1,144 results match your criteria psychotic delirious


Reactivation of COVID-19 in a neurosurgical patient with early neuropsychiatric presentation. Does seroconversion mean immunity?

Surg Neurol Int 2021 19;12:166. Epub 2021 Apr 19.

Department of Neurosurgery, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Background: In the aftermath of COVID-19 outbreak, there is a strong need to find strategies to monitor SARSCoV-2 transmission. While the application of screening techniques plays a major role to this end, there is evidence challenging the real significance of seroconversion. We reported a case of COVID-19 reactivation associated with a neurosurgical operation with early neuropsychiatric involvement presumably promoted by olfactory and gustatory impairment in the first infection. Read More

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Postpartum Psychosis after Traumatic Cesarean Delivery.

Healthcare (Basel) 2021 May 16;9(5). Epub 2021 May 16.

Department of Midwifery, University of West Attica, 12243 Athens, Greece.

An emergency cesarean delivery can be a traumatic childbirth experience for a woman and a risk factor for postpartum psychosis, especially in a patient with a history of bipolar disorder. This article describes the case of a pregnant woman with an unknown history of bipolar disorder who developed an acute psychotic reaction during the procedure of an emergency caesarian section and switched to mania. The purpose of this case study is for perinatal health care professionals to identify suspicious symptoms and promptly refer to psychiatric services so as to ensure the mother's and the newborn's safety. Read More

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Elevated Monocyte Chemoattractant Protein-1 as the Independent Risk Factor of Delirium after Cardiac Surgery. A Prospective Cohort Study.

J Clin Med 2021 Apr 9;10(8). Epub 2021 Apr 9.

Department of Cardiac Surgery, Medical University of Lodz, 92-213 Lodz, Poland.

Background: The pathogenesis of postoperative delirium is largely unknown. The primary objective of this study is to assess whether increased levels of monocyte chemoattractant protein-1 (MCP-1) and high-sensitivity C-reactive protein (hsCRP) are associated with postoperative delirium in patients who have undergone cardiac surgery. The secondary objective is to investigate whether any association between raised inflammatory biomarkers levels and delirium is related to surgical and anesthetic procedures or mediated by pre-existing psychiatric conditions associated with raised pro-inflammatory markers levels. Read More

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Promethazine-induced delirium with perceptual abnormalities: are we thinking broadly when assessing patients?

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Psychiatry, Gold Coast University Hospital, Southport, Queensland, Australia.

There is limited information about promethazine-induced delirium with psychotic symptoms. The aim is to highlight the importance of taking a detailed history including medication use/abuse of both prescribed, illicit and over-the-counter preparations. This paper describes a patient who presented with delirium in the context of overuse of promethazine (Phenergan) which was initially missed. Read More

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6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records.

Lancet Psychiatry 2021 05 6;8(5):416-427. Epub 2021 Apr 6.

Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Oxford, UK. Electronic address:

Background: Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric diagnoses in patients in the 6 months following a COVID-19 diagnosis.

Methods: For this retrospective cohort study and time-to-event analysis, we used data obtained from the TriNetX electronic health records network (with over 81 million patients). Read More

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Catatonia Presentation as a Rare Alcohol Withdrawal Symptom in a Patient With No Past Psychiatry History: A Case Report.

Cureus 2021 Mar 5;13(3):e13722. Epub 2021 Mar 5.

Psychiatry and Behavioral Sciences, Interfaith Medical Center, Brooklyn, USA.

A complicated alcohol withdrawal syndrome (AWS) includes epileptic seizures and/or delirium tremens (DT). However, there is still a dearth of literature for catatonia as a consequence of AWS especially in terms of clinical reports. Secondly, the few noted reported cases in the literature were mainly of non-American populations. Read More

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A Rare Report of Clinical Lycanthropy in Obsessive-Compulsive and Related Disorders.

Cureus 2021 Feb 15;13(2):e13346. Epub 2021 Feb 15.

Psychiatry, Mahatma Gandhi Memorial Medical College, Indore, IND.

Lycanthropy is a rare variant of a delusional misidentification syndrome specifically reverse inter-metamorphosis where patients believe that they are experiencing transformation or have transformed into an animal. A case report of this phenomenon is discussed. We report the lycanthropy phenomenon of a 25-year-old male who believed himself to be transformed into a buffalo after bestiality along with developing obsessive-compulsive features. Read More

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February 2021

[Antioxidant status of blood plasma of acutely psychotic patients and its correlation with Nrf2 activation].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(2):60-66

Alekseev Psychiatric Clinical Hospital No. 1, Moscow, Russia.

Objective: To study the correlation between the blood plasma antioxidant profile and the transcriptional activity of the Nrf2 gene in acute psychosis in patients with schizophrenia and alcoholism.

Material And Methods: The study included 40 patients with the first episode of the paranoid form of schizophrenia, 33 patients with schizophrenic psychosis who had previously received therapy, 22 patients with first-time acute alcohol psychosis, and 25 healthy volunteers. The level of Nrf2 in peripheral blood mononuclear cells was estimated by flow cytometry, and the antioxidant profile of blood plasma was estimated with chemiluminometry. Read More

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Association between components of the delirium syndrome and outcomes in hospitalised adults: a systematic review and meta-analysis.

BMC Geriatr 2021 03 5;21(1):162. Epub 2021 Mar 5.

Geriatric Medicine, Edinburgh Delirium Research Group, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.

Background: Delirium is a heterogeneous syndrome with inattention as the core feature. There is considerable variation in the presence and degree of other symptom domains such as altered arousal, psychotic features and global cognitive dysfunction. Delirium is independently associated with increased mortality, but it is unclear whether individual symptom domains of delirium have prognostic importance. Read More

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Commentary on 2 Cases of Neuropsychiatric Symptoms Occurring in Association With COVID-19.

Authors:
Amir Garakani

J Psychiatr Pract 2021 03 5;27(2):145-146. Epub 2021 Mar 5.

GARAKANI: Silver Hill Hospital, New Canaan, CT; Department of Psychiatry, Yale University School of Medicine, New Haven, CT; and Icahn School of Medicine at Mount Sinai, New York, NY.

Two cases are presented involving neuropsychiatric symptoms occurring in the context of coronavirus disease 2019 (COVID-19) infections. The first case involved a middle-age man with no known psychiatric history who presented with acute psychotic symptoms (delusions, hallucinations, disorganization) after recovery from a recent respiratory illness. This patient tested positive for COVID-19 on admission. Read More

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Abrupt Late-onset Psychosis as a Presentation of Coronavirus 2019 Disease (COVID-19): A Longitudinal Case Report.

J Psychiatr Pract 2021 Mar 5;27(2):131-136. Epub 2021 Mar 5.

Introduction: Coronavirus Disease 2019 (COVID-19) is a pandemic infection caused by the Severe Acute Respiratory Syndrome 2 Coronavirus (SARS-2-CoV). Although most prominently associated with pulmonary manifestations, COVID-19 is increasingly implicated in neuropsychiatric complications, including delirium and psychosis. There is a potential causal link between COVID-19 infection and psychotic symptoms; however, case reports to date have been incomplete, as the patients described had known psychiatric histories or other plausible medical causes for altered mental status. Read More

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Graves' disease presenting with hypomania and paranoia to the acute psychiatry service.

BMJ Case Rep 2021 Feb 9;14(2). Epub 2021 Feb 9.

Endocrinology Department, Royal Free London NHS Foundation Trust, Herts, UK.

This manuscript describes the case of a young woman, with no prior psychiatric history, who developed hypomania and paranoia as the principal presenting features of Graves' disease. After starting treatment with carbimazole and propranolol, symptoms resolved without the use of antipsychotic drugs. Close liaison between psychiatry and endocrinology services was essential. Read More

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February 2021

Pharmacological treatment during CoViD-19 and mental health issues.

Riv Psichiatr 2021 Jan-Feb;56(1):53-55

Department of Humanity and Social Science, GIFT University, Gujranwala, Pakistan.

Infection outbreak has been prevalent since previous decades. The impact of infection outbreak not merely limited to physical suffering but grounded for massive mental health issues. The fear of getting contagion and persistent exposure to diverse medication and vaccination contribute enormously to develop mental health issues among people. Read More

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February 2021

Classification of psychotherapy interventions for people with schizophrenia: development of the Nottingham Classification of Psychotherapies.

Evid Based Ment Health 2021 05 21;24(2):62-69. Epub 2020 Dec 21.

Institute of Mental Health, Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Cochrane Schizophrenia Group, Nottingham, UK.

Background: Currently, there is no accepted system for the classification of psychotherapies for application within systematic reviews. The creation of anuncomplicated, understandable and practical classification system is neccessary for conducting reliable systematic reviews.

Objective: To devise a system for classification of psychotherapy interventions-for use, initially, in systematic reviews. Read More

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Diagnosis, prevention, and management of delirium in the intensive cardiac care unit.

Am Heart J 2021 02 28;232:164-176. Epub 2020 Nov 28.

Intensive Cardiac Care Unit, Cardiology Department, Hospital Universitario 12 de Octubre and Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; CIBER de enfermedades CardioVasculares (CIBERCV), Madrid, Spain; Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. Electronic address:

Delirium is a frequent complication in patients admitted to intensive cardiac care units (ICCU) with potentially severe consequences including increased risks of mortality, cognitive impairment and dependence at discharge, and longer times on mechanical ventilation and hospital stay. Delirium has been widely documented and studied in general intensive care units and in patients after cardiac surgery, but it has barely been studied in acute nonsurgical cardiac patients. Moreover, delirium (especially in its hypoactive form) is commonly misdiagnosed. Read More

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February 2021

A rare case report of Lilliputian and Brobdingnagian hallucinations in a case of pemphigus vulgaris.

Indian J Psychiatry 2020 Jul-Aug;62(4):435-436. Epub 2020 Jul 27.

Department of Psychiatry, AIIMS, Bhopal, Madhya Pradesh, India.

Pemphigus vulgaris is an autoimmune disorder characterized by intraepithelial, blistering lesions affecting the skin and mucous membrane. Psychiatric manifestations of pemphigus vulgaris are generally described secondary to steroid and immunosuppressant therapy though recent studies highlight independent association of pemphigus with psychotic disorders. We describe a unique development of Lilliputian hallucinations, their transformation into Brobdingnagian hallucinations on treatment with steroids and gradual resolution back to Lilliputian status on treatment with risperidone. Read More

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Misuse and dependence of dimenhydrinate: A mixed studies systematic review.

J Psychiatr Res 2021 04 30;136:581-588. Epub 2020 Oct 30.

Department of Psychiatry, Queen's University, Kingston, Ontario, Canada; Substance Treatment and Rehabilitation Team, Kingston Health Sciences Centre, Canada; Department of Family Medicine, Queen's University, Kingston, Ontario, Canada.

Background: Dimenhydrinate (DMH) is an antihistamine used to treat nausea and vomiting. Although widely available in pharmacies as an over the counter medication, there have been reports of potential DMH tolerance and dependence and a possible euphoric potential accompanying heavy use (>100 mg/day). Despite the potential for misuse, there is a gap in the literature concerning patterns, characteristics, and potential mechanisms of DMH misuse. Read More

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Start low, go fast? Antipsychotic titration patterns at an inpatient psychiatric hospital.

Ment Health Clin 2020 Sep 30;10(5):275-281. Epub 2020 Sep 30.

Student, University of Arizona College of Pharmacy, Tucson, Arizona.

Introduction: Antipsychotics are commonly used to treat psychotic symptoms and severe mental illnesses. Treatment guidelines recommend antipsychotics be titrated quickly to therapeutic effect in the acute setting but acknowledge that determining the optimal dose is complicated by a delay between treatment initiation and therapeutic response. The purpose of this study was to evaluate antipsychotic titration patterns in an inpatient psychiatric hospital. Read More

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September 2020

Neuropsychological features of delusions in hospitalized older adults with neurocognitive disorders.

J Clin Exp Neuropsychol 2020 11 14;42(9):941-951. Epub 2020 Oct 14.

Department of Psychology, Butler Hospital , Providence, RI, USA.

Individuals with neurocognitive disorders (NCD) frequently experience psychotic symptoms, such as delusions. Delusions can contribute to other behavior problems, create dangers for patients and caregivers, and contribute to inpatient hospitalization of individuals with NCD. The current study aimed to identify cognitive symptoms associated with the presence of delusions and to differentiate delusion types based on cognitive profiles among hospitalized older adults with NCD. Read More

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November 2020

Exacerbation of psychotic symptoms as clinical presentation of Wernicke encephalopathy in an Alzheimer's disease patient.

J Gen Fam Med 2020 Sep 17;21(5):185-187. Epub 2020 May 17.

Department of Psycho-oncology Saitama Medical University International Medical Center Saitama Japan.

Although there have been recent reports of nonalcoholic thiamine deficiency (TD), no association has been reported between the exacerbation of the psychiatric symptoms of Alzheimer's disease patient and TD. An 89-year-old woman with dementia visited our hospital because of acute deterioration in behavioral and psychological symptoms of dementia (BPSD). Her medical history revealed a decrease in oral food intake lasting more than 2 weeks, so that TD was suspected and abnormal behavior improved significantly after thiamine administration. Read More

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September 2020

[Clinical variants of psychoses in patients using synthetic cannabinoids (Spice)].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(8):23-26

Moscow Research and Practical Centre of Addictions, Moscow, Russia.

Objective: To describe the structure of psychoses developed due to synthetic cannabinoids (Spice).

Material And Methods: Forty-six men, aged 18-35 years, with psychosis during abstinence were studied and followed up for 2 years.

Results And Conclusion: Four clinical variants with predominant delirious symptoms (27%) or hallucinatory symptoms (19%) or affective-delusions (21%) or mental automatisms (33%) were identified. Read More

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September 2020

Quinolone-induced psychosis: an updated review.

Actas Esp Psiquiatr 2020 May 1;48(3):126-37. Epub 2020 May 1.

Servicio de Psiquiatría, Hospital Universitari Vall d'Hebron. Barcelona. España Grupo de Psiquiatría, Salud Mental y Adicciones, Vall d'Hebron Research Institute (VHIR). Barcelona. España Biomedical Network Research Centre on Mental Health (CIBERSAM). Barcelona. España Departamento de Psiquiatría y Medicina Legal, Universitat Autònoma de Barcelona. Barcelona. España.

Quinolones are an antibiotic group widely used due to their antimicrobial action and security profile, however, it has been described neuropsychiatric adverse effects, being induced-psychotic episodes one of the most clinically relevant. Nevertheless, this secondary effect has been scarcely studied. A literature search using PRISMA guidelines was performed between 01/01/1962 and 01/31/2019 on PubMed and ScienceDirect, including manuscripts which described substance-induced psychotic disorder according to DSM-5 and in which the symptomatology was not attributable to an acute confusional state (delirium) or to other induced psychiatric disorders. Read More

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Acute Psychosis Consequent to Total Thyroidectomy: An Etiological Conundrum.

Cureus 2020 Jul 17;12(7):e9244. Epub 2020 Jul 17.

Endocrinology, All India Institute of Medical Sciences, Jodhpur, IND.

Total thyroidectomy has evolved from a vilipended surgery owing to its high mortality to one with commonly performed surgery with minimal complications. After a total thyroidectomy many patients are left hypothyroid and/or hypoparathyroid, and thus prone to develop neuropsychiatric complications. Although anxiety and depression are the common manifestations, acute psychosis consequent to total thyroidectomy is rarely reported. Read More

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COVID-19 Delirium with Psychosis: A Case Report.

S D Med 2020 Aug;73(8):346-349

Avera Medical Group University Psychiatry Associates, Sioux Falls, South Dakota.

COVID-19 typically presents as severe pneumonia often requiring intubation and ICU management. Descriptions of the potential neurological symptoms in this disease state exist, but minimal research has been conducted on the prevalence of delirium. This case report describes a patient with no past psychiatric history who developed psychotic symptoms in the context of acute COVID-19 delirium. Read More

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Haloperidol Induced Sudden Cardiac Arrest-Report of a Very Rare Case and Review of Literature.

Case Rep Psychiatry 2020 22;2020:1836716. Epub 2020 Jul 22.

Department of Psychiatry, Sher-I-Kashmir Institute of Medical sciences (SKIMS), Srinagar, Jammu and Kashmir, India 190011.

Haloperidol is a typical antipsychotic drug. This drug is still widely used in emergency medicine, psychiatry, and general medicine departments. It is mostly used for acute confusional state, psychotic disorders, agitation, delirium, and aggressive behaviour. Read More

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Incidence and associated factors of delirium after orthopedic surgery in elderly patients: a systematic review and meta-analysis.

Aging Clin Exp Res 2021 Jun 9;33(6):1493-1506. Epub 2020 Aug 9.

Department of Arthroplasty Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.

Background: A total of 4.5-41.2% of orthopedic surgery patients experience delirium. Read More

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Persistent psychotic symptoms following COVID-19 infection.

BJPsych Open 2020 Jul 22;6(5):e105. Epub 2020 Jul 22.

Department of Neuropsychiatry, National Hospital for Neurology and Neurosurgery, UCLH, UK.

To date, there have been no detailed reports of patients developing persistent psychotic symptoms following Coronavirus disease 2019 (COVID-19) infection. There have been reports of patients developing transient delirium (with and without hypoxia) after COVID-19 infection as well as other neurological manifestations. We report on a female patient who, post-COVID-19 infection, developed an initial delirium followed by persistent and florid psychotic symptoms consisting of persecutory delusion, complex visual and auditory hallucinations and Capgras phenomenon in the absence of hypoxia but elevated tumour necrosis factor (TNF)-α. Read More

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