984 results match your criteria ptc benign

Intratumoral Heterogeneity in Differentiated Thyroid Tumors: An Intriguing Reappraisal in the Era of Personalized Medicine.

J Pers Med 2021 Apr 23;11(5). Epub 2021 Apr 23.

Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Section of Pathology, University of Messina, 98125 Messina, Italy.

Differentiated thyroid tumors (DTTs) are characterized by significant molecular variability in both spatial and temporal intra-tumoral heterogeneity (ITH), that could influence the therapeutic management. ITH phenomenon appears to have a relevant role in tumor growth, aggressive behavior and drug resistance. Accordingly, characteristics and consequences of ITH in DTTs should be better analyzed and understood in order to guide clinical practice, improving survival. Read More

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Clinical utility of and its receptors ( and ) in thyroid nodules: evaluation based on single nucleotide polymorphisms and mRNA analysis.

Arch Endocrinol Metab 2021 Feb 24. Epub 2021 Feb 24.

Laboratório de Genética Molecular do Câncer, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.

Objective: Abnormalities involving the gene and its receptors are common in several types of cancer and often related to tumor progression. We investigated the role of single nucleotide polymorphisms (SNP) in the susceptibility to cancer, their impact on its features, as well as the role of mRNA expression of these genes in thyroid malignancy.

Methods: We genotyped , , and SNPs in 157 papillary thyroid cancer (PTC) patients and 200 healthy controls. Read More

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February 2021

Thyroid nodules in childhood-onset Hashimoto's thyroiditis: Frequency, risk factors, follow-up course, and genetic alterations of thyroid cancer.

Clin Endocrinol (Oxf) 2021 Apr 24. Epub 2021 Apr 24.

Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Objective: We evaluated the frequency, risk factors, and the follow-up outcomes of thyroid nodules, and genetic alterations in thyroid cancer, in youth with childhood-onset Hashimoto thyroiditis (HT) residing in an iodine-sufficient country.

Design: A retrospective cohort study.

Patients And Measurements: A total of 213 patients (194 females, mean age 10. Read More

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Clinical significance of immunohistochemistry to detect BRAF V600E mutant protein in thyroid tissues.

Medicine (Baltimore) 2021 Apr;100(16):e25566

Department of Pathology, The Second Hospital of Dalian Medical University.

Abstract: This study investigated the feasibility of using immunohistochemistry (IHC) instead of PCR to detect BRAF V600E mutant protein in papillary thyroid carcinoma (PTC), and to determine the value of using preoperative BRAF V600E mutant protein by IHC to assist in the diagnosis of thyroid nodule patients with Hashimoto's thyroiditis (HT).The expression of BRAFV600E mutant protein was measured in 23 cases of HT+PTC, 31 cases of PTC, and 28 cases of HT by IHC, followed by PCR in the same samples for validation. SPSS 19. Read More

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Combination of ultrasound and molecular testing in malignancy risk estimate of Bethesda category IV thyroid nodules: results from a single-institution prospective study.

J Endocrinol Invest 2021 Apr 16. Epub 2021 Apr 16.

Dipartimento di Medicina e Chirurgia, SSD Medicina Interna Ad Indirizzo Onco-Endocrinologico, Università di Parma-Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.

Purpose: Malignancy prediction in indeterminate thyroid nodules is still challenging. We prospectively evaluated whether the combination of ultrasound (US) risk stratification and molecular testing improves the assessment of malignancy risk in Bethesda Category IV thyroid nodules.

Methods: Ninety-one consecutively diagnosed Bethesda Category IV thyroid nodules were prospectively evaluated before surgery by both ACR- and EU-TIRADS US risk-stratification systems and by a further US-guided fine-needle aspiration cytology (FNAC) for the following molecular testing: BRAFV600E, N-RAS codons 12/13, N-RAS codon 61, H-RAS codons 12/13, H-RAS codon 61, K-RAS codons 12/13, and K-RAS codon 61 point-mutations, as well as PAX8/PPARγ, RET/PC1, and RET/PTC 3 rearrangements. Read More

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Ultrasonic Characteristics of Medullary Thyroid Carcinoma: Differential From Papillary Thyroid Carcinoma and Benign Thyroid Nodule.

Ultrasound Q 2021 Apr 10. Epub 2021 Apr 10.

Ultrasound Department, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Abstract: The aim of this study was to evaluate the differences in ultrasonic features of patients with medullary thyroid carcinoma (MTC), papillary thyroid carcinoma (PTC), and benign thyroid nodules. This study included 53 cases of MTC, 151 cases of PTC, and 200 cases of benign thyroid nodule which were pathologically confirmed. There were no significant differences in sex and thyroid gland involvement among the MTC, PTC, and benign thyroid nodule groups. Read More

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Prevalence of thyroid carcinoma in nodules with thy 3 cytology: the role of preoperative ultrasonography and strain elastography.

Thyroid Res 2021 Apr 9;14(1). Epub 2021 Apr 9.

European University Cyprus, 6 Diogenes Street, Engomi, 2404, Nicosia, Cyprus.

Background: Fine needle aspiration (FNA) cytology, the gold standard in assessing thyroid nodules, is limited by its inability to determine the true risk of malignancy in Thy 3 nodules. Most patients with Thy3 cytology undergo surgery to establish a histologic diagnosis. The aims of this study were to evaluate the prevalence of malignancy in Thy3 nodules, to examine the ultrasound (US) characteristics that are associated with a high cancer risk and to assess the role of real-time strain elastography. Read More

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Psychological distress and sleep disturbance throughout thyroid nodules screening, diagnosis and treatment.

J Clin Endocrinol Metab 2021 Apr 8. Epub 2021 Apr 8.

Health and Management Center, West China Hospital of Sichuan University, Chengdu, China.

Background: Many controversies exist regarding screening and treatment of thyroid cancer (TC), especially papillary thyroid microcarcinoma (PTMC). The aim of this study was to evaluate patients' psychological distress and sleep disturbance throughout thyroid nodules (TNs) screening, diagnosis and treatment.

Materials And Methods: A total of 2834 participants (1153 participants with TNs) were enrolled during the screening phase, and 1105 individuals with TNs (87 individuals with TC) were enrolled during the diagnosis phase. Read More

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Comparing Oxidative Stress Status Among Iranian Males and Females with Malignant and Non-malignant Thyroid Nodules.

Int J Endocrinol Metab 2021 Jan 26;19(1):e105669. Epub 2021 Jan 26.

Cellular & Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Oxidative stress is commonly accrued in thyroid tissue during hormone synthesis.

Objectives: We aimed to examine oxidative stress in patients with thyroid cancer, benign thyroid nodules, and healthy individuals.

Methods: In this study, 138 individuals were involved. Read More

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January 2021

Association Between the Presence of Female-Specific Tumors and Aggressive Clinicopathological Features in Papillary Thyroid Cancer: A Retrospective Analysis of 9,822 Cases.

Front Oncol 2021 11;11:611471. Epub 2021 Mar 11.

Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Engineering Laboratory of Thyroid Disease Prevention and Control, Changchun, China.

Objective: To investigate the association between the presence of female-specific tumors and aggressive clinicopathological features in papillary thyroid cancer (PTC).

Methods: This study retrospectively analyzed 9,822 female cases between June 2008 and December 2017. Odds ratios and corresponding 95% confidence intervals were calculated. Read More

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Preoperative Prediction of Cervical Nodal Metastasis in Papillary Thyroid Carcinoma: Value of Quantitative Dual-Energy CT Parameters and Qualitative Morphologic Features.

AJR Am J Roentgenol 2021 05 24;216(5):1335-1343. Epub 2021 Mar 24.

Department of Radiology, Division of Life Sciences and Medicine, The First Affiliated Hospital of the University of Science and Technology of China, Huanhu Rd 107, Hefei, Anhui 230031, PRC.

The purpose of our study was to assess the value of combining quantitative dual-energy CT (DECT) parameters with qualitative morphologic parameters for the preoperative prediction of cervical nodal metastasis from papillary thyroid carcinoma (PTC). Thirty-five patients with pathologically proven PTC underwent single-phase contrast-enhanced DECT before thyroidectomy and cervical lymphadenectomy. Analyses of quantitative DECT parameters and qualitative morphologic features of metastatic and benign lymph nodes (LNs) were independently performed. Read More

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The occurrence of Adrenocorticotropic hormone-independent Cushing's syndrome in a woman with the history of papillary thyroid carcinoma: a case report.

J Med Case Rep 2021 Mar 11;15(1):113. Epub 2021 Mar 11.

Autoimmune Disease Research Center, Kashan University of Medical Sciences, Kashan, IR, Iran.

Background: Thyroid papillary carcinoma is one of the most common endocrine tumors, and it accounts for 85% of thyroid tumors. Adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome is a rare disease. In this case report, we discuss a very rare case of coexistence of papillary thyroid carcinoma and Cushing's syndrome with an adrenal origin. Read More

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Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms.

Endocrinol Metab (Seoul) 2021 Feb 24;36(1):123-133. Epub 2021 Feb 24.

Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Izumi, Japan.

Background: Assessing nuclear features is diagnostically challenging in the aspect of thyroid pathology. The aim of this study was to determine whether pathologists could distinguish BRAF-like and RAS-like nuclear features morphologically and identify morphological features to differentiate thyroid tumors with RAS-like mutations from encapsulated papillary thyroid carcinoma (PTC) with predominant follicular growth and BRAFV600E mutation.

Methods: Representative whole slide images of 16 encapsulated thyroid tumors with predominant follicular growth were reviewed by 12 thyroid pathologists using a web browser-based image viewer. Read More

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February 2021

Positive Thyroid Peroxidase Antibody and Thyroglobulin Antibody are Associated With Better Clinicopathologic Features of Papillary Thyroid Cancer.

Endocr Pract 2021 Apr 15;27(4):306-311. Epub 2020 Dec 15.

Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address:

Objective: To compare the thyroid autoantibody status of patients with papillary thyroid cancer (PTC) and benign nodular goiter as well as possible associations between thyroid autoantibodies and clinicopathologic features of PTC.

Methods: A total of 3934 participants who underwent thyroidectomy were enrolled in this retrospective study. Patients were divided into PTC and benign nodule groups according to pathological diagnosis. Read More

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The thyroid risk score (TRS) for nodules with indeterminate cytology.

Endocr Relat Cancer 2021 Apr;28(4):225-235

Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy.

Cytology is the gold standard method for the differential diagnosis of thyroid nodules, though 25-30% of them are classified as indeterminate. We aimed to set up a 'thyroid risk score' (TRS) to increase the diagnostic accuracy in these cases. We prospectively tested 135 indeterminate thyroid nodules. Read More

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Clinical and pathologic features for predicting malignancy in thyroid follicular neoplasms.

Gland Surg 2021 Jan;10(1):50-58

Department of Surgery, College of Medicine, the Catholic University of Korea, Seoul, Korea.

Background: The cytologic findings of follicular neoplasm do not distinguish between benign follicular adenoma and follicular thyroid carcinoma (FTC). The objective of this retrospective study was to identify clinical and cytologic/pathologic features to predict malignancy in patients preoperatively diagnosed with follicular neoplasms.

Methods: In total, 416 patients with follicular neoplasms who underwent thyroidectomy were reviewed at Seoul St. Read More

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January 2021

Diagnostic Value of Serum Cytokeratin 18, Carcinoembryonic Antigen, and Thyroglobulin in Patients with Papillary Thyroid Carcinoma.

Clin Lab 2021 Feb;67(2)

Background: The current study aims to explore the expression and diagnostic value of cytokeratin 18 (CK) in patients with papillary thyroid carcinoma (PTC).

Methods: Patients diagnosed with thyroid tumor, including 127 cases of PTC and 60 cases of benign tumors and 50 healthy controls were included. Serum CK 18, carcinoembryonic antigen (CEA) and thyroglobulin (Tg) were detected using enzyme-linked immunosorbent assay (ELISA). Read More

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February 2021

Diagnostic Role of Cell-free DNA Integrity in Thyroid Cancer Particularly for Bethesda IV Cytology.

Endocr Pract 2021 Feb 16. Epub 2021 Feb 16.

Diabetes and Endocrinology Unit, Department of Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt.

Background: The cell-free DNA integrity index (cfDI) is promising for the differentiation between malignant and benign tumors, but little data has been reported on thyroid cancer (TC). We explored its diagnostic role in TC, mainly in cases of Bethesda category IV.

Methods: cfDI was evaluated by quantitative real-time polymerase chain reaction using 2 primer sets to identify cell-free DNAs (cfDNAs) Alu83 and Alu244. Read More

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February 2021

Effects of intraoperative blood loss during liver resection on patients? outcome: A single-center experience.

Turk J Med Sci 2021 Feb 12. Epub 2021 Feb 12.

Background/aim: Operative bleeding is one of the major determinants of outcome in liver surgery. This study aimed to describe the impact of intraoperative blood loss on the postoperative course of liver resection (LR).

Material And Methods: The data of 257 patients who were treated with LR between January 2007 and October 2018 were retrospectively analyzed. Read More

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February 2021

MicroRNA Profile for Diagnostic and Prognostic Biomarkers in Thyroid Cancer.

Cancers (Basel) 2021 Feb 5;13(4). Epub 2021 Feb 5.

Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.

The challenge in managing thyroid nodules is to accurately diagnose the minority of those with malignancy. We aimed to identify diagnostic and prognostic miRNA markers for thyroid nodules. In a discovery cohort, we identified 20 candidate miRNAs to differentiate between noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) and papillary thyroid carcinomas (PTC) by using the high-throughput small RNA sequencing method. Read More

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February 2021

Safety and surgical outcomes of transoral endoscopic thyroidectomy vestibular approach for papillary thyroid cancer: A two-centre study.

Eur J Surg Oncol 2021 Feb 2. Epub 2021 Feb 2.

Department of Thyroid Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000, China. Electronic address:

Objective: The transoral endoscopic thyroidectomy vestibular approach (TOETVA) has been increasingly used to treat patients with papillary thyroid cancer (PTC) with improved cosmetic outcomes. This study aimed to explore the safety and efficacy of TOETVA in patients with PTC.

Materials And Methods: This retrospective study included TOETVA patients from Yantai Yuhuangding and Xiamen Zhongshan Hospitals. Read More

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February 2021

Initial outcomes at a nascent tertiary pediatric thyroid surgical center.

Int J Pediatr Otorhinolaryngol 2021 Apr 2;143:110639. Epub 2021 Feb 2.

University of California, Irvine School of Medicine, Department of Otolaryngology- Head and Neck Surgery, Orange, CA, 92868, United States; CHOC Children's Hospital of Orange County, Division of Pediatric Otolaryngology- Head and Neck Surgery, Orange, CA, 92868, United States. Electronic address:

Objectives: Previous studies on pediatric thyroid surgical complications suggest that high-volume centers achieve improved outcomes. We hypothesize that initial outcomes from a nascent pediatric surgical practice may be comparable to higher volume centers. Furthermore, we determine whether a low-volume center can safely transition to an intermediate or high-volume center. Read More

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Routine Use of Preoperative Neck Ultrasound in Primary Hyperparathyroidism Identifies Coexisting Thyroid Disease and Improves Parathyroid Localization.

Am Surg 2021 Jan 31:3134821991991. Epub 2021 Jan 31.

Department of Surgery, 6915Mayo Clinic, Rochester, MN, USA.

Background: In Jan 2018, we began routinely obtaining neck ultrasound (US) with 123I/99Tc-sestamibi (MIBI) for parathyroid gland localization and to identify thyroid pathology in the setting of primary hyperparathyroidism (1HPT). The aim of this study is to assess if routine neck US is a useful adjunct to 123I/99Tc-MIBI in 1HPT.

Methods: Patients undergoing surgery for 1HPT with both 123I/99Tc-MIBI and US at our institution after implementation of routine US were reviewed. Read More

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January 2021

miR-1301-3p suppresses tumor growth by downregulating PCNA in thyroid papillary cancer.

Am J Otolaryngol 2021 Mar-Apr;42(2):102920. Epub 2021 Jan 9.

Department of Thyroid Surgery, Affiliated Hospital of Southwest Medical University, LuZhou, China. Electronic address:

Objective: Thyroid carcinoma is the most common endocrine tumor, and thyroid papillary carcinoma is the most common form. Although thyroid papillary carcinoma presents a good prognosis, some patients still exhibit recurrence or distant metastasis. miR-1301-3p has been found involved in the occurrence and development of some special tumors. Read More

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January 2021

The Involvement of the hsa_circ_0088494-miR-876-3p-CTNNB1/CCND1 Axis in Carcinogenesis and Progression of Papillary Thyroid Carcinoma.

Front Cell Dev Biol 2020 9;8:605940. Epub 2020 Dec 9.

Department of Respiratory Medicine, Thoracic Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Recently, growing studies have demonstrated that circular RNAs (circRNAs) function as critical players in multiple human tumors, including papillary thyroid carcinoma (PTC). However, the expression and underlying potential mechanism of circRNAs in PTC are still not fully elucidated. In this study, 14 candidate differentially expressed circRNAs (DECs) between normal thyroid tissues and benign thyroid tissues or PTC were first screened using the GSE93522 dataset by the GEO2R online tool. Read More

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December 2020

Highly accurate diagnosis of papillary thyroid carcinomas based on personalized pathways coupled with machine learning.

Brief Bioinform 2020 Dec 19. Epub 2020 Dec 19.

Konkuk University School of Medicine, South Korea.

Thyroid nodules are neoplasms commonly found among adults, with papillary thyroid carcinoma (PTC) being the most prevalent malignancy. However, current diagnostic methods often subject patients to unnecessary surgical burden. In this study, we developed and validated an automated, highly accurate multi-study-derived diagnostic model for PTCs using personalized biological pathways coupled with a sophisticated machine learning algorithm. Read More

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December 2020

Is there adenoma-carcinoma sequence between benign adenoma and papillary cancer of thyroid: A genomic linkage study.

Ann Med Surg (Lond) 2020 Dec 2;60:695-700. Epub 2020 Dec 2.

Department of Biochemistry, Surabhi Medical College, Hyderabad, Telangana, India.

Background: The adenoma-carcinoma sequence in thyroid nodules is an enigmatic phenomenon. Genomics is the only definitive modality to resolve this hypothesis. Adenomas and papillary carcinomas tend to have mutations in RAS and highly specific BRAF gene respectively. Read More

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December 2020

Papillary thyroid carcinoma presenting as a functioning thyroid nodule: report of 2 rare cases.

Liang Hu Yijun Wu

Int J Clin Exp Pathol 2020 1;13(11):2895-2906. Epub 2020 Nov 1.

Department of Thyroid Surgery, The First Hospital Affiliated to Zhejiang University, School of Medicine No. 79 Qingchun Road, Hangzhou 310000, P. R. China.

Introduction: Autonomously functioning thyroid nodules (AFTNs) are generally benign, whereas papillary thyroid carcinomas (PTCs) are mostly non-functioning. Graves' disease (GD) is the most common cause of hyperthyroidism (HD), followed by hyperfunctional adenoma or Plummer's disease. GD with AFTNs is called Marine-Lenhart syndrome, a relatively rare syndrome. Read More

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November 2020

The Prevalence of Thyroid Papillary Microcarcinoma in Patients With Benign Thyroid Fine Needle Aspiration.

Cureus 2020 Dec 1;12(12):e11820. Epub 2020 Dec 1.

Otolaryngology, King Saud University, Riyadh, SAU.

Introduction Thyroid nodules are a very common clinical finding in the general population. We use fine needle aspiration (FNA) as the gold standard workup test for a thyroid nodule, as it is capable of differentiating malignant nodules from benign in the majority of cases. Usually, FNA is done for nodules that are more than 1 cm; small malignant lesions that are less than 1 cm in size can be missed. Read More

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December 2020

Diagnostic Value of TROP2 Expression in Papillary Thyroid Carcinoma.

Appl Immunohistochem Mol Morphol 2021 03;29(3):218-222

Department of Pathology Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Papillary thyroid carcinoma (PTC) represents the most common primary malignant thyroid lesion in all age groups. As diagnosis of PTC could be challenging in some cases and borderline nuclear features could be seen in some benign mimickers, several immunohistochemical markers are proposed to be helpful for making the correct diagnosis. In this study the authors investigated the diagnostic value of transmembrane glycoprotein (TROP2) for differentiating PTC from other thyroid follicular lesions. Read More

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