45,974 results match your criteria protein crp

Pre-hemodialysis hyponatremia and extracellular water -is it simply too much water ?

Ther Apher Dial 2021 May 7. Epub 2021 May 7.

UCL Department of Nephrology, University College London, London, NW3 2PF.

Background: Observational hemodialysis (HD) studies report an association between hyponatremia and increased mortality. As volume overload is also associated with mortality, we wished to determine whether hyponatremia is linked to increased extracellular water (ECW).

Methods: We measured ECW, total body water (TBW) and body composition pre- dialysis with multifrequency bioimpedance, arm strength with pinch guage and hand grip strength (PS, HGS), standard biochemistry profiles, comorbidity and clinical frailty scores (CFS). Read More

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Elabela as a novel marker: Well-correlated with WIfI amputation risk score in lower extremity arterial disease patients.

Anatol J Cardiol 2021 May;25(5):330-337

Department of Cardiology, Faculty of Medicine, Gaziantep University; Gaziantep-Turkey.

Objective: Worldwide, over 200 million people are diagnosed with lower extremity arterial disease (LEAD). LEAD significantly increases the risk of death and amputation of the lower limb. A new classification system (WIfI) has been proposed to initially assess all patients with ischemic rest pain or wounds and also predicts 1-year amputation risk. Read More

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Systemic immune inflammation index: a novel predictor for coronary collateral circulation.

Perfusion 2021 May 7:2676591211014822. Epub 2021 May 7.

Department of Cardiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Aim: Recently, a new inflammatory and prognostic marker has emerged called as Systemic Immune Inflammation Index (SII). In the current study, we searched the relation between SII and Coronary Collateral Circulation (CCC) formation in stable Coronary Artery Disease (CAD).

Materials & Methods: 449 patients with stable CAD who underwent coronary angiography and documented coronary stenosis of 95% or more in at least one major coronary vessel were included in the study. Read More

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Effects of Vitamin D Supplementation on Cardiovascular and Glycemic Biomarkers.

J Am Heart Assoc 2021 May 7:e017727. Epub 2021 May 7.

Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.

Background Experimental and observational studies have suggested a link between vitamin D and cardiovascular and metabolic disease, but this has not been confirmed in randomized controlled trials. We sought to determine whether vitamin D supplementation reduces biomarkers of insulin resistance, inflammation, neurohormonal activation, and lipids. Methods and Results This was a prespecified, secondary analysis of the DAYLIGHT (Vitamin D Therapy in Individuals at High Risk of Hypertension) randomized controlled trial. Read More

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The Angiopoietin-like protein 4: a promising biomarker to distinguish brucella spondylitis from tuberculous spondylitis.

Clin Rheumatol 2021 May 6. Epub 2021 May 6.

Medical Imaging Center, Xinjiang Medical University Affiliated First Hospital, Urumqi, 830054, People's Republic of China.

Objective: The Angiopoietin-like protein 4 (ANGPTL-4) has been proved to be a protein associated with multiple inflammatory responses. Nevertheless, whether it contributes to distinguishing brucella spondylitis (BS) from tuberculous spondylitis (TS) remains an open question. Our study aim is to explore the capability of the ANGPTL-4 to differentiating BS from TS. Read More

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C1QTNF6 participates in the pathogenesis of PCOS by affecting the inflammatory response of granulosa cells.

Biol Reprod 2021 May 6. Epub 2021 May 6.

Reproductive Medical Center, Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan 430060, China.

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease. It has been reported that chronic low-grade inflammation might participate in its pathogenesis. C1q and TNF related 6 (C1QTNF6) is a newly identified adiponectin paralog associated with inflammation. Read More

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Fibrin-Platelet Clots in Acute Ischemic Stroke. Predictors and Clinical Significance in a Mechanical Thrombectomy Series.

Front Neurol 2021 20;12:631343. Epub 2021 Apr 20.

Department of Neurology, Hospital General Universitario de Albacete, Albacete, Spain.

The histological composition of the clot influences its mechanical properties, affects the efficacy of endovascular treatment (EVT), and could determine the clinical outcome of patients with acute ischemic stroke (AIS). Insights into clot composition may guide therapeutic decision-making prior to EVT and facilitate revascularization therapies. Consecutive patients with AIS recorded in a prospective single-center reperfusion registry from December 2015 to December 2019 and treated with EVT were included. Read More

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Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis.

Drug Des Devel Ther 2021 30;15:1779-1795. Epub 2021 Apr 30.

The Department of Cardiovascular Disease, Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, Guangdong, People's Republic of China.

Background: This study used network pharmacology, molecular docking and experimental validation to assess the effects of Huanglian Jiedu Decoction (HLJDD) on atherosclerosis (AS).

Methods: The components and targets of HLJDD were analyzed using the Traditional Chinese Medicine Systems Pharmacology database, and information on the genes associated with AS was retrieved from the GeneCards and OMIM platforms. Protein-protein interactions were analyzed using the STRING platform. Read More

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Surgical stress and metabolic response after totally laparoscopic right colectomy.

Sci Rep 2021 May 6;11(1):9652. Epub 2021 May 6.

Department Clinical Medicine and Surgery, Federico II University of Naples, Via Pansini 5, 80131, Naples, Italy.

No clear consensus on the need to perform an intracorporeal anastomosis (IA) after laparoscopic right colectomy is currently available. One of the potential benefits of intracorporeal anastomosis may be a reduction in surgical stress. Herein, we evaluated the surgical stress response and the metabolic response in patients who underwent right colonic resection for colon cancer. Read More

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A community-based randomized controlled trial providing weekly iron-folic acid supplementation increased serum- ferritin, -folate and hemoglobin concentration of adolescent girls in southern Ethiopia.

Sci Rep 2021 May 6;11(1):9646. Epub 2021 May 6.

Center for Food Science and Nutrition, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Adequate micronutrient status during adolescence can break the inter-generational cycle of malnutrition. This study evaluated the effect of community-based weekly iron-folic acid supplementation (WIFAS) on serum ferritin (SF), serum folate (SFol) and hemoglobin concentration (Hb) among adolescent girls. A community-based, individually randomized-controlled trial (RCT) was conducted in four villages of Wolaita and Hadiya zones. Read More

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The Development of Posttraumatic Stress Disorder and Depression Symptoms in Iraqi Refugees: Associations with Acculturation and C-reactive Protein.

J Nerv Ment Dis 2021 May 5. Epub 2021 May 5.

Department of Psychology, Wayne State University, Detroit Department of Family Medicine, College of Human Medicine, Michigan State University, Grand Rapids Institute of Environmental Health Sciences Department of Food and Nutrition Science, Wayne State University, Detroit, Michigan.

Abstract: Refugees experience distress from premigration trauma, often exacerbated by postmigration difficulties. To develop effective interventions, risk factors for mental health symptoms need to be determined. Male Iraqi refugees (N = 53) to the United States provided background information and reported predisplacement trauma and psychological health within 1 month of their arrival. Read More

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Clinical impact of blood pressure variability in patients with COVID-19 and hypertension.

Blood Press Monit 2021 May 6. Epub 2021 May 6.

Division of Cardiology Division of Pulmonology and Allergy Division of Rheumatology and Infectious Disease, Department of Internal Medicine, Yeungnam University Medical Center, Daegu, Republic of Korea.

Objective: This study aimed to investigate the relationship between blood pressure variability (BPV) and clinical outcomes in patients with coronavirus disease 2019 (COVID-19) and hypertension.

Methods: A total of 136 patients hospitalized with COVID-19 were enrolled in this study. Patients were grouped according to the presence of hypertension and BPV. Read More

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Clinical and laboratory prognosticators of atrophic papulosis (Degos disease): a systematic review.

Orphanet J Rare Dis 2021 May 6;16(1):203. Epub 2021 May 6.

Department of Dermatology, The Hospital for Sick Children, Toronto, ON, Canada.

Background: Degos disease is a rare vascular disorder with a cutaneous-limited form, benign atrophic papulosis (BAP), and a systemic variant, malignant atrophic papulosis (MAP). Despite the poor prognosis of MAP, no study has established features associated with systemic disease.

Objectives: The aims of this systematic review were to: (1) summarize clinical features and treatments implemented for patients with MAP and BAP (2) identify clinical and laboratory factors associated with the development of MAP, compared to BAP. Read More

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Circulating PD-L1 levels change during bevacizumab-based treatment in recurrent glioma.

Cancer Immunol Immunother 2021 May 6. Epub 2021 May 6.

Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria.

Purpose: In primary brain tumors, the efficacy of immune-modulating therapies is still under investigation as inflammatory responses are restricted by tight immunoregulatory mechanisms in the central nervous system. Here, we measured soluble PD-L1 (sPD-L1) in the plasma of patients with recurrent glioblastoma (GBM) and recurrent WHO grade II-III glioma treated with bevacizumab-based salvage therapy.

Methods: Thirty patients with recurrent GBM and 10 patients with recurrent WHO grade II-III glioma were treated with bevacizumab-based salvage therapy at the Medical University of Vienna. Read More

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Long-term impact of high-sensitivity C-reactive protein in patients with intermittent claudication due to peripheral artery disease following endovascular treatment.

Heart Vessels 2021 May 6. Epub 2021 May 6.

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Little is known about the prognostic impact of high-sensitivity C-reactive protein (hs-CRP) levels on causes of death during long-term follow-up. We, therefore, investigated the associations between hs-CRP and clinical outcomes in the patients with intermittent claudication. Three hundred thirty-five consecutive patients (mean age, 72 ± 8 years, 82% men) undergoing first intervention for de novo iliac and/or femoropopliteal artery lesions from 2009 to 2020 were studied. Read More

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A virtual reality meditative intervention modulates pain and the pain neuromatrix in patients with opioid use disorder.

Pain Med 2021 May 6. Epub 2021 May 6.

Department of Psychiatry and Behavioral Neurosciences, Wayne State University.

Objective: Standard-of-care for opioid use disorder (OUD) includes medication and counseling. However, there is an unmet need for complementary approaches to treat OUD patients coping with pain; furthermore, few studies have probed neurobiological features of pain or its management during OUD treatment. This preliminary study examines neurobiological and behavioral effects of a virtual reality-based meditative intervention in patients undergoing methadone maintenance treatment (MMT). Read More

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Application of Oblique Lateral Interbody Fusion in Treatment of Lumbar Spinal Tuberculosis in Adults.

Orthop Surg 2021 May 6. Epub 2021 May 6.

Department of Orthopaedic Surgery, Zhongshan Hospital Fudan University, Shanghai, China.

Objective: The purpose of the present paper was to evaluate the safety and clinical efficacy of mini-open retroperitoneal oblique lumbar interbody fusion (OLIF) for the treatment of lumbar spinal tuberculosis.

Methods: A total of 115 patients who suffered from lumbar spinal tuberculosis from June 2014 to December 2017 were included in this research. A total of 59 patients underwent OLIF and percutaneous pedicle screw fixation (OLIF group) and 56 patients underwent the anterior-only approach (anterior-only group). Read More

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The effect of RAAS inhibitors on acute hypoxemic respiratory failure and in-hospital mortality in the hypertensive Covid-19 patients.

Clin Exp Hypertens 2021 May 6:1-10. Epub 2021 May 6.

Department of Cardiology, University of Health Sciences Diyarbakır Gazi Yaşargil Education and Research Hospital, Diyarbakır, Turkey.

Introduction: We have aimed to investigate the relationship between use of angiotensin-converting-enzyme inhibitor (ACEI) or angiotensin-receptor-blocker (ARB) drugs and acute hypoxemic respiratory failure (AHRF) and in-hospital mortality in hypertensive Covid-19 patients.

Material And Method: Consecutive 1345 patients diagnosed with Covid-19 between April and October 2020 who met inclusion criteria were divided into two groups based on presence and absence of AHRF and mortality. The groups were compared regarding epidemiological, clinical, radiological, laboratory findings and treatments methods. Read More

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Cumulative perioperative lymphocyte/C-reactive protein ratio as a predictor of the long-term outcomes of patients with colorectal cancer.

Surg Today 2021 May 5. Epub 2021 May 5.

Department of Genomic Medicine, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Purpose: Systemic inflammatory response influences cancer development and perioperative surgical stress can affect the survival of patients with colorectal cancer (CRC). We developed a system to cumulatively assess perioperative inflammatory response and compare the prognostic value of various cumulative inflammatory and nutritional markers in patients with CRC.

Methods: We assessed perioperative cumulative markers using the trapezoidal area method in 307 patients who underwent surgery for CRC and analyzed the results statistically. Read More

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Laparoscopic left hemihepatectomy combined with right lateral hepatic lobectomy in pigs: surgical approach and comparative study of the inflammatory response versus open surgery.

Vet Res Forum 2021 15;12(1):1-6. Epub 2021 Mar 15.

Department of Animal Science, College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.

This study describes a left hemihepatectomy combined with a right lateral hepatic lobectomy. It compares the inflammatory response associated with laparoscopic hepatectomy (LH group, n = 7) with conventional open hepatectomy (OH group, n = 7). Blood was collected before surgery as well as 1, 2, 3, 5, and 7 days after surgery to determine the white blood cell count and levels of serum cortisol (COR), interleukin-6 (IL-6), and C-reactive protein (CRP). Read More

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A Network Pharmacology Study Based on the Mechanism of Citri Reticulatae Pericarpium-Pinelliae Rhizoma in the Treatment of Gastric Cancer.

Evid Based Complement Alternat Med 2021 16;2021:6667560. Epub 2021 Apr 16.

Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

Objective: To explore the mechanism of action of Citri Reticulatae Pericarpium-Pinelliae Rhizoma (CRP-PR) in treating gastric cancer (GC) by using pharmacology network.

Methods: Based on oral bioavailability and drug-likeness, the main active components of CRP-PR were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). DisGeNET Database was used to establish target databases for GC. Read More

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Long pentraxin PTX3 is upregulated systemically and centrally after experimental neurotrauma, but its depletion leaves unaltered sensorimotor deficits or histopathology.

Sci Rep 2021 May 5;11(1):9616. Epub 2021 May 5.

Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy.

Long pentraxin PTX3, a pattern recognition molecule involved in innate immune responses, is upregulated by pro-inflammatory stimuli, contributors to secondary damage in traumatic brain injury (TBI). We analyzed PTX3 involvement in mice subjected to controlled cortical impact, a clinically relevant TBI mouse model. We measured PTX3 mRNA and protein in the brain and its circulating levels at different time point post-injury, and assessed behavioral deficits and brain damage progression in PTX3 KO mice. Read More

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Metabolic Properties of Lowdensity Lipoprotein (LDL) Triglycerides in Patients with Type 2 Diabetes, Comparison with Small Dense LDL-Cholesterol.

J Atheroscler Thromb 2021 Apr 29. Epub 2021 Apr 29.

R&D Department, Denka Co., Ltd.

Aims: Abnormal compositional changes in low-density lipoprotein (LDL) particles, such as triglyceride (TG) enrichment and size reduction, are common in patients with diabetes. Several cohort studies have demonstrated that LDL-TG and sdLDL-cholesterol (C) are sensitive biomarkers for predicting atherosclerotic cardiovascular diseases beyond LDL-C. Although sdLDL has been extensively studied, little is known about the properties of LDL-TG. Read More

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Atorvastatin Reduces Circulating S100A12 Levels in Patients with Carotid Atherosclerotic Plaques - A Link with Plaque Inflammation.

J Atheroscler Thromb 2021 May 1. Epub 2021 May 1.

Division of Anti-aging and Vascular Medicine, Department of Internal Medicine, National Defense Medical College.

Aims: Inflammation is involved in various processes of atherosclerosis development. Serum C-reactive protein (CRP) levels, a predictor for cardiovascular risk, are reportedly reduced by statins. However, several studies have demonstrated that CRP is a bystander during atherogenesis. Read More

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Early 1,25-Dihydroxyvitamin D Supplementation Effectively Lowers the Incidence of Type 2 Diabetes Mellitus via Ameliorating Inflammation In KK-A Mice.

J Nutr Sci Vitaminol (Tokyo) 2021 ;67(2):84-90

Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University.

Few studies have been performed to investigate the effect of vitamin D supplementation and T2DM in type 2 diabetic animal models. The present study aimed to explore the relationship between early 1,25-dihydroxyvitamin D [1,25(OH)D] and the incidence of T2DM and determine whether early 1,25(OH)D supplementation was associated with inflammation in KK-A mice. The KK-A mice were divided into 4 vitamin D treatment groups, the low-dose vitamin D supplementation group (VDS-L, 1. Read More

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January 2021

Proteomic analysis of human frontal and temporal cortex using iTRAQ-based 2D LC-MS/MS.

Chin Neurosurg J 2021 May 5;7(1):27. Epub 2021 May 5.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 West Road, South Fourth Ring Road, Beijing, 100070, China.

Background: The human brain is the most complex organ in the body, and it is important to have a better understanding of how the protein composition in the brain regions contributes to the pathogenesis of associated neurological disorders.

Methods: In this study, a comparative analysis of the frontal and temporal cortex proteomes was conducted by isobaric tags of relative and absolute quantification (iTRAQ) labeling and two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS). Brain protein was taken from relatively normal tissue that could not be avoided of damage during emergent surgery of the TBI (traumatic brain injury) patients admitted in Beijing Tiantan Hospital from 2014 to 2017. Read More

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Bipolar disorder: an association of body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation.

Trends Psychiatry Psychother 2021 May 4. Epub 2021 May 4.

Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre (HCPA). Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Departamento de Psiquiatria e Medicina Legal da Universidade Federal do Rio Grande do Sul, Brazil.

Objective: To investigate body mass index (BMI) associations with white matter fractional anisotropy (FA) and C-reactive protein (CRP) in individuals with bipolar disorder (BD) during euthymia in comparison with a control group of healthy subjects (CTR).

Methods: The sample consisted of 101 individuals (BD n=35 and CTR n=66). Regions of interest (ROI) were defined through machine learning approach. Read More

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Genetically determined elevated C-reactive protein associated with primary colorectal cancer risk: Mendelian randomization with lifestyle interactions.

Am J Cancer Res 2021 15;11(4):1733-1753. Epub 2021 Apr 15.

Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, CA 90095, USA.

Systemic inflammation-related etiologic pathways via inflammatory cytokines in the development of colorectal cancer (CRC) have not been convincingly determined and may be confounded by lifestyle factors or reverse causality. We investigated the genetically predicted C-reactive protein (CRP) phenotype in the potential causal pathway of primary CRC risk in postmenopausal women in a Mendelian randomization (MR) framework. We employed individual-level data of the Women's Health Initiative Database for Genotypes and Phenotypes Study, which consists of 5 genome-wide association (GWA) studies, including 10,142 women, 737 of whom developed primary CRC. Read More

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Serum C-Reactive Protein Is Negatively Associated With Olfactory Identification Ability in Older Adults.

Iperception 2021 Mar-Apr;12(2):20416695211009928. Epub 2021 Apr 14.

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden.

Importance: Olfactory deficits are common in aging and associated with several conditions linked to inflammation. A few studies suggest that increased concentration of pro-inflammatory biomarkers may be related to olfactory deficits, but these associations are understudied in population-based samples.

Objective: To investigate the association between serum concentrations of C-reactive protein (CRP) and olfactory identification level as well as rate of change in aging. Read More

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Serum-derived extracellular vesicles inhibit osteoclastogenesis in active-phase patients with SAPHO syndrome.

Ther Adv Musculoskelet Dis 2021 16;13:1759720X211006966. Epub 2021 Apr 16.

State Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, No. 5 Dong Dan San Tiao, Beijing, 100005, China.

Objective: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disorder and the underlying pathogenesis is unclear. In this study, 88 SAPHO patients and 118 healthy controls were recruited to investigate the role of serum-derived extracellular vesicles (SEVs) in SAPHO syndrome.

Methods: Quantitative proteomics was applied for SEVs proteome identification, and ELISA and Western blotting was performed to verify the results of mass spectrum data. Read More

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