845,448 results match your criteria psychiatric


Resilience and Work-Related Stress May Affect Depressive Symptoms in Nursing Professionals during the COVID-19 Pandemic Era.

Psychiatry Investig 2021 Apr 25;18(4):357-363. Epub 2021 Apr 25.

Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Objective: We aimed to investigate the effect of nursing professionals' resilience on their mental health, work-related stress, and anxiety in response to the COVID-19 pandemic.

Methods: We conducted an online survey in the Asan Medical Center and Ulsan University Hospital, South Korea. We extracted data of 824 nursing professionals who consented to participate, including demographic variables and the Stress and Anxiety to Viral Epidemics-9 (SAVE-9), PHQ-9, GAD-7, and Brief Resilience Scale scores. Read More

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The Relationship of Lifestyle Factors with the Prevalence of Major Depressive Disorder by Ecological Factors.

Psychiatry Investig 2021 Apr 25;18(4):340-347. Epub 2021 Apr 25.

Department of Preventive Medicine, Kangwon National University School of Medicine, Chuncheon, Republic of Korea.

Objective: The association between ecological/lifestyle factors and major depressive disorder (MDD) have been provided but was inconsistent as characteristics of population including race, gender, etc.

Methods: Data were extracted from the Korean National Health and Nutrition Examination Survey and consisted of 35,839 adults including 1,537 with MDD. Ecological factors included age, sex, married status, education, family income, residence, occupation, BMI, self-recognition stress, and history of non-communicable disease. Read More

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Validation of the Korean Version of the Anosognosia Questionnaire for Dementia.

Psychiatry Investig 2021 Apr 25;18(4):324-331. Epub 2021 Apr 25.

Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.

Objective: Anosognosia is a common phenomenon in individuals with dementia. Anosognosia Questionnaire for dementia (AQ-D) is a well-known scale for evaluating anosognosia. This study aimed to establish a Korean version of the AQ-D (AQ-D-K) and to evaluate the reliability and validity of the AQ-D-K in patients with Alzheimer's disease (AD) dementia. Read More

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Profile Analysis of Sexual Assault Experiences among Adult Women and Their Implications for Mental Health.

Psychiatry Investig 2021 Apr 25;18(4):312-323. Epub 2021 Apr 25.

Division of Child and Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.

Objective: Extant studies indicate that just one characteristic of sexual assault cannot properly represent the whole experience of sexual assault and, especially, the severity of sexual assault. This study aimed to understand the totality of sexual assault experiences and elucidate subtypes of sexual assault victims based on the detailed characteristics of their sexual assault experiences and those relationships with mental health.

Methods: A total of 255 adult sexual violence victims who used intervention services and a comparison group were included. Read More

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Psychopathologic Profiles and Clusters in Tertiary Clinic Referred Patients with Adult Attention Deficit Hyperactivity Disorder: A Person-Centered Analysis.

Psychiatry Investig 2021 Apr 25;18(4):304-311. Epub 2021 Apr 25.

Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea.

Objective: Adult attention deficit hyperactivity disorder (ADHD) has a heterogeneous clinical presentation with patients showing very frequent emotional problems. In the present study, patients with adult ADHD were subtyped based on their psychopathology using a person-centered approach.

Methods: In the present chart review study, detailed findings of psychological evaluation conducted as part of routine care were utilized. Read More

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Antipsychotics are related to psychometric conversion to psychosis in ultra-high-risk youth.

Early Interv Psychiatry 2021 May 5. Epub 2021 May 5.

Programma2000 - Center for Early Detection and Intervention in Psychosis, Department of Mental Health, Niguarda Ca' Granda Hospital, Milan, Italy.

Background: The prescription of antipsychotics outside overt psychotic conditions remains controversial, especially in youth where it is relatively widespread. Furthermore, some studies seem to indicate that antipsychotic exposure in individuals at ultra-high-risk (UHR) for psychosis is associated with higher conversion rates. This study was set up to test whether the inter-current prescription of antipsychotics in UHR patients was related to the psychometric threshold for a diagnosis of psychosis. Read More

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[Digital Options for Treating Mental Disorders during the COVID-19 Pandemic].

Fortschr Neurol Psychiatr 2021 May 5. Epub 2021 May 5.

LVR-Institut für Versorgungsforschung.

The COVID-19 pandemic and its consequences, such as contact restrictions, pose new challenges to psychiatric-psychotherapeutic care in many parts of the world. This article provides an overview of digital methods for treating mental disorders under pandemic conditions and for reducing pandemic-related psychological distress (e.g. Read More

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Neuroinflammation in Mood Disorders: Role of Regulatory Immune Cells.

Neuroimmunomodulation 2021 May 5:1-9. Epub 2021 May 5.

Institute of Education and Research, Santa Casa BH, Belo Horizonte, Brazil.

Mood disorders are associated with chronic low-grade systemic (sterile) inflammation, with increased plasma levels of pro-inflammatory mediators targeting all tissues including the brain. Importantly, pro-inflammatory cytokines (ex., tumor-necrosis factor alpha [TNF-α], interleukin [IL]-6) regulate mood behavior and cognition by influencing neurotransmitter levels, activating stress-responsive endocrine axes, among other effects. Read More

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Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study.

Neuroepidemiology 2021 May 5:1-10. Epub 2021 May 5.

Estudios Clinicos Latinoamerica, Rosario, Argentina.

Background: Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association.

Aims: We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations.

Methods: INTERSTROKE is a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries. Read More

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Cannabidiol prevents amphetamine relapse and modulates D1- and D2-receptor levels in mesocorticolimbic brain areas of rats.

Eur Neuropsychopharmacol 2021 May 2;50:23-33. Epub 2021 May 2.

Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil; Universidade Federal do Pampa, Campus Uruguaiana, 97500-970 Uruguaiana, RS, Brazil. Electronic address:

Amphetamine (AMPH) is an addictive psychostimulant highly used worldwide and its consumption is related to neurotoxic effects. Currently, there is no pharmacotherapy approved for treating AMPH or other psychostimulant drug addiction. Different studies have shown promising properties of cannabidiol (CBD) for treating many neurological and psychiatric diseases, and recently, CBD is being considered a potential strategy for the treatment of drug addiction disorders. Read More

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Bilateral age-related atrophy in the planum temporale is associated with vowel discrimination difficulty in healthy older adults.

Hear Res 2021 Apr 11;406:108252. Epub 2021 Apr 11.

Division of Neuropsychology, Psychological Institute, University of Zurich, Switzerland; University Research Priority Program "Dynamics of Healthy Aging", University of Zurich, Switzerland; Cognitive Psychology Unit, Alpen-Adria University, Austria.

In this study we investigated the association between age-related brain atrophy and behavioural as well as electrophysiological markers of vowel perception in a sample of healthy younger and older adults with normal pure-tone hearing. Twenty-three older adults and 27 younger controls discriminated a set of vowels with altered second formants embedded in consonant-vowel syllables. Additionally, mismatch negativity (MMN) responses were recorded in a separate oddball paradigm with the same set of stimuli. Read More

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Psychometric Evaluation of the Caregiver Version of the Child PTSD Symptom Scale in a Recently Immigrated, Spanish Speaking Population.

Psychiatry Res 2021 Apr 22;301:113954. Epub 2021 Apr 22.

University of Houston Department of Psychology, Houston, Texas, United States. Electronic address:

In recent years, there has been a large increase in the number of youth and families emigrating from Central America to the United States to escape extreme violence and crime victimization. As a result, the rate of trauma-exposure and trauma-related distress among this population is alarmingly high and necessitates representation of this population in psychological research, particularly related to trauma symptom measurement. The broad aim of the current study was to examine the psychometric performance of caregiver-reported data on one such instrument intended to measure youth trauma symptoms. Read More

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COVID-19 vaccine hesitancy and related fears and anxiety.

Int Immunopharmacol 2021 Apr 27;97:107724. Epub 2021 Apr 27.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt, Universität zu Berlin, Department of Psychiatry and Psychotherapy | CCM, Charitéplatz 1, 10117 Berlin, Germany.

Background: Vaccination is crucial to limit the pandemic spread of SARS-CoV-2/COVID-19. Therefore, besides the development and supply of vaccines, it is essential that sufficient individuals are willing to get vaccinated, but concerning proportions of populations worldwide show vaccine hesitancy. This makes it important to determine factors that are associated with vaccine acceptance. Read More

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Association between metabolic syndrome and resting-state functional brain connectivity.

Neurobiol Aging 2021 Apr 1;104:1-9. Epub 2021 Apr 1.

Neuroimaging Research for Veterans Center (NeRVe), Geriatric Research Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

The objective of this study is to examine whether metabolic syndrome (MetS), the clustering of 3 or more cardiovascular risk factors, disrupts the resting-state functional connectivity (FC) of the large-scale cortical brain networks. Resting-state functional magnetic resonance imaging data were collected from seventy-eight middle-aged and older adults living with and without MetS (27 MetS; 51 non-MetS). FC maps were derived from the time series of intrinsic activity in the large-scale brain networks by correlating the spatially averaged time series with all brain voxels using a whole-brain seed-based FC approach. Read More

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Evidence of altered metabolism of cellular membranes in bipolar disorder comorbid with post-traumatic stress disorder.

J Affect Disord 2021 Apr 20;289:81-87. Epub 2021 Apr 20.

Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, TX 77054, USA.

In proton magnetic resonance spectroscopy (¹H MRS) studies, aberrant levels of choline-containing compounds that include glycerophosphocholine plus phosphocholine (GPC+PC), can signify alterations in the metabolism of cellular membrane phospholipids (MPLs) from a healthy baseline. In a recent ¹H MRS study, we reported increased GPC+PC in cortical and subcortical areas of adult patients with bipolar disorder I (BP-I). Post-traumatic stress disorder (PTSD) can worsen the severity of BP-I, but it is unclear whether the effect of a PTSD comorbidity in BP-I is associated with altered MPL metabolism. Read More

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Anxiety and depression scores in patients subjected to arterial revascularization for critical limb ischemia.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Hospital Israelita Albert Einstein, Avenida Albert Einstein, 627, bloco A1, sala 422, Morumbi. ZIP: 05652-900. São Paulo, SP Brazil.

Objectives: This study aims to examine the changes in anxiety and depression scores in 138 patients with critical limb ischemia (rest pain or gangrene) who had no previous psychiatric history, at 30 days and 6 months after surgical revascularization.

Methods: Patients were submitted to a questionnaire-based evaluation using the Beck Anxiety and Depression Inventories before surgery (no more than three days before surgery) ("Pre-Op"), 30 days after surgical revascularization ("Early PO") and at least 6 months after surgical revascularization ("Late PO"). The cut-off scores for depression were (1) < 10, no depression or minimal depression; (2) 10‒18, mild to moderate depression; (3) 19‒29, moderate to severe depression; and (4) 30‒63, severe depression. Read More

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Relating whole-brain functional connectivity to self-reported negative emotion in a large sample of young adults using group regularized canonical correlation analysis.

Neuroimage 2021 May 2:118137. Epub 2021 May 2.

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, USA; Sierra-Pacific Mental Illness Research, Education, and Clinical Center (MIRECC) Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.

The goal of our study was to use functional connectivity to map brain function to self-reports of negative emotion. In a large dataset of healthy individuals derived from the Human Connectome Project (N=652), first we quantified functional connectivity during a negative face-matching task to isolate patterns induced by emotional stimuli. Then, we did the same in a complementary task-free resting state condition. Read More

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Odor identity can be extracted from the reciprocal connectivity between olfactory bulb and piriform cortex in humans.

Neuroimage 2021 May 2:118130. Epub 2021 May 2.

Department of Clinical Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden; Monell Chemical Senses Center, Philadelphia, PA, 19104, USA; Department of Psychology, University of Pennsylvania, Philadelphia, PA, 19104, USA; Stockholm University Brain Imaging Centre, Stockholm University, 10691, Stockholm, Sweden. Electronic address:

Neuronal oscillations route external and internal information across brain regions. In the olfactory system, the two central nodes-the olfactory bulb (OB) and the piriform cortex (PC)-communicate with each other via neural oscillations to shape the olfactory percept. Communication between these nodes have been well characterized in non-human animals but less is known about their role in the human olfactory system. Read More

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Repeated neonatal isoflurane exposure is associated with higher susceptibility to chronic variable stress-induced behavioural and neuro-inflammatory alterations.

Neuroscience 2021 May 2. Epub 2021 May 2.

Department of Anaesthesiology and Operating Theatre Services, Xiangya Hospital of Central South University, Changsha city, Hunan Province, PR China; Teaching and Research Section of Anesthesia and Critical Care Medicine, Xiangya Hospital of Central South University, Changsha city, Hunan Province, PR China. Electronic address:

Numerous studies have reported that prolonged or multiple exposures to anaesthetics in early life lead to detrimental effects on brain function, most having focused on neurocognitive function, and relatively few on long term neuropsychiatric performance. The present study investigated the impact of repeated neonatal isoflurane exposure on chronic variable stress (CVS)-induced psychiatric and behavioural outcomes together with CVS-related neuronal activity and neuro-inflammatory reactivity in relevant brain circuits. In the present study, C57BL/6J mice received either three exposures to isoflurane at postnatal days 7, 8, and 9 or a control exposure. Read More

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Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.

Cell Metab 2021 Apr 30. Epub 2021 Apr 30.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Medizinische Klinik and Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

Pathologies of the micro- and macrovascular systems are a hallmark of the metabolic syndrome, which can lead to chronically elevated blood pressure. However, the underlying pathomechanisms involved still need to be clarified. Here, we report that an obesity-associated increase in serum leptin triggers the select expansion of the micro-angioarchitecture in pre-autonomic brain centers that regulate hemodynamic homeostasis. Read More

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Reward processing as a common diathesis for chronic pain and depression.

Neurosci Biobehav Rev 2021 May 2. Epub 2021 May 2.

Department of Psychology, Queen's University, Kingston, Ontario, Canada.

Pain disorders and psychiatric illness are strongly comorbid, particularly in the context of Major Depressive Disorder (MDD). While these disorders account for a significant amount of global disability, the mechanisms of their overlap remain unclear. Understanding these mechanisms is of vital importance to developing prevention strategies and interventions that target both disorders. Read More

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Decoupling Crisis Response from Policing - A Step Toward Equitable Psychiatric Emergency Services.

N Engl J Med 2021 May;384(18):1769-1773

From the Department of Psychiatry, University of California, San Diego, San Diego (E.R.-Y.), and the Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior at the University of California, Los Angeles, Los Angeles (M.O.M.) - both in California; and the Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, and the Department of Psychiatry, Weill Cornell Medicine - both in New York (D.K.C.).

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When Undoing Is Not Enough - Repairing Harms Inflicted on Immigrant Children.

N Engl J Med 2021 May 5. Epub 2021 May 5.

From the Department of Emergency Medicine (N.E.W.), and the Department of Psychiatry and Behavioral Sciences (R.M.), Stanford University School of Medicine, Stanford, CA; the Department of Pediatrics, Division of Academic General Pediatrics, Montefiore Medical Center; Albert Einstein College of Medicine; and Terra Firma: Healthcare and Justice for Immigrant Children - all in New York (A.S.).

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Association between neurological outcome and poststroke comorbid mood and anxiety disorders: A real-life experience.

Brain Behav 2021 May 5:e02158. Epub 2021 May 5.

Univ. Bordeaux, CNRS, EPHE, INCIA, UMR 5287, Bordeaux, France.

Introduction: Poststroke depression (PSD) and anxiety (PSA) are prevalent and have a strong impact on functional outcome. Beside stroke severity, little is known on their clinical determinants. This study investigated the association between stroke mechanism, neurological poststroke complications and remaining vascular risk factors and the presence of comorbid PSD and PSA, termed poststroke emotional distress (PSED). Read More

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Confirming the contribution and genetic spectrum of de novo mutation in infantile spasms: Evidence from a Chinese cohort.

Mol Genet Genomic Med 2021 May 5:e1689. Epub 2021 May 5.

Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, China.

Objective: We determined the yield, genetic spectrum, and actual origin of de novo mutations (DNMs) for infantile spasms (ISs) in a Chinese cohort. The efficacy of levetiracetam (LEV) for STXBP1-related ISs was explored also.

Methods: Targeted sequencing of 153 epilepsy-related candidate genes was applied to 289 Chinese patients with undiagnosed ISs. Read More

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From the (skin) doctor's office to the lecture hall: An innovative, practice-oriented, media-supported teaching project with supra-regional interdisciplinary usage options.

J Dtsch Dermatol Ges 2021 May 5. Epub 2021 May 5.

Department of Dermatology, Venereology and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Medical Faculty of CAU Kiel, Kiel, Germany.

Background: The transfer of practical knowledge and skills is the focus of modern medical teaching (master plan medical studies 2020). The aim of the teaching project is to provide medical students with important dermatological learning goals and contents by using innovative methods.

Methods: As part of a teaching project funded by the Federal Ministry of Education and Research (BMBF) at the Department of Dermatology, University Hospital Schleswig-Holstein in Kiel, various new, partly media-supported teaching modules were developed in addition to curricular teaching and optimized by regular acceptance evaluations during the development process. Read More

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Structural correlates of sensorimotor dysfunction in heavy cannabis users.

Addict Biol 2021 May 5:e13032. Epub 2021 May 5.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Sensorimotor dysfunction has been previously reported in persons with cannabis dependence. Such individuals can exhibit increased levels of neurological soft signs (NSS), particularly involving motor coordination and sensorimotor integration. Whether such abnormalities may also apply to non-dependent individuals with heavy cannabis use (HCU) is unknown, as much as the neural correlates underlying such deficits. Read More

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Conducting a multi-country online alcohol survey in the time of the COVID-19 pandemic: Opportunities and challenges.

Int J Methods Psychiatr Res 2021 May 5. Epub 2021 May 5.

Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.

Objectives: This contribution provides insights into the methodology of a pan-European population-based online survey, performed without external funding during the COVID-19 pandemic. We present the impact of different dissemination strategies to collect data from a non-probabilistic convenience sample and outline post-stratification weighting schemes, to provide guidance for future multi-country survey studies.

Methods: Description and comparison of dissemination strategies for five exemplary countries (Czechia, Germany, Lithuania, Norway, Spain) participating in the Alcohol Use and COVID-19 Survey. Read More

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Acute alcohol intoxication modulates the temporal dynamics of resting electroencephalography networks.

Addict Biol 2021 May 5:e13034. Epub 2021 May 5.

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technical University of Dresden, Dresden, Germany.

This study aimed to provide a currently missing link between general intoxication-induced changes in overall brain activity and the multiple cognitive control deficits typically observed during acute alcohol intoxication. For that purpose, we analyzed the effects of acute alcohol intoxication (1.1‰) on the four archetypal electroencephalography (EEG) resting networks (i. Read More

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