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Kainate receptor modulation of glutamatergic synaptic transmission in the CA2 region of the hippocampus.

J Neurochem 2021 Jul 22. Epub 2021 Jul 22.

Laboratorio de Neurociencia Celular y Plasticidad, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, ES-41013, Sevilla, Spain.

Kainate (KA) receptors (KARs) are important modulators of synaptic transmission. We studied here the role of KARs on glutamatergic synaptic transmission in the CA2 region of the hippocampus where the actions of these receptors are unknown. We observed that KA depresses glutamatergic synaptic transmission at Schaffer collateral-CA2 synapses; an effect that was antagonized by NBQX (a KA/AMPA receptors antagonist) under condition where AMPA receptors were previously blocked. Read More

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Feasibility and Effect of Reiki on the Physiology and Self-perceived Stress of Nurses in a Large US Hospital.

Holist Nurs Pract 2021 Jul 20. Epub 2021 Jul 20.

Boston Children's Hospital, Boston, Massachusetts (Mss Hailey, Fortin, and Pratt and Mr Forbes); and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (Dr McCabe).

Nurses experience stress in the workplace. We evaluated the feasibility and effect of Reiki to relieve stress of staff nurses during a work shift. All Reiki treatments were completed without interruption and lasted 30 minutes. Read More

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Cancer mortality in a population-based cohort of American Indians - The strong heart study.

Cancer Epidemiol 2021 Jul 19;74:101978. Epub 2021 Jul 19.

MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD, 20782, USA; Georgetown, Howard Universities Center for Clinical and Translational Research, Washington, DC, 2000, USA. Electronic address:

Background: Cancer mortality among American Indian (AI) people varies widely, but factors associated with cancer mortality are infrequently assessed.

Methods: Cancer deaths were identified from death certificate data for 3516 participants of the Strong Heart Study, a population-based cohort study of AI adults ages 45-74 years in Arizona, Oklahoma, and North and South Dakota. Cancer mortality was calculated by age, sex and region. Read More

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Evaluation of the HeroWear Apex back-assist exosuit during multiple brief tasks.

J Biomech 2021 Jul 9;126:110620. Epub 2021 Jul 9.

Department of Electrical and Computer Engineering, University of Wyoming. Electronic address:

Trunk exoskeletons are wearable devices that support humans during physically demanding tasks by reducing biomechanical loads on the back. While most trunk exoskeletons are rigid devices, more lightweight soft exoskeletons (exosuits) have recently been developed. One such exosuit is the HeroWear Apex, which achieved promising results in the developers' own work but has not been independently evaluated. Read More

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Improving severity scoring of food-induced allergic reactions: a global "Best-Worst Scaling" exercise.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

National Heart & Lung Institute, Imperial College London, London, UK;. Electronic address:

Background: There is no current consensus on assigning severity to food-induced allergic reactions, for example to assess the efficacy of allergen immunotherapy. Existing severity scores lack the capability to discriminate between non-anaphylaxis reactions of different severities. Attempts are ongoing to develop a more discriminatory score, which should ideally be data-driven and validated in multiple cohorts. Read More

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Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD.

Am J Kidney Dis 2021 Jul 19. Epub 2021 Jul 19.

University of Maryland School of Medicine, Department of Medicine.

Rationale & Objective: The utility of conventional upper reference limits (URL) for N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hsTnT) in chronic kidney disease (CKD) remains debated. We analyzed the distribution of hsTnT and NT-proBNP in people with CKD in ambulatory settings to examine the diagnostic value of conventional URL in this population.

Study Design: Observational study. Read More

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Low Rate of Spontaneous Closure in Premature Infants Discharged with a Patent Ductus Arteriosus: A Multicenter Prospective Study.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

The MEDNAX Center for Research, Education, Quality and Safety, Sunrise, FL; Greenville Memorial Hospital, SC.

Objectives: To assess the rate of spontaneous closure and the incidence of adverse events in infants discharged home with a patent ductus arteriosus.

Study Design: In a prospective multicenter study, we enrolled 201 premature infants (gestational age 23-32 weeks at birth) discharged home with a persistently patent ductus arteriosus (PDA) and followed their PDA status at 6-month intervals through 18 months of age. The primary study outcome was the rate and timing of spontaneous ductal closure. Read More

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Sports safety matting diminishes cardiopulmonary resuscitation quality and increases rescuer perceived exertion.

PLoS One 2021 22;16(7):e0254800. Epub 2021 Jul 22.

School of Clinical and Applied Sciences, Leeds Beckett University, Leeds, West Yorkshire, United Kingdom.

Objectives: Compliant surfaces beneath a casualty diminish the quality of cardiopulmonary resuscitation (CPR) in clinical environments. To examine this issue in a sporting environment, we assessed chest compression quality and rescuer exertion upon compliant sports safety matting.

Methods: Twenty-seven advanced life support providers volunteered (13 male/14 female; mass = 79. Read More

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Use of non-invasive intracranial pressure pulse waveform to monitor patients with End-Stage Renal Disease (ESRD).

PLoS One 2021 22;16(7):e0240570. Epub 2021 Jul 22.

Biological and Health Sciences Division, State University of Ponta Grossa-UEPG, Ponta Grossa-PR, Brazil.

End-stage renal disease (ESRD) is treated mainly by hemodialysis, however, hemodialysis is associated with frequent complications, some of them involve the increased intracranial pressure. In this context, monitoring the intracranial pressure of these patients may lead to a better understanding of how intracranial pressure morphology varies with hemodialysis. This study aimed to follow-up patients with ESRD by monitoring intracranial pressure before and after hemodialysis sessions using a noninvasive method. Read More

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Pain modulation by your partner: An experimental investigation from a social-affective perspective.

PLoS One 2021 22;16(7):e0254069. Epub 2021 Jul 22.

Department of Clinical Psychology, Justus-Liebig-University Giessen, Giessen, Germany.

Background: Social context such as the relationship between a person experiencing pain and a caregiver has been shown to affect the experience of pain, yet, results are not consistent. Possibly, differential effects of interpersonal relationships are modulated by affective states expressed by social partners. Viewing partner pictures in experimental designs is not only associated with lowered perceived pain intensity, but also affects neural responses. Read More

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Persistent homology as a new method of the assessment of heart rate variability.

PLoS One 2021 22;16(7):e0253851. Epub 2021 Jul 22.

Department of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland.

Heart rate variability (hrv) is a physiological phenomenon of the variation in the length of the time interval between consecutive heartbeats. In many cases it could be an indicator of the development of pathological states. The classical approach to the analysis of hrv includes time domain methods and frequency domain methods. Read More

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Safety, Efficacy, and Pharmacodynamics of Tremelimumab Plus Durvalumab for Patients With Unresectable Hepatocellular Carcinoma: Randomized Expansion of a Phase I/II Study.

J Clin Oncol 2021 Jul 22:JCO2003555. Epub 2021 Jul 22.

Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: This phase I/II study evaluated tremelimumab (anticytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody) and durvalumab (antiprogrammed death ligand-1 monoclonal antibody) as monotherapies and in combination for patients with unresectable hepatocellular carcinoma (HCC), including a novel regimen featuring a single, priming dose of tremelimumab (ClinicalTrials.gov identifier: NCT02519348).

Patients And Methods: Patients with HCC who had progressed on, were intolerant to, or refused sorafenib were randomly assigned to receive T300 + D (tremelimumab 300 mg plus durvalumab 1,500 mg [one dose each during the first cycle] followed by durvalumab 1,500 mg once every 4 weeks), durvalumab monotherapy (1,500 mg once every 4 weeks), tremelimumab monotherapy (750 mg once every 4 weeks [seven doses] and then once every 12 weeks), or T75 + D (tremelimumab 75 mg once every 4 weeks plus durvalumab 1,500 mg once every 4 weeks [four doses] followed by durvalumab 1,500 mg once every 4 weeks). Read More

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Remote Patient Monitoring Identifies the Need for Triage in Patients with Acute COVID-19 Infection.

Telemed J E Health 2021 Jul 22. Epub 2021 Jul 22.

Department of Rehabilitation and Human Performance and Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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Low-Power Laser Ignition of an Antenna-Type Secondary Energetic Copper Complex: Synthesis, Characterization, Evaluation, and Ignition Mechanism Studies.

Inorg Chem 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry, Ludwig Maximilian University Munich, München 81377, Germany.

In recent years, development of new energetic compounds and formulations, suitable for ignition with relatively low-power lasers, is a highly active and competitive field of research. The main goal of these efforts is focused on achieving and providing much safer solutions for various detonator and initiator systems. In this work, we prepared, characterized, and studied thermal and ignition properties of a new laser-ignitable compound, based on the 5,6-bis(ethylnitroamino)-'2,'3-dihydroxypyrazine-2,3-bis(carboximidamide) (DS3) proligand. Read More

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Elucidating the Role of Halides and Iron during Radiolysis-Driven Oxidative Etching of Gold Nanocrystals Using Liquid Cell Transmission Electron Microscopy and Pulse Radiolysis.

J Am Chem Soc 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry, University of California-Berkeley, Berkeley, California 94720, United States.

Graphene liquid cell transmission electron microscopy (TEM) has enabled the observation of a variety of nanoscale transformations. Yet understanding the chemistry of the liquid cell solution and its impact on the observed transformations remains an important step toward translating insights from liquid cell TEM to benchtop chemistry. Gold nanocrystal etching can be used as a model system to probe the reactivity of the solution. Read More

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The Effect of Preoperative Anxiety and Pain Sensitivity on Preoperative Hemodynamics, Propofol Consumption, and Postoperative Recovery and Pain in Endoscopic Ultrasonography.

Pain Ther 2021 Jul 22. Epub 2021 Jul 22.

Department of Anaesthesiology and Reanimation, Faculty of Medicine, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcın Sehir Hastanesi, Dr. Erkin Cad., Kadikoy, 34722, Istanbul, Turkey.

Introduction: The present study investigates how preoperative anxiety and pain sensitivity affect the consumption of anesthetics, time elapsed until the desired sedation level is achieved, preoperative hemodynamics, postoperative recovery time, and postoperative pain.

Methods: The present study includes 80 ASA 1-2 patients aged between 20 and 65 who were scheduled for endoscopic ultrasonography (EUS) under sedation. Patients were instructed to fill out the Spielberger State-Trait Anxiety Inventory (STAI) and Pain Sensitivity Questionnaire (PSQ) before the procedure. Read More

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Slowing down as we age: aging of the cardiac pacemaker's neural control.

Geroscience 2021 Jul 22. Epub 2021 Jul 22.

Department of Physiology & Biophysics, University of Washington, Seattle, WA, 98195, USA.

The cardiac pacemaker ignites and coordinates the contraction of the whole heart, uninterruptedly, throughout our entire life. Pacemaker rate is constantly tuned by the autonomous nervous system to maintain body homeostasis. Sympathetic and parasympathetic terminals act over the pacemaker cells as the accelerator and the brake pedals, increasing or reducing the firing rate of pacemaker cells to match physiological demands. Read More

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Noninvasive ventilation vs. high-flow nasal cannula oxygen for preoxygenation before intubation in patients with obesity: a post hoc analysis of a randomized controlled trial.

Ann Intensive Care 2021 Jul 22;11(1):114. Epub 2021 Jul 22.

Médecine Intensive Réanimation, CHU de Poitiers, Poitiers, France.

Background: Critically ill patients with obesity may have an increased risk of difficult intubation and subsequent severe hypoxemia. We hypothesized that pre-oxygenation with noninvasive ventilation before intubation as compared with high-flow nasal cannula oxygen may decrease the risk of severe hypoxemia in patients with obesity.

Methods: Post hoc subgroup analysis of critically ill patients with obesity (body mass index ≥ 30 kg·m) from a multicenter randomized controlled trial comparing preoxygenation with noninvasive ventilation and high-flow nasal oxygen before intubation of patients with acute hypoxemic respiratory failure (PaO/FiO < 300 mm Hg). Read More

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Cyclic siloxane biosurfactant-producing Bacillus cereus BS14 biocontrols charcoal rot pathogen Macrophomina phaseolina and induces growth promotion in Vigna mungo L.

Arch Microbiol 2021 Jul 22. Epub 2021 Jul 22.

Department of Botany and Microbiology, Gurukula Kangri (Deemed to be University), Haridwar, 249 404, Uttarakhand, India.

Rhizobacteria are vital component of soil-plant interfaces which helps in plant growth responses and disease management. Precisely, the role of biosurfactant production by rhizobacteria in biocontrol mechanisms is underscored. The current study explores the destructive effect of a biosurfactant-producing bacterium Bacillus cereus BS14 on fungal growth under in vitro experiments and showed in vivo reduction of disease severity in pulse crop Vigna mungo. Read More

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The Analysis of Hospital Readmission Rates After the Implementation of Hospital Readmissions Reduction Program.

J Patient Saf 2021 Jul 21. Epub 2021 Jul 21.

From the Eastern Connecticut State University, Willimantic, Connecticut Department of Industrial and Systems Engineering, Rochester Institute of Technology, Rochester, New York.

Objectives: This study aims to analyze the impact of Hospital Readmissions Reduction Program (HRRP) on the nationwide optimization efforts of length of stay (LOS) and readmissions in the United States.

Methods: We use the Nationwide Readmission Database between 2010 and 2016 provided in the Healthcare Cost and Utilization Project by the Agency for Healthcare Research and Quality. The study focuses on acute myocardial infarction, chronic obstructive pulmonary disease, congestive heart failure (CHF), pneumonia monitored by the HRRP and 2 conditions, septicemia, and mood disorders that were not monitored by the HRRP but had among the highest readmissions. Read More

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Effects of Exercise Structure and Modality on Physiological and Perceptual Responses to Exercise.

J Strength Cond Res 2021 Jul 20. Epub 2021 Jul 20.

School of Physical Education and Sports Science, National and Kapodistrian University of Athens, Athens, Greece; and Department of Kinesiology, California State University-San Marcos, San Marcos, California.

Abstract: Bogdanis, GC, Mallios, VJ, Katsikas, C, Fouseki, T, Holman, I, Smith, C, and Astorino, TA. Effects of exercise structure and modality on physiological and perceptual responses to exercise. J Strength Cond Res XX(X): 000-000, 2021-This study examined the effect of exercise mode and intensity on physiological and perceptual responses to exercise. Read More

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Cardiac arrhythmias six months following traumatic spinal cord injury.

J Spinal Cord Med 2021 Jul 22:1-7. Epub 2021 Jul 22.

Clinic for Spinal Cord Injuries, Rigshospitalet, Copenhagen, Denmark.

Objective: To investigate the incidence of cardiac arrhythmias at six months following traumatic spinal cord injury (SCI) and to compare the prevalence of arrhythmias between participants with cervical and thoracic SCI.

Design: A prospective observational study using continuous twenty-four-hour Holter monitoring.

Setting: Inpatient rehabilitation unit of a university research hospital and patient home setting. Read More

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Understanding Heart Rate Reactions to Post-Traumatic Stress Disorder (PTSD) Among Veterans: A Naturalistic Study.

Hum Factors 2021 Jul 22:187208211034024. Epub 2021 Jul 22.

265514736 Texas A&M University, College Station, USA.

Objective: We collected naturalistic heart rate data from veterans diagnosed with post-traumatic stress disorder (PTSD) to investigate the effects of various factors on heart rate.

Background: PTSD is prevalent among combat veterans in the United States. While a positive correlation between PTSD and heart rate has been documented, specific heart rate profiles during the onset of PTSD symptoms remain unknown. Read More

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Pre-operative autonomic nervous system function - a missing link for post-induction hypotension?

Anaesthesia 2021 Jul 22. Epub 2021 Jul 22.

Section of Surgical Pathophysiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

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Thermoregulation is not impaired in breast cancer survivors during moderate-intensity exercise performed in warm and hot environments.

Physiol Rep 2021 Jul;9(14):e14968

Environmental Extremes Laboratory, University of Brighton, Eastbourne, UK.

This study aimed to assess how female breast cancer survivors (BCS) respond physiologically, hematologically, and perceptually to exercise under heat stress compared to females with no history of breast cancer (CON). Twenty-one females (9 BCS and 12 CON [age; 54 ± 7 years, stature; 167 ± 6 cm, body mass; 68.1 ± 7. Read More

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Fractal correlation properties of heart rate variability as a biomarker of endurance exercise fatigue in ultramarathon runners.

Physiol Rep 2021 Jul;9(14):e14956

Faculty of Health Sciences, Department of Performance, Neuroscience, Therapy and Health, MSH Medical School Hamburg, University of Applied Sciences and Medical University, Hamburg, Germany.

Although heart rate variability (HRV) indexes have been helpful for monitoring the fatigued state while resting, little data indicate that there is comparable potential during exercise. Since an index of HRV based on fractal correlation properties, alpha 1 of detrended fluctuation analysis (DFA a1) displays overall organismic demands, alteration during exertion may provide insight into physiologic changes accompanying fatigue. Two weeks after collecting baseline demographic and gas exchange data, 11 experienced ultramarathon runners were divided into two groups. Read More

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Retrospective Lumbosacral CT Analysis and Prospective Observational Study of the Ipsilateral Tunnel View Technique for Fluoroscopy-guided Selective S1 Transforaminal Epidural Injection.

Pain Pract 2021 Jul 22. Epub 2021 Jul 22.

Department of Anesthesiology and Pain Medicine, Kangdong Sacred Heart Hospital, 150 Seongan-ro, Gangdong-gu, Seoul, 05355, South Korea.

Background: The purpose of this study was to retrospectively observe the anatomical relationship between dorsal S1 foramen (DS1F) and ventral S1 foramen (VS1F) through CT analysis and to prospectively determine the optimal angle of ipsilateral tunnel view technique for performing S1 transforaminal epidural steroid injection (S1-TFESI).

Methods: The axial lumbosacral CTs taken between in 208 consecutive patients and the following measurements were obtained on both sides: 1) the α-angle was defined as an angle between a sagittal line passing through the center of the sacrum and an imaginary line passing through the center of DS1F, 2) the largest diameter of DS1F and VS1F. The fluoroscopy was adjusted to show the largest L5/S1 intervertebral disc space which defined as the cephalad angle, and tilted to the ipsilateral oblique side until the entrance of DS1F had a well-defined, round shape which defined as the β-angle in forty humans. Read More

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Discriminationof PHIP signals through their evolution in multipulse sequences.

Chemphyschem 2021 Jul 21. Epub 2021 Jul 21.


The antiphase character of the PHIP associated signals after a hydrogenation reaction is particularly sensitive to line broadening introduced by magnetic field inhomogeneities and interferences by the presence resonance lines steaming from a large amount of thermally polarized spins. These obstacles impose a limitation in the detection of reaction products as well as in the experimental setups. A simple way to overcome these impediments consists of acquiring the signal with a train of refocusing pulses instead of a single r. Read More

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Actigraphy: Metrics reveal it is not a valid tool for determining sleep in neonates.

J Sleep Res 2021 Jul 22:e13444. Epub 2021 Jul 22.

Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA.

Study of emerging sleep-wake patterns in neonates is important for promptly identifying and treating abnormal sleep behaviours to ensure healthy infant development and neurobehavioral outcomes. Current methods to assess sleep are costly, labour intensive, and particularly difficult to implement in fragile, hospitalised infants requiring intensive medical care. The aim of the present study was to assess the validity of actigraphy as a tool for detecting sleep in preterm infants, using polysomnography (PSG) as the "gold standard". Read More

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Comparative safety of dipeptidyl peptidase-4 inhibitors and sulfonylureas among frail older adults.

J Am Geriatr Soc 2021 Jul 21. Epub 2021 Jul 21.

Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island, USA.

Background: Studies comparing dipeptidyl peptidase-4 inhibitors (DPP4Is) to sulfonylureas (SUs) are unavailable for frail older adults, especially nursing home (NH) residents. We examined the effects of DPP4Is versus SUs on severe adverse glycemic events, cardiovascular events, and death among NH residents.

Methods: We conducted a national retrospective cohort study of long-stay NH residents aged ≥65 years using 2008-2010 national US Minimum Data Set clinical assessment data and linked Medicare claims. Read More

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