1,297,121 results match your criteria public

Impact of Immunoablation and Autologous Hematopoietic Stem Cell Transplantation (AHSCT) on Treatment Cost of Multiple Sclerosis: Real-World Nationwide Study.

Value Health Reg Issues 2021 Apr 14;25:104-107. Epub 2021 Apr 14.

Medical University of Warsaw, Hematology, Oncology, and Internal Diseases, Warsaw, Poland. Electronic address:

Objectives: To provide real-world data on the impact of autologous hematopoietic stem cell transplantation (AHSCT) on treatment costs of patients with multiple sclerosis (MS) in Poland.

Methods: Medical data of 105 patients who underwent AHSCT in the years 2011 to 2016 were obtained from the National Health Fund (NHF) database. Treatment costs were calculated from the public payer's perspective per patient-year for the total available period as well as 12 months before and after AHSCT. Read More

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Trends in substances involved in polysubstance overdose fatalities in Maryland, USA 2003-2019.

Drug Alcohol Depend 2021 Apr 12;223:108700. Epub 2021 Apr 12.

Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Baltimore, MD, 21205, USA.

Background: The substances driving the overdose epidemic in the United States have changed over time. Since 2013, fentanyl-analogues have become the primary opioids driving the epidemic. Recently, polysubstance related deaths have come to the forefront of the epidemic. Read More

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Stunting, IQ, and final school attainment in the Cebu Longitudinal Health and Nutrition Survey birth cohort.

Econ Hum Biol 2021 Apr 7;42:100999. Epub 2021 Apr 7.

USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines.

School attainment is an important aspect of human capital, and a key determinant of long-term health and well-being. Early life deprivation and poor nutritional status are well known predictors of school entry and progression. We examine the persistence of early life influences and subsequent socioeconomic disadvantage (SED) across the multiple school continuation decisions that lead to final school attainment. Read More

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Environmental Awareness and sensitivity of nursing students.

Nurse Educ Today 2021 Apr 8;101:104882. Epub 2021 Apr 8.

Department of Nursing, Faculty of Health Sciences, Eastern Mediterranean University, Famagusta, North Cyprus, via Mersin 10, Turkey. Electronic address:

Objective: Currently, environmental problems have reached alarming levels, constituting a serious problem for public health. This study was conducted in order to evaluate the environmental awareness and sensitivity of nursing students.

Methods: This descriptive study was conducted on 286 nursing students of a foundation university in Northern Cyprus in the fall term of the 2016-2017 academic year. Read More

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Mycobacterium tuberculosis-stimulated whole blood culture to detect host biosignatures for tuberculosis treatment response.

Tuberculosis (Edinb) 2021 Apr 10;128:102082. Epub 2021 Apr 10.

DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Host markers to monitor the response to tuberculosis (TB) therapy hold some promise. We evaluated the changes in concentration of Mycobacterium tuberculosis (M.tb)-induced soluble biomarkers during early treatment for predicting short- and long-term treatment outcomes. Read More

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COgnitive enhancement and consumption of psychoactive Substances among Youth Students (COSYS): a cross-sectional study in France.

Public Health 2021 Apr 14;194:75-78. Epub 2021 Apr 14.

Addictovigilance Center, Fernand-Widal Hospital, Paris, France. Electronic address:

Objectives: This descriptive and analytical study investigated the consumption rates of psychoactive substances among individuals aged 18-25 years in France. More specifically, it enabled assessment of the extent of the neuroenhancement (NE) phenomenon among students in France (including study of the misuse of psychostimulant medicines).

Study Design: COgnitive enhancement and consumption of psychoactive Substances among Youth Students (COSYS) is a cross-sectional survey of students in France. Read More

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#MentalHealthArt: How Instagram artists promote mental health awareness online.

Public Health 2021 Apr 14;194:67-74. Epub 2021 Apr 14.

Department of Psychology, Bowling Green State University, Bowling Green, OH, 43403, USA. Electronic address:

Objectives: Instagram artwork about mental illness was examined to learn how artists promote awareness about mental health and mental illness.

Study Design: Mixed methods predictive and descriptive analyses were conducted on a public dataset of artwork posts from Instagram.

Methods: One thousand art images were classified by media (painting, drawing, collage, photograph, digital art, printmaking, sculpture, jewelry, or other) and style (representational, nonrepresentational, and functional). Read More

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Determinants of health-related quality of life among homeless individuals during the COVID-19 pandemic.

Public Health 2021 Mar 6;194:60-66. Epub 2021 Mar 6.

Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objective: To clarify which variables are associated with the health-related quality of life (HRQoL) among homeless individuals during the COVID-19 pandemic.

Study Design: Cross-sectional research.

Methods: Data were taken from the Hamburg survey of homeless individuals (n = 151). Read More

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Biomonitoring of occupational exposure to bisphenol A, bisphenol S and bisphenol F: A systematic review.

Sci Total Environ 2021 Apr 5;783:146905. Epub 2021 Apr 5.

French Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS), 1 rue du Morvan, 54519 Vandœuvre-Lès-Nancy, France.

Bisphenol A (BPA) and its substitutes bisphenol S (BPS) and bisphenol F (BPF) are endocrine disrupting chemicals widely used in the production of polycarbonate plastics, epoxy resins and thermal papers. The aim of the review was to identify occupational studies using human biomonitoring (HBM) as a tool for bisphenol exposure assessment and to characterize research gaps on the topic as part of the HBM4EU project. Hence, a systematic literature search using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology was conducted for articles published between 2000 and 27th March 2020 across three databases (PubMed, Scopus and Web of Science). Read More

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An integrated assessment methodology for management of potentially contaminated sites based on public data.

Sci Total Environ 2021 Apr 6;783:146913. Epub 2021 Apr 6.

Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China. Electronic address:

Ranking assessment of potentially contaminated sites (PCS) provides a great quantity of information (namely the risk screening list) that is usually examined by environmental managers, and therefore reduces the cost of risk management in terms of site investigation. Here we propose an integrated assessment methodology to establish a risk screening list of PCS in China using the Choquet integral correlation coefficient (ICC), which takes the uncertainty and interaction of PCS attributes into explicit account. The proposed method globally considers the importance and ordered positions of PCS attributes while reflecting their overall ranking. Read More

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Decreased serum testosterone levels associated with 17β-hydroxysteroid dehydrogenase activity in 7-year-old children from a dioxin-exposed area of Vietnam.

Sci Total Environ 2021 Mar 30;783:146701. Epub 2021 Mar 30.

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.

Since 2008, we have conducted epidemiological cohort studies on the relationship between dioxin exposure and disruption with children in the area sprayed with defoliants during the Vietnam War. In a long-term survey of children through the age of five, we observed androgen disruption due to decreased dehydroepiandrosterone (DHEA) and testosterone levels. In this study of 7-year-old, we separately elucidated androgen disruption for boys and girls, and discussed with respect to hormone disruption with sex differences on the steroid hormone biosynthesis process. Read More

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Risk assessment of occupational exposure to anesthesia Isoflurane in the hospital and veterinary settings.

Sci Total Environ 2021 Apr 5;783:146894. Epub 2021 Apr 5.

Environmental Health and Radiation Safety, Temple University, Philadelphia, PA, USA.

Despite the modern ventilation and waste anesthetic gas (WAG) scavenging systems, occupational exposure to common volatile anesthesia, isoflurane, can occur in the hospital and veterinary settings, but limited information exists on potential exposure and health risk of isoflurane. We assessed exposure dose rates and risks among clinicians and veterinary professionals from occupational exposure to isoflurane. Through a critical review of open literature (1965 to 2020), we summarized potential adverse effects and exposure scenarios of isoflurane among the professional groups, including anesthetists, nurses, operating room personnel, researchers, and/or veterinarians. Read More

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A de novo mutation of the SOX10 gene associated with inner ear malformation in a Guangxi family with Waardenburg syndrome type II.

Int J Pediatr Otorhinolaryngol 2021 Apr 14;145:110711. Epub 2021 Apr 14.

Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Regional Key Laboratory of Early Prevention and Treatment of High-Rise Tumors, Nanning, 530021, China. Electronic address:

Objective: Waardenburg syndrome type 2 (WS2) is a rare neural-crest disorder, characterized by heterochromic irides or blue eyes and sensorineural hearing loss. The aim of this study was to analyze the clinical features and investigate the genetic cause of WS2 in a small family from Guangxi Zhuang Autonomous region.

Methods: Whole-exome sequencing and mutational analysis were used to identify disease-causing genes in this family. Read More

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The importance of considering common sources of unknown DNA when evaluating findings given activity level propositions.

Forensic Sci Int Genet 2021 Apr 6;53:102518. Epub 2021 Apr 6.

Faculty of Law, Criminal Justice and Public Administration, School of Criminal Justice, University of Lausanne, CH-1015 Lausanne-Dorigny, Switzerland.

Evaluating forensic biological evidence considering activity level propositions is becoming more prominent around the world. In such evaluations it is common to combine results from multiple items associated with the alleged activities. The results from these items may not be conditionally independent, depending on the mechanism of cell/DNA transfer being considered and it is important that the evaluation takes these dependencies into account. Read More

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Nomophobia and the influence of time to REST among nursing students. A descriptive, correlational and predictive research.

Nurse Educ Pract 2021 Mar 19;52:103025. Epub 2021 Mar 19.

University of Granada. Faculty of Education and Sport, Melilla, Spain. Electronic address:

The inclusion of the smartphone in society has brought many advantages, but also disadvantages, such as nomophobia, considered as a digital disease generated by the excessive use of the smartphone. The general objective of the research is to know and analyse the prevalence of nomophobia among nursing students and knowing the influence of time to rest. The research design is descriptive, correlational, transversal and predictive with a quantitative research methodology. Read More

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A comparative study between the incidence and epidemiological features of Influenza-Like Illness and laboratory-confirmed COVID-19 cases in the Italian epicenter (Lombardy).

J Infect Public Health 2021 Feb 23;14(5):674-680. Epub 2021 Feb 23.

Department of Biomedical Sciences for Health, University of Milan, Milan, Italy; Interuniversity Research Center on Influenza and Other Transmissible Infections (CIRI-IT), Genoa, Italy. Electronic address:

Introduction: In Lombardy, the influenza surveillance system relies on sentinel physicians that weekly report data on the number of Influenza-Like Illness (ILI) and a part of them also collect nasopharyngeal samples for virologic analyses. This study aims at comparing the ILI incidence of 2019-2020 influenza season with the incidence of COVID-19 cases in order to better understand the current epidemic and to evaluate whether the implementation of ILI surveillance system could succeed in early detection and monitoring of COVID-19 diffusion.

Methods: The distribution of ILI cases in the seasons 2017-2018, 2018-2019 and 2019-2020 was taken in consideration and the curve trends were compared and analyzed according to geographical areas, age groups and time differences. Read More

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February 2021

Molecular identification of Sporothrix species in a hyperendemic area in Peru.

J Infect Public Health 2021 Feb 23;14(5):670-673. Epub 2021 Feb 23.

Facultad de Ciencias, Universidad Nacional de San Antonio Abad del Cusco (UNSAAC), Cusco, Peru.

To date, there have been no molecular typing studies to identify the Sporothrix species circulating in Abancay, a hyperendemic area of sporotrichosis in Peru. To identify six clinical isolates of the Sporothrix schenckii complex from Abancay, Peru, we used PCR-sequencing of the calmodulin gene, and a phylogenetic analysis was conducted with these and additional sequences from GenBank. All clinical isolates were identified as S. Read More

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February 2021

What concerns Indian general public on second wave of COVID-19? A report on social media opinions.

Diabetes Metab Syndr 2021 Apr 14;15(3):829-830. Epub 2021 Apr 14.

National Institute of Technology, Trichy, India.

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Serum untargeted metabolomics delineates the metabolic status in different subtypes of non-alcoholic fatty liver disease.

J Pharm Biomed Anal 2021 Apr 1;200:114058. Epub 2021 Apr 1.

National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, PR China. Electronic address:

Aims: The aim of this study was to identify novel serum metabolites associated with non-alcoholic fatty liver disease (NAFLD), and to explore the metabolic discrepancies between Lean-NAFLD and Obese-NAFLD.

Methods: Serum samples from patients with NAFLD (n = 161) and healthy participants (n = 149) were collected, and metabolites were analyzed with UPLC-Q-TOF MS/MS. Subgroup analyses were performed to explore the metabolic differences among Lean-NAFLD, Obese-NAFLD and healthy controls RESULTS: A total of 24 differentially present metabolites were found between patients with NAFLD and healthy controls. Read More

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Fate of antibiotic resistance genes in farmland soil applied with three different fertilizers during the growth cycle of pakchoi and after harvesting.

J Environ Manage 2021 Apr 14;289:112576. Epub 2021 Apr 14.

State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Electronic address:

The increasing prevalence of antibiotic resistance genes (ARGs) in the soil environment poses a serious threat to crop safety and even public health. In this study, the fate of ARGs in the soil was investigated during the growth period of pakchoi and after harvesting with the application of different kinds of fertilizers. The result showed that increasing rate of soil ARGs during the growth period of pakchoi followed the order of composted manure > commercial fertilizer > mineral fertilizer. Read More

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Potential medicinal value of celastrol and its synthesized analogues for central nervous system diseases.

Biomed Pharmacother 2021 Apr 14;139:111551. Epub 2021 Apr 14.

Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an 712046, Shaanxi Province, China. Electronic address:

The central nervous system (CNS) is a vital part of the human nervous system, and the incidence of CNS disease is increasing year by year, which has become a major public health problem and a prominent social problem. At present, the drugs most commonly used in the clinic are receptor regulators, and neurotransmitter inhibitors, but they are accompanied by serious side effects. Therefore, the identification of new drugs and treatment strategies for CNS disease has been a research hotspot in the medical field. Read More

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Has public health messaging during the COVID-19 pandemic reflected local risks to health?: A content analysis of tweeting practices across Canadian geographies.

Health Place 2021 Apr 13;69:102568. Epub 2021 Apr 13.

School of Earth, Environment & Society, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada. Electronic address:

During the COVID-19 pandemic, public health agencies and decision-makers have used social media to disseminate information, encourage changes to behaviour and promote community supports and resources. Their communications have served to educate the public on risks and initiate the widespread adoption of public health measures to 'flatten the curve'. We conducted a content analysis of COVID-19 Tweets by Canadian public health accounts during the first 6 months of the pandemic to explore differences in Tweeting practices by geography and identify opportunities to improve risk communication. Read More

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Effective HPV vaccination coverage in Australia by number of doses and two-dose spacing: what if one or two doses are sufficient?

Tumour Virus Res 2021 Apr 14:200216. Epub 2021 Apr 14.

VCS Population Health, VCS Foundation, Melbourne, Australia; Melbourne School of Population and Global Health, University of Melbourne, Australia.

Background: Initially, three-dose schedules were recommended for vaccines against human papillomavirus (HPV); subsequently recommendations have been updated to a schedule of two doses delivered at least six (minimum five) months apart for those aged <15 years at dose 1. We aimed to re-estimate effective HPV vaccination coverage in Australia, considering reduced-dose schedules and possible one-dose effectiveness. We also aimed to identify which of the three school visits was most commonly missed amongst two-dose only recipients, to inform optimal timing of visits. Read More

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An examination of reciprocal effects between cardiovascular morbidity, depressive symptoms and loneliness over time in a longitudinal cohort of Dutch older adults.

J Affect Disord 2021 Mar 31;288:122-128. Epub 2021 Mar 31.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands; GGZ inGeest Specialized Mental Health Care, Amsterdam, The Netherlands.

Background: Unidirectional studies suggest that the effects between cardiovascular disease, depressive symptoms and loneliness are reciprocal, but this has not been tested empirically. The aim was to study how cardiovascular morbidity, depressive symptoms and loneliness influence each other longitudinally.

Methods: Data from 2979 older adults from the Longitudinal Aging Study Amsterdam were analysed. Read More

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Assessing recurrence of depression using a zero-inflated negative binomial model: A secondary analysis of lifelog data.

Psychiatry Res 2021 Apr 1;300:113919. Epub 2021 Apr 1.

Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine / School of Public Health, Kyoto, Japan.

When studying recurrence of depression, researchers should pay attention to cases where physicians' assessment corresponds to the patients' perception. However, they should also focus on potential signs of recurrence when the recurrence is suspected by the physicians but not the patients (false-negative zeros). Because false negatives can delay diagnosis and treatment, we aimed to investigate "sitting idly" as a predictor influencing no alert sign of recurrence and estimated the counts of recurrence of depression. Read More

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Recent Trends in Human Brucellosis in the West Bank, Palestine.

Int J Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

Preventive Medicine Department, Palestinian Ministry of Health, Palestine.

Objectives: To investigate the epidemiology of human brucellosis in the West Bank over the past 20 years with a focus on recent trends in disease incidence from 2000 through 2020.

Methods: We conducted a long-term descriptive epidemiological study based on the Palestinian Ministry of Health records from 2000-2020.

Results: The total number of cases was 7935 and the average annual incidence rate (AAIR) was 9. Read More

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Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: an open-label randomized trial.

Int J Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.

Background: We examined whether existing licensed pharmacotherapies could reduce the spread of coronavirus disease 2019 (COVID-19).

Methods: An open-label parallel randomized controlled trial was performed among healthy migrant workers quarantined in a large multi-storey dormitory in Singapore. Forty clusters (each defined as individual floors of the dormitory) were randomly assigned to receive a 42-day prophylaxis regimen of either oral hydroxychloroquine (400 mg once, followed by 200 mg/day), oral ivermectin (12 mg once), povidone-iodine throat spray (3 times/day, 270 µg/day), oral zinc (80 mg/day)/vitamin C (500 mg/day) combination, or oral vitamin C, 500 mg/day. Read More

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The economic burden of diarrhea in children under five years in Bangladesh.

Int J Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

International Centre for Diarrheal Disease Research, Bangladesh (icddr,b).

Background: Diarrhea is a leading cause of morbidity and mortality among the under-five children in Bangladesh. Hospitalization for diarrhea can pose a significant burden to the households and health-systems. We aim to estimate the cost-of-illness due to diarrhea from the healthcare facility, caregiver, and societal perspectives in Bangladesh. Read More

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The sourcing and use of high physical resemblance personal protective equipment to train health care workers, improve confidence and conserve medical grade equipment.

J Hosp Infect 2021 Apr 14. Epub 2021 Apr 14.

Design Health Collab, Faculty of Art, Design and Architecture, Monash University, Caulfield, Victoria, Australia; School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia; Emergency Medicine Research, Monash Medical Centre, Clayton, Victoria, Australia; Monash Centre for Health Research and Implementation, Monash Public Health and Preventive Medicine, Monash University and Monash Health, Melbourne, Victoria, Australia. Electronic address:

Personal protective equipment (PPE) is essential for health care worker (HCW) safety. Conservation of PPE for clinical use during the COVID-19 pandemic reduced its availability for training, necessitating an innovative approach to sourcing high physical resemblance PPE (HPR-PPE). We present a case study of crowd-sourcing HPR-PPE to train HCW. Read More

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A pilot study of near-field airborne particle concentrations in young children undergoing high flow nasal cannula therapy.

J Hosp Infect 2021 Apr 14. Epub 2021 Apr 14.

Department of Pediatrics, School of Medicine, Oregon Health & Science University; OHSU-PSU School of Public Health. Electronic address:

Background: High flow nasal cannula therapy (HFNC) may increase aerosol generation, putting healthcare workers at risk, including from SARS-CoV-2.

Aim: This study examined whether use of HFNC increases near-field aerosols and if there is a relationship with flow rate.

Methods: Subjects aged four weeks to 24 months were recruited. Read More

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