2,485 results match your criteria proximal ureteral

Percutaneous Nephrolithotomy Can Reduce the Incidence of Sepsis Compared with Flexible Ureteroscopy in Treating Solitary Proximal Ureteral Stone Patients with Positive Urine Culture.

Biomed Res Int 2021 12;2021:9927498. Epub 2021 Apr 12.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Sepsis is a potentially lethal complication for both flexible ureteroscopy (fURS) and percutaneous nephrolithotomy (PCNL). This study is aimed at comparing the sepsis rate after fURS and PCNL and the risk factors for sepsis in patients with solitary proximal ureteral stone.

Methods: We reviewed the data of patients with calculi between 10 mm to 20 mm who underwent fURS or PCNL surgery from Tongji Hospital's database. Read More

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An Unusual Presentation of Pyelonephritis: Is It COVID-19 Related?

SN Compr Clin Med 2021 Apr 24:1-6. Epub 2021 Apr 24.

Department of Urology, HagaZiekenhuis, The Hague, The Netherlands.

In severe cases of COVID-19, late complications such as coagulopathy and organ injury are increasingly described. In milder cases of the disease, the exact time frame and causal path of late-onset complications have not yet been determined. Although direct and indirect renal injury by SARS-CoV-2 has been confirmed, hemorrhagic renal infection or coagulative problems in the urinary tract have not yet been described. Read More

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Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells.

Pharmacol Res 2021 Apr 28:105630. Epub 2021 Apr 28.

Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710005, China. Electronic address:

Background: DPP8 and DPP9 have been demonstrated to play important roles in multiple diseases. Evidence for increased gene expression of DPP8 and DPP9 in tubulointerstitium was found to be associated with the decline of kidney function in chronic kidney disease (CKD) patients, which was observed in the Nephroseq human database. To examine the role of DPP8 and DPP9 in the tubulointerstitial injury, we determined the efficacy of DPP8 and DPP9 on epithelial-to-mesenchymal transition (EMT) and tubulointerstitial fibrosis (TIF) as well as the underlying mechanisms. Read More

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Effects of TRPC6 Inactivation on Glomerulosclerosis and Renal Fibrosis in Aging Rats.

Cells 2021 Apr 9;10(4). Epub 2021 Apr 9.

Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA.

Canonical transient receptor potential 6 (TRPC6) channels have been implicated in familial and acquired forms of focal and segmental glomerulosclerosis (FSGS) in patients and animal models, as well as in renal fibrosis following ureteral obstruction in mice. Aging also evokes declines in renal function owing to effects on almost every renal compartment in humans and rodents. Here, we have examined the role of TRPC6 in driving inflammation and fibrosis during aging in Sprague-Dawley rats. Read More

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Development of a Novel Nomogram and a Simple Scoring System Using Ureteral Jet Flow to Predict Impacted Ureteral Stone.

J Endourol 2021 Apr 29. Epub 2021 Apr 29.

Silvan State Hospital, Department of Radiology, Diyarbakır, Turkey;

Purpose: To examine the efficacy of ureteral jet flow measured by Doppler ultrasonography (USG) together with radiological parameters obtained by non-contrast enhanced computed tomography (CT) in predicting whether a ureteral stone is impacted.

Material-method: A total of 178 patients that met the criteria were included in the study. Stone size, location, grade of hydronephrosis, HU values of the stone and the proximal and distal parts of the stone, and ureteral wall thickness (UWT) were obtained from non-contrast enhanced abdominal CT images. Read More

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Case of flank pain from ureteral injury after lumbar laminectomy.

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Urology, Sengkang General Hospital, Singapore.

We present a case of an iatrogenic complete left proximal ureteric injury after a lumbar 1 laminectomy and intradural tumour excision and lumbar 4/5 transforaminal lumbar interbody fusion. Initial management included a percutaneous nephrostomy for urinary diversion followed by definitive urinary reconstruction with an ileal ureter. Read More

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Nephrogenic adenoma of the ureter in a teenager with history of leukemia.

Radiol Case Rep 2021 Jun 9;16(6):1384-1387. Epub 2021 Apr 9.

Wake Forest Baptist Medical Center, Department of Radiology, 1 Medical Center Blvd, Winston-Salem, NC 27157, USA.

Nephrogenic adenomas represent a suspected metaplastic response of the uroepithelium to chronic inflammation and are typically associated with recurrent urinary tract infections, stones, prior radiation therapy and other irritative factors, more commonly seen in adults. Nephrogenic adenoma (also known as nephrogenic metaplasia) usually involves the bladder in adults and represents a rare lesion that can easily be misdiagnosed as a malignancy. We present the case of a 14-year-old male with prior history of acute lymphoblastic leukemia (ALL) who presented with a several month history of vague flank pain which increased in intensity, leading to an emergency department presentation with the only significant finding on exam being microhematuria. Read More

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Study of modified technique of ileal neobladder-Frog neobladder.

Urol Ann 2021 Jan-Mar;13(1):19-23. Epub 2021 Jan 19.

Department of Urology, Ruby Hall Clinic, Pune, Maharshtra, India.

Purpose: Orthotopic neobladder is a well-established technique for continent urinary diversion after radical cystectomy. In this study, we evaluated a new Frog ileal neobladder technique. Since the reconstructed neobladder appears like a frog, the name Frog Neobladder was given to it. Read More

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January 2021

Ureteral distal ends combined and inserted into the ileum: a novel anastomotic technique for urinary diversion.

BMC Urol 2021 Apr 19;21(1):65. Epub 2021 Apr 19.

Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Background: This study aimed to introduce a novel method for ureteroileal anastomosis, explore its clinical effectiveness, observe the incidence of postoperative anastomotic stricture, and compare the postoperative complications with those of other types of ureteroileal anastomosis reported in the literature.

Methods: Both ureters were first anastomosed at their distal ends and then inserted into the proximal end of the ileal loop. A postoperative follow-up analysis was performed to evaluate major complication indicators, including anastomotic stricture, anastomotic leak, and hydroureteronephrosis. Read More

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Management and endovascular therapy of ureteroarterial fistulas: experience from a single center and review of the literature.

CVIR Endovasc 2021 Apr 17;4(1):36. Epub 2021 Apr 17.

Department of Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: Ureteroarterial fistula (UAF) is a rare but potentially life threatening disease. The aim of this study was to evaluate the outcome of endovascular therapy for UAF treatment.

Methods: This retrospective case series evaluates a single center experience of percutaneous stent graft (SG) angioplasty and/or coil embolization for UAF. Read More

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A commentary on "Optimal management of large proximal ureteral stones (> 10 mm): A systematic review and meta-analysis of 12 randomized controlled trials" (Int J Surg 2020; 80:205-217).

Int J Surg 2021 Apr 18;89:105942. Epub 2021 Apr 18.

Department of Urology, Suzhou BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, 215010, China. Electronic address:

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Comparison of antegrade and retrograde ureterolithotripsy for proximal ureteral stones: a systematic review and meta-analysis.

Transl Androl Urol 2021 Mar;10(3):1179-1191

Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Background: Antegrade percutaneous ureterolithotripsy (URSL) could be a treatment option for large and/or impacted proximal ureteral stones, which are difficult to treat. To review the current approach and treatment outcomes and to compare the efficacy of retrograde and antegrade URSL for large proximal ureteral stones, we evaluated the unique perspectives of both surgical modalities.

Methods: This systematic literature review and meta-analysis was performed in July 2020. Read More

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Retrograde intrarenal surgery for renal stones in children <5 years of age.

Indian J Urol 2021 Jan-Mar;37(1):48-53. Epub 2021 Jan 1.

Department of Urology, Preeti Urology and Kidney Hospital, Hyderabad, Telangana, India.

Introduction: There are very few studies in the literature describing retrograde intrarenal surgery (RIRS) in preschool children. We have evaluated the feasibility, stone-free rate, and complications of RIRS in children <5 years of age.

Methods: All children <5 years of age and stone size <2 cm (renal/proximal ureteric), who underwent RIRS at our hospital from February 2010 to May 2020 were included in this retrospective study. Read More

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January 2021

Editorial Comment: Can extended upper pole ureterectomy prevent ureteral stump syndrome after proximal approach for duplex kidneys?

Int Braz J Urol 2021 Jul-Aug;47(4):827-828

Divisão de Urologia Pediatrica, Hospital Universitário da Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.

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Can extended upper pole ureterectomy prevent ureteral stump syndrome after proximal approach for duplex kidneys?

Int Braz J Urol 2021 Jul-Aug;47(4):821-826

Unidade de Urologia Pediátrica, Divisão de Urologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo - FMUSP, SP, Brasil.

Introduction: Symptomatic duplex kidneys usually present with recurrent urinary tract infection due to ureteral obstruction (megaureter, ureterocele or ectopic ureter) and/or vesicoureteral reflux. Upper-pole nephrectomy is a widely accepted procedure to correct symptomatic duplex systems with poor functioning moieties, also known as upper or proximal approach. The distal ureteral stump syndrome (DUSS) can be a late complication of this approach. Read More

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Lingual mucosa graft ureteroplasty for ureteral stricture: a narrative review of the current literature.

Ann Palliat Med 2021 Mar 23. Epub 2021 Mar 23.

Department of Urology, Peking University First Hospital, Beijing, China; Institute of Urology, Peking University, Beijing, China; National Urological Cancer Center, Beijing, China.

Long proximal or middle ureteral strictures remain challenging conditions. Although ileal replacement of the ureter or renal autotransplantation are possible solutions for these problems, both present complexities and considerable morbidity. In recent years, many urologists have tended to use oral mucosal grafts to repair complex proximal or middle ureteral strictures and thereby avoid ileal replacement and renal autotransplantation. Read More

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Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5.

Biochem Cell Biol 2021 Apr 8. Epub 2021 Apr 8.

Xian Jiaotong University, 12480, Biochemistry and Molecular Biology, Xi'an, Shaanxi, China.

The precise molecular mechanism of autophagy dysfunction in type 1 diabetes is not known. Herein, the role of programmed cell death 4 (PDCD4) in autophagy regulation in the pathogenesis of diabetic kidney disease (DKD) in vivo and in vitro was described. It was found that Pdcd4 mRNA and protein was upregulated in the streptozotocin (STZ)-induced DKD rats. Read More

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Factors predicting duration and success of semirigid ureteroscopy for ureteral stones in different localizations.

Arch Esp Urol 2021 Apr;74(3):335-342

Department of Urology. Dr. Sadi Konuk Training and Research Hospital. Istanbul. Turkey.

Objective: In this study, we aimed to determine the factors predicting the duration and successof semirigid ureteroscopy performed for the treatment of ureteral stones in different localizations. MATERIALS AND METHODS: Medical records of the patients whom under went semirigid ureteroscopy for urolithiasis in our centre between January 2015 and December 2019 were retrospectively reviewed. The study group composed of 170 patients and divided into three subgroups; of which 54 in proximal ureter (31. Read More

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Postnatal deletion of Bmal1 in mice protects against obstructive renal fibrosis via suppressing Gli2 transcription.

FASEB J 2021 May;35(5):e21530

Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.

Circadian clock is involved in regulating most renal physiological functions, including water and electrolyte balance and blood pressure homeostasis, however, the role of circadian clock in renal pathophysiology remains largely unknown. Here we aimed to investigate the role of Bmal1, a core clock component, in the development of renal fibrosis, the hallmark of pathological features in many renal diseases. The inducible Bmal1 knockout mice (iKO) whose gene deletion occurred in adulthood were used in the study. Read More

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Comparison of mini-percutaneous nephrolithotomy and retroperitoneal laparoscopic ureterolithotomy for treatment of impacted proximal ureteral stones greater than 15 mm.

Chin Med J (Engl) 2021 Mar 31. Epub 2021 Mar 31.

Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Background: The optimal treatment for large impacted proximal ureteral stones remains controversial. The aim of this study was to evaluate the efficacy, safety, and potential complications of mini-percutaneous nephrolithotomy (MPCNL) and retroperitoneal laparoscopic ureterolithotomy (RPLU) in the treatment of impacted proximal ureteral stones with size greater than 15 mm.

Methods: A total of 268 patients with impacted proximal ureteral stones greater than 15 mm who received MPCNL or RPLU procedures were enrolled consecutively between January 2014 and January 2019. Read More

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Inhibitory Effects of STAT3 Transcription Factor by Synthetic Decoy ODNs on Autophagy in Renal Fibrosis.

Biomedicines 2021 Mar 25;9(4). Epub 2021 Mar 25.

Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu 42472, Korea.

Autophagy in the proximal tubules may promote fibrosis by activating tubular cell death, interstitial inflammation, and the production of pro-fibrotic factors. The signal transducer and activator of transcription 3 (STAT3) is activated as a potential transcription factor, which mediates the stimulation of renal fibrosis. We investigated the role of the STAT3 in autophagy and its effect on the prevention of interstitial renal fibrosis. Read More

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Comparison of the Safety and Efficacy between Transperitoneal and Retroperitoneal Approach of Laparoscopic Ureterolithotomy for the Treatment of Large (>10mm) and Proximal Ureteral Stones: A Systematic Review and Meta-analysis.

Urol J 2020 Jul 30;18(1):11-18. Epub 2020 Jul 30.

Department of Urology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Purpose: We aimed to compare the safety and efficacy between laparoscopic transperitoneal ureterolithotomy (LTU) and laparoscopic retroperitoneal ureterolithotomy (LRU) in the treatment of large (>10mm) and proximal ureteral stones.

Materials And Methods: Electronic databases, including PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus were searched through December 2019. Comparative studies comparing the two approaches were included. Read More

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CT as a Diagnostic Tool for Emphysematous Pyelitis: A Case Report.

Cureus 2021 Feb 23;13(2):e13513. Epub 2021 Feb 23.

Radiology, Dr. Ajmera Diagnostic, New Delhi, IND.

Gas forming infections of the renal collecting system occurs because of organisms like Escherichia coli, Klebsiella, and Proteus. If the gas is restricted to the collecting system, without causing involvement of the cortex, it is called emphysematous pyelitis; whereas, invasion and penetration of the cortex imply a more gruesome diagnosis of emphysematous pyelonephritis. A 59-year-old male patient, previously diagnosed with a large right renal calculus and having multiple co-morbidities presented to the surgery department with right flank pain; Double J (DJ) stenting was done to relieve the pain from colic due to obstructive renal calculi; the patient subsequently discharged without any post-procedural complications. Read More

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February 2021

Failure of ureteral access sheath insertion in virgin ureters: A retrospective tertiary care center study.

Urol Ann 2020 Oct-Dec;12(4):331-334. Epub 2020 Aug 10.

Division of Urology, Department of Surgery, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia.

Objective: The objective of the study was to identify the failure rate of insertion of ureteral access sheath (UAS) during primary flexible ureteroscopy (FURS).

Materials And Methods: This was a single-surgeon, single-tertiary care center retrospective study. All patients who underwent primary FURS for proximal ureteric or renal stones from November 2014 to May 2018 were included in the study. Read More

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Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells.

Inflamm Res 2021 May 23;70(5):553-568. Epub 2021 Mar 23.

Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.

Background And Aim: As a proinflammatory cytokine, tumor necrosis factor-like weak inducer of apoptosis (TWEAK) participates in the progression of renal fibrosis by binding to its receptor, fibroblast growth factor-inducible 14 (Fn14). However, the effect of Fn14 inhibition on tubular epithelial cell-mediated tubulointerstitial fibrosis remains unclear. This study aimed to elucidate the role of TWEAK/Fn14 interaction in the development of experimental tubulointerstitial fibrosis as well as the protective effect of Fn14 knockdown on proximal tubular epithelial cells. Read More

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Oncological cases and complications in Urology.

Arch Ital Urol Androl 2021 Mar 19;93(1):77-81. Epub 2021 Mar 19.

Medical Oncologist, Lisbon.

This collection of cases describes some unusual urological tumors and complications related to urological tumors and their treatment. Case 1: A case of left hydronephrosis referred four years after a right radical mastectomy for lobular breast carcinoma was described. Computed tomography scan revealed a left hydronephrosis with dilated ureter up to the proximal third. Read More

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microRNA-29b prevents renal fibrosis by attenuating renal tubular epithelial cell-mesenchymal transition through targeting the PI3K/AKT pathway.

Int Urol Nephrol 2021 Mar 19. Epub 2021 Mar 19.

Department of Nephrology, Zhongnan Hospital, Wuhan University, No.169, Road East lake, Wuhan, 430071, Hubei, People's Republic of China.

Purpose: This study aimed to investigate the effects of miR-29b on renal interstitial fibrosis in the obstructed kidney of mouse with unilateral ureteral obstruction (UUO) via inhibiting phosphatidylinositol 3-kinase/protein kinaseB (PI3K/AKT) signaling pathway.

Methods: Adult male CD-1 mice were intraperitoneally injected with vehicle or PI3K inhibitor LY294002 (3 mg/kg, 30 mg/kg) daily for 1 or 2 weeks after performing UUO or sham operation. The mice were sacrificed on days 7 and 14 after surgery. Read More

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Can ureteral wall thickness (UWT) be used as a potential parameter for decision-making in uncomplicated distal ureteral stones 5-10 mm in size? A prospective study.

World J Urol 2021 Mar 18. Epub 2021 Mar 18.

Urology Ain Shams University, Cairo, Egypt.

Objective: To evaluate the correlation between ureteral wall thickness (UWT) and stone passage (SP) and its cut-off value in distal uncomplicated ureteral stones.

Patients And Methods: In the prospective study from January 2019 to January 2020 at a tertiary care hospital, we reviewed 212 patients aged above 18 years with single, symptomatic, radiopaque, and distal ureteric stone sized 5-10 mm, who were treated with MET (Silodosin 8 mg once daily) until SP or a maximum of 4 weeks. There were 2 groups: responders and non-responders. Read More

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