28,018 results match your criteria pulmonary neurologic


J Emerg Med 2021 Apr 6. Epub 2021 Apr 6.

Department of Emergency Medicine, University of California, San Diego, San Diego, California; Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, California.

Background: Thiamine deficiency is an uncommon cause of severe illness in the United States that can lead to significant morbidity because of high-output cardiac failure, peripheral neuropathy, and permanent neurologic impairment. We report the case of a middle-aged woman with extreme malnutrition caused by complications of Roux-en-Y gastric bypass (RYGB) surgery who presented with signs and symptoms of severe thiamine deficiency and septic shock.

Case Report: A 43-year-old woman who had undergone RYGB surgery and who had multiple complications presented to the emergency department with agitation, confusion, and lethargy. Read More

View Article and Full-Text PDF

Sex and Racial Differences in Autopsy-Defined Causes of Presumed Sudden Cardiac Death.

Circ Arrhythm Electrophysiol 2021 Apr 9. Epub 2021 Apr 9.

Office of the Chief Medical Examiner, City & County of San Francisco, San Francisco, CA.

- Sudden cardiac death (SCD) studies report higher incidence in men and Blacks but presume cardiac cause. We sought to identify sex and race differences in rates and causes of presumed SCDs in a prospective postmortem study in San Francisco County. - All incident presumed SCDs meeting World Health Organization definition ages 18-90 were autopsied via active surveillance of consecutive out-of-hospital deaths in the stmortem ystematic Invesigation of udden ardiac eath (POST SCD) Study (2/1/2011 - 3/1/2014). Read More

View Article and Full-Text PDF

Causes, Pattern, Predictors and Prognostic Implications of New Hospitalizations after TAVI: A Long-Term Nationwide Observational Study.

Eur Heart J Qual Care Clin Outcomes 2021 Apr 8. Epub 2021 Apr 8.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Aim: The aim of this study was to investigate the pattern, causes and predictors of all new hospitalizations in patients who underwent TAVI.

Methods And Results: The nationwide Swedish TAVI-registry was merged with other mandatory health care registries, which enabled the analysis of all TAVI-procedures, new hospital admissions and death between the years 2008 and 2017.A total of 2821 patients underwent TAVI with a mean of 2. Read More

View Article and Full-Text PDF

The Value of Anlotinib in the Treatment of Intractable Brain Edema: Two Case Reports.

Front Oncol 2021 22;11:617803. Epub 2021 Mar 22.

Center of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

About 20-30 percent of patients with cancer, such as non-small cell lung cancer, breast cancer, melanoma and renal cell carcinoma, will develop brain metastases (BM). Primary and secondary brain tumors are often accompanied by peritumoral edema. Due to the limited intracranial space, peritumoral edema will further increase the intracranial pressure and aggravate clinical symptoms. Read More

View Article and Full-Text PDF

Voltage-Gated Calcium Channel Antibody-Induced Oropharyngeal Dysphagia Presenting as a Paraneoplastic Neurological Complication in Breast Cancer.

Cureus 2021 Mar 3;13(3):e13677. Epub 2021 Mar 3.

Hematology/Oncology, Magee Women's Hospital, University of Pittsburgh Medical Center, Pittsburgh, USA.

Paraneoplastic neurologic syndromes (PNS) are a group of disorders characterized by an autoimmune response against the nervous system due to cross-reactivity between malignant and normal neural tissue. The most commonly associated malignancies include small cell lung cancer, ovarian cancer, breast cancer, and lymphoma. Multiple PNS have been reported including paraneoplastic cerebellar degeneration, retinopathy, sensorimotor peripheral neuropathy, encephalopathy, opsoclonus-myoclonus syndrome, and stiff-person syndrome. Read More

View Article and Full-Text PDF

Stroke in pediatric ventricular assist device patients-a pedimacs registry analysis.

J Heart Lung Transplant 2021 Mar 12. Epub 2021 Mar 12.

Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.

Background: Cerebralvascular accidents (CVA) are common complications of pediatric ventricular assist devices (VADs). We employed the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) to investigate rates, risk factors, and outcomes of CVA in pediatric patients supported on VAD.

Methods: Analysis of Pedimacs (September 2012-June 2019) data to determine rates of all neurologic events and specifically CVA. Read More

View Article and Full-Text PDF

Endotheliitis, endothelin, and endothelin receptor blockers in COVID-19.

Med Hypotheses 2021 Mar 23;150:110564. Epub 2021 Mar 23.

Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, United States.

We summarize the role of endothelin as a potent vasoconstrictor, pro-inflammatory, pro-oxidative agent in the pathophysiologic effects and end-organ dysfunction of coronavirus disease 2019 (COVID-19). Endotheliitis is an under-recognized pathophysiologic process that causes various types of dysfunction in end organs, including heart, lung, kidney, and brain. Endothelin receptor blockers, such as bosentan and sitaxentan, can pave a path ahead in the realm of COVID-19 therapies. Read More

View Article and Full-Text PDF

Effect of Pulmonary Valve Replacement in the Repaired Tetralogy of Fallot Patients with Trans-annular Incision: More than 20 Years of Follow-up.

Korean Circ J 2021 Apr;51(4):360-372

Division of Cardiology, Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Background And Objectives: We reviewed the long-term outcomes after tetralogy of Fallot (TOF) repair with trans-annular incision; and evaluated the effectiveness of pulmonary valve replacement (PVR) on outcomes.

Methods: This was a retrospective review of clinical outcomes of 180 of 196 TOF patients who underwent total correction with trans-annular incision from 1991 to 1997 (PVR group: 81; non-PVR group: 99).

Results: The median age of the patients was 14. Read More

View Article and Full-Text PDF

Evaluation, Treatment, and Impact of Neurologic Injury in Adult Patients on Extracorporeal Membrane Oxygenation: a Review.

Curr Treat Options Neurol 2021 31;23(5):15. Epub 2021 Mar 31.

Department of Neurosciences, Division of Neurocritical Care, La Jolla, USA.

Purpose: Extracorporeal membrane oxygen (ECMO) is increasingly used as an advanced form of life support for cardiac and respiratory failure. Unfortunately, in infrequent instances, circulatory and/or respiratory recovery is overshadowed by neurologic injury that can occur in patients who require ECMO. As such, knowledge of ECMO and its implications on diagnosis and treatment of neurologic injuries is indispensable for intensivists and neurospecialists. Read More

View Article and Full-Text PDF

[Analysis of Clinical Characteristics and Prognosis in Children with Acute Megakaryoblastic Leukemia without Down Syndrome].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Apr;29(2):374-380

Department of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong Province,

Objective: To analyze the clinical characteristics and treatment effects of children with acute megakaryoblastic leukemia without down syndrome (non-DS-AMKL).

Methods: The clinical data of 19 children with non-DS-AMKL treated in the Pediatric Hematology Ward in Sun Yat-sen Memorial Hospital of Sun Yat-sen University from May 2008 to April 2018 were analyzed retrospectively. The clinical characteristics, laboratory test and treatment methods of the children were concluded. Read More

View Article and Full-Text PDF

A Comparative Systematic Review of COVID-19 and Influenza.

Viruses 2021 03 10;13(3). Epub 2021 Mar 10.

Infectious Disease Department, Nord Franche-Comté Hospital, 90400 Trévenans, France.

Background: Both SARS-CoV-2 and influenza virus share similarities such as clinical features and outcome, laboratory, and radiological findings.

Methods: Literature search was done using PubMed to find MEDLINE indexed articles relevant to this study. As of 25 November 2020, the search has been conducted by combining the MeSH words "COVID-19" and "Influenza". Read More

View Article and Full-Text PDF

Routine Neuroimaging in Patients with Stage IV Non-Small Cell Lung Cancer: A Single Center Experience.

Curr Oncol 2021 Mar 2;28(2):1125-1136. Epub 2021 Mar 2.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Laval, QC G1V 0A6, Canada.

Background: There is a lack of consensus in current practice guidelines regarding routine neuroimaging in patients with stage IV non-small cell lung cancer (NSCLC) without neurologic symptoms, and there is a paucity of data on the impact of such imaging on overall survival (OS).

Methods: This retrospective study included 257 patients with stage IV NSCLC without neurologic symptoms diagnosed between January 1, 2013 and December 31, 2016 at (IUCPQ). The primary objective of this study was to compare the evolution of patients with stage IV NSCLC who had baseline brain imaging versus with who did not. Read More

View Article and Full-Text PDF

Optimising physiological endpoints of percutaneous coronary intervention.

EuroIntervention 2021 Apr 2;16(18):e1470-e1483. Epub 2021 Apr 2.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Invasive coronary physiology to select patients for coronary revascularisation has become established in contemporary guidelines for the management of stable coronary artery disease. Compared to revascularisation based on angiography alone, the use of coronary physiology has been shown to improve clinical outcomes and cost efficiency. However, recent data from randomised controlled trials have cast doubt upon the value of ischaemia testing to select patients for revascularisation. Read More

View Article and Full-Text PDF

Reducing refractory angina.

EuroIntervention 2021 Apr 2;16(18):e1466-e1467. Epub 2021 Apr 2.

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

View Article and Full-Text PDF

Aortotracheal fistula after slide tracheoplasty in a patient with dextrocardia, left pulmonary artery sling and tracheal stenosis: a case report.

J Cardiothorac Surg 2021 Mar 31;16(1):62. Epub 2021 Mar 31.

Department of Cardiovascular Surgery Mackay Memorial Hospital, CVICU-B, 7F, No. 92, Sec. 2, Zhongshan N. Rd, Taipei City, Taiwan.

Background: Aortotracheal fistula (ATF) is an uncommon and fatal complication of tracheal or aortic surgery, especially among pediatric patients.

Case Presentation: We reported a case in a 1-year-old boy with dextrocardia, left pulmonary artery sling and long segment tracheal stenosis. He received slide tracheoplasty at 9 months of age and had post-operative refractory granulation at distal trachea status post repeated balloon dilatation and laser vaporization. Read More

View Article and Full-Text PDF

Severe Acute Respiratory Syndrome-Associated Coronavirus 2 Infection and Organ Dysfunction in the ICU: Opportunities for Translational Research.

Crit Care Explor 2021 Mar 12;3(3):e0374. Epub 2021 Mar 12.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO.

Objectives: Since the beginning of the coronavirus disease 2019 pandemic, hundreds of thousands of patients have been treated in ICUs across the globe. The severe acute respiratory syndrome-associated coronavirus 2 virus enters cells via the angiotensin-converting enzyme 2 receptor and activates several distinct inflammatory pathways, resulting in hematologic abnormalities and dysfunction in respiratory, cardiac, gastrointestinal renal, endocrine, dermatologic, and neurologic systems. This review summarizes the current state of research in coronavirus disease 2019 pathophysiology within the context of potential organ-based disease mechanisms and opportunities for translational research. Read More

View Article and Full-Text PDF

Marijuana: A systems-based primer of adverse effects associated with use and an overview of its therapeutic utility.

SAGE Open Med 2021 9;9:20503121211000909. Epub 2021 Mar 9.

Department of Nephrology, Guthrie Robert Packer Hospital, Sayre, PA, USA.

Marijuana use is on the rise in the United States. By the end of 2019, 33 states have legalized marijuana use and marijuana byproduct use for medical purposes. However, marijuana use does not come without side effects. Read More

View Article and Full-Text PDF

The potential neurological effect of the COVID-19 vaccines: A review.

Acta Neurol Scand 2021 Mar 29. Epub 2021 Mar 29.

Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.

The coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pandemic with people infected in almost all countries. The most efficient solution to end this pandemic is a safe and efficient vaccine. Classic platforms are used to develop vaccines including live-attenuated vaccine, inactivated vaccine, protein subunit vaccine, and viral vector. Read More

View Article and Full-Text PDF

Predicting Readmission to Intensive Care After Cardiac Surgery Within Index Hospitalization: A Systematic Review.

J Cardiothorac Vasc Anesth 2021 Mar 1. Epub 2021 Mar 1.

Division of Cardiovascular Sciences, University of Manchester, ERC, Manchester University Hospital Foundation Trust, Manchester, UK.

Readmission to the cardiac intensive care unit after cardiac surgery has significant implications for both patients and healthcare providers. Identifying patients at risk of readmission potentially could improve outcomes. The objective of this systematic review was to identify risk factors and clinical prediction models for readmission within a single hospitalization to intensive care after cardiac surgery. Read More

View Article and Full-Text PDF

Coronavirus disease 2019 and dengue: two case reports.

J Med Case Rep 2021 Mar 26;15(1):171. Epub 2021 Mar 26.

Department of Internal Medicine, Indira Gandhi Memorial Hospital, Male' 20002, Maldives.

Background: The pandemic of this century has overwhelmed the healthcare systems of affected countries, and all resources have been diverted to coronavirus disease 2019. At the onset, coronavirus disease 2019 can present as any other acute febrile undifferentiated illness. In tropical regions, clinicians are increasingly challenged to differentiate these febrile illnesses without the use of diagnostics. Read More

View Article and Full-Text PDF

Outcomes of Durable Mechanical Circulatory Support in Myocarditis: Analysis of the International Society for Heart and Lung Transplantatio n Registry for Mechanically Assisted Circulatory Support Registry.

ASAIO J 2021 Mar 22. Epub 2021 Mar 22.

From the Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio Department of Surgery, The University of Alabama at Birmingham, Birmingham, Alabama Department of Cardiology, Advanced Heart Failure and Transplant Cardiology, Henry Ford Health System, Detroit, Michigan Division of Cardiovascular Sciences, University of South Florida, Tampa, Florida Deutsches Herzzentrum Berlin, Berlin, Germany Department of Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan Department of Cardiothoracic & Vascular Surgery, Newcastle/Freeman Hospital, UK, Newcastle, United Kingdom Alfred Heart Center, Melbourne, Victoria, Australia Department of Cardiovascular Surgery, Montefiore Medical Center, Bronx, New York.

Myocarditis can be refractory to medical therapy and require durable mechanical circulatory support (MCS). The characteristics and outcomes of these patients are not known. We identified all patients with clinically-diagnosed or pathology-proven myocarditis who underwent mechanical circulatory support in the International Society for Heart and Lung Transplantation Registry for Mechanically Assisted Circulatory Support registry (2013-2016). Read More

View Article and Full-Text PDF

A young man presenting with encephalopathy and seizures secondary to SARS-CoV-2.

BMJ Case Rep 2021 Mar 24;14(3). Epub 2021 Mar 24.

Internal Medicine, Baylor Scott and White Medical Center, Waxahachie, Texas, USA.

COVID-19 has now emerged from a respiratory illness to a systemic viral illness with multisystem involvement. There is still a lot to learn about this illness as new disease associations with COVID-19 emerge consistently. We present a unique case of a neurological manifestation of a patient with structural brain disease who was COVID-19 positive and developed mental status changes, new-onset seizures and findings suggestive of viral meningitis on lumbar puncture. Read More

View Article and Full-Text PDF

Gastrostomy Tubes Placed in Children With Neurologic Impairment: Associated Morbidity and Mortality.

J Child Neurol 2021 Mar 22:8830738211000179. Epub 2021 Mar 22.

Division of General Pediatrics, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

Background: Gastrostomy tube (G-tube) placement for children with neurologic impairment with dysphagia has been suggested for pneumonia prevention. However, prior studies demonstrated an association between G-tube placement and increased risk of pneumonia. We evaluate the association between timing of G-tube placement and death or severe pneumonia in children with neurologic impairment. Read More

View Article and Full-Text PDF


Harefuah 2021 Mar;160(3):144-147

Pulmonary Institute, Shaare Zedek Medical Center, Jerusalem, Israel.

Introduction: One-sided diaphragmatic paralysis is a common phenomenon which is usually a-symptomatic. In case of acute onset or if there is an underlying lung disease, the phenomenon may be symptomatic and even limiting. In this article, we present a patient who arrived with subacute shortness of breath when lying down. Read More

View Article and Full-Text PDF

Point-of-Care Ultrasound Diagnosis of Acute High Altitude Illness: A Case Report.

Wilderness Environ Med 2021 Mar 17. Epub 2021 Mar 17.

Department of Emergency Medicine, Liège University Hospital, Liège, Belgium.

With the advent of high-quality portable ultrasound machines, point-of-care ultrasound (POCUS) has gained interest as a promising diagnostic tool for patients with high altitude illness. Although POCUS is used successfully in hospital environments to detect interstitial pulmonary edema and increased intracranial pressure, the relationship between specific sonographic criteria and high altitude illness is still unclear. We report the case of a healthy 32-y-old male who developed acute respiratory distress and neurologic impairment at 4321 m while participating in a high altitude medical research expedition. Read More

View Article and Full-Text PDF

Cerebral Venous Sinus Thrombosis in COVID-19 Patients: A Multicenter Study and Review of Literature.

J Stroke Cerebrovasc Dis 2021 Mar 4;30(6):105733. Epub 2021 Mar 4.

Department of Neurosurgery, Boston Medical Center, Boston, Massachusetts, USA.

Background: COVID-19 infection has been known to predispose patients to both arterial and venous thromboembolic events such as deep venous thrombosis, pulmonary embolism, myocardial infarction, and stroke. A few reports from the literature suggest that Cerebral Venous Sinus Thrombosis (CVSTs) may be a direct complication of COVID-19.

Objective: To review the clinical and radiological presentation of COVID-19 positive patients diagnosed with CVST. Read More

View Article and Full-Text PDF

Prediction of extubation outcome in mechanically ventilated patients: Development and validation of the Extubation Predictive Score (ExPreS).

PLoS One 2021 18;16(3):e0248868. Epub 2021 Mar 18.

Universidade do Oeste de Santa Catarina (UNOESC), Joaçaba, Santa Catarina, Brazil.

Despite the best efforts of intensive care units (ICUs) professionals, the extubation failure rates in mechanically ventilated patients remain in the range of 5%-30%. Extubation failure is associated with increased risk of death and longer ICU stay. This study aimed to identify respiratory and non-respiratory parameters predictive of extubation outcome, and to use these predictors to develop and validate an "Extubation Predictive Score (ExPreS)" that could be used to predict likelihood of extubation success in patients receiving invasive mechanical ventilation (IMV). Read More

View Article and Full-Text PDF

Temporomandibular Disorders and Their Association with Sleep Disorders in Adults: A Systematic Review.

J Oral Facial Pain Headache 2021 Winter;35(1):41-53

Aims: To investigate the associations between temporomandibular disorders (TMDs) and sleep disorders in adult subjects.

Methods: The PubMed, Embase, Evidence-Based Medicine Reviews, and ProQuest Dissertations & Theses databases were searched for studies published in English up to September 2019. Unpublished/gray literature and reference lists of identified articles were also examined. Read More

View Article and Full-Text PDF

Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease.

Crit Care Med 2021 Feb 23. Epub 2021 Feb 23.

1 Hospital Universitario de Getafe & Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. 2 Department of Surgical Sciences and Integrated Diagnostics, University of Genoa & San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy. 3 Unidad de Bioestadística Clínica Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS) & Centro de Investigación en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. 4 Servicio de Neumología, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS) & Universidad de Alcalá, Madrid, Spain. 5 Medizinische Hochschule Hannover, Hannover, Germany. 6 Peking Union Medical College Hospital, Beijing, People's Republic of China. 7 University Hospital of Poitiers, Poitiers, France. 8 Hospital Nacional Alejandro Posadas, Buenos Aires, Argentina. 9 Clínica Medellín & Universidad Pontificia Bolivariana, Medellín, Colombia. 10 Interdepartmental Division of Critical Care Medicine, Toronto, ON, Canada. 11 Hospital Regional 1° de Octubre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), México DF, México. 12 Pulmonary Research Laboratory, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. 13 Hospital Universitario Sao Jose, Belo Horizonte, Brazil. 14 Hospital Universitario de Montevideo, Montevideo, Uruguay. 15 Università degli Studi G. d'Annunzio Chieti e Pescara, Chieti, Italy. 16 Department of Critical Care Medicine, Flinders University, Adelaide, SA, Australia. 17 Bombay Hospital Institute of Medical Sciences, Mumbai, India. 18 Istanbul Faculty of Medicine, Istanbul, Turkey. 19 Center for Clinical Epidemiology of Samsung Medical Center, Seoul, South Korea. 20 Hospital Fattouma Bourguina, Monastir, Tunisia. 21 Hospital de Especialidades Eugenio Espejo, Quito, Ecuador. 22 Papageorgiou Hospital, Thessaloniki, Greece. 23 Centre Hospitalier Universitarie Ibn Sina-Mohammed V University, Rabat, Morocco. 24 Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. 25 South Texas Veterans Health Care System and University of Texas Health, San Antonio, TX.

Objectives: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality.

Design: Secondary analysis of three prospective, observational, multicenter studies.

Setting: Cohort studies conducted in 2004, 2010, and 2016. Read More

View Article and Full-Text PDF
February 2021