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Is Maximum Intensity Projection an Optimal Approach for Internal Target Volume Delineation in Lung Cancer?

J Med Phys 2021 Apr-Jun;46(2):59-65. Epub 2021 Aug 7.

Department of Radiation Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Purpose: Respiratory-induced tumor motion is a major challenge in lung cancer (LC) radiotherapy. Four-dimensional computed tomography (4D-CT) using a maximum intensity projection (MIP) dataset is a commonly used and time-efficient method to generate internal target volume (ITV). This study compared ITV delineation using MIP or tumor delineation on all phases of the respiratory cycle. Read More

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Health care costs for adolescents and young adults with cancer: a Wisconsin community-based hospital study between 2005 and 2020.

Support Care Cancer 2021 Sep 26. Epub 2021 Sep 26.

Department of Medical Oncology, Gundersen Health System, La Crosse, WI, USA.

Introduction: Adolescents and young adults (AYA) with cancer are at risk of high cumulative healthcare system costs potentially associated with poor health and financial outcomes. Although this has been studied at academic centers, little data on AYA costs at community-based practices exist. The goals of this study were to understand direct health care costs for AYA patients, identify factors for high costs, and assess how total health care costs may relate to survival. Read More

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September 2021

3D Guided Dental Implant Placement: Impact on Surgical Accuracy and Collateral Damage to the Inferior Alveolar Nerve.

Dent J (Basel) 2021 Sep 2;9(9). Epub 2021 Sep 2.

Department of Engineering, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.

An increase in the number of implants placed has led to a corresponding increase in the number of complications reported. The complications can vary from restorative complications due to poor placement to damage to collateral structures such as nerves and adjacent teeth. A large majority of these complications can be avoided if the implant has been placed accurately in the optimal position. Read More

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September 2021

Two naturally derived small molecules disrupt the sineoculis homeobox homolog 1-eyes absent homolog 1 interaction to inhibit colorectal cancer cell growth.

Chin Med J (Engl) 2021 Sep 23. Epub 2021 Sep 23.

Department of Integrated Traditional and Western Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China Department of Vascular Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.

Background: Emerging evidence indicates that the sineoculis homeobox homolog 1-eyes absent homolog 1 (SIX1-EYA1) transcriptional complex significantly contributes to the pathogenesis of multiple cancers by mediating the expression of genes involved in different biological processes, such as cell-cycle progression and metastasis. However, the roles of the SIX1-EYA1 transcriptional complex and its targets in colorectal cancer (CRC) are still being investigated. This study aimed to investigate the roles of SIX1-EYA1 in the pathogenesis of CRC, to screen inhibitors disrupting the SIX1-EYA1 interaction and to evaluate the efficiency of small molecules in the inhibition of CRC cell growth. Read More

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September 2021

Advancing Our Understanding of Brain Disorders: Research Using Postmortem Brain Tissue.

Methods Mol Biol 2022 ;2389:201-208

Department of Neurology and Fixel Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.

It is thought that proliferative potential of neural progenitor cells, from postmortem tissue obtained from idiopathic PD patients, present in the substantia nigra (SN) as well as other brain regions can be maintained in vitro. While they might be lacking in factors required for differentiation into mature neurons, their regenerative potential is undeniable and suggestive that progenitor cells are found endogenously in the diseased brain. Adult stem/progenitor cells exist in several regions within the PD brain and are likely a valuable source of progenitor cells for understanding disease course, as well as useful tools for generating potential cellular and pharmacologic therapies. Read More

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January 2022

Micro-CT Imaging of Pediatric Thyroglossal Duct Cysts: A Prospective Case Series.

Front Pediatr 2021 7;9:746010. Epub 2021 Sep 7.

Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

To determine the feasibility of micro-CT as a high-resolution 3D imaging tool for thyroglossal duct cysts and to evaluate its role augmenting traditional histopathological examination of resected specimens. A single centre, prospective case series of consecutive children undergoing excision of a thyroglossal duct cyst was performed at a quaternary paediatric referral hospital in the United Kingdom. Consecutive children listed for excision of a thyroglossal duct cyst whose parents agreed to participate were included and there were no exclusion criteria. Read More

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September 2021

Is image guidance essential for external ventricular drain insertion?

World Neurosurg 2021 Sep 20. Epub 2021 Sep 20.

Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Mindlesohn Way, Birmingham, B15 2TH.

Background: This study aimed to compare the EVD placement accuracy and complication rates, between neuronavigation-guided, ultrasound-guided and free-hand techniques in our single centre cohort, and through an additional meta-analysis of the currently available literature.

Methods: A retrospective review of patients who underwent EVD insertion from January 2016 to April 2019 was conducted. Information regarding demographics, indication, Evan's index, use of image guidance, accuracy of catheter tip placement and procedural complications were extracted from electronic records and imaging systems. Read More

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September 2021

Multidisciplinary Management of Primary Sacral Tumors: A Tertiary Care Center's Experience and Literature Review.

Asian Spine J 2021 Sep 28. Epub 2021 Sep 28.

Institute of Neurosciences, Sakra World Hospital, Bangalore, India.

Sacral tumors are rare and can be benign or malignant. Their management is multifactorial and is based on the pathology, extent, and local and distant spread. Managing sacral tumors is challenging due to their proximity to visceral and neural structures. Read More

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September 2021

Residential greenness and increased physical activity in patients after coronary artery bypass graft surgery.

Eur J Prev Cardiol 2021 Sep;28(11):1184-1191

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler School of Medicine, Tel Aviv University, Israel.

Aims: Physical activity is a fundamental component of rehabilitation following coronary artery bypass (CABG) surgery. Proximity to neighbourhood green spaces may encourage physical activity. We investigated the association between residential greenness and exercise-related physical activity post-CABG surgery. Read More

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September 2021

COVID-19 outbreak in North Macedonia: an overview of its impact on dentistry.

Minerva Dent Oral Sci 2021 Sep 22. Epub 2021 Sep 22.

Department for Pediatric and Preventive Dentistry, Faculty of Dentistry, Skopje, Republic of North Macedonia.

Since the pandemic of the novel corona virus - SARS-CoV-2 - has been declared and strict social measures have been introduced in the middle of March, including curfew, the dentistry had to adjust and find ways to better adapt itself to the new situation. This article provides a brief overview of the situation with COVID-19 in our country since the beginning of the pandemic, gives a reminder of what COVID-19 is, and which its modes of transmission are, and considers the ways of protection in dental offices taking into account that dentistry is one of the riskiest activities given the patient-dentist proximity and the use of specific high-speed handpieces. This review also provides an overview of the dental preventive measures taken worldwide, including in the field of Pediatric Dentistry, as well as an overview of dental patients' management, and gives possible best ways to care for healthy, sick or patients suspected for COVID-19. Read More

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September 2021

Impact of rituximab on COVID-19 outcomes.

Ann Hematol 2021 Sep 22. Epub 2021 Sep 22.

Tisch Cancer Institute, New York, NY, USA.

Rituximab is associated with prolonged B-cell depletion and secondary hypogammaglobulinemia and is associated with a dampened humoral response and increased infectious complications. To describe the potential impact of prior rituximab therapy on clinical outcomes from SARS-CoV-2 infection and development of COVID-19 antibodies, we conducted a retrospective study of adults across the Mount Sinai Health System diagnosed with COVID-19 who received rituximab for any indication from February 2019 to October 2020. Patients' baseline characteristics, markers of disease severity, clinical outcomes, and antibody development were examined. Read More

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September 2021

Assess, Prevent, and Manage Pain; Both Spontaneous Awakening and Breathing Trials; Choice of Analgesia/Sedation; Delirium: Assess, Prevent, and Manage; Early Mobility; Family Engagement and Empowerment Bundle Implementation: Quantifying the Association of Access to Bundle-Enhancing Supplies and Equipment.

Crit Care Explor 2021 Sep 14;3(9):e0525. Epub 2021 Sep 14.

School of Nursing, Vanderbilt University, Nashville, TN.

Describe the physical environment factors (i.e., availability, accessibility) of bundle-enhancing items and the association of physical environment with bundle adherence. Read More

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September 2021

Aqueous vaginal contrast and scheduled hematocolpos with magnetic resonance imaging to delineate complex müllerian anomalies.

Fertil Steril 2021 Sep 18. Epub 2021 Sep 18.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York.

Objective: To demonstrate the advantage of using aqueous vaginal contrast and scheduled hematocolpos with magnetic resonance imaging (MRI) to improve the delineation of gynecologic anatomy and to recommend that this modality be considered in patients with complex müllerian anomalies.

Design: Video demonstration of MRI adjuncts to improve visualization of gynecologic anatomy.

Setting: Academic Hospital. Read More

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September 2021

Surviving Long Enough to Die? An Analysis of Incomplete Assessments for Medical Assistance in Dying.

J Palliat Med 2021 Sep 20. Epub 2021 Sep 20.

Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.

Medical assistance in dying (MAiD) was legalized in Canada on June 17, 2016, yet many who request MAiD do not complete the assessment process and instead experience a natural death. This analysis of patients who made a formal request for MAiD aims to clarify timelines and factors associated with completion of the MAiD assessment process, and factors associated with completion or noncompletion of MAiD once eligible. This retrospective cohort study included all patients in Nova Scotia who requested MAiD between January 1, 2018 and December 31, 2018, were deceased at the time of analysis, did not withdraw their request, and were not formally deemed ineligible for the procedure ( = 218). Read More

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September 2021

Cytotoxic edema associated with hemorrhage predicts poor outcome after traumatic brain injury.

J Neurotrauma 2021 Sep 19. Epub 2021 Sep 19.

National Institute of Neurological Disorders and Stroke, Section on Stroke Diagnostics and Therapeutics, Building 10, B1D733, NIH, Bethesda, Maryland, United States, 20892;

Magnetic resonance imaging (MRI) is rarely used in the acute evaluation of traumatic brain injury (TBI), but may identify findings of clinical importance not detected by computed tomography (CT). We aimed to characterize the association of cytotoxic edema and hemorrhage, including traumatic microbleeds, on MRI obtained within hours of acute head trauma and investigated the relationship to clinical outcomes. Patients prospectively enrolled in the Traumatic Head Injury Neuroimaging Classification study (NCT01132937) with evidence of diffusion-related findings or hemorrhage on neuroimaging were included. Read More

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September 2021

Computer-Assisted Surgical Navigation for Primary and Metastatic Bone Malignancy of the Pelvis: Current Evidence and Future Directions.

HSS J 2021 Oct 7;17(3):344-350. Epub 2021 Jul 7.

Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Computer-assisted navigation and robotic surgery have gained popularity in the treatment of pelvic bone malignancies, given the complexity of the bony pelvis, the proximity of numerous vital structures, and the historical challenges of pelvic bone tumor surgery. Initial interest was on enhancing the accuracy in sarcoma resection by improving the quality of surgical margins and decreasing the incidence of local recurrences. Several studies have shown an association between intraoperative navigation and increased incidence of negative margin bone resection, but long-term outcomes of navigation in pelvic bone tumor resection have yet to be established. Read More

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October 2021

Less Invasive Pediatric Spinal Deformity Surgery: The Case for Robotic-Assisted Placement of Pedicle Screws.

HSS J 2021 Oct 8;17(3):317-325. Epub 2021 Jul 8.

Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.

Pediatric spinal deformity involves a complex 3-dimensional (3D) deformity that increases the risk of pedicle screw placement due to the close proximity of neurovascular structures. To increase screw accuracy, improve patient safety, and minimize surgical complications, the placement of pedicle screws is evolving from freehand techniques to computer-assisted navigation and to the introduction of robotic-assisted placement. : The aim of this review was to review the current literature on the use of robotic navigation in pediatric spinal deformity surgery to provide both an error analysis of these techniques and to provide recommendations to ensure its safe application. Read More

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October 2021

Head and Neck Surgery During COVID-19 Pandemic: Experience from a Tertiary Care in India.

Indian J Surg Oncol 2021 Sep 12:1-11. Epub 2021 Sep 12.

Department of Otorhinolaryngology and,Head and Neck Surgery, All India Institute of Medical Sciences, 110029 New Delhi, India.

Head and neck pathologies requiring surgical intervention are considered a high-risk subsite in the context of COVID-19 pandemic by virtue of its close proximity to the mucosa of the upper aerodigestive tract. Retrospective review of all head and neck surgical procedures is undertaken during the pandemic from 23rd April 2020 to 30th September 2020. One hundred procedures were performed on 98 patients. Read More

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September 2021

Identifying factors that impact general dentists' referrals to orthodontists.

Am J Orthod Dentofacial Orthop 2021 Sep 16. Epub 2021 Sep 16.

Orthodontics, Division of Craniofacial and Surgical Care, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC; Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC. Electronic address:

Introduction: Referrals from general dentists are a significant source of orthodontic patients, but our knowledge of factors guiding referral decisions predates recent marketplace trends of direct-to-consumer products and broad digitization. To provide orthodontists with current, nationwide data on referral values and communication preferences, a mixed-methods study was conducted.

Methods: Semistructured interviews were conducted with practicing general dentists (n = 23), and interviews were analyzed to identify factors important to communication and referrals. Read More

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September 2021

The impact of COVD-19 on North American dermatology practices.

J Cosmet Dermatol 2021 Sep 18. Epub 2021 Sep 18.

Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.

COVID-19 continues to affect the delivery of healthcare services, as practices across North America gradually re-open with new safety measures and practice guidelines. Specifically in dermatology, clinical care is delivered in close physician-patient proximity through physical examination and the use of additional diagnostic and therapeutic procedures. We designed a 10-question survey to better understand how COVID-19 has impacted the delivery of care in North American dermatology practices. Read More

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September 2021

Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA.

Brain 2021 Sep 17. Epub 2021 Sep 17.

Department of Biotechnology, Jožef Stefan Institute, Ljubljana, Slovenia.

Repeat expansions in the C9orf72 gene are a common cause of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, two devastating neurodegenerative disorders. One of the proposed mechanisms of GGGGCC repeat expansion is their translation into non-canonical dipeptide repeats, which can then accumulate as aggregates and contribute to these pathologies. There are five different dipeptide repeat proteins (polyGA, polyGR, polyPR, polyPA and polyGP), some of which are known to be neurotoxic. Read More

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September 2021

Increased incidence of cavotricuspid isthmus atrial flutter following slow pathway ablation.

J Interv Card Electrophysiol 2021 Sep 17. Epub 2021 Sep 17.

Section of Electrophysiology, Cardiology Division, University of Colorado, Aurora, CO, 80045, USA.

Purpose: The incidence of atrial flutter following radiofrequency ablation of supraventricular tachycardias is poorly understood. Ablation of atrioventricular nodal reentry tachycardia may place patients at risk of flutter because ablation of the slow pathway is in close proximity to the cavotricuspid isthmus. This study aims to evaluate the risk of atrial flutter following ablation of atrioventricular nodal reentry tachycardia relative to ablation of other supraventricular tachycardias. Read More

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September 2021

Pre-hospital management of penetrating neck injuries: a scoping review of current evidence and guidance.

Scand J Trauma Resusc Emerg Med 2021 Sep 16;29(1):137. Epub 2021 Sep 16.

Emergency Department, St. George's Hospital Trust, Blackshaw Rd., Tooting, London, SW17 0QT, UK.

Penetrating injuries to the neck pose a unique challenge to clinicians due to the proximity of multiple significant anatomical structures with little protective soft tissue coverage. Injuries to this area, whilst low in incidence, are potentially devastating. Respiratory, vascular, gastro-oesophageal and neurological structures may all be involved, either in isolation or combination. Read More

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September 2021

Supralesional Ablation Volumes Are Feasible in the Posterior Fossa and May Provide Enhanced Symptomatic Relief.

Oper Neurosurg (Hagerstown) 2021 Sep 15. Epub 2021 Sep 15.

University of Miami Miller School of Medicine, Department of Neurological Surgery, Miami, Florida, USA.

Background: Laser interstitial thermal therapy (LITT) for posterior fossa lesions remains rare as the small size of the infratentorial compartment, proximity to the brainstem, and thickness/angulation of the occipital bone creates barriers to procedural success. Furthermore, evaluation of the effect of ablation volume on outcomes is limited.

Objective: To analyze our institutional experience with LITT in the posterior fossa stratifying perioperative and long-term outcomes by ablation volumes. Read More

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September 2021

Assessment of Relationship of ABO Blood Groups in Oral Cancer Patients - A Retrospective Study.

Ann Maxillofac Surg 2021 Jan-Jun;11(1):80-85. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

Introduction: India is a high-risk region for oropharyngeal cancer (OC) due to high prevalence of tobacco, betel nut, and alcohol and accounts for 30% of all new cases of oral cancer annually.

Materials And Methods: Records of all 73 diagnosed cases of different types of OC and oropharynx patients were analyzed who reported in "Tobacco cessation center"' of the Institute between January 2017 and December 2019. The patients' demographic details, blood groups, oral habits, and clinicohistological records were obtained from the medical records available in the hospital. Read More

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Durable Treatment of Refractory Vesicourethral Anastomotic Stenosis via Robotic-assisted Reconstruction: A Trauma and Urologic Reconstructive Network of Surgeons Study.

Eur Urol 2021 Sep 11. Epub 2021 Sep 11.

Department of Urology, New York University, New York, NY, USA. Electronic address:

Background: Refractory vesicourethral anastomotic stenosis (VUAS) after radical prostatectomy poses challenges distinct from bladder neck contracture, due to close proximity to the sphincter mechanism. Open reconstruction is technically demanding, risking de novo stress urinary incontinence (SUI) or recurrence.

Objective: To demonstrate patency and continence outcomes of robotic-assisted VUAS repair. Read More

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September 2021

The non-canonical mechanism of ER stress-mediated progression of prostate cancer.

J Exp Clin Cancer Res 2021 Sep 14;40(1):289. Epub 2021 Sep 14.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Background: The development of persistent endoplasmic reticulum (ER) stress is one of the cornerstones of prostate carcinogenesis; however, the mechanism is missing. Also, alcohol is a physiological ER stress inducer, and the link between alcoholism and progression of prostate cancer (PCa) is well documented but not well characterized. According to the canonical model, the mediator of ER stress, ATF6, is cleaved sequentially in the Golgi by S1P and S2P proteases; thereafter, the genes responsible for unfolded protein response (UPR) undergo transactivation. Read More

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September 2021

Airborne SARS-CoV-2 surveillance in hospital environment using high-flowrate air samplers and its comparison to surface sampling.

Indoor Air 2021 Sep 14. Epub 2021 Sep 14.

Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore.

Reliable methods to detect the presence of SARS-CoV-2 at venues where people gather are essential for epidemiological surveillance to guide public policy. Communal screening of air in a highly crowded space has the potential to provide early warning on the presence and potential transmission of SARS-CoV-2 as suggested by studies early in the epidemic. As hospitals and public facilities apply varying degrees of restrictions and regulations, it is important to provide multiple methodological options to enable environmental SARS-CoV-2 surveillance under different conditions. Read More

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September 2021

Blood Neurofilament Light Chain in Genetic Ataxia: A Meta-Analysis.

Mov Disord 2021 Sep 14. Epub 2021 Sep 14.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

Background: No comprehensive meta-analysis has ever been performed to assess the value of neurofilament light chain (NfL) as a biomarker in genetic ataxia.

Objective: We conducted a meta-analysis to summarize NfL concentration and evaluate its utility as a biomarker in genetic ataxia.

Methods: Studies were included if they reported NfL concentration of genetic ataxia. Read More

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September 2021

Myxopapillary ependymomas; proximity to the conus and its effect on presentation and outcomes.

Surg Neurol Int 2021 30;12:429. Epub 2021 Aug 30.

Department of Neurologic Surgery Mayo Clinic, Rochester, Minnesota, United States.

Background: Myxopapillary ependymomas (MPE) are intradural spinal tumors with a predilection to the filum terminale. Damage to conus medullaris during surgery can result in sphincteric and sexual dysfunction. The purpose of this study is to determine how myxopapillary ependymoma proximity to the conus impacts patient presentation, extent of resection, and clinical outcomes. Read More

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