125,190 results match your criteria pulmonary arterial


Role of Imaging in Obstetric Interventions: Criteria, Considerations, and Complications.

Radiographics 2021 Jun 11:200163. Epub 2021 Jun 11.

From the Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Ave, Box 0628, San Francisco, CA 94143-0628 (P.J., V.A.F.); Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (M.V.R.); Department of Radiology, Winthrop University Hospital, Mineola, NY (D.S.K.); and Department of Radiology, University of Washington, Seattle, Wash (M.M.).

US has an established role in the prenatal detection of congenital and developmental disorders. Many pregnant women undergo US at 18-20 weeks of gestation for assessment of fetal anatomy and detection of structural anomalies. With advances in fetoscopy and minimally invasive procedures, in utero fetal interventions can be offered to address some of the detected structural and physiologic fetal abnormalities. Read More

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Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors.

Intensive Care Med Exp 2021 Jun 11;9(1):28. Epub 2021 Jun 11.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.

Background: The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular tone and immune function, and it has been implicated in the pathophysiology of a range of cardiovascular and inflammatory conditions. This study uses a series of transgenic murine models to explore for the first time the role of the hypoxia-inducible factors, HIF-1α and HIF-2α in the pulmonary and systemic circulations as potential regulators of systemic vascular function in normoxic or hypoxic conditions and in response to inflammatory stress. We developed a series of transgenic mouse models, the HIF-1α Tie2Cre, deficient in HIF1-α in the systemic and pulmonary vascular endothelium and the L1Cre, a pulmonary endothelium specific knockout of HIF-1α or HIF-2α. Read More

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Acute effects of inhaled iloprost on intracardiac conduction in patients with pulmonary arterial hypertension.

Herz 2021 Jun 10. Epub 2021 Jun 10.

Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, University of Health Sciences, İstasyon Mah. Turgut Özal Bulvarı No:11 Küçükçekmece, Istanbul, Turkey.

Background: Pulmonary arterial hypertension (PAH) is a severe, life-threatening disorder despite the availability of specific drug therapy. A lack of endogenous prostacyclin secondary to downregulation of prostacyclin synthase in PAH may contribute to vascular pathologies. Therefore, prostacyclin and its analogs including inhaled iloprost may decrease pulmonary arterial pressure and ventricular pressure. Read More

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Spatial relationship between the pulmonary trunk and the left coronaries: Systematic risk assessment based on automated three-dimensional distance measurements.

Heart Rhythm O2 2020 Apr 27;1(1):14-20. Epub 2020 Apr 27.

Informatics for Life, Heidelberg, Germany.

Background: Catheter ablation of right ventricular outflow tract ventricular arrhythmias from above the pulmonary valve is being increasingly reported.

Objective: The purpose of this study was to systematically analyze the spatial relationship between the pulmonary trunk and the left coronaries.

Methods: Contrast-enhanced computed tomographic scans from 58 patients were analyzed. Read More

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Acute submassive pulmonary embolism after SARS-CoV-2 infection: a case report of reinfection or prolonged hypercoagulable state.

Eur Heart J Case Rep 2021 Mar 24;5(3):ytab103. Epub 2021 Mar 24.

Department of Cardiology, Loyola University Medical Center, 2160 S 1st Ave, Maywood, IL 60153, USA.

Background: Coronavirus disease 19 (COVID-19) reinfection has been a topic of discussion with data still emerging. Viral antibodies are known to develop upon initial infection; however, it is unclear the amount of protection this confers against reinfection. Additionally, COVID-19-associated coagulopathy (CAC) is a well-documented phenomenon; however, there are no high-quality studies to support the treatment of outpatients beyond standard indications of venous thromboembolism (VTE) prophylaxis. Read More

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Immunoglobulin G4-related masses surrounding coronary arteries: a case report.

Eur Heart J Case Rep 2021 Mar 8;5(3):ytab055. Epub 2021 Mar 8.

Department of Cardiovascular Medicine, Nara Prefecture General Medical Centre, 2-897-5, Shichijonishimachi, Nara-City, Nara 630-8581, Japan.

Background: Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is an immune-mediated fibroinflammatory condition with high serum IgG4 levels affecting various organs, such as the pancreas, lacrimal and salivary glands, thyroid, kidney, and lung. Typical cardiovascular manifestations of IgG4-RD include periaortitis, coronary arteritis, and pericarditis. However, reports of IgG4-RD associated with coronary arteritis are rare. Read More

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Coronary Artery Fistula Aneurysm: Pathological Analysis After Surgery.

Cureus 2021 May 8;13(5):e14903. Epub 2021 May 8.

Cardiology, Kawasaki Municipal Ida Hospital, Kawasaki, JPN.

An asymptomatic 75-year-old woman was identified with a 40-mm-sized, round-shaped lesion beside the pulmonary artery on computed tomography (CT). Coronary angiography showed a coronary artery fistula (CAF) with an aneurysm branching from the left anterior descending artery toward the pulmonary artery. The CAF aneurysm (CAFA) was resected and coronary artery bypass graft surgery using the left internal thoracic artery was performed successfully. Read More

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Evolution of CT findings after anticoagulant treatment for acute pulmonary embolism in patients with and without an ultimate diagnosis of CTEPH.

Eur Respir J 2021 Jun 10. Epub 2021 Jun 10.

Department of Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Introduction: The pulmonary arterial morphology of patients with pulmonary embolism (PE) is diverse and it is unclear how the different vascular lesions evolve after initiation of anticoagulant treatment. A better understanding of the evolution of CTPA findings after the start of anticoagulant treatment may help to better identify those PE patients prone to develop CTEPH. We aimed to assess the evolution of various thromboembolic lesions on CTPA over time after the initiation of adequate anticoagulant treatment in individual acute PE patients with and without an ultimate diagnosis of CTEPH. Read More

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[Application of extracorporeal membrane oxygenation in critically ill pregnant women].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):605-608

Department of Intensive Care Unit, Nanjing Drum Tower Hospital, the Affiliated Hospital to Nanjing University Medical School, Nanjing 210009, Jiangsu, China. Corresponding author: Gu Qin, Email:

Objective: To investigate the safety and effectiveness of extracorporeal membrane oxygenation (ECMO) in emergency treatment of critically ill pregnant women.

Methods: Clinical data of 8 pregnant women with severe cardiopulmonary dysfunction during the perinatal period treated by ECMO in the department of intensive care unit (ICU) of Nanjing Drum Tower Hospital, the Affiliated Hospital to Nanjing University Medical School from September 2017 to November 2020 were retrospectively analyzed.

Results: For the 8 pregnant women, the mean age was (32. Read More

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[Celastrol alleviates sepsis-induced acute lung injury in rats by inhibiting the Toll-like receptor 4/nuclear factor-κB inflammatory pathway].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):541-545

Department of Intensive Care Unit, Jiangxi Provincial People's Hospital, Nanchang 330006, Jiangxi, China.

Objective: To investigate the protective effect and mechanism of celastrol in acute lung injury (ALI) of septic rats.

Methods: According to random number table, 24 male Sprague-Dawley (SD) rats were divided into control group (Con group), Sham operation group (Sham group), sepsis-induced ALI group by cecal ligation and perforation (CLP group) and celastrol intervention group (CLP+celastrol group, 2 mg/kg intraperitoneal administration 1 hour before surgery), 6 rats in each group. The abdominal aortic blood of the rats was collected for blood gas analysis 24 hours after the surgery, and then the rats were sacrificed and the lung tissues were taken to calculate the lung wet to dry weight ratio (W/D). Read More

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Venoarterial Extracorporeal Membrane Oxygenator Support in Lung Cancer Resection.

Ann Thorac Surg 2021 Jun 7. Epub 2021 Jun 7.

Department of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy; Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy. Electronic address:

Cardiovascular comorbidities often prevent patients with otherwise resectable early-stage lung cancer from undergoing surgery due to prohibitive peri-operative risk. Here we describe the first intraoperative use of venoarterial (VA) ECMO in a stage cIIA lung cancer patient with arterial infiltration and severe post-ischemic dilated cardiomyopathy (EF 23%) undergoing left upper lobectomy with pulmonary artery angioplasty. Providing intra-operative cardiovascular and respiratory function support, VA-ECMO represents a suitable option for patients with heart failure, ensuring adequate hemodynamic profile and reducing the risk of complications. Read More

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Cutting balloon angioplasty on branch pulmonary artery stenosis in pediatric patients.

Catheter Cardiovasc Interv 2021 Jun 10. Epub 2021 Jun 10.

Pediatric Cardiology, Arkansas Children's Hospital, Little Rock, Arkansas, USA.

Objectives: To identify medium-term results following cutting balloon angioplasty (CBA) for branch pulmonary artery stenosis (PAS) and predictors of successful intervention.

Background: CBA has emerged as a successful alternative therapy for PAS resistant to conventional balloon angioplasty techniques but there is little information on medium and long-term outcomes.

Methods: This is a descriptive, single center, retrospective chart review of pediatric patients who underwent CBA for PAS at Arkansas Children's Hospital between May 2005 and December 2020. Read More

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Exercise hemodynamics in heart failure patients with preserved and mid-range ejection fraction: key role of the right heart.

Clin Res Cardiol 2021 Jun 10. Epub 2021 Jun 10.

Department of Cardiology, Kerckhoff-Klinik GmbH, Benekestr 2-8, 61231, Bad Nauheim, Germany.

Objective: We sought to explore whether classification of patients with heart failure and mid-range (HFmrEF) or preserved ejection fraction (HFpEF) according to their left ventricular ejection fraction (LVEF) identifies differences in their exercise hemodynamic profile, and whether classification according to an index of right ventricular (RV) function improves differentiation.

Background: Patients with HFmrEF and HFpEF have hemodynamic compromise on exertion. The classification according to LVEF implies a key role of the left ventricle. Read More

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Current advances in cardiac magnetic resonance imaging in systemic sclerosis.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3718-3736

Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Systemic sclerosis (SSc) is a systemic autoimmune disorder characterized by inflammation, fibroproliferative vasculopathy, and progressive fibrosis. Cardiac involvement is common in SSc and may affect the myocardium, pericardium, heart valves, conduction system, as well as coronary arteries. However, it remains asymptomatic for a long time, which leads to delayed diagnosis and poor prognosis. Read More

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Does patent foramen ovale presence procure favourable outcomes in patients with severe rheumatic mitral stenosis?

Int J Cardiovasc Imaging 2021 Jun 9. Epub 2021 Jun 9.

Cardiology Department, Mehmet Akif Ersoy Thoracic And Cardiovascular Surgery Training and Research Hospital, University Of Health Sciences Istanbul, Turgut Ozal Bulvarı no:11, 34303, Istanbul, Küçükçekmece, Turkey.

Mitral stenosis (MS) is tolerated for an extended period in patients with atrial septal defect (ASD) known as Lutembacher syndrome due to depressurizing effect. In a similar way, patients with patent foramen ovale (PFO) may have clinical benefits in severe MS. We aim to evaluate the clinical effects of PFO in rheumatic MS. Read More

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Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report.

Eur Heart J Case Rep 2021 May 22;5(5):ytab149. Epub 2021 May 22.

Cardiology Department, Centro Hospitalar e Universitário de Coimbra, Praceta Mota Pinto, 3000-075 Coimbra, Portugal.

Background: Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Thus, a prompt diagnosis and early intervention are crucial.

Case Summary: A 39-year-old pregnant women presented with persistent severe hypoxaemia after the diagnosis of influenza B and an elective caesarean delivery at 33 weeks. Read More

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Non-bacterial thrombotic endocarditis manifested by ventricular fibrillation in a patient with low grade ovarian carcinoma: case report and literature review.

Eur Heart J Case Rep 2021 Apr 21;5(4):ytab120. Epub 2021 Apr 21.

Department of cardiology, Heart Centre OLVG, Oosterparkstraat 9, 1091 AC Amsterdam, the Netherlands.

Background: Non-bacterial thrombotic endocarditis (NBTE) is a rare form of endocarditis notably described in patients with advanced malignancy and auto-immune diseases. It is characterized by the formation of sterile, fibrin-containing vegetations on cardiac endothelium, in the absence of positive blood cultures. It is predominantly located on the mitral- and aortic valve (AV). Read More

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A bronchopulmonary artery fistula in a horse.

J Vet Med Sci 2021 Jun 10. Epub 2021 Jun 10.

Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University.

A 24-year-old, Thoroughbred gelding presented with difficulty breathing for a few days and intermittent nose bleeding before dying. At necropsy, the bronchoesophageal artery and the bronchial artery that flowed into the left anterior lobe were tortuous and dilated, and it was found that dilated tortuous branches of the bronchial artery ran over the dorsal and ventral surfaces of the left anterior lobe. Histopathologically, an anastomosis between a muscular artery and an elastic artery were demonstrated, which were identified as bronchial and pulmonary arteries, respectively. Read More

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Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial.

BMJ 2021 06 9;373:n1205. Epub 2021 Jun 9.

Department of Medicine, McGill University, Montreal, QC, Canada.

Objective: To determine the efficacy and safety of dalteparin postoperative bridging treatment versus placebo for patients with atrial fibrillation or mechanical heart valves when warfarin is temporarily interrupted for a planned procedure.

Design: Prospective, double blind, randomised controlled trial.

Setting: 10 thrombosis research sites in Canada and India between February 2007 and March 2016. Read More

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Congenitally corrected transposition of the great arteries (CCTGA).

BMJ Case Rep 2021 Jun 9;14(6). Epub 2021 Jun 9.

Department of Cardiology, Mater Dei Hospital, Msida, Malta.

A 33-year-old man presented with a 3-week history of breathlessness and cough. He disclosed that he was informed regarding a heart defect as a child in his home country but was unaware of its nature and was never followed up. Examination revealed a pansystolic murmur (loudest at the apex), a hyperdynamic, displaced apex, and pulmonary oedema. Read More

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EGFR-mutant NSCLC presenting with stroke and massive systemic embolization as the first manifestation: case report.

BMC Neurol 2021 Jun 9;21(1):221. Epub 2021 Jun 9.

Department of Neurology, The Second Hospital of Hebei Medical University, 309 Zhonghuabei Street, Hebei, 050000, Shijiazhuang, People's Republic of China.

Background: Presentation with massive systemic embolization as the initial manifestation of occult malignancy is infrequent. The standard management of cancer-related arterial thromboembolism has not yet been established.

Case Presentation: We described a case of Trousseau's syndrome resulting in acute ischemic stroke concomitant with multiple embolizations in the spleen and kidney during oral administration of dabigatran for pulmonary embolism preceding the diagnosis of a malignant tumor. Read More

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Mediating effect of social support on the relationship between illness concealment and depression symptoms in patients with pulmonary arterial hypertension.

Heart Lung 2021 Jun 6;50(5):706-713. Epub 2021 Jun 6.

Department of Nursing, College of Medical, National Cheng Kung University, Tainan City, Taiwan. Electronic address:

Background: Depression symptoms are common in patients with pulmonary arterial hypertension (PAH). Social support may mediate the effect of illness concealment on depression symptoms.

Objective: To examine the relationships between illness concealment, dimensions of social support, and depression symptoms and the mediating effect of the dimensions of social support on depression symptoms in PAH patients. Read More

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Multiple Manifestations of Systemic Sclerosis Affect Walk Distance.

Am J Respir Crit Care Med 2021 Jun 9. Epub 2021 Jun 9.

University of California Los Angeles, 8783, Division of Rheumatology, Department of Medicine, Los Angeles, California, United States.

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Alterations in arterial CO rather than pH affect the kinetics of neurovascular coupling in humans.

J Physiol 2021 Jun 9. Epub 2021 Jun 9.

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, V1V 1V7, Canada.

Key Points: We investigated the influence of arterial PCO (PaCO ) with and without acute experimental metabolic alkalosis on neurovascular coupling (NVC). We assessed stepwise iso-oxic alterations in PaCO prior to and following intravenous sodium bicarbonate (NaHCO ) to acutely elevate arterial pH and bicarbonate ([HCO ]). The NVC response was not altered following NaHCO between stepwise PaCO stages; therefore, NVC is acutely mediated by PaCO rather than the prevailing arterial [H ]/pH. Read More

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Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional study.

PLoS One 2021 9;16(6):e0252351. Epub 2021 Jun 9.

Clinical Neurosciences Group, Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.

Background: COVID-19 may predispose to both venous and arterial thromboembolism event (TEE). Reports on the prevalence and prognosis of thrombotic complications are still emerging.

Objective: To describe the rate of TEE complications and its influence in the prognosis of hospitalized patients with COVID-19 after a cross-sectional study. Read More

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Sintilimab induced diabetic ketoacidosis in a patient with small cell lung cancer: A case report and literature review.

Medicine (Baltimore) 2021 May;100(19):e25795

Department of Endocrinology and Metabolism.

Rationale: Sintilimab is a novel programmed cell death receptor-1 (PD-1) inhibitor approved in the treatment of classical Hodgkin's lymphoma and undergoing clinical trials for various malignancies. As a PD-1 inhibitor, sintilimab is known to cause autoimmune adverse events similar to other PD-1 inhibitors. Diabetic ketoacidosis (DKA) is a rare but severe adverse event of this therapy. Read More

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[Stent ductal implant by axillary via in a newborn with ductal dependent pulmonary blood flow].

Andes Pediatr 2021 Apr;92(2):274-280

Facultad de Medicina, Universidad CES, Medellin, Colombia.

Introduction: Ductus arteriosus stenting is a palliative alternative for neonates with ductal-dependent pulmonary flow.

Objective: To present an alternative of arterial access for percutaneous coronary intervention in neonates.

Clinical Case: A term neonate with low weight diagnosed with pulmonary atresia with intact ventricular septum and severe hypoplasia of the tricuspid valve with dependent coronary circu lation. Read More

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Predicting Risk of Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus: CSTAR Cohort Study.

Arthritis Rheumatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Objectives: Pulmonary arterial hypertension is a life-threatening complication of systemic lupus erythematosus. However, there is no algorithm to identify those at high risk. We aimed to develop a prediction model for pulmonary arterial hypertension in lupus patients that provides individualized risk estimates. Read More

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