1,333,289 results match your criteria proteins associated


Cancers associated with human gammaherpesviruses.

FEBS J 2021 Sep 18. Epub 2021 Sep 18.

Department of Microbiology & Immunology & Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA.

Epstein-Barr virus (EBV; human herpesvirus 4; HHV-4) and Kaposi sarcoma-associated herpesvirus (KSHV; human herpesvirus 8; HHV-8) are human gammaherpesviruses that have oncogenic properties. EBV is a lymphocryptovirus, whereas HHV-8/KSHV is a rhadinovirus. As lymphotropic viruses, EBV and KSHV are associated with several lymphoproliferative diseases or plasmacytic/plasmablastic neoplasms. Read More

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September 2021

Exploring the effect of two different teaching strategies on first-year nursing students' understanding of nutritional concepts: A mixed-method approach.

Nurse Educ Pract 2021 Sep 4;56:103193. Epub 2021 Sep 4.

Basque Nurse Education Research Group, Department of Nursing I, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Bº Sarriena s/n, 48940 Leioa, Spain; Biocruces Bizkaia Health Research Institute, Cruces Plaza, 48903 Barakaldo, Spain. Electronic address:

Aim: The aim of the study was twofold. First, to explore understanding difficulties in nutritional concepts among nursing students and second, to analyse the effect of two teaching strategies on the level of understanding.

Background: Previous studies have pointed out the need to improve the nutritional care education offered to undergraduates in health sciences. Read More

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September 2021

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists.

Eur J Med Chem 2021 Sep 9;226:113812. Epub 2021 Sep 9.

Department of Chemistry, Tsinghua University, Beijing, 100084, PR China; State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China; Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, PR China; National & Local United Engineering Lab for Personalized Anti-tumor Drugs, Shenzhen Kivita Innovative Drug Discovery Institute, Tsinghua Shenzhen International Graduate School, Shenzhen, 518055, PR China. Electronic address:

Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid-leucine-arginine sequence-contained chemokines CXCs (ELR CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block CXCLs/CXCR2 axis, and are widely used in regulating immune cell migration, tumor metastasis, apoptosis and angiogenesis. Read More

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September 2021

Relationship between the amino acid release kinetics of feed proteins and nitrogen balance in finishing pigs.

Animal 2021 Sep 15;15(10):100359. Epub 2021 Sep 15.

Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, PR China.

In current nutrition requirements of swine, although the protein diets are formulated based on the ileal digestibility of protein and amino acid (AA), there is a difference in nitrogen utilisation among various protein diets, which might be related to the AA release kinetics. To evaluate the relationship between AA release kinetics of feed proteins and nitrogen balance in finishing pigs, pigs were fed diets based on casein (CAS) or corn gluten meal (CGM) at normal or low-protein concentrations, and the AA release patterns were assessed. A 2 × 2 full factorial experimental design was used. Read More

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September 2021

mA modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.

Biochem Pharmacol 2021 Sep 15:114766. Epub 2021 Sep 15.

(DrugMetabolism and Toxicology), (Faculty of Pharmaceutical Sciences); (WPINano Life Science Institute (WPI-NanoLSI),Kanazawa University, Kakuma-machi), (Kanazawa 920-1192), (Japan).

Methylation of adenosine at the N position to form N-methyladenosine (mA) is the most prevalent epitranscriptomic modification of mammalian mRNA. This modification is catalyzed by a methyltransferase-like 3 (METTL3)-METTL14 complex and is erased by demethylases such as fat mass and obesity-associated protein (FTO) or AlkB homolog 5 (ALKBH5). mA modification regulates mRNA stability, nuclear export, splicing, and/or protein translation via recognition by reader proteins such as members of YT521-B homology (YTH) family. Read More

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September 2021

Secretion of a low-molecular-weight species of endogenous GRP94 devoid of the KDEL motif during endoplasmic reticulum stress in Chinese hamster ovary cells.

Traffic 2021 Sep 18. Epub 2021 Sep 18.

Department of Biotechnology, Graduate School of Engineering.

GRP94 (glucose-regulated protein 94) is a well-studied chaperone with a KDEL (lysine, aspartic acid, glutamic acid, and leucine) motif at its C-terminal, which is responsible for GRP94 localization in the endoplasmic reticulum (ER). GRP94 is upregulated during ER stress to help fold unfolded proteins or direct proteins to ER-associated degradation. In a previous study, engineered GRP94 without the KDEL motif stimulated a powerful immune response in vaccine cells. Read More

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September 2021

Omp31 of Brucella Inhibits NF-κB p65 Signaling Pathway by Inducing Autophagy in BV-2 Microglia.

Neurochem Res 2021 Sep 18. Epub 2021 Sep 18.

Neurology Center, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, China.

Neurobrucellosis is a serious central nervous system (CNS) inflammatory disorder caused by Brucella, and outer membrane protein-31 (Omp31) plays an important role in Brucella infection. This study aims to determine whether Omp31 can induce autophagy in BV-2 microglia. Another goal of the study is to further examine the effect of autophagy on the nuclear transcription factor κB (NF-κB) p65 signaling pathway. Read More

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September 2021

HSC70 as a sensor of low temperature: Role in cold-triggered autoinflammatory disorders.

FEBS J 2021 Sep 18. Epub 2021 Sep 18.

CSIR-Centre for Cellular and Molecular Biology, Hyderabad, 500007, India.

Familial cold auto-inflammatory syndrome (FCAS) is a subset of heritable auto-inflammatory disorders wherein inflammatory symptoms aggravate upon exposure of the individual to subnormal temperature. In the past two decades, several mutations in various genes like NLRP3, NLRP12, PLCG2 and NLRC4 have been identified that cause cold-triggered inflammation. However, our understanding about the mechanisms by which cells perceive subnormal temperature, and what keeps the inflammation under check until exposure to low-temperature, is very limited. Read More

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September 2021

Development and validation of a PBRM1-associated immune prognostic model for clear cell renal cell carcinoma.

Cancer Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Anesthesiology, Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Alteration in the polybromo-1 (PBRM1) protein encoding gene PBRM1 is the second most frequent mutation in clear cell renal cell carcinoma (ccRCC). It causes a series of changes in the tumorigenesis, progression, prognosis, and immune response of ccRCC patients. This study explored the PBRM1-associated immunological features and identified the immune-related genes (IRGs) linked to PBRM1 mutation using bioinformatics methods. Read More

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September 2021

High-resolution mapping of the quantitative trait locus (QTLs) conferring resistance to false smut disease in rice.

J Appl Genet 2021 Sep 17. Epub 2021 Sep 17.

School of Agricultural Biotechnology, Punjab Agricultural University, Ludhiana, Punjab, 141004, India.

Rice false smut (RFS), an emerging major fungal disease worldwide caused by Ustilaginoidea virens, affects rice grain quality and yield. RFS cause 2.8-49% global yield loss depending upon disease severity and cultivars. Read More

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September 2021

DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis.

Sci Rep 2021 Sep 17;11(1):18532. Epub 2021 Sep 17.

Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Leydig cells in the testes produce testosterone in the presence of gonadotropins. Therefore, male testosterone levels must oscillate within a healthy spectrum, given that elevated testosterone levels augment the risk of cardiovascular disorders. We observed that the expression of death-associated protein-like 1 (DAPL1), which is involved in the early stages of epithelial differentiation and apoptosis, is considerably higher in the testes of sexually mature mice than in other tissues. Read More

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September 2021

Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion.

Cell Death Dis 2021 Sep 17;12(10):854. Epub 2021 Sep 17.

Department of Translational Brain Research, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

Dopaminergic (DA) cell death in Parkinson's disease (PD) is associated with the gradual appearance of neuronal protein aggregates termed Lewy bodies (LBs) that are comprised of vesicular membrane structures and dysmorphic organelles in conjunction with the protein alpha-Synuclein (α-Syn). Although the exact mechanism of neuronal aggregate formation and death remains elusive, recent research suggests α-Syn-mediated alterations in the lysosomal degradation of aggregated proteins and organelles - a process termed autophagy. Here, we used a combination of molecular biology and immunochemistry to investigate the effect of α-Syn on autophagy turnover in cultured human DA neurons and in human post-mortem brain tissue. Read More

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September 2021

Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway.

Transl Psychiatry 2021 Sep 17;11(1):480. Epub 2021 Sep 17.

Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Autism spectrum disorder (ASD) and Alzheimer's disease (AD) are two different neurological disorders that share common clinical features, such as language impairment, executive functions, and motor problems. A genetic convergence has been proposed as well. However, the molecular mechanisms of these pathologies are still not well understood. Read More

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September 2021

Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins.

Cell Death Discov 2020 Sep 18;6(1):90. Epub 2020 Sep 18.

Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978, Israel.

The canonical function of Bcl-2 family proteins is to regulate mitochondrial membrane integrity. In response to apoptotic signals the multi-domain pro-apoptotic proteins Bax and Bak are activated and perforate the mitochondrial outer membrane by a mechanism which is inhibited by their interaction with pro-survival members of the family. However, other studies have shown that Bax and Bak may have additional, non-canonical functions, which include stress-induced nuclear envelope rupture and discharge of nuclear proteins into the cytosol. Read More

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September 2020

Gestational Weight Gain Influences the Adipokine-Oxidative Stress Association during Pregnancy.

Obes Facts 2021 Sep 14:1-9. Epub 2021 Sep 14.

Research Division, Instituto Nacional de Perinatologia, Mexico City, Mexico.

Introduction And Objective: The weight gained during pregnancy could determine the immediate and future health of the mother-child dyad. Excessive gestational weight gain (EGWG) due to abnormal adipose tissue (AT) accumulation is strongly associated with adverse perinatal outcomes as gestational diabetes, macrosomia, obesity, and hypertension further in life. Dysregulation of adipokine, AT dysfunction, and an imbalance in the prooxidant-antioxidant systems are critical features in altered AT accumulation. Read More

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September 2021

DDX3X and DDX3Y are redundant in protein synthesis.

RNA 2021 Sep 17. Epub 2021 Sep 17.

University of California, San Francisco;

DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X- and Y-linked paralogs DDX3X and DDX3Y. While DDX3X is ubiquitously expressed in human tissues and essential for viability, DDX3Y is male-specific and shows lower and more variable expression than DDX3X in somatic tissues. Heterozygous genetic lesions in DDX3X mediate a class of developmental disorders called DDX3X syndrome, while loss of DDX3Y is implicated in male infertility. Read More

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September 2021

Compound heterozygous mutations in the LTBP2 gene associated with microspherophakia in a Chinese patient: a case report and literature review.

BMC Med Genomics 2021 Sep 17;14(1):227. Epub 2021 Sep 17.

Research Laboratory of Ophthalmology and Vision Sciences, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, 610000, Sichuan Province, China.

Background: Microspherophakia (MSP, OMIM 251,750) is a rare inherited autosomal recessive eye disorder characterized by small spherically shaped lens. Several studies have indicated that the transforming growth factor-beta (TGF-beta) binding proteins(LTBP2) gene mutation is the predominant cause of MSP. In our study, novel compound heterozygous mutations in the LTBP2 gene associated with MSP were reported, which was different from previous reported homozygous mutations. Read More

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September 2021

Dairy protein intake is inversely related to development of non-alcoholic fatty liver disease.

Clin Nutr 2021 Aug 25;40(10):5252-5260. Epub 2021 Aug 25.

Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Gyeonggi-do, 16995, Republic of Korea. Electronic address:

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is closely related to metabolic dysfunction, including insulin resistance, obesity, and metabolic syndrome. Dairy protein, rich in casein and whey protein, could help to reduce metabolic diseases. Therefore, we investigated the relationship between dairy protein intake and incident NAFLD. Read More

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Expanding the toolbox of exosome-based modulators of cell functions.

Biomaterials 2021 Sep 12;277:121129. Epub 2021 Sep 12.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, 90089, USA; Department of Chemistry, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, 90089, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90089, USA; Research Center for Liver Diseases, University of Southern California, Los Angeles, CA, 90089, USA. Electronic address:

Exosomes are cell-derived extracellular vesicles and play important roles in mediating intercellular communications. Due to their unique advantages in transporting a variety of biomolecules, exosomes have been emerging as a new class of nanocarriers with great potential for therapeutic applications. Despite advancements in loading chemotherapeutics and interfering RNAs into exosomes, active incorporation of protein molecules into exosomes remains challenging owing to their distinctive physicochemical properties and/or a lack of knowledge of cargo sorting during exosome biogenesis. Read More

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September 2021

The largest isoform of Ankyrin-G is required for lattice structure of the axon initial segment.

Biochem Biophys Res Commun 2021 Sep 8;578:28-34. Epub 2021 Sep 8.

State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing, 100871, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China. Electronic address:

Alzheimer's disease (AD) is the most frequent neurodegenerative disease and a common dementia in elderly individuals. Previous studies found a strong correlation between axon initial segment (AIS) defects and AD, but it remains unclear whether AD itself changes the arrangement of AIS components, and the mechanisms by which adaptor proteins and ion channels in the AIS are disturbed in AD are not well understood. With super-resolution structured illumination microscopy (SIM) revealing axonal structures, here we imaged the lattice structure of completely assembled AIS in APP/PS1 neurons. Read More

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September 2021

BORIS/CTCFL expression activates the TGFβ signaling cascade and induces Drp1 mediated mitochondrial fission in neuroblastoma.

Free Radic Biol Med 2021 Sep 14. Epub 2021 Sep 14.

Department of Applied Biology, CSIR- Indian Institute of Chemical Technology (IICT), Tarnaka, Hyderabad, 50007, India. Electronic address:

The cancer-testis antigen CTCFL/BORIS (Brother of Regulator of Imprinted Sites) also known, as a paralog of CTCF -the "master weaver of the genome" is a key transcriptional regulator. Both CTCF and BORIS can bind to the same promoter sequence and recruit diverse proteins. BORIS is also known to be associated with actively translating ribosomes suggesting new roles of BORIS in gene expression. Read More

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September 2021

Genome-wide analysis of the MYB-related transcription factor family and associated responses to abiotic stressors in Populus.

Int J Biol Macromol 2021 Sep 14. Epub 2021 Sep 14.

Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, China; National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China. Electronic address:

MYB proteins are one of the most abundant transcription factor families in the plant kingdom. Evidence has increasingly revealed that MYB-related proteins function in diverse plant biological processes. However, little is known about the genome-wide characterization and functions of MYB-related proteins in Populus, an important model and commercial tree species. Read More

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September 2021

COPII Sec23 proteins form isoform-specific endoplasmic reticulum exit sites with differential effects on polarized growth.

Plant Cell 2021 Sep 17. Epub 2021 Sep 17.

Department of Biological Sciences, Dartmouth College, Hanover, NH.

COPII, a coat protein complex that forms vesicles on the endoplasmic reticulum (ER), mediates trafficking to the Golgi. While metazoans have few genes encoding each COPII component, plants have expanded these gene families, leading to the hypothesis that plant COPII has functionally diversified. In the moss Physcomitrium (Physcomitrella) patens, the Sec23/24 gene families are each composed of seven genes. Read More

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September 2021

Insm1, Neurod1, and Pax6 promote murine pancreatic endocrine cell development through overlapping yet distinct RNA transcription and splicing programs.

G3 (Bethesda) 2021 Aug 26. Epub 2021 Aug 26.

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.

Insm1, Neurod1, and Pax6 are essential for the formation and function of pancreatic endocrine cells. Here, we report comparative immunohistochemical, transcriptomic, functional enrichment, and RNA splicing analyses of these genes using gene knock-out mice. Quantitative immunohistochemical analysis confirmed that elimination of each of these three factors variably impairs the proliferation, survival, and differentiation of endocrine cells. Read More

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MiR-200c-3p maintains stemness and proliferative potential in adipose-derived stem cells by counteracting senescence mechanisms.

PLoS One 2021 17;16(9):e0257070. Epub 2021 Sep 17.

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Adipose-derived mesenchymal stem cells (ASCs) are promising therapeutic tools in regenerative medicine because they possess self-renewal, differentiation and immunomodulatory capacities. After isolation, ASCs are passaged multiple times in vitro passages to obtain a sufficient amount of cells for clinical applications. During this time-consuming procedure, ASCs become senescent and less proliferative, compromising their clinical efficacy. Read More

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September 2021

Altered expression of junctional proteins as a potential biomarker in oral precancerous and cancerous patients.

Tissue Barriers 2021 Sep 17. Epub 2021 Sep 17.

Department of E.N.T., Silchar Medical College and Hospital, Silchar, Ghungoor, Assam, India.

Due to a lower survival rate in patients with advanced clinical stages of oral cancer, discovering a biomarker that could diagnose and predict disease progression is vital. Cell-cell junctional proteins play a crucial role in the maintenance of tissue architecture but are often deregulated in different cancer. The present study investigates the expression of cell-cell junctional proteins : e-cadherin (E-cad) and zonula occludens-1 (ZO-1) in oral precancerous (OED) and cancerous (OSCC) patients to monitor if they can serve as practicable molecular markers. Read More

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September 2021

Extracellular Matrix Proteome Remodeling in Human Glioblastoma and Medulloblastoma.

J Proteome Res 2021 Sep 17. Epub 2021 Sep 17.

Parasitology Department, Instituto de Ciências Biomédicas (ICBUSP), Universidade de Sao Paulo, Sao Paulo, Sao Paulo 05508-000, Brazil.

Medulloblastomas (MBs) and glioblastomas (GBMs) are high-incidence central nervous system tumors. Different origin sites and changes in the tissue microenvironment have been associated with the onset and progression. Here, we describe differences between the extracellular matrix (ECM) signatures of these tumors. Read More

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September 2021

Controlling gene expression in mammalian cells using multiplexed conditional guide RNAs for Cas12a.

Angew Chem Int Ed Engl 2021 Sep 17. Epub 2021 Sep 17.

Technische Universitat Munchen, Physik-Department E14 and ZNN/WSI, Am Coulombwall 4a, 85748, Garching, GERMANY.

Spatiotemporal control of the activity of CRISPR-associated (Cas) proteins is of considerable interest for basic research and therapeutics. Here, we show that conditional guide RNAs (gRNAs) for Cas12a can be transcribed in mammalian cells by RNA polymerase II, followed by activation via input-dependent processing of the 3' tail of the gRNA transcript. We demonstrate processing using an RNA strand displacement mechanism, as well as microRNA-dependent processing, and cleavage by a guanine-responsive ribozyme. Read More

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September 2021

Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets.

J Cell Physiol 2021 Sep 17. Epub 2021 Sep 17.

Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi, India.

Glioblastoma (GBM) is the most aggressive, malignant, and therapeutically challenging Grade IV tumor of the brain. Although the possibility of distant metastasis is extremely rare, GBM is known to cause intracranial metastasis forming aggressive secondary lesions resulting in a dismal prognosis. Metastasis also plays an important role in tumor dissemination and recurrence making GBM largely incurable. Read More

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September 2021

Whole genome sequencing of Enterobacter mori, an emerging pathogen of kiwifruit and the potential genetic adaptation to pathogenic lifestyle.

AMB Express 2021 Sep 17;11(1):129. Epub 2021 Sep 17.

State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

Members of the Enterobacter genus are gram-negative bacteria, which are used as plant growth-promoting bacteria, and increasingly recovered from economic plants as emerging pathogens. A new Enterobacter mori strain, designated CX01, was isolated as an emerging bacterial pathogen of a recent outbreak of kiwifruit canker-like disease in China. The main symptoms associated with this syndrome are bleeding cankers on the trunk and branch, and brown leaf spots. Read More

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September 2021