26,918 results match your criteria provided pain


Quality of life in multiple sclerosis is dominated by fatigue, disability and self-efficacy.

J Neurol Sci 2021 Apr 9;426:117437. Epub 2021 Apr 9.

Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK. Electronic address:

Background And Objective: Quality of life in multiple sclerosis (MS) reflects complex relationships between symptoms (fatigue, spasticity pain, and bladder or vision dysfunction), disability, health perceptions, and self-efficacy.

Methods: In this cross-sectional study, a self-report questionnaire pack of patient reported outcome measures was collected from 5695 people with MS (pwMS) alongside clinical data from their neurologists. Each patient reported outcome measure was converted to interval-scaled estimates following fit to the Rasch model. Read More

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Long Term Outcomes After Arthroscopic Transosseous Equivalent Repair: Clinical and MRI Results of Rotator Cuff Tears at a Minimum Follow-up of 10 Years.

J Shoulder Elbow Surg 2021 May 12. Epub 2021 May 12.

Department of Orthopedics and Traumatology, Koc University School of Medicine, Istanbul, Turkey. Electronic address:

Purpose: The objective of this study was to evaluate long-term functional outcomes and structural integrity of medium to massive rotator cuff tears at 10 to 12 years of follow-up after arthroscopic transosseous equivalent repair (TOE).

Methods: A retrospective view was performed on a consecutive series of patients who underwent primary arthroscopic TOE repair of medium to massive size degenerative rotator cuff tears by a single surgeon between January 2007 and August 2009. Patients were examined at a minimum follow-up of 10 years and magnetic resonance imaging (MRI) was performed to assess tendon integrity. Read More

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Headache teleconsultation in the era of COVID-19: patients' evaluation and future directions.

Eur J Neurol 2021 May 15. Epub 2021 May 15.

Neurology Department, Centro Hospitalar Universitário de São João, E.P.E, Porto, Portugal.

Introduction: Literature regarding Headache teleconsultation and patient satisfaction is scarce. The SARS-CoV-2 pandemic led to the restructuration of traditional clinical activity, by adopting telemedicine.

Objectives: To evaluate patients' satisfaction with Headache teleconsultation by telephone during the SARS-CoV-2 pandemic, and assess patients' preferred model of appointment (face-to-face, teleconsultation by telephone, or both). Read More

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Guidelines of the International Headache Society for clinical trials with neuromodulation devices for the treatment of migraine.

Cephalalgia 2021 May 14:3331024211010413. Epub 2021 May 14.

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.

Background: Although the European Medicines Agency and the US Food and Drug Administration have cleared several devices that use neuromodulation to provide clinical benefits in the acute or preventive treatment of migraine, the Clinical Trials Committee of the International Headache Society has not developed guidelines specifically for clinical trials of neuromodulation devices. In recognition of the distinct needs and challenges associated with their assessment in controlled trials, the Committee provides these recommendations for optimizing the design and conduct of controlled trials of neuromodulation devices for the acute and/or preventive treatment of migraine.

Methods: An international group of headache scientists and clinicians with expertise in neuromodulation evaluated clinical trials involving neuromodulation devices that have been published since 2000. Read More

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The current status of inpatient cancer rehabilitation provided by designated cancer hospitals in Japan.

Jpn J Clin Oncol 2021 May 15. Epub 2021 May 15.

Department of Musculoskeletal Oncology and Rehabilitation, National Cancer Center Hospital, Tokyo, Japan.

Objective: This survey was conducted to clarify the current status of inpatient cancer rehabilitation provided by designated cancer hospitals in Japan.

Methods: A survey questionnaire was sent to 427 designated cancer hospitals in Japan. Information was sought regarding whether inpatient cancer rehabilitation was provided by the center, and if so, whether respondents regarded such provision as satisfactory. Read More

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A Comparison of Anesthetic Quality Between Interscalene Block and Superior Trunk Block for Arthroscopic Shoulder Surgery: A Randomized Controlled Trial.

Pain Physician 2021 May;24(3):235-242

Department of Anesthesiology and Pain Medicine, Anam Hospital, Korea University College of Medicine, Seoul.

Background: Interscalene block is the most commonly used nerve block for shoulder surgery, and superior trunk block has been investigated as a phrenic-sparing alternative. This randomized controlled trial compared ultrasound-guided interscalene block and superior trunk block as anesthesia for arthroscopic shoulder surgery.

Objectives: Our aims were to determine the superiority of anesthesia quality and compare the risk of hemidiaphragmatic paralysis between these 2 blocks. Read More

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Clinical characteristics and therapeutic outcomes of paroxysmal nocturnal hemoglobinuria patients in Turkey: a multicenter experience.

Ann Hematol 2021 May 14. Epub 2021 May 14.

Ankara Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

The aim of this study is to collect paroxysmal nocturnal hemoglobinuria (PNH) patient data from hematology centers all over Turkey in order to identify clinical features and management of PNH patients. Patients with PNH were evaluated by a retrospective review of medical records from 19 different institutions around Turkey. Patient demographics, medical history, laboratory findings, and PNH-specific information, including symptoms at the diagnosis, complications, erythrocyte, and granulocyte clone size, treatment, and causes of death were recorded. Read More

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The lived experience of anxiety and the many facets of pain: A qualitative, arts-based approach.

Can J Pain 2020 Sep 24;4(3):6-18. Epub 2020 Sep 24.

College of Nursing, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

: Findings reported in this article emerged from the study titled "Youth's Voices: Their Lives and Experiences of Living with an Anxiety Disorder." Though the initial focus of this study was not on the pain experiences of youth living with an anxiety disorder, it became apparent from the very first interviews that pain and suffering was key in the youth lived experience, permeating their everyday lives and impeding their participation and functioning in the world. : The aim of this article is to highlight the ways in which pain is a central experience for young people living with an anxiety disorder. Read More

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September 2020

Finding self-worth-Experiences during a multimodal rehabilitation program when living at a residency away from home.

Can J Pain 2020 Oct 5;4(1):237-246. Epub 2020 Oct 5.

Department of Community Medicine, Umeå University, Umeå, Sweden.

Background: Patients with chronic pain who live in rural areas often need to travel long distances to participate in multimodal rehabilitation programs. To reduce traveling during the programs, patients sometimes live at a residency close to the clinic and thus far from home.

Aims: The aim of this study was to explore how patients with chronic pain experience participation in an multimodal rehabilitation program while living at a residency. Read More

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October 2020

Diagnostic and Management Errors in an Immunodeficient Patient with Pneumococcal Pneumonia with Bacteraemia due to Incorrect Assessment of the Patient's Immune Status.

Eur J Case Rep Intern Med 2021 26;8(4):002557. Epub 2021 Apr 26.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Mibu, Tochigi, Japan.

A 79-year-old woman presented with fever and pleural chest pain. Based on the assessment of mild community pneumonia in an immunocompetent patient, outpatient follow-up was planned. However, the patient was admitted several hours later with a diagnosis of pneumococcal pneumonia with bacteraemia. Read More

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Musculoskeletal symptoms and work ability in a context of electronic judicial process.

Rev Bras Med Trab 2021 Apr 30;19(1):3-12. Epub 2021 Apr 30.

School of Nursing, Universidade Estadual de Campinas, Campinas, SP, Brazil.

Introduction: The recent transformations undergone by Brazilian labor court, especially with the introduction of electronic process of law ( [PJe]), had a significant influence on how people work.

Objectives: This study aimed to evaluate the occurrence of musculoskeletal symptoms and work ability in public sector employees working in a specialized labor court body.

Methods: A cross-sectional study was conducted with 449 workers, who provided demographic and occupational information and completed the Nordic Musculoskeletal Questionnaire (NMQ) and the Work Ability Index (WAI). Read More

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Prevalence of Cannabinoid Use in Patients With Hip and Knee Osteoarthritis.

J Am Acad Orthop Surg Glob Res Rev 2021 02 2;5(2). Epub 2021 Feb 2.

From the Department of Orthopedics, Mayo Clinic Arizona, Phoenix, AZ (Dr. Deckey, Dr. Lara, Dr. Hassebrock, Dr. Spangehl, and Dr. Bingham), and the Department of Orthopedics, Loma Linda Medical Center, Loma Linda, CA (Dr. Gulbrandsen).

Introduction: State legalization and widespread marketing efforts have increased the accessibility and consumption of off-label, non-FDA-approved, cannabinoid (CBD) products. Although clinical evidence is largely absent for the treatment of musculoskeletal pain, patients are experimenting with these products in efforts to relieve joint pain. Assessment of the prevalence, perceived efficacy compared with other nonsurgical modalities, and usage patterns is warranted. Read More

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February 2021

Parent values and preferences underpinning treatment decision making in poor prognosis childhood cancer: a scoping review protocol.

BMJ Open 2021 May 13;11(5):e046284. Epub 2021 May 13.

Faculty of Health Sciences, University of Southamptom, Southampton, UK.

Introduction: Parents of a child with cancer want to be involved in making treatment decisions for their child. Underpinning and informing these decisions are parents' individual values and preferences. Parents of a child who has a poor prognosis cancer and who subsequently dies can experience decisional regret. Read More

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The Effect of Low-intensity Shockwave Therapy on Non-neurogenic Lower Urinary Tract Symptoms: A Systematic Review and Meta-analysis of Preclinical and Clinical Studies.

Eur Urol Focus 2021 May 10. Epub 2021 May 10.

Department of Urology, Martha-Maria Hospital Nuremberg, Nuremberg, Germany. Electronic address:

Context: Low-intensity shockwave therapy (LiST) has emerged as an effective treatment for pain in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), and it has been postulated that LiST may also be effective in patients with lower urinary tract symptoms (LUTS).

Objective: To perform a systematic review and meta-analysis of experimental and clinical studies exploring the effect of LiST on LUTS in an attempt to provide clinical implications for future research.

Evidence Acquisition: We systematically searched PubMed, Cochrane Library, and Scopus databases from inception to March 2021 for relevant studies. Read More

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Arthroscopic Resection of Distal Clavicular Osteochondroma: A Case Report.

JBJS Case Connect 2021 05 13;11(2). Epub 2021 May 13.

Consultorio de Patología Ortopédica, Buenos Aires, Argentina.

Case: A 23-year-old boy presented with a 3-month history of right shoulder pain. Radiographs and computed tomography showed an exostosis on the inferior aspect of the distal clavicle. It was osteotomized and removed by arthroscopy. Read More

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Role of smoking in functional dyspepsia and irritable bowel syndrome: three random population-based studies.

Aliment Pharmacol Ther 2021 May 13. Epub 2021 May 13.

Department of Psychology, Macquarie University, North Ryde, NSW, Australia.

Background: It is uncertain if functional dyspepsia (FD) or irritable bowel syndrome (IBS) are linked to smoking, and smoking cessation is not part of the routine advice provided to these patients.

Aim: To assess if smoking is an independent risk factor for FD and IBS.

Methods: Three population-based endoscopy studies in Sweden with 2560 community individuals in total (mean age 51. Read More

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Implementation of the Uniformed Services University Pain Registry Biobank: A Military and Veteran Population Focused Biobank and Registry.

Pain Med 2021 May 13. Epub 2021 May 13.

Defense and Veterans Center for Integrative Pain Management, Uniformed Services University, 11300 Rockville Pike, Rockville, MD.

Objective: The objective of this overview is to discuss the development, implementation, data content, and structure of the Uniformed Services University Pain Registry Biobank. Additionally, procedures and policies for accessing samples for pain-related research purposes are detailed.

Design: Cross-sectional overview. Read More

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Value Analysis of Anatomic and Reverse Shoulder Arthroplasty for Glenohumeral Osteoarthritis with an Intact Rotator Cuff.

J Bone Joint Surg Am 2021 May;103(10):913-920

Holy Cross Orthopedic Institute, Fort Lauderdale, Florida.

Background: While anatomic total shoulder arthroplasty (TSA) has historically been considered the ideal treatment for end-stage glenohumeral osteoarthritis, reverse shoulder arthroplasty (RSA) has recently gained popularity. With substantial differences in implant design and cost between TSA and RSA, further investigation of outcomes and value is needed to support recent trends. The purpose of this study was to use the average and incremental cost-effectiveness ratio (ACER and ICER) and the procedure value index (PVI) to examine differences in outcomes and value between TSA and RSA for treatment of glenohumeral osteoarthritis with an intact rotator cuff. Read More

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Comparing 4-Year Changes in Patient-Reported Outcomes Following Ankle Arthroplasty and Arthrodesis.

J Bone Joint Surg Am 2021 May;103(10):869-878

VA Puget Sound Health Care System, Seattle, Washington.

Background: The rate of total ankle arthroplasty (TAA) is increasing relative to ankle arthrodesis (AA) for patients seeking surgical treatment for end-stage ankle arthritis. Patients and providers would benefit from a more complete understanding of the rate of improvement, the average length of time to achieve maximal function and minimal pain, and whether there is a greater decline in function or an increase in pain over time following TAA compared with AA. The objectives of this study were to compare treatment changes in overall physical and mental function and ankle-specific function, as well as pain intensity at 48 months after TAA or AA in order to determine if the improvements are sustained. Read More

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Diagnostic delay is common for patients with axial spondyloarthritis: results from the National Early Inflammatory Arthritis Audit.

Rheumatology (Oxford) 2021 May 12. Epub 2021 May 12.

Rheumatology Department, Norfolk and Norwich University Hospital, Norwich, UK.

Objectives: Updated guidelines for patients with axial spondyloarthritis (axSpA) have sought to reduce diagnostic delay by raising awareness amongst clinicians. We used the National Early Inflammatory Arthritis Audit (NEIAA) to describe baseline characteristics and time to diagnosis for newly-referred patients with axSpA in England and Wales.

Methods: Analyses were performed on sociodemographic and clinical metrics, including time to referral and assessment, for axSpA patients (n = 784) recruited to NEIAA between May 2018 and March 2020. Read More

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Momentary pain assessments reveal benefits of endoscopic discectomy: a prospective cohort study.

Pain Rep 2021 17;6(1):e906. Epub 2021 Mar 17.

Center for Translational Pain Research, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Lumbar disc herniation (LDH) is a common back disorder that evokes back and/or leg pain. Percutaneous endoscopic lumbar discectomy (PELD) is a minimally invasive surgery for patients with LDH. However, there is little evidence of effectiveness of PELD compared with conservative treatments. Read More

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Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

Pain Rep 2021 21;6(1):e895. Epub 2021 Jan 21.

Johnson and Johnson, Titusville, NJ, USA.

Although certain risk factors can identify individuals who are most likely to develop chronic pain, few interventions to prevent chronic pain have been identified. To facilitate the identification of preventive interventions, an IMMPACT meeting was convened to discuss research design considerations for clinical trials investigating the prevention of chronic pain. We present general design considerations for prevention trials in populations that are at relatively high risk for developing chronic pain. Read More

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January 2021

Repeat Epidural Injections of SP-102 (Dexamethasone Sodium Phosphate Injectable Gel) in Subjects with Lumbosacral Radiculopathy.

J Pain Res 2021 5;14:1231-1239. Epub 2021 May 5.

Global Research and Development, Scilex Pharmaceuticals Inc, Palo Alto, CA, USA.

Purpose: SP-102 is a novel epidural steroid injection (ESI) formulation of 10 mg dexamethasone sodium phosphate in a viscous gel solution. Repeat dosing of ESIs is possible if required for pain relief, but with consideration of hypothalamic-pituitary-adrenal (HPA) axis suppression from prolonged systemic exposure. This phase I/II study investigated the effect of initial and repeat SP-102 injections on HPA suppression and analgesia. Read More

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Slipping rib syndrome: case report of an iatrogenic result following video-assisted thoracic surgery and chest tube placement.

Pain Manag 2021 May 13. Epub 2021 May 13.

Anesthesiology & Pain Medicine, Henry Ford Health Systems, Detroit, MI 48202, USA.

The aim of this case report is to shed light on slipping rib syndrome (SRS), a painful and overlooked condition. A 62-year old man reported intermittent, self-resolving sharp rib pain that began after a video-assisted thoracic surgery and chest tube placement 4 years prior to presentation. The patient's pain was associated with a rigid protrusion in the right upper quadrant, and home use of acetaminophen provided no relief. Read More

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Inferior Articular Process Fracture in a Collegiate Athlete Causing Back Pain: A Case Report of Surgical Treatment.

JBJS Case Connect 2021 04 19;11(2). Epub 2021 Apr 19.

Hospital for Special Surgery, New York, New York.

Case: A 20-year-old male athlete presented with 8 months of low back pain. Conservative management had been unsuccessful. He noted lumbar spine pain with extension, and imaging showed features of an L4-5 inferior articular facet tip fracture. Read More

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Prepatellar Glomus Tumor of the Knee without an Identifiable Mass on MRI: A Case Report.

JBJS Case Connect 2021 04 14;11(2). Epub 2021 Apr 14.

Department of Orthopaedic Surgery, NYU Langone Medical Center, New York, New York.

Case: A 71-year-old man presented with extreme anterior knee pain. His history, physical examination, and imaging were consistent with prepatellar bursitis, but his pain seemed out of proportion for these findings. The patient eventually underwent marginal excision of the inflamed prepatellar bursa which histopathology identified as a glomangioma. Read More

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An Isolated Iliac Wing Stress Fracture in a Male Marathon Runner: A Case Report.

JBJS Case Connect 2021 04 19;11(2). Epub 2021 Apr 19.

Department of Orthopaedic Surgery, Nippon Medical School, Tokyo, Japan.

Case: A 49-year-old man, who had started jogging 3 months before his first participation in a marathon race, presented with acute pain and difficulty walking that began during the marathon race. Tumors and bone metabolism factors were ruled out by blood examination and various imaging findings. Isolated iliac wing fatigue fracture was diagnosed and treated with conservative therapy. Read More

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Acute Arthrodesis of Ipsilateral Pilon and Talus Fracture: A Case Report.

Authors:
Drew Sanders

JBJS Case Connect 2021 04 14;11(2). Epub 2021 Apr 14.

University of Texas Southwestern Medical Center, Parkland Health and Hospital System, Dallas, Texas.

Case: We report a unique case of an ipsilateral distal tibia pilon fracture and talar body after motor vehicle collision. Our patient was successfully treated with acute arthrodesis of the tibiotalar joint, with return to good function 1-year after surgery.

Conclusion: Pilon and talus fractures are complex injuries. Read More

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Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography.

J Neural Eng 2021 May 12. Epub 2021 May 12.

Biomedical Engineering, Duke University, 2167 CIEMAS, Duke Box 3382, 101 Science Drive, Durham, North Carolina, 27708, UNITED STATES.

Objective: The peripheral nervous system (PNS) connects the central nervous system (CNS) with the rest of the body to regulate many physiological functions and is therapeutically targeted to treat diseases such as epilepsy, depression, intestinal dysmotility, chronic pain, and more. However, we still lack understanding of PNS innervation in most organs because the large span, diffuse nature, and small terminal nerve bundle fibers have precluded whole-organism, high resolution mapping of the PNS. We sought to produce a comprehensive peripheral nerve atlas for use in future interrogation of neural circuitry and selection of targets for neuromodulation. Read More

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Neural basis of affective touch and pain: A novel model suggests possible targets for pain amelioration.

J Neuropsychol 2021 May 12. Epub 2021 May 12.

Utrecht University, The Netherlands.

Pain is one of the most common health problems and has a severe impact on quality of life. Yet, a suitable and efficient treatment is still not available for all patient populations suffering from pain. Interestingly, recent research shows that low threshold mechanosensory C-tactile (CT) fibres have a modulatory influence on pain. Read More

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