40,609 results match your criteria pulmonary aortic

A novel algorithm for the computation of the diastolic pressure ratio in the invasive assessment of the functional significance of coronary artery disease.

Panminerva Med 2021 Jun;63(2):206-213

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University, Latina, Italy -

Background: Invasive functional assessment is a mainstay in the management of patients with coronary artery disease (CAD), but there is uncertainty on the comparative accuracy of diagnostic indices of functional significance. We aimed to validate the diagnostic performance of a novel non-hyperemic diastolic pressure ratio (dPR).

Methods: We performed a retrospective analysis including two separate registries (VERIFY 2, Latina, Italy) of patients in whom functional indices were measured for lesions with angiographically moderate severity. Read More

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Survival After Endovascular Aneurysm Sealing Compared With Endovascular Aneurysm Repair.

J Endovasc Ther 2021 Jun 21:15266028211025030. Epub 2021 Jun 21.

Department of Radiology, Auckland City Hospital, Auckland, New Zealand.

Introduction: Endovascular aneurysm sealing (EVAS) is a sac-filling device with a blunted systemic inflammatory response compared to conventional endovascular aneurysm repair (EVAR), with a suggested impact on all-cause mortality. This study compares mortality after both EVAS and EVAR.

Materials And Methods: This is a retrospective observational study including data from 2 centres, with ethical approval. Read More

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Current and new imaging techniques in risk stratification of asymptomatic severe aortic stenosis.

Acta Cardiol 2021 Jun 21:1-9. Epub 2021 Jun 21.

Cardiology Department, Abderrahmane Mami's Hospital, Ariana, Tunisia.

Aortic stenosis (AS) is one of the most common valvular diseases in clinical practice. The prevalence of calcified AS with moderate or severe stenosis exceeds 2% after 75 years. The optimal timing of intervention for asymptomatic severe AS is uncertain and controversial. Read More

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A study of the clinical application value of ultrasound and electrocardiogram in the differential diagnosis of cardiomyopathy.

Am J Transl Res 2021 15;13(5):5200-5207. Epub 2021 May 15.

Department of Ultrasound, The First Affiliated Hospital of Hainan Medical University Haikou 570102, Hainan, China.

Objective: To investigate the clinical application values of electrocardiogram (ECG) combined with ultrasound cardiogram (UCG) in the differential diagnosis of cardiomyopathy.

Methods: A total of 120 patients with cardiomyopathy who were admitted to our hospital were randomly divided into the dilated cardiomyopathy (DCM) group (60 cases) and the ischemic cardiomyopathy (ICM) group (60 cases). Both groups were examined using ECG combined with UCG. Read More

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A Role for Heme and Iron in Calcific Aortic Valve Disease?

Can J Cardiol 2021 Jun 17. Epub 2021 Jun 17.

Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada. Electronic address:

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Follicular Dendritic Cell Sarcoma of the Chest.

Ann Thorac Surg 2021 Jun 17. Epub 2021 Jun 17.

Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Follicular dendritic cell sarcoma is a rare, low-grade cancer derived from follicular dendritic cells, which serve as accessory cells to the lymphoid system. Here, we describe the case of a 57-year-old man who had a mediastinal mass with aortic involvement incidentally identified during evaluation for indeterminate pulmonary nodules. The mass, later diagnosed as follicular dendritic cell sarcoma, was successfully treated with surgical resection aided by placement of endovascular aortic stent graft. Read More

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Semin Thorac Cardiovasc Surg 2021 Jun 16. Epub 2021 Jun 16.

Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.

Our aim was to analyze outcomes of patients aged 70 years or above presenting with type A acute aortic dissection (TAAAD) and cerebrovascular accident (CVA). A retrospective analysis of the International Registry of Acute Aortic Dissection (IRAD) was conducted. Patients aged 70 years or above (n = 1449) were stratified according to presence or absence of CVA before surgery (CVA: n = 110, 7. Read More

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Incidental floating aortic thrombus in severe pulmonary COVID-19 infection.

Indian J Med Res 2021 Jun 19. Epub 2021 Jun 19.

Department of Radiodiagnosis, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi 110 095, India.

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Multilevel Airway Stenosis Being Bypassed by a Customized Tracheostomy Tube in an Infant with Myhre Syndrome.

Pediatr Allergy Immunol Pulmonol 2021 Jun;34(2):83-87

Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Myhre syndrome is a rare connective tissue disorder caused by heterozygous pathogenic variants in the gene. Although recognizing Myhre syndrome in early childhood is challenging, it is important to manage airway stenosis in patients with Myhre syndrome. We report the case of a 2-month-old boy who initially presented with severe multilevel airway stenosis, dysmorphic face, and multiple abnormalities. Read More

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A Pseudocoarctation of the Aorta With a Left Subclavian Artery Aneurysm, A Case Report and A Review of the Literature.

Vasc Endovascular Surg 2021 Jun 18:15385744211022536. Epub 2021 Jun 18.

Department of Cardiovascular Surgery, Kocaeli University Medical Faculty, Kocaeli, Turkey.

Here we present a 47-year-old male diagnosed with a pseudocoarctation of the aorta and a funnel-like subclavian artery aneurysm with a large orifice and severe aortic valve insufficiency. The patient underwent a two-stage repair for both pathologies. After an aortic valve replacement, postcardiotomy pericardial effusion occurred and was medically managed. Read More

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Williams syndrome.

Nat Rev Dis Primers 2021 Jun 17;7(1):42. Epub 2021 Jun 17.

Department of Paediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Williams syndrome (WS) is a relatively rare microdeletion disorder that occurs in as many as 1:7,500 individuals. WS arises due to the mispairing of low-copy DNA repetitive elements at meiosis. The deletion size is similar across most individuals with WS and leads to the loss of one copy of 25-27 genes on chromosome 7q11. Read More

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Invasive para-aortic : a multidisciplinary management challenge.

BMJ Case Rep 2021 Jun 17;14(6). Epub 2021 Jun 17.

Pharmacy, Royal Devon and Exeter Hospital, Exeter, UK.

A 69-year-old man was admitted with recurrent fungal bloodstream infection on a background of abdominal aneurysm, diabetes and chronic obstructive pulmonary disease. Investigations revealed a para-aortic mass, previously thought to be lymphoma, which was culture positive for on biopsy. Diagnosis and management involved multidisciplinary teamwork, diagnostic uncertainty and significant risk taking. Read More

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Cardiovascular complications in cystic fibrosis: A review of the literature.

J Cyst Fibros 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Cystic fibrosis is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, leading to dysfunction of the CFTR protein. CFTR dysfunction leads to disease in the respiratory and gastrointestinal systems. Disorders of the cardiovascular system in individuals with CF are usually attributed to secondary effects from progressive lung disease. Read More

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Impact of Predilation During Transcatheter Aortic Valve Replacement: Insights From the PARTNER 3 Trial.

Circ Cardiovasc Interv 2021 Jun 18:CIRCINTERVENTIONS120010336. Epub 2021 Jun 18.

Department of Cardiology, Baylor Scott and White, The Heart Hospital Plano, TX (K.A.-A., M.S., S.P., M.H., M.J.M.).

Background: The use of predilation during transcatheter aortic valve replacement (TAVR) is variable, and its association with outcomes remains unknown. We evaluated the impact of predilation versus no predilation (direct TAVR) in the low-risk population enrolled in the PARTNER 3 trial (Placement of Aortic Transcatheter Valves).

Methods: In the PARTNER 3 trial, 495 patients with severe symptomatic aortic stenosis underwent TAVR with the SAPIEN 3 valve. Read More

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Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.

Bioorg Med Chem Lett 2021 Jun 14:128202. Epub 2021 Jun 14.

Medicinal Chemistry Division, Pharmacology Division, Computational Chemistry, India. Electronic address:

Cathepsin C plays a key role in the activation of several degradative enzymes linked to tissue destruction in chronic inflammatory and autoimmune diseases. Therefore, Cathepsin C inhibitors could potentially be effective therapeutics for the treatment of diseases such as chronic obstructive pulmonary disease (COPD) or acute respiratory distress syndrome (ARDS). In our efforts towards the development of a novel series of Cathepsin C inhibitors, we started working around AZD5248 (1), an α-amino acid based scaffold having potential liability of aortic binding. Read More

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Echocardiographic versus Angiographic Measurement of the Patent Ductus Arteriosus in Extremely Low Birth Weight Infants and the Utility of Echo Guidance for Transcatheter Closure.

J Am Soc Echocardiogr 2021 Jun 14. Epub 2021 Jun 14.

Division of Pediatric Cardiology, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, TN.

Background: Transthoracic echocardiography (TTE) is increasingly utilized for guiding transcatheter closure of patent ductus arteriosus (PDA) in extremely low birth weight (ELBW) infants. The objectives of this study were to compare PDA size measurements by TTE with angiographic measurements and to describe TTE techniques used in guiding transcatheter PDA closure (TCPC) in ELBW infants.

Methods: 125 consecutive ELBW infants (gestational age < 27-weeks, birth weight < 1kg) who underwent TCPC before 8-weeks of age under TTE guidance were included. Read More

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Pseudoaneurysm of the mitral-aortic intervalvular fibrosa with fistulous communication to the left atrium causing congestive heart failure.

Clin Case Rep 2021 Jun 10;9(6):e04301. Epub 2021 Jun 10.

Icahn School of Medicine at Mount Sinai New York NY USA.

Pseudoaneurysms of the mitral-aortic intervalvular fibrosa can rupture and form fistulous communications between the left ventricle and left atrium. Pulmonary venous systolic flow reversal in such cases reflects elevated left atrial pressure due to shunting. This finding, particularly in the setting of endocarditis, is not specific for severe mitral regurgitation. Read More

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Tetralogy of Fallot with pulmonary atresia and aortopulmonary window may mimic common arterial trunk.

Cardiol Young 2021 Jun 17:1-5. Epub 2021 Jun 17.

Queensland Pediatric Cardiac Research, University of Queensland, Brisbane, Australia.

Tetralogy of Fallot with pulmonary atresia is a group of congenital cardiac malformations, which is defined by the absence of luminal continuity between both ventricles and the pulmonary artery, and an interventricular communication. Pulmonary arterial supply in patients with tetralogy of Fallot with pulmonary atresia can be via the arterial duct or from collateral arteries arising directly or indirectly from the aorta (systemic-to-pulmonary artery collaterals), or rarely both. The rarest sources of pulmonary blood flow are aortopulmonary window and fistulous communication with the coronary artery. Read More

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Trends in Early Discharge and Associated Costs after Transcatheter Aortic Valve Replacement: A National Perspective.

Innovations (Phila) 2021 Jun 16:15569845211013355. Epub 2021 Jun 16.

459812287 Division of Cardiac Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Objective: The current study aims to report trends of early discharges and identify associated direct costs using a nationally representative database of real-world data experience.

Methods: We used nationally weighted data on all patients who had transfemoral transcatheter aortic valve replacement (TAVR) from 2012 to 2017 and discharged alive from the National Inpatient Sample. Patients were divided into early (discharge ≤3 days of admission) and late discharge. Read More

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Transplacental Transfer and Fetal Pharmacodynamics of Sildenafil in the Pregnant Sheep Model.

Fetal Diagn Ther 2021 Jun 16:1-10. Epub 2021 Jun 16.

Department of Development and Regeneration, Katholieke Universiteit, Leuven, Belgium.

Background: Sildenafil is a phosphodiesterase-5 inhibitor considered for antenatal use for a variety of indications. We sought to assess sildenafil pharmacokinetics in the pregnant ewe and fetus and evaluate its physiological fetal effects.

Methods: Twelve fetal lambs (127-133 days GA, term 145) were chronically catheterized in utero. Read More

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A rare case of paradoxical pulmonary embolism in spontaneous aortocaval fistula.

BJR Case Rep 2021 May 6;7(3):20200183. Epub 2021 Jan 6.

Department of Vascular Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Aortocaval fistula (ACF) is a rare complication of abdominal aortic aneurysm (AAA), occurring in less than 1% of all AAAs. Paradoxical embolism can rarely be associated with ACF, pulmonary embolism may originate from dislodgment of thrombotic material from the AAA in the inferior vena cava (IVC) through the ACF. We report a case of a patient admitted to the emergency department with abdominal pain and shortness of breath who immediately underwent thoraco-abdominal CT. Read More

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Transcatheter pulmonic valve implantation: Techniques, current roles, and future implications.

World J Cardiol 2021 May;13(5):117-129

Division of Cardiology, University of Arizona College of Medicine, Tuscon, AZ 85724, United States.

Right ventricular outflow tract (RVOT) obstruction is present in a variety of congenital heart disease states including tetralogy of Fallot, pulmonary atresia/stenosis and other conotruncal abnormalities After surgical repair, these patients develop RVOT residual abnormalities of pulmonic stenosis and/or insufficiency of their native outflow tract or right ventricle to pulmonary artery conduit. There are also sequelae of other surgeries like the Ross operation for aortic valve disease that lead to right ventricle to pulmonary artery conduit dysfunction. Surgical pulmonic valve replacement (SPVR) has been the mainstay for these patients and is considered standard of care. Read More

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Simulation of Fluid-Structure Interaction in Extracorporeal Membrane Oxygenation Circulatory Support Systems.

J Cardiovasc Transl Res 2021 Jun 14. Epub 2021 Jun 14.

Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

Extracorporeal membrane oxygenation (ECMO) is a vital mechanical circulatory support modality capable of restoring perfusion for the patient in circulatory failure. Despite increasing adoption of ECMO, there is incomplete understanding of its effects on systemic hemodynamics and how the vasculature responds to varying levels of continuous retrograde perfusion. To gain further insight into the complex ECMO:failing heart circulation, computational fluid dynamics simulations focused on perfusion distribution and hemodynamic flow patterns were conducted using a patient-derived aorta geometry. Read More

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[Clinical application value of transthoracic echocardiography during perioperative period in patients undergoing left ventricular assist device implantation].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):610-614

Adult Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.

To observe the changes of parameters derived from transthoracic echocardiography (TTE) before and after left ventricular assist device (LVAD) implantation, and to evaluate the clinical value of TTE in the perioperative period of LVAD implantation. This is a retrospective study. The data of patients who underwent LVAD implantation in Fuwai Hospital from January 2018 to December 2020 were analyzed retrospectively. Read More

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Platypnea and orthodeoxia syndrome as an uncommon clinical indication for a challenging percutaneous patent foramen ovale closure: a case report.

Eur Heart J Case Rep 2021 Apr 17;5(4):ytab029. Epub 2021 Apr 17.

Department of Cardiovascular Sciences, O.U. of Interventional Cardiology, San Camillo Hospital, Rome, Italy.

Background: Platypnea and Orthodeoxia Syndrome (POS) is a rare clinical condition characterized by positional dyspnoea and arterial desaturation. Various mechanisms are related to this syndrome. The simultaneous presence of abnormal anatomical findings [aortic root dilatation, atrial septal aneurysm (ASA), Lipomatous septum, and patent foramen ovale (PFO)] and an occurring ventilation/perfusion mismatch can modify intracardiac haemodynamics leading to POS in elderly patients. Read More

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Da-Huang-Fu-Zi-Tang Ameliorates Severe Acute Pancreatitis by Elevation of M2 Kupffer Cells in Rats.

Evid Based Complement Alternat Med 2021 2;2021:5561216. Epub 2021 Jun 2.

Department of Emergency Medicine, The Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China.

Introduction: Severe acute pancreatitis (SAP) is a clinical emergency often accompanied by inflammatory response syndrome (SIRS), which eventually leads to acute lung injury and failure of other organs. The activation of liver Kupffer cells (KCs) plays a major role in the process of SIRS and multiorgan damage caused by SAP. Da-Huang-Fu-Zi-Tang (DHFZT), a traditional Chinese prescription, has been widely used for SAP in the clinic. Read More

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Blood Transfusion and Acute Kidney Injury After Total Aortic Arch Replacement for Acute Stanford Type A Aortic Dissection.

Heart Lung Circ 2021 Jun 10. Epub 2021 Jun 10.

Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Aortic Disease Center, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China. Electronic address:

Aim: To evaluate the effect of packed red blood cells (pRBCs), fresh frozen plasma (FFP), and platelet concentrate (PC) transfusions on acute kidney injury (AKI) in patients with acute Stanford type A aortic dissection (ATAAD) with total arch replacement (TAR).

Method: From December 2015 to October 2017, 421 consecutive patients with ATAAD undergoing TAR were included in the study. The clinical data of the patients and the amount of pRBCs, FFP, and PC were collected. Read More

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Dexamethasone reduces the formation of thoracic aortic aneurysm and dissection in a murine model.

Exp Cell Res 2021 Jun 10:112703. Epub 2021 Jun 10.

Department of Vascular Surgery, Peking University People's Hospital, Beijing, People's Republic of China. Electronic address:

Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening vascular disease with no effective pharmaceutical therapies currently available. Inflammation plays a key role in the progression of aneurysms. Dexamethasone (DEX), a synthetic glucocorticoid, has showed alleviating effects on cells in vitro from TAAD patients. Read More

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Aortic Angiosarcoma in Association with Endovascular Aneurysm Repair: Case Report and Review of the Literature.

Am J Case Rep 2021 Jun 12;22:e931740. Epub 2021 Jun 12.

Division of Clinical Pathology, Niigata University Faculty of Medicine, Niigata, Japan.

BACKGROUND Primary aortic sarcoma often poses diagnostic challenges for pathologists and clinicians because of a very low incidence and controversy over nomenclature and definition. We report a case of aortic angiosarcoma in association with a graft. We also conducted a clinicopathological review of cases of primary aortic sarcomas associated with implanted grafts. Read More

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