11,634 results match your criteria ptc

Associations between essential microelements exposure and the aggressive clinicopathologic characteristics of papillary thyroid cancer.

Biometals 2021 May 7. Epub 2021 May 7.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China.

Aim of this study was to evaluate the association between multiple essential microelements exposure and the aggressive clinicopathologic characteristics of papillary thyroid carcinoma (PTC). The concentrations of 10 essential microelements in urine [cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), manganese (Mn), molybdenum (Mo), selenium (Se), strontium (Sr), zinc (Zn), and iodine (I)] were measured in 608 patients newly diagnosed with PTC, including 154 males and 454 females. Chi square test and Wilcoxon rank sum test were used to compare general characteristics among males and females. Read More

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Evaluation of Clinical Characteristics and Outcomes of Postoperative Infections in Living Liver Donors.

Int J Clin Pract 2021 May 6:e14324. Epub 2021 May 6.

Department of Infectious Diseases and Clinical Microbiology, Inonu University Faculty of Medicine, 44280, Malatya, Turkey.

Aim: To analyze developing infections after living donor hepatectomy (LDH) in living liver donors (LLDs).

Methods: Demographic and clinical charecteristics of 1106 LLDs were retrospectively analysed in terms of whether postoperative infection development. Therefore, LLDs were divided into two group: with (n=190) and without (n=916) antimicrobial agent use. Read More

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A Pro-Tumorigenic Effect of Heparanase 2 (Hpa2) in Thyroid Carcinoma Involves Its Localization to the Nuclear Membrane.

Front Oncol 2021 20;11:645524. Epub 2021 Apr 20.

Department of Otolaryngology, Head and Neck Surgery, Carmel Medical Center, Haifa, Israel.

Activity of the endo-beta-glucuronidase heparanase, capable of cleaving heparan sulfate (HS), is most often elevated in many types of tumors, associating with increased tumor metastasis and decreased patients' survival. Heparanase is therefore considered to be a valid drug target, and heparanase inhibitors are being evaluated clinically in cancer patients. Heparanase 2 (Hpa2) is a close homolog of heparanase that gained very little attention, likely because it lacks HS-degrading activity typical of heparanase. Read More

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Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1.

Sci Rep 2021 May 6;11(1):9737. Epub 2021 May 6.

Division of Biomedical Sciences, Research Center for Genomic Medicine, Saitama Medical University, 1397-1, Yamane Hidaka, Saitama, 350-1241, Japan.

A non-canonical PRC1 (PRC1.6) prevents precocious meiotic onset. Germ cells alleviate its negative effect by reducing their amount of MAX, a component of PRC1. Read More

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Rapid Increase of Gastrointestinal P-Glycoprotein Functional Activity in Response to Etoposide Stimulation.

Biol Pharm Bull 2021 ;44(5):701-706

Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare.

We previously reported that exposure of human colon adenocarcinoma (Caco-2) cells to the bitter substance phenylthiocarbamide (PTC) rapidly enhanced the transport function of P-glycoprotein (P-gp). In this study, we investigated the short-term effect of etoposide, another bitter-tasting P-gp substrate, on P-gp transport function in the same cell line. We found that etoposide exposure significantly increased both the P-gp protein level in the plasma membrane fraction and the efflux rate of rhodamine123 (Rho123) in Caco-2 cells within 10 min. Read More

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January 2021

Renal Biopsy and Clinical Outcomes in Patients With ABO-Incompatible Renal Transplant: Experience From a Tertiary Care Hospital.

Exp Clin Transplant 2021 May 6. Epub 2021 May 6.

From the Department of Renal Pathology, Division of Histopathology, Sir Ganga Ram Hospital, New Delhi, India.

Objectives: Renal transplant with ABO-incompatible donors expands the donor pool. Earlier studies have focused the use of protocol biopsies in ABOincompatible transplant patients. Our study described outcomes of indication (for cause) renal biopsies and clinical outcomes in patients with ABO-incompatible renal transplant. Read More

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Cribiform-morular variant of papillary thyroid carcinoma and familial adenomatous polyposis: Report of a case.

Acta Biomed 2021 Apr 30;92(S1). Epub 2021 Apr 30.

General Surgery Unit, Parma University Hospital, Italy .

Cribiform-morular thyroid carcinoma is a rare variant of papillary thyroid carcinoma. It is usually related to Familial Adenomatous Polyposis (FAP) but rarely it may be sporadic. This variant of PTC occurs in young females and it is rare in the elderly. Read More

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Phonon thermal conductivity of the stanene/hBN van der Waals heterostructure.

Phys Chem Chem Phys 2021 May 4. Epub 2021 May 4.

Department of Mechanical Engineering, Wayne State University, Detroit MI - 48202, USA.

We use classical non-equilibrium molecular dynamics (NEMD) simulations to investigate the phonon thermal conductivity (PTC) of hexagonal boron nitride (hBN) supported stanene. At first, we examine the length dependent PTCs of bare stanene and hBN, and the stanene/hBN heterostructure and realize the dominance of the hBN layer to dictate the PTC in the heterostructure system. Afterward, we assess the length-independent bulk PTCs of these materials. Read More

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Risk factors for central lymph node metastasis in the cervical region in papillary thyroid carcinoma: a retrospective study.

World J Surg Oncol 2021 Apr 30;19(1):138. Epub 2021 Apr 30.

Department of Thyroid Surgery, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Kunming, 650032, Yunnan, China.

Background: To investigate the influence of different risk factors on central lymph node metastasis (CLNM) in the cervical region in patients with papillary thyroid carcinoma (PTC).

Methods: This retrospective study included 2586 PTC patients. Potential risk factors were identified by univariate analysis, and the relationships between these factors and CLNM were ascertained by multivariable analysis. Read More

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Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough.

PLoS Biol 2021 May 3;19(5):e3001221. Epub 2021 May 3.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

Premature termination codons (PTC) cause over 10% of genetic disease cases. Some aminoglycosides that bind to the ribosome decoding center can induce PTC readthrough and restore low levels of full-length functional proteins. However, concomitant inhibition of protein synthesis limits the extent of PTC readthrough that can be achieved by aminoglycosides like G418. Read More

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Thyroid Lobectomy for Low-Risk Papillary Thyroid Cancer: A National Survey of Low- and High-Volume Surgeons.

Ann Surg Oncol 2021 May 3. Epub 2021 May 3.

Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Background: The 2015 American Thyroid Association guidelines endorsed lobectomy for patients with low-risk papillary thyroid cancer (PTC) measuring 1-4 cm. Attitudes about the use of lobectomy for these patients are lacking, particularly from low-volume surgeons who perform the majority of thyroidectomies in the US.

Methods: A survey was mailed to 1000 surgeons stratified by specialty (500 general surgeons and 500 otolaryngologists) registered with the American Medical Association, to evaluate beliefs and practices about the extent of surgery for low-risk PTC. Read More

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Stratifying Deterioration Risk by Acuity at Admission Offers Triage Insights for Coronavirus Disease 2019 Patients.

Crit Care Explor 2021 Apr 5;3(4):e0400. Epub 2021 Apr 5.

PeraHealth, Inc., Charlotte, NC.

Objectives: Triaging patients at admission to determine subsequent deterioration risk can be difficult. This is especially true of coronavirus disease 2019 patients, some of whom experience significant physiologic deterioration due to dysregulated immune response following admission. A well-established acuity measure, the Rothman Index, is evaluated for stratification of patients at admission into high or low risk of subsequent deterioration. Read More

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SQSTM1/p62 Promotes Cell Growth and Triggers Autophagy in Papillary Thyroid Cancer by Regulating the AKT/AMPK/mTOR Signaling Pathway.

Front Oncol 2021 15;11:638701. Epub 2021 Apr 15.

Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Thyroid cancer is one of the most common endocrine malignancies worldwide, and papillary thyroid cancer (PTC) is the most common pathologic type of thyroid cancer. SQSTM1/p62 activity mediates different biological functions. This study aimed to investigate the effect of SQSTM1/p62, a multifunctional receptor, on biological function and autophagy characteristics in the human PTC cell line TPC-1. Read More

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Polycomb group protein Bmi1 is required for the neuronal differentiation of mouse induced pluripotent stem cells.

Exp Ther Med 2021 Jun 14;21(6):619. Epub 2021 Apr 14.

College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zheijiang 310053, P.R. China.

Induced pluripotent stem cells (iPSCs) reprogrammed by somatic cells may be used as a potentially novel treatment regimen in stem cell regenerative medicine, particularly in the central nervous system (CNS). In the present study, iPSCs were generated using mouse embryonic fibroblasts by ectopic overexpression of Sox-2, Oct-3/4, Klf-4 and c-Myc, and cultured under the same conditions as that used for embryonic stem cells. The neuronal differentiation capacity of mouse iPSCs was examined, and the involvement of the formation of embryoid bodies was assessed. Read More

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One-step Percutaneous Transhepatic Cholangioscopy Combined With High-frequency Needle-knife Electrotomy in Biliary Strictures After Liver Transplantation.

Surg Laparosc Endosc Percutan Tech 2021 May 3. Epub 2021 May 3.

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Endoscopic management is the mainstay for biliary strictures after liver transplantation. However, this method is often failed in cases associated with hepatolithiasis or refractory strictures. The aim of this study is to investigate whether 1-step percutaneous transhepatic biliary cholangiography (PTC) combined with high-frequency needle-knife electrotomy can be an alternative method in biliary strictures after liver transplantation that could not be treated by endoscopic management. Read More

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Force transduction creates long-ranged coupling in ribosomes stalled by arrest peptides.

Biophys J 2021 Apr 28. Epub 2021 Apr 28.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

Force-sensitive arrest peptides regulate protein biosynthesis by stalling the ribosome as they are translated. Synthesis can be resumed when the nascent arrest peptide experiences a pulling force of sufficient magnitude to break the stall. Efficient stalling is dependent on the specific identity of a large number of amino acids, including amino acids which are tens of angstroms away from the peptidyl transferase center (PTC). Read More

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A case of presacral teratoid cyst in an adult patient.

Folia Med (Plovdiv) 2021 Apr;63(2):287-291

Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Presacral teratoid cyst (PTC) is a congenital structural abnormality located in the pararectal area and containing tissues from different germ layers. Cases of diagnosis and treatment of PTC in adults are extremely rare and there is little information about the treatment tactics and prognosis. We describe a case of PTC in a 28-year-old woman, with a description of the diagnostic process, preoperative and postoperative management, as well as a brief review of the literature on this topic. Read More

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Multiple components-pharmacokinetic studies on ten bioactive constituents of Peiyuan Tongnao Capsule, using parallel reaction monitoring mode.

Biomed Chromatogr 2021 Apr 30:e5153. Epub 2021 Apr 30.

State Key Laboratory of Component-based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China.

Peiyuan Tongnao Capsule (PTC) plays an important role in clinical application due to its excellent curative efficacy in the treatment of ischemic stroke and chronic cerebral circulation insufficiency. To standardize and rationalize the clinical application of PTC, a rapid and sensitive method based on ultra-high performance liquid chromatography/quadrupole-Orbitrap mass spectrometry (UHPLC/Q-Orbitrap-MS) with parallel reaction monitoring mode (PRM) was developed and validated for the pharmacokinetic study. Ten bioactive compounds (aucubin, salidroside, echinacoside, paeoniflorin, verbascoside, liquiritin, 2, 3, 5, 4'-tetrahydroxy stilbene-2-O-β-D-glucoside, coumarin, glycyrrhizic acid, and emodin) were simultaneously determined in rat plasma. Read More

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Circular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis.

Bioengineered 2021 Dec;12(1):1484-1494

Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

Circular RNAs (circRNAs) feature prominently in regulating the progression of tumors, including papillary thyroid carcinoma (PTC). This work is designated to delve into the role of circ_0062389 in PTC. Generally, quantitative real-time polymerase chain reaction (qRT-PCR) was employed to detect circ_0062389, miR-1179 and high mobility group box 1 (HMGB1) mRNA expression levels. Read More

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December 2021

Fusion Genes in Thyroid Carcinomas: Clinicopathological Characteristics and Their Impacts on Prognosis.

Cancers (Basel) 2021 Apr 16;13(8). Epub 2021 Apr 16.

Department of Molecular Endocrinology, Institute of Endocrinology, 11694 Prague, Czech Republic.

Chromosomal rearrangements of genes are oncogenic driver mutations in thyroid cancer (TC). This study aimed to identify fusion-positive thyroid tumors and to correlate them with clinical and pathological data and determine their prognostic significance. The cohort consisted of 989 different TC samples. Read More

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Genetic Determinants for Prediction of Outcome of Patients with Papillary Thyroid Carcinoma.

Cancers (Basel) 2021 Apr 23;13(9). Epub 2021 Apr 23.

IPATIMUP-Instituto de Patologia e Imunologia Molecular da Universidade do Porto, 4200-135 Porto, Portugal.

Papillary thyroid carcinoma (PTC) usually presents an excellent prognosis, but some patients present with aggressive metastatic disease. BRAF, RAS, and TERT promoter (TERTp) genes are altered in PTC, and their impact on patient outcomes remains controversial. We aimed to determine the role of genetic alterations in PTC patient outcomes (recurrent/persistent disease, structural disease, and disease-specific mortality (DSM)). Read More

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Intratumoral Heterogeneity in Differentiated Thyroid Tumors: An Intriguing Reappraisal in the Era of Personalized Medicine.

J Pers Med 2021 Apr 23;11(5). Epub 2021 Apr 23.

Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Section of Pathology, University of Messina, 98125 Messina, Italy.

Differentiated thyroid tumors (DTTs) are characterized by significant molecular variability in both spatial and temporal intra-tumoral heterogeneity (ITH), that could influence the therapeutic management. ITH phenomenon appears to have a relevant role in tumor growth, aggressive behavior and drug resistance. Accordingly, characteristics and consequences of ITH in DTTs should be better analyzed and understood in order to guide clinical practice, improving survival. Read More

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Widespread Alternative Splicing Changes in Metastatic Breast Cancer Cells.

Cells 2021 Apr 9;10(4). Epub 2021 Apr 9.

School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea.

Aberrant alternative splicing (AS) is a hallmark of cancer and a potential target for novel anti-cancer therapeutics. Breast cancer-associated AS events are known to be linked to disease progression, metastasis, and survival of breast cancer patients. To identify altered AS programs occurring in metastatic breast cancer, we perform a global analysis of AS events by using RNA-mediated oligonucleotide annealing, selection, and ligation coupled with next-generation sequencing (RASL-seq). Read More

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Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome.

Antibiotics (Basel) 2021 Apr 5;10(4). Epub 2021 Apr 5.

Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.

Chloramphenicol (CHL) is a ribosome-targeting antibiotic that binds to the peptidyl transferase center (PTC) of the bacterial ribosome and inhibits peptide bond formation. As an approach for modifying and potentially improving the properties of this inhibitor, we explored ribosome binding and inhibitory properties of a semi-synthetic triphenylphosphonium analog of CHL-CAM-C4-TPP. Our data demonstrate that this compound exhibits a ~5-fold stronger affinity for the bacterial ribosome and higher potency as an in vitro protein synthesis inhibitor compared to CHL. Read More

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Properties of Surface Heating Textile for Functional Warm Clothing Based on a Composite Heating Element with a Positive Temperature Coefficient.

Nanomaterials (Basel) 2021 Apr 1;11(4). Epub 2021 Apr 1.

Department of Fashion Industry, Incheon University, Incheon 22012, Korea.

A high-stretch positive temperature coefficient (PTC) surface heating textile (PTC-SHT) was fabricated using a composite of PTC powder and multiwall carbon nanotubes (MWCNTs). The PTC-SHT (heating area = 100 × 100 mm) was produced by screen-printing the PTC-MWCNT composite paste onto a high-stretch textile with embroidered electrodes. Overall, the temperature increased to 56. Read More

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Site-Specific Metastasis and Survival in Papillary Thyroid Cancer: The Importance of Brain and Multi-Organ Disease.

Cancers (Basel) 2021 Apr 1;13(7). Epub 2021 Apr 1.

Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Introduction-heterogeneity in clinical outcomes and survival was observed in patients with papillary thyroid cancer (PTC) and distant metastases. Here, we investigated the effect of distant metastases sites on survival in PTC patients. Methods-patients with a diagnosis of PTC and known metastases were identified using the Surveillance, Epidemiology, and End Results database (1975-2016). Read More

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Lateral Neck Dissection for Well-Differentiated Thyroid Carcinoma: Is Prophylactic Level V Neck Dissection Necessary? A Retrospective Cohort Study.

Ear Nose Throat J 2021 Apr 29:1455613211003805. Epub 2021 Apr 29.

Department of Otolaryngology-Head and Neck, Maxillofacial Surgery, Israel.

Objective: The presence of clinically detectable papillary thyroid carcinoma (PTC) metastases in the lateral neck is an indication for neck dissection (ND) and thyroidectomy. Although there is a consensus regarding the importance of therapeutic selective ND of involved levels II to IV in patients with clinically evident locoregional metastatic disease, the prognostic benefit of level V prophylactic ND remains debatable.

Methods: All patients who underwent thyroidectomy with ND for metastatic PTC between 2006 and 2019 were included in a single-institution retrospective study. Read More

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Diagnostic Utility of p62 Expression in Intranuclear Inclusions in Thyroid Core Needle Biopsy Specimens.

In Vivo 2021 May-Jun;35(3):1769-1775

Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea;

Background/aim: Core needle biopsy (CNB) has been widely used as an alternative method to ultrasound-guided fine-needle aspiration cytology for histological diagnosis of thyroid specimens. However, nuclear artifactual vacuoles (NuVas) produced during tissue processing can be very difficult and sometimes impossible to distinguish from intranuclear inclusions (NuIns). P62 is an autophagy receptor that recognizes, targets, and eliminates toxic cellular materials during autophagy. Read More

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January 2021