28,865 results match your criteria prostatic hyperplasia

Re: Water Vapor Thermal Therapy to Alleviate Catheter-dependent Urinary Retention Secondary to Benign Prostatic Hyperplasia.

Eur Urol 2021 Sep 14. Epub 2021 Sep 14.

Department of Urology, Clinic Favoriten, Sigmund Freud Private Medical University, Vienna, Austria. Electronic address:

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September 2021

3-T MRI and clinical validation of ultrasound-guided transperineal laser ablation of benign prostatic hyperplasia.

Eur Radiol Exp 2021 Sep 17;5(1):41. Epub 2021 Sep 17.

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133, Rome, Italy.

Background: Transperineal laser ablation (TPLA) of the prostate is a novel, mini-invasive option for men with lower urinary tract symptoms (LUTS) due to benign prostate hyperplasia (BPH). Our aim was to assess the impact of ultrasound-guided TPLA regarding urodynamic improvement and sexual function, monitoring clinical data, postprocedural complications and imaging findings at 3-T multiparametric magnetic resonance imaging.

Methods: Forty-four patients aged ≥ 50 affected with moderate to severe LUTS (International Prostate Symptoms score ≥ 12) due to benign prostatic obstruction and refractoriness, intolerance or poor compliance to medical therapies underwent US-guided TPLA between May 2018 and February 2020. Read More

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September 2021

Dihydroartemisinin attenuates benign prostatic hyperplasia in rats by inhibiting prostatic epithelial cell proliferation.

Ann Transl Med 2021 Aug;9(15):1246

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Benign prostatic hyperplasia (BPH) is a common urological condition in aging men. While dihydroartemisinin (DHA) exhibits a wide range of pharmacological activities, to date, there have been no studies examining the effects of DHA on BPH.

Methods: An BPH model was constructed in rats via daily subcutaneous injection of testosterone propionate (TP) for 28 consecutive days. Read More

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Combination therapy with curcumin plus tamsulosin and finasteride in the treatment of men with benign prostatic hyperplasia: a single center, randomized control study.

Transl Androl Urol 2021 Aug;10(8):3432-3439

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: To perform a prospective, randomized, single center study to investigate the efficacy of combined use of curcumin, an anti-inflammatory agent, with the best standard management (BSM, tamsulosin and finasteride) in benign prostatic hyperplasia (BPH) patients.

Methods: One hundred and twenty-two consecutive patients were randomized to receive tamsulosin 0.2 mg, finasteride 5 mg, and curcumin 2,250 mg once a day (curcumin + BSM group, n=61) versus tamsulosin 0. Read More

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A randomized placebo-controlled study: Phellodendron Bawei tablets combined with standard management can improve storage symptoms, sleep quality, and medication compliance in patients with benign prostatic hyperplasia compared to placebo with standard management.

Transl Androl Urol 2021 Aug;10(8):3423-3431

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Benign prostatic hyperplasia (BPH) is a common micturition disorder in middle-aged and elderly males, and it is one of the most common urology-related diseases worldwide. However, standard therapeutic drugs (α1-receptor blockers + 5α reductase inhibitors) do not provide anti-inflammatory or anti-infective effects. The Phellodendron Bawei tablet is a proprietary Chinese medicine with anti-inflammatory and anti-infective effects. Read More

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Combination of transurethral resection of the prostate and flexible and rigid ureteroscopy for benign prostatic hyperplasia and ureteral calculus.

Transl Androl Urol 2021 Aug;10(8):3395-3401

Department of Urology Surgery, Hengshui People's Hospital, Hengshui, China.

Background: Combination of transurethral resection of the prostate (TURP) and flexible and rigid ureteroscopy (URS/RIRS) is a successful approach for patients with benign prostatic hyperplasia (BPH) and ureteral calculus (UC), and the sequence is URS/RIRS followed by TURP. This research aims to compare TURP followed by URS/RIRS with URS/RIRS followed by TURP in terms of clinical efficiency and safety.

Methods: From June 2009 to June 2021, 173 patients with BPH and upper urinary tract stones were recruited through the Harrison International Peace Hospital and were divided into intervention (TURP followed by URS/RIRS) and control groups (URS/RIRS followed by TURP). Read More

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N-Myc promotes angiogenesis and therapeutic resistance of prostate cancer by TEM8.

Med Oncol 2021 Sep 14;38(10):127. Epub 2021 Sep 14.

Department of Pathology, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.

Although patients with early localized prostate cancer can survive longer, castration-resistant prostate cancer (CRPC) has gradually emerged with the use of androgen deprivation therapy (ADT). N-Myc and TEM8 play a vital role in the progression of several cancer types. However, the underlying mechanism of how N-Myc and TEM8 promote the progression of prostate cancer remains unclear. Read More

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September 2021

U-shape incision on prostate capsule: New intraperitoneal laparoscopic technique in simple prostatectomy: A case report.

Ann Med Surg (Lond) 2021 Sep 4;69:102787. Epub 2021 Sep 4.

Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: and importance: Laparoscopy is a known technique for simple prostatectomy using intraperitoneal or extraperitoneal approaches. In the present study, a novel method is suggested for easier access to the whole body and even the head of the adenoma.

Case Presentation: This method was performed on 6 patients with prostate hyperplasia. Read More

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September 2021

Association of mycoplasma with prostate cancer: A systematic review and meta-analysis.

Cancer Epidemiol 2021 Sep 10;75:102021. Epub 2021 Sep 10.

Department of Pathology, Botucatu Medical School, Universidade Estadual Paulista, UNESP, Botucatu, São Paulo, Brazil; Division of Infectious Diseases, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Taft Avenue, Manila, Philippines. Electronic address:

Mycoplasmas are emerging sexually transmitted pathogens usually associated with male urinary tract infection, non-gonococcal urethritis (NGU), infertility, and prostate cancer. In this study, we review the evidence linking mycoplasma infection and prostate cancer. We conducted a systematic review and meta-analysis based on PRISMA guidelines. Read More

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September 2021

The Firmicutes/Bacteroidetes ratio of the human gut microbiota is associated with prostate enlargement.

Prostate 2021 Sep 13. Epub 2021 Sep 13.

Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.

Background: The pathophysiology of the prostate enlargement underlying lower urinary tract symptoms is unknown. Meanwhile, the gut microbiota can contribute to various host conditions. We hypothesized that the gut microbiota plays a role in prostate enlargement. Read More

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September 2021

What Is the Interaction between Urine C-Reactive Protein, Prostatic Inflammation, and Doxazosin Treatment in Patients with Benign Prostatic Hyperplasia? A Pilot Study.

Urol Int 2021 Sep 7:1-5. Epub 2021 Sep 7.

Department of Urology, Ankara Numune Research and Training Hospital, University of Health Sciences, Ankara, Turkey.

Introduction: It was aimed to show the relationship between benign prostatic hyperplasia and inflammation by measuring urinary C-reactive protein values before and after alpha-blocker treatment.

Methods: A total of 71 patients with a total prostate-specific antigen <3.5 ng/mL, International Prostate Symptom Score >7, and maximum urinary flow rate <15 mL/s were included in the study. Read More

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September 2021

Increased Sensitivity of Detection of and DNA Fragments in Serum of Prostate Cancer Patients: Optimisation of Diagnostics Using OBBPA-ddPCR.

Cancers (Basel) 2021 Sep 4;13(17). Epub 2021 Sep 4.

Institute of Clinical Chemistry and Laboratory Medicine, Carl Gustav Carus University Hospital, Technische Universität Dresden, Fetscherstr. 74, D-01307 Dresden, Germany.

Identification of aberrant DNA methylation is a promising tool in prostate cancer (PCa) diagnosis and treatment. In this study, we evaluated a two-step method named optimised bias-based preamplification followed by digital PCR (OBBPA-dPCR). The method was used to identify promoter hypermethylation of 2 tumour suppressor genes and in the circulating cell-free DNA (cfDNA) from serum samples of PCa patients ( = 75), benign prostatic hyperplasia (BPH, = 58), and healthy individuals (controls, = 155). Read More

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September 2021

Benign Prostatic Hyperplasia.

Steven A Kaplan

J Urol 2021 Sep 9:101097JU0000000000002218. Epub 2021 Sep 9.

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September 2021

for the treatment of lower urinary tract symptoms due to benign prostatic enlargement: A systematic review and meta-analysis.

Investig Clin Urol 2021 Sep;62(5):520-534

Department of Health Science, Universidad Nacional de La Matanza, San Justo, Buenos Aires, Argentina.

Purpose: To assess the effects of alone or in combination with other phytotherapy compared to placebo in men with LUTS due to benign prostatic enlargement.

Materials And Methods: Following a registered protocol (CRD42021226655), we searched (December 2020) MEDLINE, CENTRAL, Embase, ClinicalTrials.gov, WHO-ICTRP trials platform and other sources with no restrictions on language, publication date or status. Read More

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September 2021

BPA-induced prostatic hyperplasia in vitro is correlated to the unbalanced gene expression of AR and ER in the epithelium and stroma.

Toxicol Ind Health 2021 Sep 5:7482337211042986. Epub 2021 Sep 5.

NHC Key Lab.of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), 70579Pharmacy School of Fudan University, Shanghai, China.

As a typical environmental endocrine disruptor (EED), bisphenol A (BPA) can induce pathological hyperplasia of the prostatic epithelium and stroma. This study concentrates mainly on the effect and underlying mechanisms of BPA on prostatic hyperplasia, which is based on the culture of primary human prostate epithelial cells (HPEpiC) and human prostate fibroblasts (HPrF). In an effect to screen the optimal pro-survival BPA levels, HPEpiC and HPrF were, respectively, exposed to concentration gradients of BPA (10 M-10 M) solution diluted with two corresponding medium and incubated for 72 h at 37°C. Read More

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September 2021

MicroRNA-199b-3p suppresses malignant proliferation by targeting Phospholipase Cε and correlated with poor prognosis in prostate cancer.

Biochem Biophys Res Commun 2021 Oct 28;576:73-79. Epub 2021 Aug 28.

Department of Urology Surgery, The First Affiliated Hospital of Chongqing Medical University.No.1, Youyi Road, Chongqing, 400016, PR China. Electronic address:

Objectives: MicroRNA-199b-3p (miR-199b-3p) plays a crucial role in the malignant development of various cancers, but little known in prostate cancer (PCa). The aim of our study was to demonstrate the function of miR-199b-3p in PCa.

Methods: Quantitative real-time polymerase chain reaction (RT-qPCR) was used to detect miR-199b-3p expression in PCa and benign prostatic hyperplasia (BPH) tissue samples. Read More

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October 2021

Ultrasonographic Features of Hypertrophic Interureteral Cristae in Transabdominal and Transrectal Ultrasonography.

Ultrasound Q 2021 Sep;37(3):244-247

Department of Ultrasound, The Second Hospital of Lanzhou University, Lanzhou, Gansu, China.

Purpose: The aim of this study was to determine the value of transrectal ultrasound in the definitive diagnosis of hypertrophic interureteral cristae and to provide a definitive diagnostic basis for clinical treatment.

Materials And Methods: When the patient's bladder fills moderately, the ultrasound physician uses the transabdominal ultrasound probe to examine the patient's bladder and prostate carefully, focusing on bilateral ureterovesical portals, a cord-like hyperechoic structure visible between the bilateral ureterovesical portals. For further detailed observation, transrectal probe was used to measure the size of Hypertrophic Interureteral Cristae and describe the shape and internal echo. Read More

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September 2021

Experimental ex-vivo performance study comparing a novel, pulsed thulium solid-state laser, chopped thulium fibre laser, low and high-power holmium:YAG laser for endoscopic enucleation of the prostate.

World J Urol 2021 Sep 3. Epub 2021 Sep 3.

Faculty of Medicine, Department of Urology, University of Freiburg-Medical Centre, Hugstetter Str. 55, 79106, Freiburg, Germany.

Purpose: The aim of this study was to compare the enucleation performances of four different types of laser devices in an ex-vivo experiment: a novel, pulsed Tm:YAG solid-state laser evaluation model (p-Tm:YAG), chopped thulium fibre laser (TFL), low-power Ho:YAG laser (LP-Ho:YAG), and a high-power Ho:YAG laser (HP-Ho:YAG).

Methods: Our primary aim was to endoscopically separate the fascial layers of a porcine belly using laser fibres within a time period of 60 s. The size of a "tissue pocket" was assessed numerically. Read More

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September 2021

Integration of quantitative diffusion kurtosis imaging and prostate specific antigen in differential diagnostic of prostate cancer.

Medicine (Baltimore) 2021 Sep;100(35):e27144

Department of Radiology, Yuyao People's Hospital, Yuyao, Zhejiang, China.

Abstract: This study aimed to evaluate the diagnostic performance of diffusion kurtosis imaging (DKI) and prostate-specific antigen (PSA) biomarkers in differentiating prostate cancer (PCa) and benign prostatic hyperplasia (BPH).A total of 43 cases of prostate diseases verified by pathology were enrolled in the present study. These cases were assigned to the BPH group (n = 20, 68. Read More

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September 2021

[A Case of Mucinous Adenocarcinoma Extending to Bladder Neck and Prostate].

Hinyokika Kiyo 2021 Aug;67(8):395-398

The Department of Pathology, Aichi Medecal University Hospital.

A 56-year-old man visited a clinic with the chief complaint of frequent micturition and residual sensation of urine. He was referred to our hospital for close examination. Cystoscopy showed a tumor protruding toward the bladder neck from the prostate with stones and debris on the surface. Read More

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[Analysis of Bladder Tamponade at a Regional Hospital].

Hinyokika Kiyo 2021 Aug;67(8):359-362

The Department of Urology, Takayama Red Cross Hospital.

We retrospectively analyzed 134 patients (male, n=84 ; female, n=50) with bladder tamponade at a regional hospital. The median age was 84.9 years. Read More

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Monopolar Transurethral Resection of Prostate for Benign Prostatic Hyperplasia in Patients With and Without Preoperative Urinary Catheterization: A Prospective Comparative Study.

Cureus 2021 Jul 28;13(7):e16705. Epub 2021 Jul 28.

Urology, National Academy of Medical Sciences, Bir Hospital, Kathmandu, NPL.

Background A significant proportion of patients undergo surgery for benign prostatic hyperplasia following acute urinary retention. Studies have reported conflicting results of improvement following transurethral surgery in these patients. Objective To compare perioperative complications and postoperative voiding parameters in patients undergoing monopolar transurethral resection of prostate with and without preoperative Foley catheterization. Read More

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Robotic Freyer's prostatectomy: Operative technique and single-center experience.

Indian J Urol 2021 Jul-Sep;37(3):247-253. Epub 2021 Jul 1.

Department of Pathology, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, Maharashtra, India.

Introduction: Transurethral resection of prostate replaced open surgery and remained the gold standard in surgical management of benign prostatic hyperplasia (BPH). Holmium laser enucleation and bipolar resection of prostate managed even larger glands. Open simple prostatectomy remains an option for large glands and concurrent pathologies. Read More

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Joint effect between bisphenol A and alcohol consumption on benign prostatic hyperplasia: A case-control study in Hong Kong Chinese males.

Prostate 2021 Aug 31. Epub 2021 Aug 31.

JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.

Background: Whether bisphenol A (BPA) exposure is a contributing factor to benign prostatic hyperplasia (BPH) remains unclear. This study evaluated the association between chronic BPA exposure and BPH risk, and explored whether this association was modified by alcohol drinking.

Methods: This study included a total of 650 BPH cases and 650 controls recruited from the same hospital in Hong Kong during 2011-2016. Read More

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The role of benign prostatic hyperplasia treatments in ejaculatory dysfunction.

Fertil Steril 2021 09;116(3):611-617

Division of Urology, Department of Surgery, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Ejaculatory dysfunction is not only psychologically distressing but can become a significant obstacle for men who wish to conceive. Dysfunction comes in the form of anejaculation, reduced ejaculation, retrograde ejaculation, painful ejaculation, or premature ejaculation. Most treatments for lower urinary tract symptoms related to benign prostatic hyperplasia, which commonly occurs in aging men, carry significant risks of absent, reduced, or retrograde ejaculation. Read More

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September 2021

Iatrogenic male infertility: medical and surgical treatments that impair male fertility.

Mark Sigman

Fertil Steril 2021 09;116(3):609-610

Division of Urology, Warren Alpert Medical School of Brown University and Rhode Island and The Miriam Hospitals, Providence, Rhode Island. Electronic address:

Many medical and surgical treatments result in impaired male fertility. Sometimes impairments are permanent, while other times they may be reversible. Clinicians who treat urologic and nonurologic problems, as well as those of us who treat male and female infertility should understand what treatments affect which aspects of reproduction and what options for management are available. Read More

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September 2021

Aerobic exercises ameliorate benign prostatic hyperplasia via IGF-1/IGF-1R/ERK/AKT signalling pathway in prostate tissue of high-fat-diet-fed mice with insulin resistance.

Steroids 2021 Aug 27;175:108910. Epub 2021 Aug 27.

Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai 200438, China. Electronic address:

This study investigated the changes in the prostate of high-fat diet (HFD)-fed mice with insulin resistance (IR) and explored the possible mechanisms of the effects of 8-week treadmill aerobic exercise on prostatic hyperplasia in insulin-resistant mice through the IGF-1/IGF-1R/ERK/AKT signalling pathway. Results showed IR in mice caused an increase in prostate-related indicators, such as prostate weight (PW) and prostate volume (PV), resulting in prostatic hyperplasia. The area of the glandular lumen and the height of the glandular epithelium in mice with IR were increased, which indicating that it caused prostatic hyperplasia through epithelial cell proliferation. Read More

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Frequent expression of a novel cancer testis antigen, protein kinase human monopolar spindle 1 (hMps1/TTK) in human urinary bladder transitional cell carcinoma.

Drug Discov Ther 2021 Aug 28. Epub 2021 Aug 28.

Department of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Urothelial bladder cancer (UBC) is a frequently occurring malignancy of the urinary tract. The present study was undertaken to evaluate the mRNA and immunohistochemical (IHC) expression of protein kinase human monopolar spindle 1 (hMps1/TTK) gene in transitional cell carcinoma (TCC) of the bladder and correlate its expression with the clinicopathological characteristics of patients. In the present study, quantitative real-time reverse-transcriptase polymerase chain reaction (qRT-PCR) was used to evaluate TTK mRNA expression in TCC. Read More

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[Office-based therapies for benign prostatic hyperplasia : Update on new minimally invasive surgery therapies].

Prog Urol 2021 Aug 26. Epub 2021 Aug 26.

Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Autriche.

Introduction: Several minimally invasive surgical therapies have been developed for the treatment of Lower Urinary Tract Symptoms (LUTS) associated with Benign Prostate Hyperplasia (BPH). The objective was to report an update on these new office-based therapies.

Methods: This simple review is based on the data available in the literature on office-based minimally invasive surgical techniques for treating BPH. Read More

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