Kidney Int 2022 Jun 29. Epub 2022 Jun 29.
The University of Arizona R. Ken Coit College of Pharmacy, Skaggs Pharmaceutical Sciences Center, 1703 E. Mabel St. 85721, Tucson, AZ. USA; The University of Arizona College of Medicine, 501 N Campbell Ave. 85724, Tucson, AZ. USA; The University of Arizona, BIO5 Institute, 1657 E Helen St. 85719, Tucson, AZ. USA; Southern Arizona VA Health Care System, USA. Electronic address:
The β adrenergic receptor agonist, formoterol, is an inducer of mitochondrial biogenesis and restorer of mitochondrial and kidney function in acute and chronic models of kidney injury. Unfortunately, systemic administration of formoterol has the potential for adverse cardiovascular effects, increased heart rate, and decreased blood pressure. To minimize these effects, we developed biodegradable and biocompatible polymeric nanoparticles containing formoterol that target the kidney, thereby decreasing the effective dose, and lessen cardiovascular effects while restoring kidney function after injury. Read More