64,996 results match your criteria proteinuria rapidly

Precision medicine in immunoglobulin A nephropathy: still a journey ahead.

Nephrol Dial Transplant 2021 Jun;36(Supplement_2):24-30

Division of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany.

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide and since its first description extensive research has identified a number of key central pathogenetic contributors, including genetic, immunological and environmental factors. Along with its multifaceted pathophysiology, the clinical presentation of IgAN varies, ranging from mild forms with only minor urinary findings and preserved renal function to cases that rapidly progress to end-stage renal disease. Because of this, early identification of patients at risk for a progressive course is urgently needed. Read More

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Role of fibroblast specific protein 1 expression in the progression of adriamycin-induced glomerulosclerosis.

Biochem Biophys Res Commun 2021 Jun 18;567:148-153. Epub 2021 Jun 18.

Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui, Japan. Electronic address:

Focal segmental glomerulosclerosis (FSGS) is a commonly occurring cause of steroid-resistant nephrotic syndrome and frequently progresses to renal failure. Podocyte epithelial-mesenchymal transition (EMT) is thought to induce podocyte detachment in glomerular diseases, and severe degeneration and shedding of glomerular podocytes plays a major role in the progression of FSGS. We showed that fibroblast specific protein 1 (FSP1), an EMT marker, is strongly expressed in podocytes of FSGS patients, but the significance of podocyte expression of FSP1 to the pathophysiology of FSGS remained unclear. Read More

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Congenital nephrotic syndrome in IL7Rα-SCID - a rare feature of materno-foetal graft-versus-host disease.

J Allergy Clin Immunol Pract 2021 Jun 18. Epub 2021 Jun 18.

Primary Immunodeficiencies Unit, Hospital Dona Estefânia - CHLC, EPE, Lisbon, Portugal;; CEDOC, Chronic Diseases Research Center, NOVA Medical School, Lisbon, Portugal. Electronic address:

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Retrospective study of factors associated with progression and remission/regression of diabetic kidney disease-hypomagnesemia was associated with progression and elevated serum alanine aminotransferase levels were associated with remission or regression.

Diabetol Int 2021 Jul 2;12(3):268-276. Epub 2021 Jan 2.

Department of Medicine, Nerima General Hospital, 1-24-1 Asahigaoka, Nerima-ku, Tokyo, 176-8530 Japan.

Aim: This study was aimed at retrospectively investigating some common clinical factors, including the serum level of magnesium (Mg), associated with progression and remission/regression of diabetic kidney disease (DKD).

Methods: The subjects were 690 Japanese patients with type 2 diabetes mellitus who were receiving treatment with oral antidiabetic drugs other than SGLT2 inhibitors. Routine clinical data were collected on the first and last day of the observation period. Read More

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PPARγ Mediates the Anti-Epithelial-Mesenchymal Transition Effects of FGF1 in Chronic Kidney Diseases via Inhibition of TGF-β1/SMAD3 Signaling.

Front Pharmacol 2021 3;12:690535. Epub 2021 Jun 3.

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Podocytes are essential components of the glomerular basement membrane. Epithelial-mesenchymal-transition (EMT) in podocytes results in proteinuria. Fibroblast growth factor 1 (FGF1) protects renal function against diabetic nephropathy (DN). Read More

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Therapeutic inertia in proteinuria management among type 2 diabetes (T2DM) patients in primary care settings: prevalence and associated risk factors.

BMC Fam Pract 2021 Jun 21;22(1):118. Epub 2021 Jun 21.

Department of Family Medicine and General Out-Patient Clinics, Kowloon Central Cluster, Hospital Authority, Rm 807, Block S, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong.

Background: Therapeutic inertia (TI), defined as physicians' failure to increase therapy when treatment goals are unmet, is an impediment to chronic disease management. This study aimed to identify the prevalence of TI in proteinuria management among T2DM patients managed in primary care settings and to explore possible associating factors.

Methods: This was a cross-sectional study. Read More

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Preoperative proteinuria may be a risk factor for postoperative acute kidney injury:a meta-analysis.

Ren Fail 2021 Dec;43(1):958-967

Department of Nephropathy, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, P. R. China.

Objective: To investigate the relationship between preoperative proteinuria and postoperative acute kidney injury (AKI).

Methods: We performed a search on databases included PubMed, Embase, the Cochrane Library, and Web of Science, from December 2009 to September 2020. Data extracted from eligible studies were synthesized to calculate the odds ratio (OR) and 95% confidence interval (CI). Read More

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December 2021

Positive renal familial history in IgA nephropathy is associated with worse renal outcomes: a single-center longitudinal study.

BMC Nephrol 2021 Jun 19;22(1):230. Epub 2021 Jun 19.

Department of Internal Medicine, Division of Nephrology, Showa University School of Medicine, Fujigaoka Hospital, 1-30 Fujigaoka, Aobaku, Yokohama, Kanagawa, 227-8501, Japan.

Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Although most IgAN cases are sporadic, few show a familial aggregation. However, the prevalence and prognosis of IgAN individuals with positive familial history (FH) of renal disorders remains uncertain. Read More

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Urinary Dickkopf-3 (uDKK3): a new biomarker for CKD progression and mortality?

Nephrol Dial Transplant 2021 Jun 17. Epub 2021 Jun 17.

Department of Nephrology., Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Background: Kidney fibrosis has been reported to be a prognostic factor in CKD progression. Previous studies have shown that the assessment of urinary Dickkopf-3 (uDKK3), a stress induced tubular epithelial-derived profibrotic glycoprotein, might be a potential tubulointerstitial fibrosis biomarker and might identify patients at short-term risk of eGFR loss. We aim to evaluate uDKK3 as a potential biomarker for progression of CKD in a cohort with various etiologies of CKD, and subsequently in an overt diabetic nephropathy cohort. Read More

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A Rare Cause of Nephrotic Syndrome in Adults - Collagenofibrotic Glomerulopathy.

Saudi J Kidney Dis Transpl 2021 Jan-Feb;32(1):223-226

Department of Pathology, K S Hegde Medical Academy, Mangalore, Karnataka, India.

Adult-onset nephrotic syndrome (NS) is commonly caused by minimal change disease, focal segmental glomerulosclerosis, andmembranous nephropathy. Rare causes of NS include amyloidosis, immunoglobulin deposition disease, fibronectin glomerulopathy, and Collagenofibrotic glomerulopathy (CG). CG is caused by deposition of Type 3 collagen in the mesangium and subendothelial area. Read More

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Impact of Therapeutic Dose Monitoring of Mycophenolic Acid on the Outcome of Live-Donor Kidney Transplant Recipients - A Prospective Controlled Study.

Saudi J Kidney Dis Transpl 2021 Jan-Feb;32(1):128-136

Urology and Nephrology Center, Nephrology Unit, Mansoura University, Mansoura, Egypt.

Immunosuppressive therapy is the backbone to renal transplantation. Although an adequate level of immunosuppression is required to dampen the immune response to the allograft, the level of chronic immunosuppression is slowly decreased over time (as the risk of acute rejection decreases) to help lower the overall risk of infection and malignancy. Several studies have discussed the clinical use of therapeutic drug monitoring of mycophenolic acid (MPA) in kidney transplant recipients. Read More

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Prevalence of Cardiac Abnormalities in Children with Chronic Kidney Disease: A Cross-sectional Study from a Developing Country.

Saudi J Kidney Dis Transpl 2021 Jan-Feb;32(1):92-100

Department of Pediatric Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.

Improved therapeutic modalities in chronic kidney diseases (CKD) children and consequent extension of life expectancy, draws more attention towards secondary complications. Cardiovascular adaptations precipitating such terminal events, begin in pre-dialysis CKD. Hence, it's imperative to identify modifiable risk factors to direct care and resources in haltering CKD progression, evade long-term dialysis and anticipate kidney transplantation to avert cardiac complications in predialysis period. Read More

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Clinicopathological Correlation with Mesangial C4d Deposition in Primary Immunoglobulin A Nephropathy - A Descriptive study.

Saudi J Kidney Dis Transpl 2021 Jan-Feb;32(1):42-48

Department of Pathology, St. John's Medical College and Hospital, Bengaluru, Karnataka, India.

In immunoglobulin A (IgA) nephropathy, activation of lectin pathway leads to severe renal damage and more pronounced histological damage. As C4d is a marker of lectin pathway activation, the presence of mesangial C4d positivity will help in identifying those patients at risk. The study was conducted to study the prevalence of mesangial C4d positivity in patients with primary IgA nephropathy and to compare the clinical and histopathological features with C4d-positive and C4d-negative cases. Read More

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Urinary Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (uTWEAK) and Urinary Monocyte Chemo-attractant Protein-1 (uMCP-1): Promising Biomarkers of Lupus Nephritis Activity?

Saudi J Kidney Dis Transpl 2021 Jan-Feb;32(1):19-29

Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.

There is no single biomarker to detect lupus nephritis (LN) activity. Renal biopsy is still the gold standard method but it is invasive and mainly used in the initial assessment of the patients. Urinary tumor necrosis factor-like weak inducer of apoptosis (uTWEAK) and urinary monocyte chemo-attractant protein-1 (uMCP-1) can be secreted in the urine of active LN. Read More

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Improvement of renal and non-renal SLE outcome measures on sirolimus therapy - A 21-year follow-up study of 73 patients.

Clin Immunol 2021 Jun 16;229:108781. Epub 2021 Jun 16.

Division of Rheumatology, Department of Medicine, College of Medicine, State University of New York, Syracuse, NY 13210, USA; Department of Microbiology and Immunology, College of Medicine, State University of New York, Syracuse, NY 13210, USA; Department of Biochemistry and Molecular Biology, College of Medicine, State University of New York, Syracuse, NY 13210, USA. Electronic address:

To define the safety, tolerance, and selected renal and non-renal outcome measures in 73 SLE patients who received sirolimus therapy for more than 3 months in our institution over the past 21 years. In 12 patients who had lupus nephritis, proteinuria (p = 0.0287), hematuria (p = 0. Read More

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Megalin-mediated albumin endocytosis in renal proximal tubules is involved in the antiproteinuric effect of angiotensin II type 1 receptor blocker in a subclinical acute kidney injury animal model.

Biochim Biophys Acta Gen Subj 2021 Jun 16;1865(9):129950. Epub 2021 Jun 16.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Rio de Janeiro Innovation Network in Nanosystems for Health - NanoSAUDE/FAPERJ, Rio de Janeiro, Brazil; Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa, INCT-Regenera, Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCTIC, Rio de Janeiro, Brazil. Electronic address:

Background: Tubule-interstitial injury (TII) is one of the mechanisms involved in the progression of renal diseases with progressive proteinuria. Angiotensin II (Ang II) type 1 receptor blockers (ARBs) have been successfully used to treat renal diseases. However, the mechanism correlating treatment with ARBs and proteinuria is not completely understood. Read More

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Surufatinib for the treatment of advanced extrapancreatic neuroendocrine tumors.

Expert Rev Anticancer Ther 2021 Jun 18. Epub 2021 Jun 18.

Department of Clinical Pharmacy, Linyi Central Hospital, Linyi, Shandong, China.

: Surufatinib (also known as HMPL-012, sulfatinib) is a novel oral tyrosine kinase inhibitor (TKI), which has the dual activity of anti-angiogenesis and immune regulation. In December 2020, surufatinib was approved as a monotherapy for unresectable locally advanced or metastatic, progressive non-functioning, well differentiated (grade 1 or 2) extrapancreatic neuroendocrine tumours (epNETs) in China.: In this paper, the chemical properties, mechanism of action, pharmacokinetics, clinical efficacy, safety and tolerability of surufatinib for treatment of advanced extrapancreatic NETs are introduced in detail. Read More

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Artefactual bands on urine protein immunofixation gels.

Clin Chem Lab Med 2021 Jun 22;59(7):e283-e284. Epub 2021 Jan 22.

Medical Laboratory Sciences, Zefat Academic College and Central Laboratory of Haifa and Western Galilee, Clalit Health Services, Tel Aviv-Yafo, Israel.

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All-Cause Mortality and Incidence of Major Adverse Cardiac Events in Sickle Cell Nephropathy: A Comparative Study.

Cureus 2021 May 16;13(5):e15059. Epub 2021 May 16.

Internal Medicine, Grand Strand Medical Center, Myrtle Beach, USA.

Background Sickle cell disease (SCD) is an autosomal recessive disease resulting in hemolytic anemia and recurrent vaso-occlusive events. Consequently, it can result in a broad range of functional and structural renal and cardiac alterations. Chronic kidney disease (CKD), in SCD, is associated with proteinuria, microalbuminuria, and hemoglobinuria. Read More

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Assessment of Carotid Intima Media Thickness and Left Ventricular Mass Index in Children with Idiopathic Nephrotic Syndrome.

Vasc Health Risk Manag 2021 10;17:349-356. Epub 2021 Jun 10.

Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt.

Background: Children with nephrotic syndrome (NS) are at a greater risk of atherosclerosis due to recurrent exposures to hyperlipidemia, hypertension, and immunosuppressive medications. CIMT (carotid intima media thickness) is a reliable marker for assessment of atherosclerosis of large and medium-sized blood vessels; endothelial dysfunction and increased CIMT usually precede the development of cardiovascular diseases. Some manifestations of NS, like proteinuria and hyperlipidemia, are associated with an increased risk of cardiac morbidity and mortality. Read More

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Blockade of interleukin-6 as a possible therapeutic target for AA amyloidosis.

Nefrologia 2021 Jun 14. Epub 2021 Jun 14.

Servicio de Nefrología, Hospital Universitario Virgen Macarena, Sevilla, España.

Introduction: AA (secondary) amyloidosis is a severe complication of chronic inflammatory disorders. It is characterized by the systemic deposition of an abnormal protein called amyloid, affecting mainly renal function. IL-6 is a cytokine with a relevant role in this disease development. Read More

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Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys.

PLoS One 2021 17;16(6):e0253197. Epub 2021 Jun 17.

Department of Inflammation & Immunity, Cleveland Clinic, Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.

The mechanism of pathogenesis associated with APOL1 polymorphisms and risk for non-diabetic chronic kidney disease (CKD) is not fully understood. Prior studies have minimized a causal role for the circulating APOL1 protein, thus efforts to understand kidney pathogenesis have focused on APOL1 expressed in renal cells. Of the kidney cells reported to express APOL1, the proximal tubule expression patterns are inconsistent in published reports, and whether APOL1 is synthesized by the proximal tubule or possibly APOL1 protein in the blood is filtered and reabsorbed by the proximal tubule remains unclear. Read More

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Management Of Childhood Steroid Dependent Nephrotic Syndrome With Cyclophosphamide - An Experience At Ayub Teaching Hospital, Abbottabad.

J Ayub Med Coll Abbottabad 2021 Apr-Jun;33(2):213-216

Department of Paediatrics, Ayub Medical College Abbottabad, KMU Institute of Medical Sciences, Kohat, Pakistan.

Background: This study has been done in children with Steroid dependent nephrotic syndrome (SDNS) to check for the response to cyclophosphamide and relapse on follow up for one year after completion of treatment.

Methods: This study was conducted over two years and nine months. Patients were taken as steroid dependent when there were two consecutive relapses occur on steroids tapering or within two weeks of stopping treatment. Read More

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Donor-Derived ALECT2 Amyloidosis and Recurrent Fibrillary Glomerulonephritis in a Transplant Allograft.

Kidney Med 2021 May-Jun;3(3):433-437. Epub 2021 Feb 16.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

The occurrence of renal amyloidosis and fibrillary glomerulonephritis in the same biopsy specimen is exceptional and poses a diagnostic challenge. We describe the case of a non-Hispanic White patient with end-stage kidney disease due to fibrillary glomerulonephritis who received a second living donor kidney from a Hispanic individual. A 40-month-posttransplantation biopsy performed for an elevated serum creatinine level revealed interstitial congophilic deposits and glomerular noncongophilic fibrillary deposits, in addition to rejection. Read More

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February 2021

Single-Cell Profiling Reveals Transcriptional Signatures and Cell-Cell Crosstalk in Anti-PLA2R Positive Idiopathic Membranous Nephropathy Patients.

Front Immunol 2021 31;12:683330. Epub 2021 May 31.

Department of Nephrology, Xiangya Hospital, Central South University, Changsha, China.

Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the kidney glomerulus. It may gradually progress to end-stage renal disease (ESRD) characterized by increased proteinuria, which leads to serious consequences. Although substantial advances have been made in the understanding of the molecular bases of IMN in the last 10 years, certain questions remain largely unanswered. Read More

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Earlier onset of proteinuria or hypertension is a predictor of progression from gestational hypertension or gestational proteinuria to preeclampsia.

Sci Rep 2021 Jun 16;11(1):12708. Epub 2021 Jun 16.

Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita-ku N15 W7, Sapporo, 060-8638, Japan.

Although gestational hypertension (GH) is a well-known disorder, gestational proteinuria (GP) has been far less emphasized. According to international criteria, hypertensive disorders of pregnancy include GH but not GP. Previous studies have not revealed the predictors of progression from GP to preeclampsia or those of progression from GH to preeclampsia. Read More

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From Proteinuria to Fibrosis: An Update on Pathophysiology and Treatment Options.

Kidney Blood Press Res 2021 Jun 15:1-10. Epub 2021 Jun 15.

Department of Renal Medicine, St. George Hospital, Sydney, New South Wales, Australia.

Background: Proteinuria is a key biomarker in nephrology. It is central to diagnosis and risk assessment and the primary target of many important therapies. Etiologies resulting in pathological proteinuria include congenital and acquired disorders, as well as both glomerular (immune/non-immune mediated) and tubular defects. Read More

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Long-Term Outcomes of Kidney Transplants from Older/Marginal Donors: A Cohort Study.

Nephron 2021 Jun 15:1-11. Epub 2021 Jun 15.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.

Introduction: To safely expand the donor pool, we introduced a strategy of biopsy-guided selection and allocation to single or dual transplantation of kidneys from donors >60 years old or with hypertension, diabetes, and/or proteinuria (older/marginal donors). Here, we evaluated the long-term performance of this approach in everyday clinical practice.

Methods: In this single-center cohort study, we compared outcomes of 98 patients who received one or two biopsy-evaluated grafts from older/marginal donors ("recipients") and 198 patients who received nonhistologically assessed single graft from ideal donors ("reference-recipients") from October 2004 to December 2015 at the Bergamo Transplant Center (Italy). Read More

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Lower ambulatory nocturnal SBP is associated with less cardiovascular and renal damage in normotensive hospitalized patients with chronic kidney disease.

J Hypertens 2021 Jun 14. Epub 2021 Jun 14.

Department of Nephrology Department of Laboratory Medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China Jun Zhang and Jun Song contributed equally to this work.

Objective: The impact of nocturnal blood pressure (BP) on target organ damage (TOD) in chronic kidney disease (CKD) patients with normotension has not been established. In this study, we determined whether nocturnal BP is correlated with cardiovascular and renal damage independent of the 24-h BP in CKD patients with normotension or hypertension.

Methods: A total of 1166 hospitalized patients with CKD not requiring dialysis were enrolled in this cross-sectional study, 421 and 745 of whom had normotension and hypertension, respectively. Read More

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Nephrosclerosis impacts time trajectory of renal function and outcomes in elderly individuals with chronic kidney disease.

J Investig Med 2021 Jun 14. Epub 2021 Jun 14.

Nephrology and Dialysis Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, Calabria, Italy

Despite hypertension ranks among the leading causes of chronic kidney disease (CKD), the impact of chronic hypertensive nephropathy, the so-called 'nephrosclerosis' (NS), on CKD progression is often unpredictable, particularly in elderly population. We have conducted a prospective, observational study to define renal function patterns and outcomes in elderly CKD individuals with or without NS. Three hundred four individuals with an already established CKD were categorized according to the etiology of CKD. Read More

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