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Molecules 2021 Mar 8;26(5). Epub 2021 Mar 8.

LAQV-REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences (FCUP), University of Porto, 4169-007 Porto, Portugal.

pv. (Psa) is the pathogenic agent responsible for the bacterial canker of kiwifruit (BCK) leading to major losses in kiwifruit productions. No effective treatments and measures have yet been found to control this disease. Read More

Front Oncol 2021 11;11:599602. Epub 2021 Mar 11.

Department of Molecular Diagnosis, Northern Jiangsu Hospital, Yangzhou University Clinical College, Yangzhou, China.

Objective: By virtue of largely disparate clinical outcomes of prostate cancer (PCA), there is a pressing need to search for useful biomarkers for PCA prognosis. Cell-free DNA (cfDNA) is a promising biomarker for detecting, monitoring, and predicting survival of prostate cancer (PCA). However, the utility of total cfDNA quantitation in PCA in clinical setting remains elusive. Read More

BMC Urol 2021 Mar 27;21(1):47. Epub 2021 Mar 27.

Division of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of Medicine, 660 S. Euclid Ave., Campus Box 8100, St. Louis, MO, 63110, USA.

Background: Existing evidence suggests that there is an association between body size and prevalent Benign Prostatic Hyperplasia (BPH)-related outcomes and nocturia. However, there is limited evidence on the association between body size throughout the life-course and incident BPH-related outcomes.

Methods: Our study population consisted of men without histories of prostate cancer, BPH-related outcomes, or nocturia in the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (n = 4710). Read More

Clin Imaging 2021 Mar 20;78:98-103. Epub 2021 Mar 20.

Department of Radiology, Kocaeli University Hospital, Kocaeli, Turkey.

Purpose: To investigate the diagnostic performance of Prostate Imaging-Reporting and Data System version 2.0 (PI-RADSv2.0) for differentiating clinically significant prostate cancer (csPCa) from benign prostate disease on prebiopsy multiparametric MRI stratified by total prostate specific antigen (PSA) concentration. Read More

J Nanobiotechnology 2021 Mar 12;19(1):73. Epub 2021 Mar 12.

Department of Bioscience and Biotechnology, Konkuk University, Seoul, Korea.

Background: Blood prostate-specific antigen (PSA) levels are widely used as diagnostic biomarkers for prostate cancer. Lateral-flow immunoassay (LFIA)-based PSA detection can overcome the limitations associated with other methods. LFIAbased PSA detection in clinical samples enables prognosis and early diagnosis owing to the use of high-performance signal reporters. Read More

Cancer Rep (Hoboken) 2021 Mar 12:e1367. Epub 2021 Mar 12.

Department of Medical Oncology and Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Background: ModraDoc006 is an oral formulation of docetaxel, which is co-administered with the cytochrome P450 3A4 and P-glycoprotein inhibitor ritonavir (r): ModraDoc006/r. Weekly treatment with ModraDoc006/r had been evaluated in phase I trials in patients with different types of advanced solid tumors, but up to this point in time not in patients with metastatic castration-resistant prostate cancer (mCRPC).

Aim: We assessed safety and pharmacokinetics (PK) of ModraDoc006/r to establish the recommended phase 2 dose (RP2D) in patients with mCRPC. Read More

Membranes (Basel) 2021 Feb 27;11(3). Epub 2021 Feb 27.

Department of Chemical Engineering, Army Academy, No.750, Longdong Rd., Chung-Li District, Taoyuan City 320316, Taiwan.

Many studies have been conducted on hydrogen production, storage, purification, and transportation. The use of fixed-bed adsorption towers for hydrogen purification is common. The operating variables involved that could affect the adsorption behavior, such as the amount of adsorbents used, the flow rate, and the concentration of the adsorbate, should be discussed further. Read More

Pharmaceuticals (Basel) 2021 Feb 12;14(2). Epub 2021 Feb 12.

Department of Analytical Chemistry, Faculty of Pharmacy, Medical University of Lodz, ul. Muszyńskiego 1, 90-151 Łódź, Poland.

Several chromatographic parameters ( and obtained from RP-18 TLC with methanol-pH 7.4 phosphate buffer mobile phases by extrapolation to zero concentration of methanol; and obtained from RP-18 TLC with acetonitrile-pH 7.4 phosphate buffer 70:30 / as a mobile phase) and calculated molecular descriptors (molecular weight-; molar volume-; polar surface area-; total count of nitrogen and oxygen atoms-(); H-bond donor count-; H-bond acceptor count-; distribution coefficient-log ; total energy-; binding energy-; hydration energy-; energy of the highest occupied molecular orbital-; energy of the lowest unoccupied orbital-; electronic energy-; surface area-; octanol-water partition coefficient-log ; dipole moment-; refractivity-, polarizability-) and their combinations (/, /, /) were tested in order to generate useful models of solutes' skin permeability coefficient log . Read More

Life (Basel) 2021 Feb 22;11(2). Epub 2021 Feb 22.

Department of Nuclear Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Lu-DOTAGA-(l-y)fk(Sub-KuE) a.k.a. Read More

Sci Rep 2021 Mar 3;11(1):5040. Epub 2021 Mar 3.

Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.

Prostate cancer is the most commonly diagnosed neoplasm in American men. Although existing biomarkers may detect localized prostate cancer, additional strategies are necessary for improving detection and identifying aggressive disease that may require further intervention. One promising, minimally invasive biomarker is cell-free DNA (cfDNA), which consist of short DNA fragments released into circulation by dying or lysed cells that may reflect underlying cancer. Read More

Ann Clin Lab Sci 2021 Jan;51(1):3-11

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

Prostate Health Index () and percent free PSA (%fPSA) are used in patients with a PSA concentration between 4-10 μg/L as an aid to distinguish prostate cancer (PCa) from benign conditions, and to assist in the decision of whether to proceed to biopsy. This study assesses the clinical performance and diagnostic accuracy of versus %fPSA in a cohort of Mayo Clinic's patients. Of 4065 orders received from May 2017-August 2018, concordance between and %fPSA results was evaluated on 2845 results with a total PSA within 4-10 μg/L. Read More

Microb Cell Fact 2021 Mar 2;20(1):56. Epub 2021 Mar 2.

Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, Republic of Korea.

Background: Antibiotic-resistant bacteria have emerged as a serious problem; bacteriophages have, therefore, been proposed as a therapeutic alternative to antibiotics. Several authorities, such as pharmacopeia, FDA, have confirmed their safety, and some bacteriophages are commercially available worldwide. The demand for bacteriophages is expected to increase exponentially in the future; hence, there is an urgent need to mass-produce bacteriophages economically. Read More

Diagn Microbiol Infect Dis 2021 Feb 10;100(2):115343. Epub 2021 Feb 10.

Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil.

Minimal inhibitory concentrations (MICs) of ticarcillin/clavulanic acid (TLc), ceftolozane/tazobactam (C/T), and aztreonam (AT) were determined for 6 SPM-1-producing Pseudomonas aeruginosa (PSA) using Etest® strips and the synergistic effect of such antimicrobials against was evaluated by gradient diffusion strip crossing (GDSC) test. The fraction inhibitory concentration indexes (FICI) were calculated and showed a synergistic (n = 3) and additive (n = 2) effects of TLc + AT against SPM-1 producers, while TLc + C/T combination caused no effect. Average MIC reduction of TLc and AT by GDSC was 3-fold and 2-fold dilutions, respectively. Read More

Scand J Rheumatol 2021 Mar 2:1-10. Epub 2021 Mar 2.

Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway.

: This study aimed to identify the therapeutic target concentration and frequency of anti-drug antibodies (ADAbs) in golimumab-treated patients with inflammatory joint disease (IJD).: Associations between golimumab concentration, ADAbs, and treatment response were examined in 91 patients with IJD [41 axial spondyloarthritis (axSpA), 20 rheumatoid arthritis (RA), and 30 psoriatic arthritis (PsA)] included in the NOR-DMARD study. Treatment response was defined by Ankylosing Spondylitis Disease Activity Score (ASDAS) clinically important improvement in axSpA, European League Against Rheumatism (EULAR) good/moderate response in RA, and improvement of ≥ 50% in modified Disease Activity index for PSoriatic Arthritis (DAPSA) (28 swollen/tender joint counts) in PsA. Read More

Anal Chim Acta 2021 Apr 4;1152:338282. Epub 2021 Feb 4.

Materials Genome Institute, Shanghai University, China. Electronic address:

Prostate specific antigen (PSA) has become a potential biomarker for detecting prostate cancer (PCa) in the early stage. Herein, we report a target-induced resolution for the detection of PSA sensitively and specifically by amperometric electrochemical measurements. To meet a satisfactory performance, three conformations of pre-design DNA aptamers including two stem-loop structures and a double strand structure have been investigated and compared. Read More

Eur J Pharm Sci 2021 Jun 25;161:105774. Epub 2021 Feb 25.

College of Pharmacy, Yanbian University, 977 Gongyuan Road, Yanji, Jilin, 133002, China; Department of Pharmaceutical Sciences, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, 110016, China. Electronic address:

The purpose of present study was to develop a long-acting drug-in-adhesive patch of rivastigmine (RVS) to achieve controlled release under high drug loading. Formulation factors including ion-pair, pressure sensitive adhesive (PSA), drug-loading and permeation enhancers were investigated through in vitro skin permeation experiments. Optimized patch was evaluated by pharmacokinetic study. Read More

J Anal Methods Chem 2021 4;2021:6626257. Epub 2021 Feb 4.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Quality and Standard of Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.

A simple, accurate, and high-throughput analytical method was developed to detect 123 pesticide residues in Chinese medicinal herb (PRA) by introducing nano-MgO as a highly efficient purification material based on quick, easy, cheap, effective, rugged, and safe (QuEChERS) design concept. Various PRA samples were extracted using 8 mL 0.5% acetic acid-acetonitrile solution and purified by a dispersive solid-phase extraction method with 30 mg nano-MgO, 40 mg primary secondary amine (PSA), and 40 mg octadecylsilane (C18) as the cleanup adsorbents, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Read More

Saudi J Biol Sci 2021 Feb 8;28(2):1477-1486. Epub 2020 Dec 8.

Botany and Microbiology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.

The present study was focused on synthesis and characterization of copper nanoparticles to evaluate their efficacy against fruit rot pathogen of chilli crop. The green synthesis of nanoparticles was carried out by using extracts of Eucalyptus and Mint leaves. The synthesis of copper nanoparticles was confirmed by XRD, PSA, SEM and TEM. Read More

Postepy Dermatol Alergol 2020 Dec 4;37(6):1001-1008. Epub 2020 May 4.

Department of Arthroscopy, Minimally Invasive Surgery, and Sports Traumatology, Medical University of Lodz, Lodz, Poland.

Introduction: Psoriatic arthritis (PsA) is a chronic, seronegative spondyloarthropathy characterised by joint inflammation and psoriatic skin changes. Recent data indicate that interleukin-18 (IL-18) and interleukin-20 (IL-20) may be involved in the aetiopathogenesis of PsA.

Aim: To evaluate the potential role of IL-18, IL-20, and matrix metalloproteinases (MMP-1, MMP-3) in the pathogenesis of PsA and their correlations with other markers of inflammation and destruction of joint cartilage, as well as clinical changes. Read More

Postepy Dermatol Alergol 2020 Dec 14;37(6):995-1000. Epub 2020 Jul 14.

Department of Arthroscopy, Minimally Invasive Surgery and Sports Traumatology, Medical University of Lodz, Lodz, Poland.

Introduction: Effective treatment in psoriatic arthritis (PsA) patients can protect them from severe musculoskeletal complications. For appropriate monitoring of anti-tumour necrosis factor α (anti-TNF-α) treatment in PsA, specific biomarkers are needed.

Aim: To investigate whether biological treatment with anti-TNF-α (etanercept 50 mg once a week subcutaneously) affects the activity of selected mediators of inflammation and destruction of articular cartilage: interleukin-6 (IL-6), interleukin-18 (IL-18), matrix metalloproteinases 1 and 3 (MMP-1, MMP-3), cartilage oligomeric matrix protein (COMP), human cartilage glycoprotein (YKL-40) in serum of patients with PsA. Read More

Chemosphere 2021 Jun 8;272:129902. Epub 2021 Feb 8.

Institute of Environment for Sustainable Development, College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai, 200092, PR China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, PR China. Electronic address:

In this study, hydrous manganese dioxide (HMO) modified poly(sodium acrylate) (PSA) hydrogel was produced for the first time to remove tetracycline(TC) and lead(Pb(II)) from water. The as-prepared composite was characterized using various techniques, such as SEM-EDS, FTIR, XRD, BET, and XPS, to elucidate the successful loading of HMO and analyze subsequent sorption mechanisms. Different influencing parameters such as adsorbent dose, initial concentration of adsorbates, reaction time, solution pH, and temperature were also investigated. Read More

Environ Sci Pollut Res Int 2021 Feb 9. Epub 2021 Feb 9.

Biological Screening and Preclinical Trial Laboratory, Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.

Male infertility is considered one of the most critical health problems that are expected to expand worldwide. Ulva lactuca is a species of green seaweeds which is known to be a rich source of many important nutrients. Accordingly, this study is designated to investigate the therapeutic role of Ulva lactuca water fraction (UL) against monosodium glutamate (MSG)-induced male reproductive system disorders in male rats. Read More

Neuroendocrinology 2021 Feb 5. Epub 2021 Feb 5.

The estrous cycle is caused by the changing concentration of ovarian hormones, particularly 17β-Estradiol, a hormone whose effect on excitatory circuits has been extensively reported. However, fewer studies have tried to elucidate how this cycle, or this hormone, affects the plasticity of inhibitory networks and the structure of interneurons. Among these cells, somatostatin expressing O-LM neurons of the hippocampus have a role in the modulation of theta oscillations, and they receive direct input from the entorhinal cortex, which place them in the center of hippocampal function. Read More

J Chromatogr A 2021 Feb 24;1639:461940. Epub 2021 Jan 24.

Department of Chemistry and Physics, Analytical Chemistry Area, University of Almería, Research Centre for Mediterranean Intensive Agrosystems and Agri-Food Biotechnology (CIAIMBITAL), Agrifood Campus of International Excellence ceiA3, Carretera de Sacramento s/n, E-04120 Almería, Spain. Electronic address:

The development and validation of a method for the analysis of traces of 3-monochloropropanediol (3-MCPD) esters (19) and glycidyl esters (7) of fatty acids in vegetable oils, margarine, biscuits and croissants was performed. An extraction method based on the use of solvents (tert‑butyl methyl ether (20% ethyl acetate, v/v)) was carried out and cleaning of the extract with a mixture of sorbents (Si-SAX, PSA and Z-sep+) was optimized for the elimination of fatty interferents. The analysis of the targeted compounds was carried out by ultra-high-performance liquid chromatography coupled to tandem mass spectrometry, using a triple quadrupole analyzer (UHPLC-MS/MS-QqQ). Read More

Biomed Res Int 2021 19;2021:8822645. Epub 2021 Jan 19.

Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.

The biological synthesis of nanoparticles, due to their environmental and biomedical properties, has been of particular interest to scientists and physicians. Here, iron nanoparticles (FeNPs) were synthesized using essential oil. Then, the chemical, functional, and morphological properties of these nanoparticles were characterized by typical experiments such as Uv-Vis, FTIR, XRD, FE-SEM, PSA, zeta potential, EDX, and EDX mapping. Read More

World J Urol 2021 Feb 1. Epub 2021 Feb 1.

Department of Urology, Université de Versailles-Saint-Quentin-en-Yvelines, Hôpital Foch, Service d'urologie40 rue Worth, 92150, Suresnes, France.

Purpose: PSA is known to be lowered in obese patients. There is a lack of data regarding patients with prostate cancer. Our objective was to prospectively assess the relationship PSA concentration, PSA mass and BMI in a cohort of patients with localized prostate cancer. Read More

Bioelectrochemistry 2021 Jun 18;139:107744. Epub 2021 Jan 18.

Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Prostatic specific antigen (PSA) is known as a biomarker of prostate cancer. In males, prostate cancer is ranked second as leading cause of death out of more than 200 different cancer types1. As a result, early detection of cancer can cause a significant reduction in mortality. Read More

Biomed Res Int 2021 9;2021:4140767. Epub 2021 Jan 9.

Department of Urology, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province 550002, China.

Background: There is increasing evidence that dietary intake of sugars may be a risk factor for prostate cancer (PCa) and elevate the concentration of serum prostate-specific antigen (PSA). However, there is limited evidence of the correlation between total dietary intake of sugars and serum PSA concentrations for adult American males. Herein, we evaluated the association between total dietary intake of sugars and serum PSA concentrations in men without a malignant tumor diagnosis in the United States (US) National Health and Nutrition Examination Survey (NHANES) database. Read More

ACS Sens 2021 03 25;6(3):1305-1311. Epub 2021 Jan 25.

Department of Chemistry, Pusan National University, Busan 46241, Korea.

The duplex detection of both total and active enzyme concentrations without interferences at a single working electrode is challenging, especially when two different assays are combined. It is also challenging to obtain two different redox-cycling reactions without interference. Here, we present a simple but sensitive combined assay that is based on two redox-cycling reactions using two incubation periods and applied potentials at a single electrode. Read More

J Oncol 2021 5;2021:8820366. Epub 2021 Jan 5.

National Cancer Institute, Santariskiu Street 1, Vilnius, LT 08660, Lithuania.

A set of prostate tumors tend to grow slowly and do not require active treatment. Therefore, stratification between patients with clinically significant and clinically insignificant prostate cancer (PC) remains a vital issue to avoid overtreatment. Fast development of genetic technologies accelerated development of next-generation molecular tools for reliable PC diagnosis. Read More