6,064 results match your criteria ptc patients

BRAF Inhibitors Induce Feedback Activation of RAS Pathway in Thyroid Cancer Cells.

Int J Mol Sci 2021 May 27;22(11). Epub 2021 May 27.

Molecular Mechanisms Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

is the most frequent oncogenic mutation identified in papillary thyroid cancer (PTC). In PTC patients who do not respond to standard treatment, BRAF inhibitors are currently tested as alternative strategies. However, as observed for other targeted therapies, patients eventually develop drug resistance. Read More

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Higher EU-TIRADS-Score Correlated with BRAF V600E Positivity in the Early Stage of Papillary Thyroid Carcinoma.

J Clin Med 2021 May 25;10(11). Epub 2021 May 25.

Department of Oncological Endocrinology and Nuclear Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.

The data demonstrating a correlation between sonographic markers of malignancy of thyroid cancer (TC) and its genetic status are scarce. This study aimed to assess whether the addition of genetic analysis at the preoperative step of TC patients' stratification could aid their clinical management. The material consisted of formalin-fixed paraffin-embedded tumor fragments of 49 patients who underwent thyroidectomy during the early stages of papillary TC (PTC). Read More

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Prospective Analysis of Promoter Mutations in Papillary Thyroid Carcinoma at a Single Institution.

J Clin Med 2021 May 18;10(10). Epub 2021 May 18.

Department of Surgery, Inha University Hospital & College of Medicine, Inchoen 22332, Korea.

Background: Papillary thyroid cancer (PTC) has the highest cancer incidence in Korea. It is known that some thyroid cancers have aggressive clinical behavior and a poor prognosis. Genomic studies have described some somatic mutations that are related to the aggressive features of thyroid cancer, such as the mutation. Read More

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Properties of Non-Aminoglycoside Compounds Used to Stimulate Translational Readthrough of PTC Mutations in Primary Ciliary Dyskinesia.

Int J Mol Sci 2021 May 7;22(9). Epub 2021 May 7.

Institute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, Poland.

Primary ciliary dyskinesia (PCD) is a rare disease with autosomal recessive inheritance, caused mostly by bi-allelic gene mutations that impair motile cilia structure and function. Currently, there are no causal treatments for PCD. In many disease models, translational readthrough of premature termination codons (PTC-readthrough) induced by aminoglycosides has been proposed as an effective way of restoring functional protein expression and reducing disease symptoms. Read More

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A Stepwise Approach Using Metastatic Lymph Node Ratio-Combined Thyroglobulin for Customization of [F]FDG-PET/CT Indication to Detect Persistent Disease in Patients with Papillary Thyroid Cancer.

Diagnostics (Basel) 2021 May 6;11(5). Epub 2021 May 6.

Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun-gun 58128, Korea.

We investigated whether an indication for [F]FDG-PET/CT to detect FDG-avid persistent disease (PD) could be identified precisely using the extent of metastatic lymph nodes (MLNs) and serum thyroglobulin (Tg) in papillary thyroid cancer (PTC) patients. This retrospective study included 429 PTC patients who underwent surgery and radioactive iodine (RAI) therapy. [F]FDG-PET/CT and serum Tg were evaluated just before RAI therapy. Read More

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Tall cell percentage alone in PTC without aggressive features should not guide patients' clinical management.

J Clin Endocrinol Metab 2021 Jun 1. Epub 2021 Jun 1.

Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa.

Purpose: Recent diagnostic criteria updates of the tall cell variant of papillary thyroid carcinoma (TCPTC) by the World Health Organization (WHO) have determined the inclusion of tumours with 30-49% of tall cells. However, the impact of tall cell percentage on papillary thyroid carcinoma (PTC) patients' prognosis is still debated. We aimed to evaluate whether tall cell percentage affects patients' outcome in the absence of aggressive features. Read More

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The incidence of noninvasive follicular neoplasm with papillary like nuclear features: A meta-analysis assessing worldwide impact of the reclassification.

Thyroid 2021 Jun 1. Epub 2021 Jun 1.

Kameda Medical Center, 13770, Pathology, 929 Higashi-cho, Kamogawa, Japan, 296-8602.

BACKGROUND Noninvasive follicular neoplasm with papillary like nuclear features (NIFTP) reclassification has significantly influenced the field of thyroidology. However, the extent of this impact depends upon the incidence of NIFTP in a given population. In this meta-analysis, we aimed to obtain robust information about the actual incidence of NIFTP worldwide by reviewing the published data. Read More

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Automated Quantitative Relaxometry for Deep Neuromuscular Blockade in Robot-Assisted Prostatectomy.

Rom J Anaesth Intensive Care 2020 Jul 10;27(1):29-34. Epub 2020 Aug 10.

Professor and Senior Consultant, Institute of Anesthesiology, University Hospital Zurich, 8091 Zurich, Switzerland.

Purpose: During pneumoperitoneum (PP) for robot-assisted prostatectomy, a deep neuromuscular block (NMB) is necessary. New relaxometry equipment permits maintenance of profound NMB in order to improve patient safety and surgical conditions.

Methods: Twenty adult patients undergoing robot-assisted prostatectomy were included. Read More

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Investigating F-FDG PET/CT Parameters as Prognostic Markers for Differentiated Thyroid Cancer: A Systematic Review.

Front Oncol 2021 13;11:648658. Epub 2021 May 13.

Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.

The aim of this study was to determine whether F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) parameters might be prognostic markers for patients with differentiated thyroid carcinoma (DTC). We searched for eligible articles in PubMed, EMBASE (Ovid), Cochrane Library, and ClinicalTrials.gov from inception to February 2021. Read More

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The landscape of tumors-infiltrate immune cells in papillary thyroid carcinoma and its prognostic value.

PeerJ 2021 21;9:e11494. Epub 2021 May 21.

Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Introduction: Thyroid cancer is a very common malignant tumor in the endocrine system, while the incidence of papillary thyroid carcinoma (PTC) throughout the world also shows a trend of increase year by year. In this study, we constructed two models: ICIscore and Riskscore. Combined with these two models, we can make more accurate and reasonable inferences about the prognosis of PTC patients. Read More

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Recurrence Factors and Characteristic Trends of Papillary Thyroid Cancer over Three Decades.

Int J Endocrinol 2021 10;2021:9989757. Epub 2021 May 10.

Diabetes and Thyroid Center, Theptarin Hospital, Bangkok, Thailand.

Background: The prevalence of thyroid cancer is rising worldwide. Although thyroid cancer has a favorable prognosis, up to 20% of patients experienced recurrent disease during the follow-up period. The present study aimed to examine the trend of incidence and factors associated with recurrence and outcomes of papillary thyroid cancer (PTC) in Thai patients over the last 30 years. Read More

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Preoperative ultrasound characteristics in determining the likelihood of cytologically confirmed (Bethesda VI), 1-4 cm papillary thyroid tumours requiring completion thyroidectomy.

Asian J Surg 2021 May 26. Epub 2021 May 26.

Endocrine Surgical Services Unit, Sir Charles Gairdner Hospital, Western Australia, Australia.

Background: Papillary thyroid carcinoma (PTC) is the most commonly diagnosed differentiated thyroid carcinoma. There is controversy about performing upfront lobectomy vs thyroidectomy for smaller well differentiated thyroid carcinoma.

Methods: A retrospective study from 2015 to 2020 was conducted consisting of consecutive patients with a preoperative malignant (Bethesda VI) cytology on fine needle aspirate (FNA) consistent with PTC. Read More

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The diagnostic accuracy of fine-needle aspiration cytology for thyroid nodules is not affected by coexistent chronic autoimmune thyroiditis: Results from a cyto-histological series of patients with indeterminate cytology.

Eur J Endocrinol 2021 May 1. Epub 2021 May 1.

L Chiovato, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

Objective Indeterminate cytological result at Fine-needle-aspiration-cytology (FNAC) remains a clinical challenge for endocrinologists. Aim of the present study was to evaluate whether a coexistent Chronic-Autoimmune-Thyroiditis (CAT) might affect the diagnostic accuracy of fine-needle aspiration cytology for thyroid nodules. Design and Methods A retrospective cohort study was designed including all nodules receiving an indeterminate cytology result (TIR3A or TIR3B) undergoing thyroid surgery and subsequent histological confirmation. Read More

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Venetoclax Combined With FLAG-IDA Induction and Consolidation in Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia.

J Clin Oncol 2021 May 27:JCO2003736. Epub 2021 May 27.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: Sixty percent of newly diagnosed patients with acute myeloid leukemia (ND-AML) receiving frontline therapy attain a complete response (CR), yet 30%-40% of patients relapse. Relapsed or refractory AML (R/R-AML) remains a particularly adverse population necessitating improved therapeutic options. This phase Ib/II study evaluated the safety and efficacy of fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin combined with the B-cell lymphoma-2 inhibitor venetoclax in ND-AML and R/R-AML. Read More

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Is Postoperative Adjuvant Radioactive Iodine Ablation Therapy Always Necessary for Intermediate-Risk Papillary Thyroid Cancer Patients With Central Neck Metastasis?

Ann Surg Oncol 2021 May 27. Epub 2021 May 27.

Department of Otorhinolaryngology-Head and Neck Surgery, Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea.

Background: Papillary thyroid cancer (PTC) is commonly associated with neck lymph node metastasis (LNM), and recurrence does occur after radioactive iodine (RAI) ablation therapy. This study aimed to analyze the effectiveness of RAI ablation with regard to disease recurrence in intermediate-risk PTC patients with neck LNM. In addition, the study identified possible predisposing risk factors that might benefit from RAI ablation and analyzed common RAI therapy complications among these patients. Read More

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Metastasis of cN0 Papillary Thyroid Carcinoma of the Isthmus to the Lymph Node Posterior to the Right Recurrent Laryngeal Nerve.

Front Endocrinol (Lausanne) 2021 10;12:677986. Epub 2021 May 10.

Department of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

Objective: The association between metastasis to the lymph node posterior to the right recurrent laryngeal nerve (LN-prRLN) and cN0 papillary thyroid carcinoma (PTC) located in the thyroid isthmus remains unknown; therefore, our goal was to analyze the characteristics of LN-prRLN metastasis of cN0 PTCs of the thyroid isthmus and determine its potential predictors.

Patients And Methods: This retrospective study included patients who underwent bilateral central neck dissection between January 2018 and January 2021. The specimen was divided into five groups of prelaryngeal lymph node (LN), pretracheal LN, left paratracheal LN, lymph node anterior to the right recurrent laryngeal nerve (LN-arRLN), and LN-prRLN. Read More

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An Analysis of Computed Tomography-Related Radiation Exposure in Pediatric Trauma Patients.

Pediatr Emerg Care 2021 Jun;37(6):296-302

Department of Radiology.

Objective: To compare radiation doses used for pediatric computed tomography (CT) scans at community-based referring facilities (RF) to those at a designated pediatric trauma center (PTC) to assess the consistency of radiation exposure.

Methods: In this retrospective study, patients 0 to 18 years of age with CT imaging performed either at a RF or at a PTC from January 1, 2015, to January 5, 2016, were identified. Data about patients, CT radiation dose, and characteristics of the RFs were compared. Read More

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Warthin-like and classic papillary thyroid cancer have similar clinical presentation and prognosis.

Arch Endocrinol Metab 2021 May;64(5):542-547

Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Objective: Warthin-like papillary thyroid cancer (WL-PTC) is an uncommon variant of PTC, usually associated with lymphocytic thyroiditis. Scarce evidence suggests that WL-PTC has similar clinical presentation to classic PTC (C-PTC), with no studies comparing risks of recurrence and response to treatment between both variants. Our objective was to describe the clinical presentation and prognosis of WL-PTC and compare it to C-PTC. Read More

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Ultrasonographical, clinical and histopathological features of 1264 nodules with papillary thyroid carcinoma and microcarcinoma based on tumor size.

Arch Endocrinol Metab 2021 May;64(5):533-541

Ankara Yildirim Beyazit University, Faculty of Medicine, Ataturk Education and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.

Objective: We aimed to evaluate the patients diagnosed with papillary thyroid carcinoma (PTC) and papillary thyroid microcarcinoma (PTMC) in terms of clinical, ultrasonographical (US) and histopathological features and their relationships with tumor size.

Methods: We retrospectively evaluated 881 patients who underwent thyroid surgery in our clinic and diagnosed with PTC histopathologically were enrolled the study. Demographic characteristics, US findings and histopathological features were evaluated. Read More

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The BRAF mutation analysis and risk stratification in papillary thyroid carcinoma.

Arch Endocrinol Metab 2021 May;64(6):751-757

Unidade de Tireoide, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil,

Objective: Although the prognostic role of BRAF mutation in papillary thyroid carcinoma (PTC) is controversial, the American Thyroid Association (ATA) includes the mutational status in their risk stratification system. To evaluate the impact of the BRAF mutation status on PTC risk stratification.

Methods: PTC patients attending a university-based hospital who had the analysis of the BRAF mutation were included. Read More

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Should tall cell thyroid cancers be evaluated differently from well-differentiated thyroid cancers?

Ann Ital Chir 2021 ;92:123-130

Objective: In this study, we aimed to investigate the clinical features of Papillary thyroid carcinoma(PTC) Tall cell variant(TCV), long-term outcomes and surgical experience in papillary thyroid carcinoma.

Material-method: 33 patients who were operated in our clinic between August 2012 and March 2018 and diagnosed as TCV in their pathology evaluation were included in the study. The demographic and clinical features of the patients, pathological features of the tumor and long-term results were examined. Read More

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January 2021

Predicting nodal metastases in papillary thyroid carcinoma using artificial intelligence.

Am J Surg 2021 May 13. Epub 2021 May 13.

Department of Pathology, MSC08 4640, University of New Mexico, Albuquerque, NM, 87131, USA.

Background: The presence of nodal metastases is important in the treatment of papillary thyroid carcinoma (PTC). We present our experience using a convolutional neural network (CNN) to predict the presence of nodal metastases in a series of PTC patients using visual histopathology from the primary tumor alone.

Methods: 174 cases of PTC were evaluated for the presence or absence of lymph metastases. Read More

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Neurophysiological indices in amyotrophic lateral sclerosis correlate with functional outcome measures, staging and disease progression.

Clin Neurophysiol 2021 Jul 7;132(7):1564-1571. Epub 2021 Apr 7.

NEuroMuscular Omnicentre, Fondazione Serena Onlus, Piazza Ospedale Maggiore 3, 20162 Milano, Italy; NeMO LAB S.r.l., Milan Italy. Electronic address:

Objective: This study examined neurophysiological (NI), split-hand (SI) and split-leg (SLI) index in patients with amyotrophic lateral sclerosis (ALS), and their correlation with functional status, disease duration, staging and survival.

Methods: Eighty-two patients underwent nerve conduction study to analyze NI, SI and SLI. Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R), disease progression rate (ΔFS), Milano-Torino (MiToS) and King's staging systems, Forced Vital Capacity (FVC), and survival data were collected. Read More

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A case report of simultaneous medullary and papillary carcinoma of thyroid.

Endocr Regul 2021 May 21;55(2):83-88. Epub 2021 May 21.

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Medullary (MTC) and papillary (PTC) thyroid carcinoma are two different types of thyroid carcinoma with significant differences in origin. Their co-occurrence in a patient is a rare phenomenon. We report a patient with simultaneous presentation of both MTC and PTC. Read More

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Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages.

Cell 2021 May 20;184(11):2988-3005.e16. Epub 2021 May 20.

Columbia Center for Translational Immunology (CCTI), Columbia University Irving Medical Center (CUMC), New York, NY 10032, USA; Department of Urology, Herbert Irving Comprehensive Cancer Center (HICC), New York, NY 10032, USA; HICC, Columbia University, New York, NY, USA. Electronic address:

Clear cell renal carcinoma (ccRCC) is a heterogeneous disease with a variable post-surgical course. To assemble a comprehensive ccRCC tumor microenvironment (TME) atlas, we performed single-cell RNA sequencing (scRNA-seq) of hematopoietic and non-hematopoietic subpopulations from tumor and tumor-adjacent tissue of treatment-naive ccRCC resections. We leveraged the VIPER algorithm to quantitate single-cell protein activity and validated this approach by comparison to flow cytometry. Read More

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Influence Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: Hashimoto's Thyroiditis Has a Weak Effect on Central or Lateral Lymph Node Metastasis.

Cancer Manag Res 2021 14;13:3953-3961. Epub 2021 May 14.

Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, 250012, People's Republic of China.

Purpose: To analyze the effect of Hashimoto's thyroiditis (HT) concurrent with papillary thyroid cancer (PTC) on cervical lymph node metastasis (LNM).

Methods: Two thousand nine hundred twenty-six patients who underwent thyroidectomy and lymph node dissection between January 2015 and December 2018 were enrolled in this study. Patient demographics and clinicopathologic features were analyzed. Read More

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Implications of a background of Hashimoto's thyroiditis on the current conservative surgical trend towards papillary thyroid carcinoma.

Updates Surg 2021 May 20. Epub 2021 May 20.

Department of General Surgery and Urology, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, 22110, Jordan.

The purpose is to delineate the clinico-pathologic features of papillary thyroid carcinoma (PTC) occurring in a background of Hashimoto's thyroiditis (HT). A retrospective analysis of consecutive PTC patients who underwent surgery at an academic center between Jan. 2010 and Jan. Read More

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Clinical implications of TPO and AOX1 in pediatric papillary thyroid carcinoma.

Transl Pediatr 2021 Apr;10(4):723-732

Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, China.

Background: Thyroid carcinoma is a common pediatric head and neck cancer, of which papillary thyroid cancer (PTC) is the most common type. Previously, we found that thyroid peroxidase () and aldehyde oxidase 1 () were differentially expressed in PTC. This study explored the clinical importance of and in the diagnosis and prognosis of PTC in children. Read More

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Correlation Between Thyroid Fine Needle Aspiration Cytology and Postoperative Histology: A 10-Year Single-Centre Experience.

Cureus 2021 Apr 15;13(4):e14504. Epub 2021 Apr 15.

Department of Otolaryngology/Head and Neck Surgery, Lancashire Teaching Hospitals National Health Service (NHS) Foundation Trust, Preston, GBR.

Introduction Fine needle aspiration cytology (FNAC) forms part of the routine workup for suspicious thyroid nodules. Whilst cytological analysis is less precise than histological assessment, it is quick and easy to perform and may avoid the need for invasive and potentially risky surgery. Methods This retrospective study spanned a 10-year period comparing preoperative FNAC with postoperative histology results to establish the accuracy of diagnosis and malignancy rates within our population. Read More

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Results of an international crowdsourcing survey on the treatment of non-ST segment elevation ACS patients at high-bleeding risk undergoing percutaneous intervention.

Int J Cardiol 2021 May 15. Epub 2021 May 15.

Inselspital, University Hospital Bern, Bern, Switzerland. Electronic address:

Aims: Choosing an antiplatelet strategy in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) at high bleeding risk (HBR), undergoing post-percutaneous coronary intervention (PCI), is complex. We used a unique open-source approach (crowdsourcing) to document if practices varied across a small, global cross-section of antiplatelet prescribers in the post-PCI setting.

Methods And Results: Five-hundred and fifty-nine professionals from 70 countries (the 'crowd') completed questionnaires containing single- or multi-option and free form questions regarding antiplatelet clinical practice in post-PCI NSTE-ACS patients at HBR. Read More

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