extremely challenging. Here, we propose a colloidal-based double-network (DN) hydrogel as printable inks for high-precision fabrication of ionic skins. Read More

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The Long-lived Protein Degradation Assay: an Efficient Method for Quantitative Determination of the Autophagic Flux of Endogenous Proteins in Adherent Cell Lines.

Bio Protoc 2018 May 5;8(9):e2836. Epub 2018 May 5.

The Autophagy Team, Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway.

Autophagy is a key player in the maintenance of cellular homeostasis in eukaryotes, and numerous diseases, including cancer and neurodegenerative disorders, are associated with alterations in autophagy. The interest for studying autophagy has grown intensely in the last two decades, and so has the arsenal of methods utilised to study this highly dynamic and complex process. Changes in the expression and/or localisation of autophagy-related proteins are frequently assessed by Western blot and various microscopy techniques. Read More

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Assessing Prepulse Inhibition of Startle in Mice.

Bio Protoc 2018 Apr 5;8(7):e2789. Epub 2018 Apr 5.

INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.

Animal models are an important tool for studying neuropsychiatric disorders. However, a major challenge for researchers working with laboratory rodents is trying to reproduce 'core' symptoms of complex human disorders such as schizophrenia. Despite this challenge, however, it is still conceivable to use animal models designed to reproduce some of the disease's 'endo-phenotypes'. Read More

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Repurposing colchicine's journey in view of drug-to-drug interactions. A review.

Toxicol Rep 2021 9;8:1389-1393. Epub 2021 Jul 9.

Department of Cardiology, General Hospital of Athens "G.Gennimatas", Athens, Greece.

Colchicine's medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. Read More

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Desmin Correlated with Cx43 May Facilitate Intercellular Electrical Coupling during Chronic Heart Failure.

Evid Based Complement Alternat Med 2021 3;2021:6621132. Epub 2021 Jul 3.

Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.

Desmin is one of five major intermediate filament proteins in cardiomyocytes. Desmin contributes to the maintenance of healthy muscle. The desmin content in cardiomyocytes directly affects the long-term prognosis of patients with heart failure, and lack of desmin leads to myocyte contractile dysfunction. Read More

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Infrared chemical imaging through non-degenerate two-photon absorption in silicon-based cameras.

Light Sci Appl 2020 Jul 20;9(1):125. Epub 2020 Jul 20.

Department of Chemistry, University of California, Irvine, CA, 92697, USA.

Chemical imaging based on mid-infrared (MIR) spectroscopic contrast is an important technique with a myriad of applications, including biomedical imaging and environmental monitoring. Current MIR cameras, however, lack performance and are much less affordable than mature Si-based devices, which operate in the visible and near-infrared regions. Here, we demonstrate fast MIR chemical imaging through non-degenerate two-photon absorption (NTA) in a standard Si-based charge-coupled device (CCD). Read More

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Understanding Reaction Networks through Controlled Approach to Equilibrium Experiments Using Transient Methods.

J Am Chem Soc 2021 Jul 19;143(29):10998-11006. Epub 2021 Jul 19.

Biological and Chemical Science and Engineering Department, Idaho National Laboratory, Idaho Falls, Idaho 83415, United States.

We report a combined experimental/theoretical approach to studying heterogeneous gas/solid catalytic processes using low-pressure pulse response experiments achieving a controlled approach to equilibrium that combined with quantum mechanics (QM)-based computational analysis provides information needed to reconstruct the role of the different surface reaction steps. We demonstrate this approach using model catalysts for ammonia synthesis/decomposition. Polycrystalline iron and cobalt are studied via low-pressure TAP (temporal analysis of products) pulse response, with the results interpreted through reaction free energies calculated using QM on Fe-BCC(110), Fe-BCC(111), and Co-FCC(111) facets. Read More

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Acute Effects of Pimobendan on Cardiac Function in Dogs With Tachycardia Induced Dilated Cardiomyopathy: A Randomized, Placebo-Controlled, Crossover Study.

Front Vet Sci 2021 1;8:646437. Epub 2021 Jul 1.

QTest Labs, Columbus, OH, United States.

Pimobendan provides a significant survival benefit in dogs with cardiac disease, including degenerative mitral valve disease and dilated cardiomyopathy (DCM). Its positive inotropic effect is well-known, however, it has complex effects and the mechanisms behind the survival benefit are not fully characterized. Secondary hemodynamic effects may decrease mitral regurgitation (MR) in DCM, and the benefits of pimobendan may extend to improved cardiac relaxation and improved atrial function. Read More

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Transport phenomena in complex systems (part 1).

Philos Trans A Math Phys Eng Sci 2021 Sep 19;379(2205):20200301. Epub 2021 Jul 19.

Department of Theoretical and Mathematical Physics, Laboratory of Multi-Scale Mathematical Modeling, Ural Federal University, Ekaterinburg, 620000, Russian Federation.

The issue, in two parts, is devoted to theoretical, computational and experimental studies of transport phenomena in various complex systems (in porous and composite media; systems with physical and chemical reactions and phase and structural transformations; in biological tissues and materials). Various types of these phenomena (heat and mass transfer; hydrodynamic and rheological effects; electromagnetic field propagation) are considered. Anomalous, relaxation and nonlinear transport, as well as transport induced by the impact of external fields and noise, is the focus of this issue. Read More

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September 2021

Cardiopulmonary assessment of patients diagnosed with Gaucher's disease type I.

Mol Genet Genomic Med 2021 Jul 18:e1757. Epub 2021 Jul 18.

Division of Cardiology, University Clinical Center of Serbia, Belgrade, Serbia.

Background: Understanding the basis of the phenotypic variation in Gaucher's disease (GD) has proven to be challenging for efficient treatment. The current study examined cardiopulmonary characteristics of patients with GD type 1.

Methods: Twenty Caucasian subjects (8/20 female) with diagnosed GD type I (GD-S) and 20 age- and sex-matched healthy controls (C), were assessed (mean age GD-S: 32. Read More

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Characterization of viscoelastic media combining ultrasound and magnetic-force induced vibrations on an embedded soft magnetic sphere.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Jul 16;PP. Epub 2021 Jul 16.

We report a method to locally assess the complex shear modulus of a viscoelastic medium. The proposed approach is based on the application of a magnetic force to a millimetre-sized steel sphere embedded in the medium and the subsequent monitoring of its dynamical response. A coil is used to create a magnetic field inducing the displacement of the sphere located inside a gelatin phantom. Read More

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Flexible ptychography platform to expand the potential of imaging at free electron lasers.

Opt Express 2021 Jul;29(14):22345-22365

Ptychography, a scanning coherent diffraction imaging method, can produce a high-resolution reconstruction of a sample and, at the same time, of the illuminating beam. The emergence of vacuum ultraviolet and X-ray free electron lasers (FELs) has brought sources with unprecedented characteristics that enable X-ray ptychography with highly intense and ultra-fast short-wavelength pulses. However, the shot-to-shot pulse fluctuations typical for FEL pulses and particularly the partial spatial coherence of self-amplified spontaneous emission (SASE) FELs lead to numerical complexities in the ptychographic algorithms and ultimately restrict the application of ptychography at FELs. Read More

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