1,351,493 results match your criteria psychiatric disorders

Enhancing Translational Developmental Cognitive Neuroscience with Advanced Neuroimaging Analyses.

Seth M Levine

Dev Neurosci 2021 May 12:1-3. Epub 2021 May 12.

Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

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Structural neuroimaging phenotypes of a novel multi-gene risk score in youth bipolar disorder.

J Affect Disord 2021 Apr 28;289:135-143. Epub 2021 Apr 28.

University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: Bipolar disorder (BD) is among the most heritable psychiatric disorders, particularly in early-onset cases, owing to multiple genes of small effect. Here we examine a multi-gene risk score (MGRS), to address the gap in multi-gene research in early-onset BD.

Methods: MGRS was derived from 34 genetic variants relevant to neuropsychiatric diseases and related systemic processes. Read More

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Internet-based cognitive assessment tool: Sensitivity and validity of a new online cognition screening tool for patients with bipolar disorder.

J Affect Disord 2021 Apr 27;289:125-134. Epub 2021 Apr 27.

Digital Health Section, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark; Copenhagen Center for Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.

Background: The International Society for Bipolar Disorders Targeting Cognition Task Force recommends the Screen for Cognitive Impairment in Psychiatry (SCIP) to screen for cognitive impairment in bipolar disorder. However, SCIP must be administered by a healthcare professional, which is often impossible due to time and resource constraints. Web-based, self-administered cognition screening tools may enable assessment and monitoring of patients' cognition at a much larger scale to a reduced cost. Read More

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Associations between interpersonal dependency and severity of prolonged grief disorder symptoms in bereaved surviving family members.

Compr Psychiatry 2021 Apr 30;108:152242. Epub 2021 Apr 30.

Cornell Center for Research on End-of-Live Care, 321 Lasdon House, 420 East 70(th) Street, Weill Cornell Medicine, NY, New York 10021, United States of America; Department of Medicine, Division of Geriatrics and Palliative Medicine, Baker Pavilion 14(th) Floor, East 68(th) Street, Weill Cornell Medicine, NY, New York 10021, United States of America. Electronic address:

Background: Several studies have shown that interpersonal dependency is a risk factor for prolonged grief disorder (PGD), a disorder that has been recently approved by the American Psychiatric Association Assembly for inclusion in the Diagnostic and Statistical Manual of Mental Disorders-5-Text Revision (DSM-5-TR). Nevertheless, it remains unclear whether this relationship is independent of depression, which may also be related to both loss and interpersonal dependency. Furthermore, anaclitic dependency (maladaptive and immature) compared to relatedness (more adaptive and mature) dependency, and the relationships between these types of dependency and PGD, have not been examined. Read More

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Ubiquitous Dopamine Deficit Hypotheses in Cocaine Use Disorder Lack Support: Response to Leyton.

Am J Psychiatry 2021 May;178(5):469-470

University of Ottawa Institute of Mental Health Research, affiliated with The Royal, Ottawa (Cassidy); Department of Psychiatry, Columbia University College of Physicians and Surgeons, and New York State Psychiatric Institute, New York (Cassidy, Abi-Dargham, Martinez, Horga); Department of Psychiatry, Rutgers University, Piscataway, N.J. (Konova); Department of Psychiatry, Stony Brook University, Stony Brook, N.Y. (Abi-Dargham).

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Better Evidence for Pharmacological Maintenance Treatment in Nonaffective Psychoses: Implications for Relapse Prevention.

William G Honer

Am J Psychiatry 2021 May;178(5):369-371

Department of Psychiatry, University of British Columbia, and British Columbia Mental Health and Substance Use Services Research Institute, Vancouver, Canada.

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Brain Damage and Patterns of Neurovascular Disorder after Ionizing Irradiation. Complications in Radiotherapy and Radiation Combined Injury.

Radiat Res 2021 May 12. Epub 2021 May 12.

Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

Exposure to ionizing radiation, mechanical trauma, toxic chemicals or infections, or combinations thereof (i.e., combined injury) can induce organic injury to brain tissues, the structural disarrangement of interactive networks of neurovascular and glial cells, as well as on arrays of the paracrine and systemic destruction. Read More

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Evaluating Ineffective Treatments: A Proposed Model for Discussing Futility in Psychiatric Illness.

Harv Rev Psychiatry 2021 May-Jun 01;29(3):240-245

From the Cleveland Clinic Foundation, Cleveland, OH (Dr. Coulter); Louis Stokes Cleveland VA Medical Center, Cleveland, OH (Dr. Schuermeyer); PrairieCare Medical Group Southern Minnesota, Rochester, MN (Dr. Sola).

Background: Treatment futility and terminality discussions arise rarely in psychiatric practice, frequently instilling apprehension, as there is little written that defines these terms in relation to mental illness. It therefore remains uncertain how to deal with cases that are refractory to multimodal interventions and that demonstrate limited improvement or even a worsening trajectory. Any viable solution needs to respect patient autonomy and maintain both beneficence and nonmaleficence, while taking into account the strained resources of the mental health care system as a whole. Read More

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Universal and Selective Interventions to Prevent Poor Mental Health Outcomes in Young People: Systematic Review and Meta-analysis.

Harv Rev Psychiatry 2021 May-Jun 01;29(3):196-215

From the Early Psychosis: Interventions and Clinical-Detection (EPIC) Laboratory, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London (Drs. Salazar de Pablo, De Micheli, Catalan, Verdino, Di Maggio, Radua, Provenzani, Montealegre, Signorini, and Fusar-Poli, and Mr. Oliver); Departments of Child and Adolescent Psychiatry (Dr. Salazar de Pablo) and of Psychosis Studies (Drs. Bonoldi and Baccaredda Boy), Institute of Psychiatry, Psychology & Neuroscience, King's College London; Institute of Psychiatry and Mental Health. Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, Madrid (Drs. Salazar de Pablo and Arango); National Institute for Health Research, Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London (Drs. De Micheli and Fusar-Poli); Department of Brain and Behavioral Sciences, University of Pavia (Drs. Di Maggio, Provenzani, Ruzzi, Calorio, Nosari, Di Marco, Famularo, Molteni, Filosi, Mensi, Balottin, Politi, and Fusar-Poli); Neurosciences Department, University of Padova (Dr. Solmi); Mental Health Department, Biocruces Bizkaia Health Research Institute, Basurto University Hospital, Facultad de Medicina y Odontología, Campus de Leioa, University of the Basque Country, UPV/EHU, Barakaldo, Bizkaia, Spain (Dr. Catalan); Department of Molecular and Developmental Medicine, Division of Psychiatry, University of Siena (Dr. Verdino); Imaging of Mood- and Anxiety-Related Disorders (IMARD) group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona (Dr. Radua); Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm (Dr. Radua); Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Mondino Foundation, Child and Adolescent Neuropsychiatric Unit (Dr. Mensi); Department of Paediatrics, Yonsei University College of Medicine, Seoul (Dr. Shin); Zucker Hillside Hospital, Department of Psychiatry, Northwell Health, Glen Oaks, NY (Dr. Correll); Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY (Dr. Correll); Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY (Dr. Correll); Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin (Dr. Correll); OASIS service, South London and Maudsley NHS Foundation Trust, London (Dr. Fusar-Poli).

Background: Much is not known about the efficacy of interventions to prevent poor mental health outcomes in young people by targeting either the general population (universal prevention) or asymptomatic individuals with high risk of developing a mental disorder (selective prevention).

Methods: We conducted a PRISMA/MOOSE-compliant systematic review and meta-analysis of Web of Science to identify studies comparing post-test efficacy (effect size [ES]; Hedges' g) of universal or selective interventions for poor mental health outcomes versus control groups, in samples with mean age <35 years (PROSPERO: CRD42018102143). Measurements included random-effects models, I2 statistics, publication bias, meta-regression, sensitivity analyses, quality assessments, number needed to treat, and population impact number. Read More

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Systems genetic analysis of binge-like eating in a C57BL/6J x DBA/2J-F2 cross.

Genes Brain Behav 2021 May 12:e12751. Epub 2021 May 12.

Laboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry, Boston University School of Medicine, Boston, MA, USA.

Binge eating is a heritable trait associated with eating disorders and refers to the rapid consumption of a large quantity of energy-dense food that is associated with loss of control and negative affect. Binge Eating Disorder is the most common eating disorder in the US; however, the genetic basis is unknown. We previously identified robust mouse inbred strain differences between C57BL/6J and DBA/2J in binge-like eating of sweetened palatable food in an intermittent access, conditioned place preference paradigm (PF-CPP). Read More

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The Potential Use of Peripheral Blood Mononuclear Cells as Biomarkers for Treatment Response and Outcome Prediction in Psychiatry: A Systematic Review.

Mol Diagn Ther 2021 May 12. Epub 2021 May 12.

Faculty of Medicine and Health Sciences, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, R3.22, Building R, Campus Drie Eiken, Universiteitsplein 1, 2610, Antwerp, Belgium.

Background: Psychiatric disorders have a major impact on the global burden of disease while therapeutic interventions remain insufficient to adequately treat a large number of patients. Regrettably, the efficacy of several psychopharmacological treatment regimens becomes apparent only after 4-6 weeks, and at this point, a significant number of patients present as non-responsive. As such, many patients go weeks/months without appropriate treatment or symptom management. Read More

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Maternal Exposure to Pesticides and Risk of Autism Spectrum Disorders in Offspring: A Meta-analysis.

J Autism Dev Disord 2021 May 12. Epub 2021 May 12.

Mental Health Center, Renmin Hospital of Wuhan University, Jiefang Road 238#, Wuchang District, Wuhan, 430060, People's Republic of China.

This meta-analysis was conducted to estimate the overall association between maternal exposure to pesticides and risk of ASD in offspring. PubMed, EMBASE, Web of Science, and the PsycINFO were searched until December 30, 2020 to include eligible studies. Eight studies with 50,426 participants, 5810 of whom had ASD, were involved in the study. Read More

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Identifying Return to Work Self-Efficacy Trajectories in Employees with Mental Health Problems.

J Occup Rehabil 2021 May 12. Epub 2021 May 12.

Tranzo Scientific Center for Care and Wellbeing, Tilburg School of Social and Behavioral Sciences, Tilburg University, Professor Cobbenhagenlaan 125, 5037 DB, Tilburg, The Netherlands.

Purpose Return to work self-efficacy (RTW-SE) is a strong predictor of return to work (RTW) in employees with mental health problems (MHPs). However, little is known about the development of RTW-SE during the RTW process. In this study, we aimed to identify RTW-SE trajectories in the year following sick leave in employees with MHPs and provided a description of the trajectories in terms of personal and work characteristics, and RTW status. Read More

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Polygenic Liability and Recurrence of Depression in Patients With First-Onset Depression Treated in Hospital-Based Settings.

JAMA Psychiatry 2021 May 12. Epub 2021 May 12.

National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark.

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Inferring Thalamocortical Monosynaptic Connectivity In-Vivo.

J Neurophysiol 2021 May 12. Epub 2021 May 12.

Coulter Department of Biomedical Engineering, Georgia Institute of Technology, United Statesgrid.213917.f.

As the tools to simultaneously record electrophysiological signals from large numbers of neurons within and across brain regions become increasingly available, this opens up for the first time the possibility of establishing the details of causal relationships between monosynaptically connected neurons and the patterns of neural activation that underlie perception and behavior. Although recorded activity across synaptically connected neurons has served as the cornerstone for much of what we know about synaptic transmission and plasticity, this has largely been relegated to ex-vivo preparations that enable precise targeting under relatively well-controlled conditions. Analogous studies in-vivo, where image-guided targeting is often not yet possible, rely on indirect, data-driven measures, and as a result such studies have been sparse and the dependence upon important experimental parameters has not been well studied. Read More

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Patient Experiences of Health Care Providers in Premenstrual Dysphoric Disorder: Examining the Role of Provider Specialty.

J Womens Health (Larchmt) 2021 Apr 1. Epub 2021 Apr 1.

Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.

Premenstrual dysphoric disorder (PMDD) is a severe mood disorder that affects ∼5% of menstruating individuals. Although symptoms are limited to the luteal phase of the menstrual cycle, PMDD causes significant distress and impairment across a range of activities. PMDD is under-recognized by health care providers, can be difficult to diagnose, and lies at the intersection of gynecology and psychiatry. Read More

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The diagnostic competence of Glial Fibrillary Acidic Protein in mild traumatic brain injury and its prognostic value in patient recovery.

Turk Neurosurg 2020 Jul 6. Epub 2020 Jul 6.

Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Aim: Aim: In clinical assessments and literature conducted on TBI, the mild TBI is less studied, because the initial symptoms are non-specific and subjective, and have overlap with psychological disorders. Glial Fibrillary Acidic Protein (GFAP) is a protein expressed by most of the abundant cells of the CNS. Therefore, this paper attempted to show whether the GFAP levels are significantly higher in the serum of patients with mild traumatic brain injury Material and Methods: The level of serum GFP was measured in 176 patients suffering from brain trauma. Read More

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Perspectives: involving persons with lived experience of mental health conditions in service delivery, development and leadership.

BJPsych Bull 2021 May 12:1-4. Epub 2021 May 12.

Global Mental Health Peer Network, Roodepoort, South Africa.

Globally, there has been an emphasis on the importance and value of involving people with lived experience of mental health conditions in service delivery, development and leadership. Such individuals have taken on various roles, from peer support specialists and other specialised professions to leadership in mainstream industries. There are, however, still obstacles to overcome before it is possible to fully include people with lived experience at all levels in the mental health and related sectors. Read More

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Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants.

World J Biol Psychiatry 2021 May 12:1-68. Epub 2021 May 12.

Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.

More than 40 drugs are available to treat affective disorders. Individual selection of the optimal drug and dose is required to attain the highest possible efficacy and acceptable tolerability for every patient. This review, which includes more than 500 articles selected by 30 experts, combines relevant knowledge on studies investigating the pharmacokinetics, pharmacodynamics and pharmacogenetics of 33 antidepressant drugs and of 4 drugs approved for augmentation in cases of insufficient response to antidepressant monotherapy. Read More

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Gender Moderates the Association Between Exposure to Interpersonal Violence and Intermittent Explosive Disorder Diagnosis.

J Interpers Violence 2021 May 12:8862605211013951. Epub 2021 May 12.

McLean Hospital, Belmont, MA, USA.

Exposure to interpersonal violence (EIV) is a prevalent risk-factor for aggressive behavior; however, it is unclear whether the effect of EIV on clinically significant aggressive behavior is similar across gender. We examined whether gender moderates the association between experiencing and witnessing interpersonal violence and the diagnosis of intermittent explosive disorder (IED). We also examined potential pathways that might differentially account for the association between EIV and IED in men and women, including emotion regulation and social information processing (SIP). Read More

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Lactoferrin for Mental Health: Neuro-Redox Regulation and Neuroprotective Effects across the Blood-Brain Barrier with Special Reference to Neuro-COVID-19.

J Diet Suppl 2021 May 12:1-35. Epub 2021 May 12.

N-terminus Research Laboratory, Yorba Linda, California, USA.

Overall mental health depends in part on the blood-brain barrier, which regulates nutrient transfer in-and-out of the brain and its central nervous system. Lactoferrin, an innate metal-transport protein, synthesized in the substantia nigra, particularly in dopaminergic neurons and activated microglia is vital for brain physiology. Lactoferrin rapidly crosses the blood-brain barrier receptor-mediated transcytosis and accumulates in the brain capillary endothelial cells. Read More

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Interpreting the role of the striatum during multiple phases of motor learning.

FEBS J 2021 May 11. Epub 2021 May 11.

Departments of Psychiatry, Neurology, Pharmacology, Biology, Columbia University: Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA, 10032.

The synaptic pathways in the striatum are central to basal ganglia functions including motor control, learning, and organization, action selection, the acquisition of motor skills, cognitive function, and emotion. Here we review the role of the striatum and its connections in motor learning and performance. The development of new techniques to record neuronal activity and animal models of motor disorders using neurotoxin, pharmacological, and genetic manipulations are revealing pathways that underlie motor performance and motor learning, as well as how they are altered by pathophysiological mechanisms. Read More

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Characterizing the role of early alcohol re-exposure in associations of prenatal alcohol exposure with adolescent alcohol outcomes.

Alcohol Clin Exp Res 2021 May 11. Epub 2021 May 11.

Syracuse University, Department of Psychology, Syracuse, NY, USA.

Background: Prenatal alcohol exposure has been linked to a host of negative outcomes, although it remains largely unknown whether prenatal exposure leads to earlier age of alcohol use initiation and/or exacerbates early alcohol initiation. The current study examined whether adolescents exposed to heavy drinking during gestation began drinking earlier than their non-exposed peers and whether earlier age of alcohol re-exposure in adolescence exacerbated associations with alcohol outcomes.

Methods: Adolescents (17 years of age; 57% female; 96% White) from a longitudinal, population-based cohort study, the Avon Longitudinal Study of Parents and Children (ALSPAC), reported on their age at first whole drink and alcohol behaviors. Read More

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Symptoms of depression and anxiety during the COVID-19 pandemic: implications for mental health.

Med J Aust 2021 May 11. Epub 2021 May 11.

Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

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Prevalence of depression and its impact on quality of life in frontline otorhinolaryngology nurses during the COVID-19 pandemic in China.

PeerJ 2021 20;9:e11037. Epub 2021 Apr 20.

Department of Public Health and Medicinal Administration & Centre for Cognitive and Brain Sciences, University of Macau, Macau SAR, China.

Objective: Exposure to the coronavirus disease 2019 (COVID-19) was associated with high risk of mental health problems among frontline nurses. This study examined the prevalence of depressive symptoms (depression hereafter) and its impact on quality of life (QOL) in otorhinolaryngology (ENT) nurses during the COVID-19 pandemic in China.

Methods: An online study was conducted between March 15 and March 20, 2020. Read More

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Protracted Hiccups Induced by Aripiprazole and Regressed after Administration of Gabapentin.

Case Rep Psychiatry 2021 22;2021:5567152. Epub 2021 Apr 22.

Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 57, 56100 Pisa, Italy.

Hiccups are sudden, repeated, and involuntary contractions of the diaphragm muscle (myoclonic contraction). It involves a reflex arc that, once activated, causes a strong contraction of the diaphragm immediately followed by the closure of the glottis translating into the classic "hic" sound. Hiccups can be short, persistent, and intractable depending on the duration. Read More

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Chemical Analysis of the Ingredients of 20% Aqueous Ethanol Extract of through Phytochemical Study and Evaluation of Anti-Neuroinflammatory Component.

Evid Based Complement Alternat Med 2021 22;2021:5901653. Epub 2021 Apr 22.

Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea.

spp. have been widely used in Asia as a folk medicine. In particular, the extracts of , a species that grows in China, India, and Tibet, have been used to treat mental disorders, hyperlipidemia, hypertension, and convulsions. Read More

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GRK3 deficiency elicits brain immune activation and psychosis.

Mol Psychiatry 2021 May 12. Epub 2021 May 12.

Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

The G protein-coupled receptor kinase (GRK) family member protein GRK3 has been linked to the pathophysiology of schizophrenia and bipolar disorder. Expression, as well as protein levels, of GRK3 are reduced in post-mortem prefrontal cortex of schizophrenia subjects. Here, we investigate functional behavior and neurotransmission related to immune activation and psychosis using mice lacking functional Grk3 and utilizing a variety of methods, including behavioral, biochemical, electrophysiological, molecular, and imaging methods. Read More

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Identification of a methylomics-associated nomogram for predicting overall survival of stage I-II lung adenocarcinoma.

Sci Rep 2021 May 11;11(1):9938. Epub 2021 May 11.

Department of Cardiothoracic Surgery, Zhengzhou Central Hospital Affiliated To Zhengzhou University, Zhengzhou, 450000, China.

The aim of this paper was to identify DNA methylation based biomarkers for predicting overall survival (OS) of stage I-II lung adenocarcinoma (LUAD) patients. Methylation profile data of patients with stage I-II LUAD from The Cancer Genome Atlas (TCGA) database was used to determine methylation sites-based hallmark for stage I-II LUAD patients' OS. The patients were separated into training and validation datasets by using median risk score as cutoff. Read More

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