12,748 results match your criteria pts

Identification of Very Low-Risk Subgroups of Patients with Primary Mediastinal Large B-Cell Lymphoma Treated with R-CHOP.

Oncologist 2021 Apr 19. Epub 2021 Apr 19.

Department of Hematology and Bone Marrow Transplantation.

Background: R-CHOP can cure approximately 75% of patients with primary mediastinal large B-cell lymphoma (PMLBCL), but prognostic factors have not been sufficiently evaluated yet. R-da-EPOCH is potentially more effective but also more toxic than R-CHOP. Reliable prognostic classification is needed to guide treatment decisions. Read More

View Article and Full-Text PDF

Synthetic production of prenylated naringenins in yeast using promiscuous microbial prenyltransferases.

Metab Eng Commun 2021 Jun 19;12:e00169. Epub 2021 Mar 19.

Graduate School of Science, Technology and Innovation, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan.

Reconstitution of prenylflavonoids using the flavonoid biosynthetic pathway and prenyltransferases (PTs) in microbes can be a promising attractive alternative to plant-based production or chemical synthesis. Here, we demonstrate that promiscuous microbial PTs can be a substitute for regiospecific but mostly unidentified botanical PTs. To test the prenylations of naringenin, we constructed a yeast strain capable of producing naringenin from l-phenylalanine by genomic integration of six exogenous genes encoding components of the naringenin biosynthetic pathway. Read More

View Article and Full-Text PDF

Posttraumatic Stress Symptoms, Quality of Life, and Stress Burden in Caregivers of Patients With Severe Mental Illness: An Underestimated Health Concern.

Front Psychiatry 2021 1;12:623499. Epub 2021 Apr 1.

El Mamoura Psychiatric Hospital, Alexandria, Egypt.

Caregivers of patients with severe mental disorders experience a heavy stress burden that can manifest as psychiatric symptoms mimicking posttraumatic stress disorder (PTSD) and can negatively impact interpersonal relationships and work performance. The present study investigated the prevalence of PTSD symptoms, quality of life (QoL), and stress burden in caregivers of patients with severe mental illness. A total of 70 caregivers of severely mentally ill patients and 70 control subjects who were caregivers of patients with a chronic debilitating medical illness (cardiovascular disease) were recruited from university hospital outpatient facilities. Read More

View Article and Full-Text PDF

Temporal-spatial features and key factors' analysis of vertical eddy diffusivities in Taihu Lake, China.

Environ Sci Pollut Res Int 2021 Apr 18. Epub 2021 Apr 18.

School of Hydrology and Water Resources, Nanjing University of Information Science and Technology, 219 Ningliu Rd, Nanjing, 210044, China.

Vertical eddy diffusivity (VED) is used to quantify the vertical mixing of water column, which has a profound influence on the evolution of aquatic ecosystems. Based on half-hourly water temperature measured at -20 cm and -150 cm depths from 2015 to 2017 at stations of Pingtaishan (PTS), Dapukou (DPK), Bifenggang (BFG), and Xiaoleishan (XLS) in Taihu Lake, the daily average VED is calculated according to the phase lag of water temperature series at two depths. The temporal and spatial features and possible evolution characters of vertical turbulences are then deliberated. Read More

View Article and Full-Text PDF

A Narrative Review on the Epidemiology, Prevention, and Treatment of Venous Thromboembolic Events in the Context of Chronic Venous Disease.

J Vasc Surg Venous Lymphat Disord 2021 Apr 15. Epub 2021 Apr 15.

Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI. Electronic address:

Background: Chronic venous disease (CVD) describes a spectrum of conditions associated with venous hypertension. The association between various CVD etiologies and subsequent risk of venous thromboembolic (VTE) events, such as deep vein thrombosis or pulmonary embolism, is a topic of considerable clinical interest. The aims of this review are to characterize the risk of VTE according to CVD etiology and to determine the optimal anticoagulation strategy for treatment or prevention of VTE in patients with CVD. Read More

View Article and Full-Text PDF

Pharmacovigilance network as an additional tool for the surveillance of antimicrobial resistance.

Pharmacoepidemiol Drug Saf 2021 Apr 17. Epub 2021 Apr 17.

Department de Farmacologia, Terapèutica i Toxicologia. Universitat Autònoma de Barcelona (UAB), Spain.

Background: The WHO Programme for International Drug Monitoring (PIDM) is a large Pharmacovigilance network of countries sharing Adverse Drug Reaction (ADR) reports. Pharmacovigilance Experts have suggested that antimicrobial resistance (AMR) is an overlooked adverse event. We undertook this study to investigate the potential role of Pharmacovigilance databases in the surveillance of antimicrobial resistance. Read More

View Article and Full-Text PDF

Catheter directed thrombolysis and mechanical intervention in deep venous thrombosis: What is the status after the ATTRACT Trial?

Postgrad Med 2021 Apr 16. Epub 2021 Apr 16.

Division of Interventional Radiology, Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California.

Deep venous thrombosis (DVT) is a major cause of acute and chronic morbidity, mortality, and increased healthcare costs. Endovascular methods of thrombus removal and re-establishing venous patency are increasing in both scope and usage. The most commonly used method of endovascular thrombectomy is catheter directed thrombolysis (CDT). Read More

View Article and Full-Text PDF

Intimate Partner Violence and Posttraumatic Stress Symptoms: Indirect Effects Through Negative and Positive Emotion Dysregulation.

J Interpers Violence 2021 Apr 15:8862605211006371. Epub 2021 Apr 15.

University of Rhode Island, Kingston, USA.

Women who experience intimate partner violence (IPV) are at heightened risk for developing posttraumatic stress (PTS). Emotion dysregulation has been linked to both IPV and PTS, separately, however, unknown is the role of emotion dysregulation in the relation of IPV to PTS among women who experience IPV. Moreover, existing investigations in this area have been limited in their focus on negative emotion dysregulation. Read More

View Article and Full-Text PDF

A Nitrogen Metabolic Enzyme Provides Fitness Advantage by Promoting Utilization of Microbiota-Derived Carbon Source.

ACS Infect Dis 2021 Apr 14. Epub 2021 Apr 14.

Department of Food and Animal Biotechnology, Seoul National University, Seoul 08826, Republic of Korea.

Microbes support their growth in vertebrate hosts by exploiting a large variety of dietary components as nutrients, which determines the composition of gut microbiota. A pathogen expands by utilizing 1,2-propanediol, a microbiota-fermented product, during mucosal inflammation. However, it remains largely unknown how the pathogen decides which nutrient to consume from the complex mixture in the gut. Read More

View Article and Full-Text PDF

Supplementary Bovine Colostrum Feedings to Formula-Fed Preterm Pigs Improve Gut Function and Reduce Necrotizing Enterocolitis.

J Pediatr Gastroenterol Nutr 2021 Apr 12. Epub 2021 Apr 12.

Comparative Pediatrics and Nutrition, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Neonatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China; Department of Neonatology, Rigshospitalet, Copenhagen, Denmark; Hans Christian Andersen Children's Hospital, Odense, Denmark.

Objectives: Exclusive feeding with bovine colostrum (BC) protects preterm pigs against necrotizing enterocolitis (NEC) and BC has recently been tested as a supplement to mother's own milk or formula (FOR) for very preterm infants. Using preterm pigs as model for infants, we investigated if BC has gut- and NEC-protective effects at different proportions of the daily enteral intake given as BC.

Methods: Sixty-eight caesarean-delivered preterm piglets (90% gestation) were allocated into four groups with increasing proportions of eight daily bolus feedings as BC: BC00 (only FOR feeding), BC25 (25% BC), BC50 (50% BC), or BC75 (75% BC). Read More

View Article and Full-Text PDF

Stroke Risk Scores as Predictors of Severe Outcomes in Atrial Fibrillation: A Comprehensive Review.

Am J Ther 2021 Apr 7. Epub 2021 Apr 7.

Carol Davila University of Medicine and Pharmacy, Department of Internal Medicine, Bucharest, Romania; and Cardiology Department, Colentina University Hospital, Bucharest, Romania.

Background: Atrial fibrillation (AF) is the most frequent sustained arrhythmia. It increases the risk of stroke, heart failure, death, hospitalizations, and costs.

Area Of Uncertainty: Several scores were introduced to stratify the stroke risk and need for anticoagulation in patients (pts) with AF . Read More

View Article and Full-Text PDF

Phyllodes tumor of the vulva: A case report and literature review highlighting a novel manifestation of Cowden syndrome.

Gynecol Oncol Rep 2021 May 23;36:100752. Epub 2021 Mar 23.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL, USA.

Cowden syndrome is a rare hereditary cancer syndrome characterized by a germline mutation which results in an increased risk of developing breast, thyroid, and endometrial carcinoma, as well as widespread benign hamartomas. Phyllodes tumor (PT) is a rare fibroepithelial tumor that accounts for less than 1% of all breast tumors. As mammary-type glands can be found in the anogenital region, PTs can rarely arise in this location. Read More

View Article and Full-Text PDF

Tissue printing for engineering transplantable human parathyroid patch to improves parathyroid engraftment, integration, and hormone secretion.

Biofabrication 2021 Apr 13. Epub 2021 Apr 13.

Seoul National University Bundang Hospital, bundang-gu, Seongnam, 13620, Korea (the Republic of).

During thyroid surgery, some parathyroid glands fail to maintain their function, therefore, they are unavoidably detached from the patient. For the purpose of re-preservation of the function, they are minced into small segments and transplanted into the fat or muscle layer. Yet, this method of auto-grafting the parathyroid glands is frequently unsuccessful due to its poor interaction and engraftment with the native tissue, eventually leading to the dysfunction of the parathyroid hormone (PTH) secretion. Read More

View Article and Full-Text PDF

The return to professional activity patients treated surgically due to advanced gonarthrosis.

Int J Occup Med Environ Health 2021 04 9. Epub 2021 Apr 9.

Medical University of Lodz, Łódź, Poland (Orthopedics and Pediatrics Orthopedics Department).

Objectives: The goal of this work is to analyze the issue of return to professional activity by working-age patients who have been treated surgically with total knee arthroplasty (TKA) due to gonarthrosis.

Material And Methods: Overall, 88 working-age patients were examined, with a total of 91 TKA procedures performed due to advanced gonarthrosis. The average age of the patients was 54. Read More

View Article and Full-Text PDF

COPD significantly increases cerebral and cardiovascular events in hypertensives.

Sci Rep 2021 Apr 12;11(1):7884. Epub 2021 Apr 12.

Department of Medical and Surgical Sciences, University Magna Græcia, Viale Europa-Loc. Germaneto, 88100, Catanzaro, Italy.

Essential hypertension and chronic obstructive pulmonary disease often coexist in the same patient. The aim of this study was to evaluate whether the addition of chronic obstructive pulmonary disease modifies the risk of cardiovascular events in hypertensives. We enrolled 1728 hypertensives. Read More

View Article and Full-Text PDF

Compression hosiery to avoid post-thrombotic syndrome (CHAPS) protocol for a randomised controlled trial (ISRCTN73041168).

BMJ Open 2021 Apr 12;11(4):e044285. Epub 2021 Apr 12.

Academic Section of Vascular Surgery, Imperial College London, London, UK.

Introduction: Up to 50% of patients develop post-thrombotic syndrome (PTS) after an above knee deep vein thrombosis (DVT). The aim of the study was to determine the effect of graduated compression stockings in preventing PTS after DVT.

Methods And Analysis: Pragmatic, UK multicentre randomised trial in adults with first above knee DVT. Read More

View Article and Full-Text PDF

Safety and Efficacy of First-Line Pembrolizumab in Black Patients with Metastatic Non-Small-Cell Lung Cancer.

Oncologist 2021 Apr 12. Epub 2021 Apr 12.

MedStar Georgetown University Hospital, Washington, DC.

Introduction: Pembrolizumab, an immune checkpoint inhibitor (ICI), has become an integral part of front-line treatment of metastatic non-small-cell lung cancer (NSCLC). However, pivotal trials had significant underrepresentation of Black patients (pts). Lack of sufficient evidence regarding safety and efficacy of ICIs among minority racial groups poses a challenge in delivery of optimal cancer directed care. Read More

View Article and Full-Text PDF

SETD2 alterations and histone H3K36 trimethylation in phyllodes tumor of breast.

Breast Cancer Res Treat 2021 Apr 12. Epub 2021 Apr 12.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Ngan Shing Street, Shatin, NT, Hong Kong SAR.

Purpose: SETD2 is one of the key epigenetic regulatory genes involved in histone modifications. Its alterations were potentially oncogenic and commonly found in cancers. Interestingly, SETD2 is one of the most frequent mutated genes found exclusively in phyllodes tumor of the breast (PT). Read More

View Article and Full-Text PDF

Renal dysfunction in systemic sclerosis beyond scleroderma renal crisis.

Rheumatol Int 2021 Apr 12. Epub 2021 Apr 12.

Department of Rheumatology, University of Patras Medical School, Patras, Greece.

Research regarding renal involvement in SSc has almost exclusively focused on scleroderma renal crisis (SRC). There are relatively limited data regarding renal impairment in SSc beyond SRC. We performed an electronic search using the key words systemic sclerosis or scleroderma combined with each of the following: renal dysfunction, kidney, glomerular filtration rate (GFR), proteinuria and hematuria. Read More

View Article and Full-Text PDF

Certified personal trainers' beliefs about providing personal training for adults with intellectual disability in a community fitness facility.

Disabil Health J 2021 Mar 27:101100. Epub 2021 Mar 27.

Department of Behavioral Health and Nutrition, University of Delaware, Newark, DE, 19713, USA.

Background: Numerous barriers limit the participation of adults with intellectual disability (ID) in community fitness facilities (CFFs). Lack of disability-related certification requirements for personal trainers (PTs) highlights the need to revise certification standards and develop training modules that prepare PTs to provide individualized training for individuals with ID. Therefore, insight from PTs is needed. Read More

View Article and Full-Text PDF

Fatty acid synthase inhibition ameliorates diabetes induced liver injury in rodent experimental model.

Eur J Pharmacol 2021 Apr 9;901:174078. Epub 2021 Apr 9.

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India. Electronic address:

The abnormal dietary life style leads to hyperlipidemia and insulin resistance with ectopic lipid accumulation and elevated levels of hepatic glucose development which are the underlying pathological characteristics of fatty liver diseases. The pharmacological inhibition of fatty acid synthase of de novo lipogenesis may regulate the dysfunctional lipid biotransformation and reverse the pathological state of diabetic liver injury. The three pharmacological interventions (PTS; Pterostilbene, ARB; Arbutin, PUR; Purpurin) were administered to manage the condition of diabetic liver injury against the high fat diet (HFD) + Streptozotocin (STZ) 30 mg/kg b. Read More

View Article and Full-Text PDF

Active surveillance for non-muscle invasive bladder cancer: A systematic review and pooled-analysis.

Cancer Treat Res Commun 2021 Apr 3;27:100369. Epub 2021 Apr 3.

IRCCS Humanitas Research Hospital - Rozzano, Milan, Italy.

Introduction: One of the Non-Muscle Invasive Bladder Cancer (NMIBC) treatment options recently recommended by International Guidelines is represented by Active Surveillance (AS),. Herein we carried out a systematic review and pooled-analysis of currently available evidences in order to provide recommendations for daily urological practice.

Material And Methods: The PubMed, EMBASE, and Coch rane Library databases were searched with the terms "Non-Muscle Invasive" or "pTa/pT1" and "Bladder Cancer" or "Bladder Tumor". Read More

View Article and Full-Text PDF

Occurrence of parabens in outdoor environments: Implications for human exposure assessment.

Environ Pollut 2021 Apr 1;282:117058. Epub 2021 Apr 1.

International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, China; Heilongjiang Provincial Key Laboratory of Polar Environment and Ecosystem (HPKL-PEE), Harbin, 150090, China. Electronic address:

Parabens (PBs) are widely used as preservatives in food, pharmaceuticals and personal care products (PCPs). Due to their potential characteristics, similar to endocrine-disrupting compounds, their safety in our daily products and frequent exposure to human health have become public concerns. Nevertheless, little information is available about the occurrence of PBs in outdoor environments and their implications for human exposure. Read More

View Article and Full-Text PDF

Assessment of hearing screening programmes across 47 countries or regions III: provision of childhood hearing screening after the newborn period.

Int J Audiol 2021 Apr 9:1-8. Epub 2021 Apr 9.

Department of Otorhinolaryngology and Head, Neck Surgery and Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Objective: To inventory provision and features of childhood hearing screening after the newborn period (CHS), primarily in Europe.

Design: From each participating country or region, experts provided information through an extensive questionnaire: implementation year, age at screening, test method, pass criteria, screening location, screener profession, and quality indicators: coverage, referral, follow-up and detection rates, supplemented by literature sources.

Study Sample: Forty-two European countries or regions, plus Russia, Malawi, Rwanda, India, and China. Read More

View Article and Full-Text PDF

Efficacy and safety of S-1 following gemcitabine with cisplatin for advanced biliary tract cancer.

Invest New Drugs 2021 Apr 9. Epub 2021 Apr 9.

Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Sunto-gun, Shizuoka, 411-8777, Japan.

Background Combination therapy of gemcitabine with cisplatin (GC) is a standard first-line therapy for unresectable or recurrent biliary tract cancer (BTC). S-1 is often used as a second-line therapy in clinical practice, based on the results of some clinical studies investigating its efficacy and safety following gemcitabine monotherapy. However, few studies have reported on the clinical outcomes of S-1 following GC. Read More

View Article and Full-Text PDF

Real-world analysis of clinical and economic impact of 21-gene recurrence score (RS) testing in early-stage breast cancer (ESBC) in Ireland.

Breast Cancer Res Treat 2021 Apr 9. Epub 2021 Apr 9.

Department of Medical Oncology, St Vincent's University Hospital, Dublin 4, Ireland.

Purpose: Results from TAILOR-X suggest that up to 70% of hormone receptor-positive (HR+) node-negative (N0) ESBC patients (pts) may avoid chemotherapy (CT) with RS ≤ 25. We assess clinical and economic impacts of RS testing on treatment using real-world data.

Methods: From October 2011 to February 2019, a retrospective, cross-sectional observational study was conducted of HR+ N0 ESBC pts who had RS testing in Ireland. Read More

View Article and Full-Text PDF

[Quality assurance in dMMR and MSI diagnostics].

Pathologe 2021 Apr 9. Epub 2021 Apr 9.

Qualitätssicherungs-Initiative Pathologie QuIP GmbH, Berlin, Deutschland.

Deficient mismatch repair (dMMR) and microsatellite instability (MSI) have therapeutic relevance not only for colorectal carcinomas but also for carcinomas of other entities (endometrium, biliary tract, pancreas). In order to guarantee the knowledge and good technical quality necessary for adequate implementation of the corresponding analyses in pathology institutes, the Pathology Quality Assurance Initiative ("Die Qualitätssicherung-Initiative Pathologie") has been offering proficiency tests (PT) for years. It has been shown for the dMMR PT that various antibody clones from different manufacturers provide comparable results in immunohistological examinations, except for slight variations. Read More

View Article and Full-Text PDF

The effect of gender, age, and body mass index on the medial and lateral posterior tibial slopes: a magnetic resonance imaging study.

Knee Surg Relat Res 2021 Apr 8;33(1):12. Epub 2021 Apr 8.

King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.

Background: The posterior tibial slope (PTS) is crucial in knee joint stability and in maintaining the natural movement of the knee. An increase in the PTS is associated with various knee pathologic conditions, such as anterior cruciate ligament (ACL) injury and anterior tibial translation (ATT). In the present study, we aimed to establish native medial and lateral PTS values for adult Saudis and to identify any association between PTS and gender, age, and body mass index (BMI). Read More

View Article and Full-Text PDF

APBI versus ultra APBI in the elderly with low-risk breast cancer: a comparative analysis of oncological outcome and late toxicity.

Int J Radiat Oncol Biol Phys 2021 Apr 5. Epub 2021 Apr 5.

Department of Radiation Oncology, Antoine Lacassagne Cancer Center & University of Cote d'Azur, Nice, FRANCE.

Aim: Accelerated partial breast irradiation (APBI) represents a validated technique for low-risk breast cancer. Recently, ultra APBI (uAPBI) using fewer than 5 fractions were described in literature. We compared clinical outcome and late toxicity after APBI or uAPBI in the elderly. Read More

View Article and Full-Text PDF