J Pediatr Gastroenterol Nutr 2021 Apr 12. Epub 2021 Apr 12.
Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Neonatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China; Department of Neonatology, Rigshospitalet, Copenhagen, Denmark; Hans Christian Andersen Children's Hospital, Odense, Denmark.
Objectives: Exclusive feeding with bovine colostrum (BC) protects preterm pigs against necrotizing enterocolitis (NEC) and BC has recently been tested as a supplement to mother's own milk or formula (FOR) for very preterm infants. Using preterm pigs as model for infants, we investigated if BC has gut- and NEC-protective effects at different proportions of the daily enteral intake given as BC.
Methods: Sixty-eight caesarean-delivered preterm piglets (90% gestation) were allocated into four groups with increasing proportions of eight daily bolus feedings as BC: BC00 (only FOR feeding), BC25 (25% BC), BC50 (50% BC), or BC75 (75% BC). Read More