9,348 results match your criteria ptx


Current strategies for intratumoural immunotherapy - Beyond immune checkpoint inhibition.

Eur J Cancer 2021 Sep 21. Epub 2021 Sep 21.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA. Electronic address:

Immunotherapy has revolutionised cancer treatment through restoration of host antitumour immune response. Immune checkpoint inhibitors (ICIs) confer durable responses in only a subset of patients. Mechanisms of ICI resistance to improve durable response rates and overall survival are an area of intense clinical research. Read More

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September 2021

Hidden threat in familial Mediterranean fever: subclinical inflammation, oxidative stress and their relationship with vitamin D status.

Turk J Med Sci 2021 Sep 21. Epub 2021 Sep 21.

Background/aim: Vitamin D levels have been investigated in children with familial Mediterranean fever (FMF), but the relationship between vitamin D status and inflammation/oxidative stress indicators could not be clearly demonstrated. This study aimed to investigate the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with FMF during an attack-free period.

Materials And Methods: In the cross-sectional study, ninety children with FMF in the attack-free period and 30 healthy children were included in the study. Read More

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September 2021

CircATL2 enhances paclitaxel resistance of ovarian cancer via impacting miR-506-3p/NFIB axis.

Drug Dev Res 2021 Sep 19. Epub 2021 Sep 19.

Department of Radiotherapy, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Circular RNAs (circRNAs) play vital regulatory roles in the development of ovarian cancer (OC). However, the functions of circRNA Atlastin GTPase 2 (circATL2) in paclitaxel (PTX) resistance of OC are still unclear. As a result, circATL2 was upregulated in PTX-resistant OC tissues and cells. Read More

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September 2021

A Unique Presentation of Birt-Hogg-Dube Syndrome.

Cureus 2021 Aug 16;13(8):e17227. Epub 2021 Aug 16.

Pulmonary and Critical Care Medicine, Edward Via College of Osteopathic Medicine-Carolinas, Spartanburg, USA.

Birt-Hogg-Dube (BHD) syndrome is a rare autosomal dominant condition identified by the triad of cutaneous fibrofolliculomas, pulmonary cysts, and renal cell carcinoma. The vast majority of patients with BHD syndrome initially present with spontaneous pneumothorax. This unique case describes a patient with BHD syndrome who presented with sebaceous cysts and perifollicular fibromas. Read More

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Observational Management of Penetrating Occult Pneumothoraces: Outcomes and Risk Factors for Interval Thoracostomy Tube Placement.

J Trauma Acute Care Surg 2021 Sep 16. Epub 2021 Sep 16.

Department of Surgery, University of California San Francisco, East Bay, Oakland, CA Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA.

Background: Guidelines for penetrating occult pneumothoraces (OPTXs) are based on blunt injury. Further understanding of penetrating OPTX pathophysiology is needed. In observational management of penetrating OPTX we hypothesized that specific clinical and radiographic features may be associated with interval thoracostomy tube (TT) placement. Read More

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September 2021

Evaluation and Management of Traumatic Pneumothorax: A Western Trauma Association Critical Decisions Algorithm.

J Trauma Acute Care Surg 2021 Sep 16. Epub 2021 Sep 16.

Medical College of Wisconsin, Milwaukee, WI Oregon Heatlh Science University, Portland, OR Dell Medical School, University of Texas at Austin, Austin, TX Indiana University School of Medicine, Indianapolis, IN University of Southern California, Los Angeles, CA Cedars-Sinai Medical Center, Los Angeles, CA Ernest E Moore Shock Trauma center, Denver, CO Scripps Mercy Hospital, San Diego, CA Inova Trauma Center, Falls Church, VA Children's Hospital, Cincinnati, OH University of Pittsburgh, Pittsburgh, PA St. Joseph's Hospital and Medical Center, Phoenix, AZ.

This is a recommended algorithm of the Western Trauma Association for the management of a traumatic pneumothorax (PTX). The current algorithm and recommendations are based on available published prospective cohort, observational, and retrospective studies and the expert opinion of the Western Trauma Association members. The algorithm (Figure 1) and accompanying text represents a safe and reasonable approach to this common problem. Read More

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September 2021

Comparison and prediction of artefact severity due to total hip replacement in 1.5 T versus 3 T MRI of the prostate.

Eur J Radiol 2021 Sep 11;144:109949. Epub 2021 Sep 11.

University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225 Dusseldorf, Germany. Electronic address:

Purpose: To evaluate image quality and diagnostic value of multiparametric prostate MRI (mpMRI) in patients with total hip replacement (THR) at 1.5 and 3 Tesla.

Methods: In this retrospective multicenter cohort study patients with uni- or bilateral THR and 1. Read More

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September 2021

Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay.

Biomed Pharmacother 2021 Sep 15;143:112173. Epub 2021 Sep 15.

Department of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE, USA.

We explored the utility of the real-time FLIPR Membrane Potential (FMP) assay as a method to assess kappa opioid receptor (KOR)-induced hyperpolarization. The FMP Blue dye was used to measure fluorescent signals reflecting changes in membrane potential in KOR expressing CHO (CHO-KOR) cells. Treatment of CHO-KOR cells with kappa agonists U50,488 or dynorphin [Dyn (1-13)NH] produced rapid and concentration-dependent decreases in FMP Blue fluorescence reflecting membrane hyperpolarization. Read More

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September 2021

Inhibitory G protein-mediated modulation of slow delayed rectifier potassium channels contributes to increased susceptibility to arrhythmogenesis in aging heart.

Heart Rhythm 2021 Sep 15. Epub 2021 Sep 15.

Department of Pharmacology, Hebei Medical University; The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Province. Electronic address:

Background: Slow delayed rectifier potassium current (I) is an important component of repolarization reserve during sympathetic nerve excitement. However, little is known about age-related functional changes of I and its involvement in age-dependent arrhythmogenesis.

Objective: To investigate age-related alteration of the I response to β-adrenergic receptor (βAR) activation. Read More

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September 2021

Reversing Multidrug Resistance by Inducing Mitochondrial Dysfunction for Enhanced Chemo-Photodynamic Therapy in Tumor.

ACS Appl Mater Interfaces 2021 Sep 17. Epub 2021 Sep 17.

State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian 116024, P.R. China.

Efficiency of standard chemotherapy is dramatically hindered by intrinsic multidrug resistance (MDR). Recently, to amplify therapeutic efficacy, photodynamic therapy (PDT)-induced mitochondrial dysfunction by decorating targeting moieties on nanocarriers has obtained considerable attention. Nevertheless, low targeting efficiency, complex synthesis routes, and difficulty in releasing contents become the major obstacles in further clinical application. Read More

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September 2021

Microfluidic assembly of small-molecule prodrug cocktail nanoparticles with high reproducibility for synergistic combination of cancer therapy.

Int J Pharm 2021 Sep 14;608:121088. Epub 2021 Sep 14.

The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, PR China.

Therapeutic nanoparticles (NPs) self-assembled from small molecular (pro)drug entities, opens up novel avenues for the generation of a wide range of drug delivery systems. Particularly, cocktail NPs created by co-assembly of multiple therapeutics often show profound efficacy beyond their individual agents. However, fabrication of synergistic NPs with high reproducibility and capability to deliver multiple therapeutics in a predefined ratio remains a challenge, which deters NP therapeutics from further clinical translation. Read More

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September 2021

Surface modified halloysite nanotubes with different lumen diameters as drug carriers for cancer therapy.

Chem Commun (Camb) 2021 Sep 16;57(74):9470-9473. Epub 2021 Sep 16.

Hunan Key Lab of Mineral Materials and Application, School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China.

Paclitaxel (PTX) is successfully loaded by surface modification of distearoyl phosphoethanolamine (DSPE) on halloysite nanotubes (HNTs) with different inner lumen diameters. Drug loading of DSPE-HNTs-PTX attains 18.44% of DSPE content with a nearly complete release (near 100%) achieved. Read More

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September 2021

Genetic Diversity of Clinical ST2 Strains in comparison with Vaccine Reference Strains of India.

J Genomics 2021 3;9:38-42. Epub 2021 Sep 3.

Department of Clinical Microbiology, Christian Medical College, Vellore - 632 004, India.

Pertussis is a highly contagious disease of the respiratory tract caused by , a bacterium that lives in the mouth, nose, and throat. Current study reports the highly accurate complete genomes of two clinical strains from India for the first time. Complete genome sequencing was performed for two strains using Ion Torrent PGM and Oxford nanopore sequencing method. Read More

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September 2021

Phase I/II study of biweekly nab-paclitaxel in patients with platinum-pretreated non-small cell lung cancer: NJLCG1402.

Thorac Cancer 2021 Sep 14. Epub 2021 Sep 14.

Department of Palliative Medicine, Tohoku University School of Medicine, Sendai, Japan.

Background: NJLCG1402 was a phase I/II trial investigating biweekly nanoparticle albumin-bound paclitaxel (nab-PTX) in patients with advanced non-small cell lung cancer (NSCLC).

Methods: The study included patients aged ≥20 years with previously treated NSCLC. Nab-PTX (100-150 mg/m ) was administered biweekly in a 28-day cycle. Read More

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September 2021

[A Case of Non-Resectable Advanced Gastric Cancer for Which Nivolumab Was Markedly Effective].

Gan To Kagaku Ryoho 2021 Sep;48(9):1165-1167

Dept. of Pharmacy, Koyama Memorial Hospital.

A 74-year-old man presented to our hospital because of anorexia. Upper gastrointestinal endoscopy revealed type 3 gastric cancer. Further examination disclosed metastasis to the perigastric lymph nodes and to the liver, and a diagnosis of non- resectable advanced gastric cancer(cT4N2H1P0M0)in cStage Ⅳ was made. Read More

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September 2021

Thoracostomy Tube Removal in Pediatric Trauma: Film or No Film?

J Surg Res 2021 Sep 11;269:51-58. Epub 2021 Sep 11.

Department of Surgery, Division of Pediatric Surgery, Indiana University School of Medicine, Indianapolis, IN; Riley Trauma Program, Riley Hospital for Children, Indiana University Health, Indianapolis, IN. Electronic address:

Background: Use of routine chest x-rays (CXR) following thoracostomy tube (TT) removal is highly variable and its utility is debated. We hypothesize that routine post-pull chest x-ray (PP-CXR) findings following TT removal in pediatric trauma would not guide the decision for TT reinsertion.

Methods: Patients ≤ 18 y who were not mechanically ventilated and undergoing final TT removal for a traumatic hemothorax (HTX) and/or pneumothorax (PTX) at a level I pediatric trauma center from 2010 to 2020 were retrospectively reviewed. Read More

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September 2021

Design and Invitro Characterization of Green Synthesized Magnetic Nanoparticles Conjugated with Multitargeted Poly Lactic Acid Copolymers for Co-delivery of siRNA and Paclitaxel.

Eur J Pharm Sci 2021 Sep 11;167:106007. Epub 2021 Sep 11.

Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address:

Background: The self-assembling of various amphipathic copolymers is a simple method that allows the preparation of complex nanoparticles with several useful properties. In the present study, the polylactic acid-polyethylene glycol-folate (PLA-PEG-FA) (PPF), PLA-PEG-T7 peptide (PPT) and PLA-Chitosan-Spermine (PCS) copolymers were synthesized separately.

Methods: These copolymers combined with FeO magnetic core and loaded with paclitaxel (PTX)/siRNA-FAM to form magnetic PCS/PPF/PPT/PTX/siRNA micelles (MPCSFT/PTX/siRNA) and were characterized using physicochemical and biological analysis. Read More

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September 2021

Combined chemotherapy for triple negative breast cancer treatment by paclitaxel and niclosamide nanocrystals loaded thermosensitive hydrogel.

Eur J Pharm Sci 2021 Sep 11;167:105992. Epub 2021 Sep 11.

Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Triple negative breast cancer (TNBC) is the most dangerous subtype of breast cancer accompanying by unfavorable prognosis due to lack of specific therapeutic targets. Paclitaxel (PTX) is the first-line chemotherapeutic drug for TNBC and niclosamide (NLM) was identified as an inhibitor for TNBC and breast cancer stem cells (BCSCs). Intratumoral drug delivery system was a hopeful alternative for chemotherapeutic drug administration due to its targeting efficiency with lower systemic toxicity. Read More

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September 2021

Better lesion conspicuity translates into improved prostate cancer detection: comparison of non-parallel-transmission-zoomed-DWI with conventional-DWI.

Abdom Radiol (NY) 2021 Sep 12. Epub 2021 Sep 12.

Department of Radiology, The Sixth Affiliated People's Hospital, Shanghai Jiao Tong University, No. 600, Yi Shan Road, Shanghai, 200233, China.

Purpose: To compare advanced non-parallel transmission zoomed diffusion-weighted imaging (nonPTX zoom-DWI) to conventional DWI (conv-DWI) for the assessment of prostate cancer (PCa).

Methods: This retrospective study included 98 patients who underwent conv-DWI, nonPTX zoom-DWI, and T2-weighted imaging of the prostate. The image qualities of the two DWI sets, including the distortion of the prostate and the existence of artifacts, were evaluated. Read More

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September 2021

Lung Ultrasonography for Pneumothorax in Dogs and Cats.

Authors:
Søren R Boysen

Vet Clin North Am Small Anim Pract 2021 Sep 9. Epub 2021 Sep 9.

Veterinary Emergency and Critical Care, Department of Veterinary Clinical and Diagnostic Sciences, University of Calgary, 11877 85 Street NW, Calgary, AB T3R 1J3, USA. Electronic address:

A sonographic diagnosis of pneumothorax (PTX) traditionally relies on excluding the presence of lung sliding, lung pulse, and/or B lines/lung consolidations, and identifying the lung point. However, these criteria can be difficult to identify, particularly in critically ill patients with respiratory disorders, and the lung point is infrequently used. Newer sonographic findings, such as mirrored ribs, reverse lung sliding, and abnormal curtain signs, have been identified to try to increase the accuracy of diagnosing PTX. Read More

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September 2021

Temperature and pH-responsive in situ hydrogels of gelatin derivatives to prevent the reoccurrence of brain tumor.

Biomed Pharmacother 2021 Sep 9;143:112144. Epub 2021 Sep 9.

College of Pharmacy, Gachon Institute of Pharmaceutical Science, Gachon University, 21936 Incheon, South Korea. Electronic address:

Glioblastoma multiforme (GBM) is a grade IV malignant brain tumor with a median survival time of approximately 12-16 months. Because of its highly aggressive and heterogeneous nature it is very difficult to remove by surgical resection. Herein we have reported dual stimuli-responsive and biodegradable in situ hydrogels of oligosulfamethazine-grafted gelatin and loaded with anticancer drug paclitaxel (PTX) for preventing the progress of Glioblastoma. Read More

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September 2021

Enhanced chemo-photodynamic therapy of an enzyme-responsive prodrug in bladder cancer patient-derived xenograft models.

Biomaterials 2021 Aug 27;277:121061. Epub 2021 Aug 27.

Department of Urology, Institute of Urology, Huaxi MR Research Center (HMRRC), National Clinical Research Center for Geriatrics, Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:

Patient-derived xenograft (PDX) models are powerful tools for understanding cancer biology and drug discovery. In this study, a polymeric nano-sized drug delivery system poly (OEGMA)[email protected] ([email protected]) composed of a photosensitizer chlorin e6 (Ce6) and a cathepsin B-sensitive polymer-paclitaxel (PTX) prodrug was constructed. The photochemical internalization (PCI) effect and enhanced chemo-photodynamic therapy (PDT) were achieved via a two-stage light irradiation strategy. Read More

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PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models.

J Exp Clin Cancer Res 2021 Sep 10;40(1):286. Epub 2021 Sep 10.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Department of Oncology, via M. Negri 2, 20156, Milan, Italy.

Background: Scarce drug penetration in solid tumours is one of the possible causes of the limited efficacy of chemotherapy and is related to the altered tumour microenvironment. The abnormal tumour extracellular matrix (ECM) together with abnormal blood and lymphatic vessels, reactive stroma and inflammation all affect the uptake, distribution and efficacy of anticancer drugs.

Methods: We investigated the effect of PEGylated recombinant human hyaluronidase PH20 (PEGPH20) pre-treatment in degrading hyaluronan (hyaluronic acid; HA), one of the main components of the ECM, to improve the delivery of antitumor drugs and increase their therapeutic efficacy. Read More

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September 2021

RECURRENT PERIOCULAR BASAL CELL CARCINOMA. CASE REPORT.

Cesk Slov Oftalmol 2021 ;77(4):208-213

Aim: We present the management of a severe case of recurrent periocular basal cell carcinoma, orbital invasion and exenteration.

Case Report: The present case is of a recurrent basal cell carcinoma in a 84-year-old male presenting with non-healing lesion above right eyelid. A tumor excision was performed in May 2014. Read More

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September 2021

Self-Assembly Engineering Nanodrugs Composed of Paclitaxel and Curcumin for the Combined Treatment of Triple Negative Breast Cancer.

Front Bioeng Biotechnol 2021 24;9:747637. Epub 2021 Aug 24.

Department of Breast Surgery, The Second Hospital of Jilin University, Changchun, China.

The clinical outcomes of triple-negative breast cancer (TNBC) chemotherapy are unsatisfactory. Water solubility and biosafety of chemo drugs are also major barriers for achieving satisfactory treatment effect. In this study, we have reported a combinational strategy by self-assembly engineering nanodrugs PC NDs, which were composed of paclitaxel (PTX) and curcumin (Cur), for effective and safe TNBC chemotherapy. Read More

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The first reported use of autologous blood pleurodesis for treatment of prolonged air leak in COVID-19-related spontaneous pneumomediastinum and pneumothorax: A case report.

Respirol Case Rep 2021 Oct 5;9(10):e0840. Epub 2021 Sep 5.

KPJ Johor Specialist Hospital Johor Bahru Malaysia.

Spontaneous pneumomediastinum (SPM) and pneumothorax (PTX) have been described as rare complications of COVID-19 pneumonia. We present a case of COVID-19 pneumonia which was complicated by SPM on Day 13 of admission with progression to spontaneous PTX 2 days later which necessitated intercostal chest drainage. It was complicated by prolonged air leak (PAL) for the next 9 days despite being on continued low-dose suction and another additional larger bore intercostal drain inserted. Read More

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October 2021

Luminescent halido(aryl) Pt(IV) complexes obtained oxidative addition of iodobenzene or diaryliodonium salts to bis-cyclometalated Pt(II) precursors.

Dalton Trans 2021 Sep 9. Epub 2021 Sep 9.

Departamento de Química Inorgánica, Facultad de Química, Universidad de Murcia, Campus de Espinardo, 19, 30100 Murcia, Spain.

The synthesis of bis-cyclometalated halido(aryl) Pt(IV) complexes [PtX(Ar)(C^N)], with C^N = cyclometalated 4-(-butyl)-2-phenylpyridine (bppy), 2-(-tolyl)pyridine (tpy), 2-(2-thienyl)pyridine (thpy), or 1-phenylisoquinoline (piq), X = I, Cl, or F, and Ar = Ph (for all C^N ligands) or -BuPh (for C^N = tpy), and the photophysical properties of the chlorido and fluorido series is reported. The oxidative addition of iodobenzene to -[Pt(C^N)] precursors is demonstrated to occur in MeCN under irradiation with visible light to give complexes [PtI(Ph)(C^N)], presumably involving radical species that also produce the activation of the solvent to give cyanomethyl complexes [PtI(CHCN)(C^N)]. The introduction of an aryl ligand can also be achieved by reacting -[Pt(C^N)] with (ArI)PF (Ar = Ph, -BuPh), which affords cationic intermediates of the type [Pt(Ar)(C^N)(NCMe)]. Read More

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September 2021

[Effects of idiopathic hypoparathyroidism on tooth eruption of rats].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Sep;56(9):880-891

Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

To explore the effects of reduced parathyroid function in early growth and development on tooth eruption and enamel development by establishing an animal model of idiopathic hypoparathyroidism (IHP) and to explore the mechanism of IHP affecting tooth eruption with a view to provide experimental basis for early diagnosis and clinical treatment of IHP. Forty-eight SD rats at postnatal day 7 were randomly and equally divided into sham operation group and IHP group. The bilateral parathyroidectomy (PTX) was performed by using carbon nanoparticles technique to establish an IHP rat model, while no parathyroids were removed in the sham operation group using the same technique. Read More

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September 2021

Microbiota metabolite butyrate constrains neutrophil functions and ameliorates mucosal inflammation in inflammatory bowel disease.

Gut Microbes 2021 Jan-Dec;13(1):1968257

Center for IBD Research, Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Host-microbial cross-talk plays a crucial role in maintenance of gut homeostasis. However, how microbiota-derived metabolites, e.g. Read More

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September 2021

Cryoprotective Effect of Pentoxifylline on Spermatogonial Stem Cell During Transplantation into Azoospermic Torsion Mouse Model.

Reprod Sci 2021 Sep 7. Epub 2021 Sep 7.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Preserving the spermatogonial stem cells (SSCs) in long periods of time during the treatment of male infertility using stem cell banking systems and transplantation is an important issue. Therefore, this study was conducted to develop an optimal cryopreservation protocol for SSCs using 10 mM pentoxifylline (PTX) as an antioxidant in basal freezing medium. Testicular torsion-a mouse model for long-term infertility-was used to transplant fresh SSCs (n = 6), fresh SSCs treated with PTX (n = 6), cryopreserved SSCs with basal freezing medium (n = 6), and cryopreserved SSCs treated with PTX (n = 6). Read More

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September 2021