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Genetic and Non Genetic Hearing Loss and Associated Disabilities: An Epidemiological Survey in Emilia-Romagna Region.

Audiol Res 2021 Sep 16;11(3):463-473. Epub 2021 Sep 16.

Mental Health Department, AUSL Toscana Centro, 50053 Empoli, Italy.

Hearing loss is one of the most common congenital sensory disorders. It can be associated with several comorbidities, in particular developmental disabilities (DD). In Emilia-Romagna (ER), a region in Northern Italy, Child and Adolescent Mental Health Services (CAMHS) provide the diagnostic framework and treatment for these conditions. Read More

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September 2021

Adenoma to carcinoma: A portrait of molecular and immunological profiles of colorectal sporadic tumors.

Int Immunopharmacol 2021 Sep 22;100:108168. Epub 2021 Sep 22.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Cancer Genomics Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Big Data Research Institute, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

An in-depth investigation of the molecular and immunologic properties of colorectal adenoma is important for understanding the mechanisms of colorectal cancer (CRC) initiation and development through the adenoma pathway. We performed a meta-analysis of the gene expression data from seven CRC and colorectal sporadic conventional adenoma datasets. We compared the enrichment levels of immune signatures between adenoma, normal colon, and CRC, then applied immunohistochemistry to compare the CD3 + and CD8 + T cells infiltration using samples of adenoma, contiguous adenoma, and CRC. Read More

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September 2021

Exercise as Treatment for Neuropathy in the Setting of Diabetes and Pre-diabetic Metabolic Syndrome: a Review of Animal Models and Human Trials.

Curr Diabetes Rev 2021 Sep 23. Epub 2021 Sep 23.

Physical Therapy and Athletic Training, University of Utah, Salt Lake City, United States.

Background: Peripheral neuropathy is among the most common complications of diabetes, but a phenotypically identical distal sensory predominant, painful axonopathy afflicts patients with prediabetic metabolic syndrome, exemplifying a spectrum of risk and continuity of pathogenesis. No pharmacological treatment convincingly improves neuropathy in the setting of metabolic syndrome, but evolving data suggests that exercise may be a promising alternative.

Objective: To review in depth current literature regarding exercise treatment of metabolic syndrome neuropathy in humans and animal models, highlight the diverse mechanisms by which exercise exerts beneficial effects, and examine adherence limitations, safety aspects, modes and dose of exercise. Read More

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September 2021

Factors affecting Iranian nurses' intention to leave or stay in the profession during the COVID-19 pandemic.

Int Nurs Rev 2021 Sep 25. Epub 2021 Sep 25.

Department of Health Sciences, The Swedish Red Cross University College, Stockholm, Sweden.

Aim: This study was conducted to explore the factors affecting nurses' intentions to leave or stay in their profession during the coronavirus pandemic in Iran.

Introduction: Because the effectiveness of a healthcare response to a disaster depends on an available, skilled, and motivated healthcare workforce, it is essential to understand and address potential barriers to and reasons for the intentions of medical staff to leave or stay in their profession.

Methods: A qualitative study with a conventional content analysis approach was conducted. Read More

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September 2021

Evaluation of Twitter data for an emerging crisis: an application to the first wave of COVID-19 in the UK.

Sci Rep 2021 Sep 24;11(1):19009. Epub 2021 Sep 24.

Department of Physics and Astronomy, University College London, Gower Street, London, WC1E 6BT, UK.

In the absence of nationwide mass testing for an emerging health crisis, alternative approaches could provide necessary information efficiently to aid policy makers and health bodies when dealing with a pandemic. The following work presents a methodology by which Twitter data surrounding the first wave of the COVID-19 pandemic in the UK is harvested and analysed using two main approaches. The first is an investigation into localized outbreak predictions by developing a prototype early-warning system using the distribution of total tweet volume. Read More

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September 2021

Regulation and functions of NLRP3 inflammasome in cardiac fibrosis: Current knowledge and clinical significance.

Biomed Pharmacother 2021 Sep 21;143:112219. Epub 2021 Sep 21.

Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine,Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Cardiovascular Disease, ShuGuang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Cardiac fibrosis can lead to heart failure, arrhythmia, and sudden cardiac death, representing one of the leading causes of death due to cardiovascular diseases. Cardiac fibrosis involves several multifactorial processes that cannot be effectively controlled by the available therapies. Therefore, current research has focused on the development of novel drugs that can be used to prevent cardiac fibrosis. Read More

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September 2021

What contributes to good outcomes? The perspective of young people on short-term psychoanalytic psychotherapy for depressed adolescents.

PLoS One 2021 24;16(9):e0257334. Epub 2021 Sep 24.

Research Department of Clinical, Educational and Health Psychology, University College London, London [UCL], United Kingdom.

Depression is the fourth leading cause of adolescent illness and disability worldwide. A growing evidence base demonstrates that Short Term Psychoanalytic Psychotherapy [STPP] is an efficacious treatment for moderate to severe adolescent depression. However, with research in its infancy, key factors contributing to efficacy are unknown. Read More

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September 2021

: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications.

Am J Chin Med 2021 Sep 23:1-46. Epub 2021 Sep 23.

School of Pharmacy, Shaanxi University of Chinese Medicine, Xian Yang, Shaanxi 712046, P. R. China.

Rehd. et Wils () is a single species of genus, family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. Read More

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September 2021

"I Felt I Was Screaming Under the Water": Domestic Violence Victims' Experiences in Iran's Police Departments and Criminal Courts.

Violence Against Women 2021 Sep 24:10778012211032703. Epub 2021 Sep 24.

5972University of Delaware, Newark DE, USA.

This exploratory study, the first attempt at capturing the experiences of victims of DV with the criminal justice system in Iran, explores their plight in the absence of legislation that defines and criminalizes DV. Drawing on 15 in-depth interviews with Iranian women who turned to police departments and courts, we demonstrate the flaws inherent in Iran's judiciary and law enforcement organizations, suggesting they reinforce the integrity of the family as a patriarchal unit through readings of religious commands, stabilize the boundary between public and private, and dissuade women from claiming their rights. We provide suggestions for future research for reform, given the growing influence of feminist movements toward gender equality. Read More

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September 2021

Facilitators, barriers and considerations for the implementation of healthcare innovation: A qualitative rapid systematic review.

Health Soc Care Community 2021 Sep 23. Epub 2021 Sep 23.

Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.

Family caregiving scholars recommend that health providers receive competency-based education to partner with and support family caregivers to care and to maintain their own health. While it may be relatively easy to develop competency-based education for healthcare providers, ensuring widespread uptake and spread and scale of healthcare education is critical to ensuring consistent person-centered support for all family caregivers (FCGs) throughout the care trajectory. The development of novel healthcare innovations requires implementation strategies for uptake and spread, with implementation involving the use of strategies to integrate a novel innovation into healthcare. Read More

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September 2021

Isolate and Culture Neural Stem Cells from the Mouse Adult Spinal Cord.

Methods Mol Biol 2022 ;2389:45-56

Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM , Montpellier, France.

Whereas neural stem cells and their niches have been extensively studied in the brain, little is known on these cells, their environment, and their function in the adult spinal cord. Adult spinal cord neural stem cells are located in a complex niche surrounding the central canal, and these cells expressed genes which are specifically expressed in the caudal central nervous system (CNS). In-depth characterization of these cells in vivo and in vitro will provide interesting clues on the possibility to utilize this endogenous cell pool to treat spinal cord damages. Read More

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January 2022

Genome and transcriptome analysis of the beet armyworm Spodoptera exigua reveals targets for pest control.

G3 (Bethesda) 2021 Sep 2. Epub 2021 Sep 2.

Laboratory of Virology, Wageningen University & Research, 6708 PB Wageningen, The Netherlands.

The genus Spodoptera (Lepidoptera: Noctuidae) includes some of the most infamous insect pests of cultivated plants including Spodoptera frugiperda, Spodoptera litura, and Spodoptera exigua. To effectively develop targeted pest control strategies for diverse Spodoptera species, genomic resources are highly desired. To this aim, we provide the genome assembly and developmental transcriptome comprising all major life stages of S. Read More

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September 2021

A Systematic Literature Review on Particle Swarm Optimization Techniques for Medical Diseases Detection.

Comput Math Methods Med 2021 13;2021:5990999. Epub 2021 Sep 13.

Hazara University, Mansehra, KPK, Pakistan.

Artificial Intelligence (AI) is the domain of computer science that focuses on the development of machines that operate like humans. In the field of AI, medical disease detection is an instantly growing domain of research. In the past years, numerous endeavours have been made for the improvements of medical disease detection, because the errors and problems in medical disease detection cause serious wrong medical treatment. Read More

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September 2021

Preparing a financial incentive program to improve retention in HIV care and viral suppression for scale: using an implementation science framework to evaluate an mHealth system in Tanzania.

Implement Sci Commun 2021 Sep 23;2(1):109. Epub 2021 Sep 23.

School of Public Health, University of California Berkeley, Berkeley, CA, USA.

Background: Viral suppression is key to ending the HIV epidemic, yet only 58% of people living with HIV (PLHIV) in sub-Saharan Africa are suppressed. Cash transfers are an effective strategy to improve retention in care, but little is known about optimization of implementation; for example, designing effective programs that integrate into existing clinic workflows. We studied implementation of an mHealth system to deliver cash transfers to support retention. Read More

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September 2021

Reaction mechanisms relevant to the formation and utilization of [Ru(edta)(NO)] complexes in aqueous media.

J Inorg Biochem 2021 Sep 3;225:111595. Epub 2021 Sep 3.

Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland; Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Egerlandstr. 1, 91058 Erlangen, Germany. Electronic address:

The advancement of Ru(edta) complexes (edta = ethylenediamineteraacetate) mediated reactions, including NO generation and its utilization, has not been systematically reviewed to date. This review aims to report the research progress that has been made in exploring the application of Ru(edta) complexes in trapping and generation of NO. Furthermore, utilization of the potential of Ru(edta) complexes to mimic NO synthase and nitrite reductase activity, including thermodynamics and kinetics of NO binding to Ru(edta) complexes, their NO scavenging (in vitro), and antitumor activity will be discussed. Read More

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September 2021

Care Burden and Coping Strategies among Caregivers of Paediatric HIV/AIDS in Northern Uganda: A Cross-Sectional Mixed-Method Study.

AIDS Res Treat 2021 13;2021:6660337. Epub 2021 Sep 13.

Department of Paediatrics and Child Health, Lira University, P.O. Box 1035, Lira, Uganda.

Background: Family caregivers provide the bulk of care to children living with HIV. This places an enormous demand and care burden on the caregivers who often struggle to cope in various ways, some of which may be maladaptive. This may adversely affect their quality of care. Read More

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September 2021

Long noncoding RNA SOX2OT promotes pancreatic cancer cell migration and invasion through destabilizing FUS protein via ubiquitination.

Cell Death Discov 2021 Sep 22;7(1):261. Epub 2021 Sep 22.

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People's Republic of China.

Pancreatic cancer is a highly aggressive and lethal digestive system malignancy. Our previous studies revealed the correlation of high levels of lncRNA SOX2OT expression with patients' poor survival outcomes, the promoting role of SOX2OT in proliferation and cycle progression of pancreatic cancer cells, and the in vivo binding of SOX2OT to RNA binding protein FUS, which destabilized the protein expression of FUS. However, the mechanism of SOX2OT binding and inhibiting FUS protein stability remains unclear. Read More

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September 2021

Comprehensive molecular analysis of inflammatory myofibroblastic tumors reveals diverse genomic landscape and potential predictive markers for response to crizotinib.

Clin Cancer Res 2021 Sep 22. Epub 2021 Sep 22.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, and Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, KU Leuven

Purpose: The clinical phase II trial EORTC 90101 "CREATE" showed high anti-tumor activity of crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK)/ROS1, in patients with advanced inflammatory myofibroblastic tumor (IMFT). However, recent findings suggested that other molecular targets in addition to ALK/ROS1 might also contribute to the sensitivity of this kinase inhibitor. We therefore performed an in-depth molecular characterization of archival IMFT tissue, collected from patients enrolled in this trial, with the aim to identify other molecular alterations which could play a role in the response to crizotinib. Read More

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September 2021

A multimodal mentorship intervention to improve surgical quality in Tanzania's Lake Zone: a convergent, mixed methods assessment.

Hum Resour Health 2021 Sep 23;19(1):115. Epub 2021 Sep 23.

Department of Curative Services, Ministry of Health, Community Development, Gender, Elderly, and Children, Dodoma, Tanzania.

Background: Safe, high-quality surgical care in many African countries is a critical need. Challenges include availability of surgical providers, improving quality of care, and building workforce capacity. Despite growing evidence that mentoring is effective in African healthcare settings, less is known about its role in surgery. Read More

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September 2021

Next generation sequencing - a science tool or routine pathology?

Cesk Patol 2021 ;57(3):136-143

Molecular assays for translocation detection in different tumors have gradually been incorporated into routine diagnostics. However, conventional methods such as fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR come with several drawbacks. Next-generation sequencing (NGS) can provide in-depth detection of numerous gene alterations. Read More

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September 2021

Data-Based Self-awareness as the Foundation for Effective Leadership.

J Nurs Adm 2021 Oct;51(10):478-480

Author Affiliations: Founder and CEO (Mr Friedman), J3P Healthcare Solutions, Princeton, New Jersey; and Senior Director (Dr Hancock), Leadership Development, American Organization for Nursing Leadership (AONL); and Chief Executive Officer Emeritus (Ms Thompson), AONL, Chicago, Illinois.

The AONL Nurse Executive Fellowship supports nurses who are new to an executive role in developing critical executive competencies. Participants engage in an in-depth specialized assessment process to help them understand themselves and the impact on their leadership. Learnings from the 1st 2 cohorts of fellowship participants provide insight into challenges faced by new executives and how self-awareness can improve performance to address those challenges. Read More

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October 2021

Are citizen juries and assemblies on climate change driving democratic climate policymaking? An exploration of two case studies in the UK.

Clim Change 2021 16;168(1-2). Epub 2021 Sep 16.

Sustainability Research Institute, University of Leeds, Leeds, UK.

In light of increasing pressure to deliver climate action targets and the growing role of citizens in raising the importance of the issue, deliberative democratic processes (e.g. citizen juries and citizen assemblies) on climate change are increasingly being used to provide a voice to citizens in climate change decision-making. Read More

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September 2021

Inhaled nano-based therapeutics for inflammatory lung diseases: Recent advances and future prospects.

Life Sci 2021 Sep 20;285:119969. Epub 2021 Sep 20.

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India. Electronic address:

Inflammatory lung diseases related morbidity and mortality impose a significant financial burden. Inflammation is a hallmark of many diseases of the respiratory system which is directly or indirectly linked to adverse health conditions, air pollution, rapid lifestyle changes, and regular outbreaks of microbial infections. The unique anatomical and physiological features of the lungs make them an ideal target organ in the treatment of inflammatory respiratory disease and with the help of inhaled therapy lungs can be targeted directly. Read More

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September 2021

Pirfenidone is a renal protective drug: Mechanisms, signalling pathways, and preclinical evidence.

Eur J Pharmacol 2021 Sep 20;911:174503. Epub 2021 Sep 20.

Department of Nephrology, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Changchun, 130041, China. Electronic address:

Renal fibrosis, a characteristic of all chronic kidney diseases, lacks effective therapeutic drugs currently. Pirfenidone (PFD), a small molecule drug with good oral bioavailability, is widely used in idiopathic pulmonary fibrosis and exerts anti-fibrotic, anti-inflammatory, antioxidant, and anti-apoptotic effects. These effects have been attributed to the suppression of cell growth factors (in particular, but not exclusively, transforming growth factor-β) and the epithelial-mesenchymal transition, as well as the possible down-regulation of pro-inflammatory mediators (such as tumour necrosis factor-α), the protection of mitochondrial function, and the regulation of inflammatory cells. Read More

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September 2021

Exploring Associations of Housing, Relocation, and Active and Healthy Aging in Sweden: Protocol for a Prospective Longitudinal Mixed Methods Study.

JMIR Res Protoc 2021 Sep 21;10(9):e31137. Epub 2021 Sep 21.

Department of Health Sciences, Lund University, Lund, Sweden.

Background: While housing and neighborhood features have the potential to impact opportunities for active aging, there is a lack of knowledge related to how older people reason regarding their housing situation and how housing and fulfillment of relocation are associated with active and healthy aging.

Objective: The objectives of Prospective RELOC-AGE are to study housing choices and relocation and explore effects on active and healthy aging among men and women aged 55 years and older in Sweden considering relocation.

Methods: The estimated sample (2800) will include people aged 55 years and older being listed for relocation at either of two housing companies: a local public housing company in Southern Sweden and a national condominium provider. Read More

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September 2021

Diversity Interventions in the Classroom: From Resistance to Action.

CBE Life Sci Educ 2021 Dec;20(4):ar52

Faculty Affairs and Department of Psychology, University of Colorado Colorado Springs, Colorado Springs, CO 80918.

What goes into faculty decisions to adopt a classroom intervention that closes achievement gaps? We present a theoretical model for understanding possible resistance to and support for implementing and sustaining a diversity-enhancing classroom intervention. We propose, examine, and refine a "diversity interventions-resistance to action" model with four key inputs that help explain faculty's decision to implement (or not) an evidence-based intervention: 1) notice that underrepresentation is a problem, 2) interpret underrepresentation as needing immediate action, 3) assume responsibility, and 4) know how to help. Using an embedded mixed-methods design, we worked with a sample of 40 biology faculty from across the United States who participated in in-depth, semistructured, qualitative interviews and surveys. Read More

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December 2021

Grandparents' Mental Health and Lived Experiences while Raising Their Grandchildren at the Forefront of COVID-19 in Saudi Arabia.

J Gerontol Soc Work 2021 Sep 21:1-17. Epub 2021 Sep 21.

College of Applied Sciences, Al Maarefa University, Riyadh, Saudi Arabia.

Understanding grandparents' lived experiences and healthy aging is essential to designing efficient, effective, and safe services to support a family structure in which grandparents care for their grandchildren. However, no study to date has explored this concept in an Arab and Muslim country during a pandemic. The purpose of this study was to examine grandparents' experiences raising their grandchildren to provide recommendations for needed mental health interventions during and after COVID-19. Read More

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September 2021

Four challenges when conducting bibliometric reviews and how to deal with them.

Environ Sci Pollut Res Int 2021 Sep 20. Epub 2021 Sep 20.

Group of Applied Instrumental Analysis, Department of Chemistry, Federal University of São Carlos, Rod. Washington Luís, km 235, São Carlos, SP, 13565-905, Brazil.

The evidence base in environmental sciences is increasing steadily. Environmental researchers have been challenged to handle massive volumes of data to support more comprehensive studies, assess the current status of science, and move research towards future progress. Bibliometrics can provide important insights into the research directions by providing summarized information for several end users. Read More

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September 2021

Client perspectives on choice of abortion method in England and Wales.

BMJ Sex Reprod Health 2021 Sep 20. Epub 2021 Sep 20.

Centre for Reproductive Research & Communication, British Pregnancy Advisory Service, London, UK.

Introduction: The National Institute for Health and Care Excellence, the Royal College of Obstetricians and Gynaecologists and the World Health Organization recommend that services provide a choice between medical and surgical methods of abortion. We analysed qualitative study data to examine patient perspectives on abortion method choice and barriers to meeting them.

Methods: In-depth interviews with 24 clients who had an abortion at British Pregnancy Advisory Service clinics were carried out between December 2018 and July 2019 to examine perspectives of quality of abortion care. Read More

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September 2021

Designing dual compartment HIV prevention products: Women's sensory perceptions and experiences of suppositories for rectal and vaginal use.

AIDS Res Hum Retroviruses 2021 Sep 21. Epub 2021 Sep 21.

ImQuest Life Sciences Inc, 536423, Frederick, Maryland, United States;

Dual compartment suppositories are being developed to prevent HIV and STIs. Such products, for use in either the rectum, the vagina, or both, could have a significant public health impact by decreasing global incidence of these diseases. In this study, 16 women each used two rheologically distinct suppositories in their vagina and rectum. Read More

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September 2021