30 results match your criteria prospero repository

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The guidelines and policies that influence the conduct of Animal-Assisted Activities in Residential Aged-Care Facilities: A systematic integrative review.

Complement Ther Clin Pract 2021 May 3;44:101395. Epub 2021 May 3.

School of Health, Medical and Applied Science, Central Queensland University, Central Queensland University, 6 University Drive, Branyan Queensland, 4670, Australia. Electronic address:

Introduction: For some time, Residential Aged Care Facilities (RACF) have incorporated animals into their environment to relieve loneliness and isolation for aged-care residents. However, research examining this practice is not as developed. This paper aims to identify the policies and practices influencing the conduct of Animal-Assisted Activities (AAA) in RACF focusing on the Australian context. Read More

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Human mesenchymal stem cells for the management of systemic sclerosis. Systematic review.

Autoimmun Rev 2021 Jun 18;20(6):102831. Epub 2021 Apr 18.

Research Institute, Fundación Universitaria De Ciencias De La Salud, University of Health Sciences, Bogota, Colombia.

Introduction: Sistemic Sclerosis (SSc) is a heterogeneous autoimmune disease with a high rate of progression and therapeutic failure, and treatment is a challenge, new therapeutic proposals being needed, being mesenchymal stem cells (MSCs) considered as alternative therapy for SSc for its immunomodulatory capacity. We evaluated the efficacy and safety of human MSC (hMSC) in patients with SSc through a systematic literature review (SLR).

Methods: SLR (PRISMA guideline) on MEDLINE/OVID, LILACS, EMBASE, and Cochrane/OVID bases (until July 2020, without limits). Read More

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Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers for COVID-19: A living systematic review of randomized clinical trials.

Medwave 2021 Mar 3;21(2):e8105. Epub 2021 Mar 3.

Interdisciplinary Centre for Health Studies (CIESAL), Universidad de Valparaíso, Cochrane Chile Associate Centre, Viña del Mar, Chile. Email: Address: Angamos 655 Reñaca, Viña del Mar, Chile. ORCID: 0000-0002-8095-5549.

Objective: This living systematic review aims to provide a timely, rigorous, and continuously updated summary of the evidence available on the role of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) in the treatment of patients with COVID-19.

Data Sources: We conducted searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature and in a centralized repository in L·OVE (Living OVerview of Evidence), which retrieves articles from multiple sources such as PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, Embase, among other pre-print and protocols repositories. In response to the COVID-19 emergency, L·OVE (Living OVerview of Evidence) was adapted to expand the range of evidence and customized to group all COVID-19 evidence in one place on a daily search basis. Read More

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Cell-based therapies for COVID-19: A living, systematic review.

Medwave 2020 Dec 17;20(11):e8079. Epub 2020 Dec 17.

Hematology and Oncology Department, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; University Hospital, Cleveland Medical Center, Ohio, United States. ORCID: 0000-0002-5485-3944.

Objective: This living, systematic review aims to provide a timely, rigorous, and continuously updated summary of the available evidence on the role of cell-based therapies in the treatment of patients with COVID-19.

Data Sources: We conducted searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature, and in a centralized repository in L·OVE (Living OVerview of Evidence). L·OVE is a platform that maps PICO questions to evidence from the Epistemonikos database. Read More

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December 2020

Exercise training modalities for heart transplant recipients: a systematic review and network meta-analysis protocol.

BMJ Open 2020 12 29;10(12):e044975. Epub 2020 Dec 29.

Graduate Program in Cardiology and Cardiovascular Sciences, Universidade Federal do Rio Grande do Sul, Hospital das Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

Introduction: Heart transplantation is the gold standard treatment for selected patients with end-stage heart failure. Although this procedure can improve quality and prolong life expectancy, several of these patients persist with decreased exercise tolerance. Evidence suggests that exercise training can bring multifactorial benefits to heart transplant (HTx) recipients. Read More

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December 2020

Macrolides for the treatment of COVID-19: a living, systematic review.

Medwave 2020 Dec 14;20(11):e8074. Epub 2020 Dec 14.

Department of Research, Fundación Cardioinfantil, Cochrane Colombia Affiliate Centre, Bogotá, Colombia. Adress: Calle 163A # 13B-60, Bogotá D.C., Colombia. Email: ORCID: 0000-0001-5752-7653.

Objective: This living, systematic review aims to provide a timely, rigorous, and continuously updated summary of the evidence available on the role of macrolides for treating patients with COVID-19.

Design: A living, systematic review.

Database: We conducted searches in the centralized repository L·OVE (Living OVerview of Evidence). Read More

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December 2020

Sexual transmission of SARS-CoV-2 virus and its role in the spread of COVID-19: A living systematic review protocol.

Medwave 2020 Nov 13;20(10):e8062. Epub 2020 Nov 13.

UC Evidence Center, Cochrane Chile Associated Center, Pontificia Universidad Católica de Chile, Santiago, Chile; Epistemonikos Foundation, Santiago, Chile; Internal Medicine Department, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. ORCID: 0000-0003-2435-0710.

Objective: To provide a review of the literature on the presence of SARS-CoV-2 in the sexual fluids of patients with COVID-19 and to observe its possible sexual transmission in a timely, rigorous, and continuously updated manner.

Data Sources: We will conduct searches in PubMed/Medline, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature, and a centralized repository in L·OVE (Living OVerview of Evidence). L·OVE is a platform that maps PICO questions to evidence from the Epistemonikos database. Read More

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November 2020

Adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia: Systematic review and meta-analysis.

PLoS One 2020 10;15(11):e0241811. Epub 2020 Nov 10.

Department of Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Background: The magnitude of adverse birth outcome among diabetic pregnant women is high in low-and-middle income countries, like Ethiopia. Precise epidemiological evidence is necessary to plan, evaluate and improve effective preventive measures. This systematic review and meta-analysis is the first to estimate the pooled prevalence of adverse birth outcome and associated factors among diabetic pregnant women in Ethiopia. Read More

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January 2021

Vitamin C for COVID-19: A living systematic review.

Medwave 2020 Jul 28;20(6):e7978. Epub 2020 Jul 28.

UC Evidence Center, Cochrane Chile Associated Center, Pontificia Universidad Católica de Chile, Santiago, Chile; Fundación Epistemonikos, Santiago, Chile; Internal Medicine Department, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. ORCID: 0000-0003-2435-0710.

Objective: This living systematic review aims to provide a timely, rigorous, and continuously updated summary of the available evidence on the role of vitamin C in treating patients with COVID-19.

Data Sources: We conducted searches in PubMed/MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature, and in a centralized repository in L·OVE (Living OVerview of Evidence). In response to the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it comprises and has been customized to group all COVID-19 evidence in one place. Read More

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Immunization coverage in Ethiopia among 12-23 month old children: systematic review and meta-analysis.

BMC Public Health 2020 Jul 20;20(1):1134. Epub 2020 Jul 20.

Department of Population and Family Health, Institute of Health Sciences, Jimma University, Jimma, Ethiopia.

Background: Immunization is a cost-effective public health strategy. Immunization averts nearly three million deaths annually but immunization coverage is low in some countries and some regions within countries. The aim of this systematic review and meta-analysis is to assess pooled immunization coverage in Ethiopia. Read More

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Women's knowledge towards neonatal danger signs and its associated factors in Ethiopia: a systematic review and meta-analysis.

BMC Pediatr 2020 05 14;20(1):217. Epub 2020 May 14.

Department of Medical Laboratory Sciences, College of Health Sciences, Woldia University, P.O.Box:400, Woldia, Ethiopia.

Introduction: Reducing neonatal mortality is an essential part of the third Sustainable Development Goal, to end preventable child deaths. Neonatal danger signs are the most common cause of neonatal mortality and morbidity. In Ethiopia, most babies are born at home or are discharged from the health institutions in the first 24 h, as a result enhancing women's knowledge towards neonatal danger signs and its complication might reduce neonatal morbidity and mortality. Read More

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Prevalence of hypertension and its risk factors among cotton textile workers in low- and middle-income countries: a protocol for a systematic review.

Syst Rev 2020 05 2;9(1):99. Epub 2020 May 2.

Department of Community Health Sciences, The Aga Khan University, Stadium Road, PO Box 3500, Karachi, 74800, Pakistan.

Background: Cotton workers are exposed to various hazards in the textile industry that might result in different ailments including hypertension (HTN). However, few attempts have been made to systematically review the prevalence of hypertension and its risk factor among cotton textile workers in low-and middle-income countries (LMICs). The objective of this study will be to evaluate the prevalence of hypertension and its risk factors among adult cotton textile workers in low- and middle-income countries. Read More

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Hyperosmolar therapy for acute brain injury: study protocol for an umbrella review of meta-analyses and an evidence mapping.

BMJ Open 2020 02 6;10(2):e033913. Epub 2020 Feb 6.

INCLIVA Health Research Institute, Valencia, Spain

Introduction: Acute brain injury is a challenging public health problem worldwide. Elevated intracranial pressure is a common complication after acute brain injury. Hyperosmolar therapy is one of the main therapeutic strategies for the management of intracranial hypertension. Read More

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February 2020

HIV/AIDS treatment failure and associated factors in Ethiopia: meta-analysis.

BMC Public Health 2020 Jan 20;20(1):82. Epub 2020 Jan 20.

Department of Epidemiology, University of Groningen, Groningen, The Netherlands.

Background: The national burden of human immunodeficiency virus treatment failure and associated factors in the Ethiopian context is required to provide evidence towards a renewed ambitious future goal.

Methods: We accessed Ethiopian Universities' online repository library, Google Scholar, PubMed, Web of Science, and Scopus to get the research articles. We run I-squared statistics to see heterogeneity. Read More

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January 2020

Which public health interventions are effective in reducing morbidity, mortality and health inequalities from infectious diseases amongst children in low-income and middle-income countries (LMICs): protocol for an umbrella review.

BMJ Open 2019 12 29;9(12):e032981. Epub 2019 Dec 29.

Institute of Health & Society / CHAIN, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK.

Introduction: Despite significant progress in the last few decades, infectious diseases remain a significant threat to children's health in low-income and middle-income countries. Effective means of prevention and control for these diseases exist, making any differences in the burden of these diseases between population groups or countries inequitable. Yet, gaps remain in our knowledge of the effect these public health interventions have on health inequalities in children, especially in low-income and middle-income countries. Read More

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December 2019

Intradialytic training in patients with end-stage renal disease: a systematic review and meta-analysis of randomized clinical trials assessing the effects of five different training interventions.

J Nephrol 2020 Apr 21;33(2):251-266. Epub 2019 Dec 21.

Graduate Program in Cardiology and Cardiovascular Sciences, School of Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350-Santa Cecília, Porto Alegre, RS, 90035-003, Brazil.

Objective: Patients with end-stage renal disease (ESRD) undergoing hemodialysis may have reduced dialysis adequacy (Kt/V), low cardiorespiratory fitness, and worse prognosis. Different types of intradialytic training (IDT) may serve as an adjunct therapy for the management of the ESRD. This systematic review and meta-analysis aimed to assess the impact of different types of IDT on clinical outcomes and functional parameters in ESRD. Read More

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A systematic review identifying common data items in neonatal trials and assessing their completeness in routinely recorded United Kingdom national neonatal data.

Trials 2019 Dec 16;20(1):731. Epub 2019 Dec 16.

Neonatal Medicine, School of Public Health, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, SW10 9NH, UK.

Background: We aimed to test whether a common set of key data items reported across high-impact neonatal clinical trials could be identified, and to quantify their completeness in routinely recorded United Kingdom neonatal data held in the National Neonatal Research Database (NNRD).

Methods: We systematically reviewed neonatal clinical trials published in four high-impact medical journals over 10 years (2006-2015) and extracted baseline characteristics, stratification items and potential confounders used to adjust primary outcomes. Completeness was examined using data held in the NNRD for identified data items, for infants admitted to neonatal units in 2015. Read More

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December 2019

Current state of science in machine learning methods for automatic infant pain evaluation using facial expression information: study protocol of a systematic review and meta-analysis.

BMJ Open 2019 12 11;9(12):e030482. Epub 2019 Dec 11.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA

Introduction: Infants can experience pain similar to adults, and improperly controlled pain stimuli could have a long-term adverse impact on their cognitive and neurological function development. The biggest challenge of achieving good infant pain control is obtaining objective pain assessment when direct communication is lacking. For years, computer scientists have developed many different facial expression-centred machine learning (ML) methods for automatic infant pain assessment. Read More

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December 2019

Global knowledge gaps in acute febrile illness etiologic investigations: A scoping review.

PLoS Negl Trop Dis 2019 11 15;13(11):e0007792. Epub 2019 Nov 15.

Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

Background: Acute febrile illness (AFI), a common reason for people seeking medical care globally, represents a spectrum of infectious disease etiologies with important variations geographically and by population. There is no standardized approach to conducting AFI etiologic investigations, limiting interpretation of data in a global context. We conducted a scoping review to characterize current AFI research methodologies, identify global research gaps, and provide methodological research standardization recommendations. Read More

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November 2019

The effect of dose on the antimalarial efficacy of artesunate-mefloquine against malaria: a protocol for systematic review and individual patient data (IPD) meta-analysis.

BMJ Open 2019 06 27;9(6):e027738. Epub 2019 Jun 27.

WorldWide Antimalarial Resistance Network (WWARN), Oxford, UK.

Introduction: Antimalarial posology based on weight bands leaves patients at the margins vulnerable to receiving either lower or higher weight-adjusted (mg/kg) dosages. This article aims to describe the protocol for systematic review and individual patient meta-analysis (MA) for a study of the distribution of artesunate and mefloquine dosage administered in patients with uncomplicated malaria treated with an artesunate-mefloquine (AS-MQ) regimen. Relationship between mg/kg dose and therapeutic outcomes will be assessed through a one-stage individual participant data (IPD) MA. Read More

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Protocol for a systematic review and qualitative synthesis of information quality frameworks in eHealth.

BMJ Open 2019 03 5;9(3):e024722. Epub 2019 Mar 5.

Department of Primary Care and Public Health, Imperial College London, London, UK.

Introduction: Electronic health (eHealth) applications have become a very large repository of health information which informs critical decisions relating to the diagnosis, treatment and prognosis of patients. Poor information quality (IQ) within eHealth may compromise patient safety. Evaluation of IQ in eHealth is therefore necessary to promote patient safety. Read More

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Traditional knowledge-based lifestyle interventions in the prevention of obesity and type 2 diabetes in Indigenous children in Canada: a systematic review protocol.

Syst Rev 2019 03 6;8(1):69. Epub 2019 Mar 6.

Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.

Background: Approximately 50% of all youth-onset type 2 diabetes mellitus (T2DM) in Canada occurs in Indigenous children. In adults, cardiovascular disease is one of the leading causes of mortality in First Nations communities, and diabetes is a significant contributor to the risk of developing this disorder. The early onset of diabetes may predispose these children to premature cardiovascular disease and influence their longevity and quality of life. Read More

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Total energy expenditure in adults aged 65 years and over measured using doubly-labelled water: international data availability and opportunities for data sharing.

Nutr J 2018 03 26;17(1):40. Epub 2018 Mar 26.

Department of Nutrition, Dietetics & Food, Monash University, Level 1, 264 Ferntree Gully Road, Notting Hill, VIC, 3168, Australia.

Background: Increasing population lifespan necessitates a greater understanding of nutritional needs in older adults (65 year and over). A synthesis of total energy expenditure in the older population has not been undertaken and is needed to inform nutritional requirements. We aimed to establish the extent of the international evidence for total energy expenditure (TEE) using doubly-labelled water (DLW) in older adults (65 years and over), report challenges in obtaining primary data, and make recommendations for future data sharing. Read More

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Evaluating characteristics of PROSPERO records as predictors of eventual publication of non-Cochrane systematic reviews: a meta-epidemiological study protocol.

Syst Rev 2018 03 9;7(1):43. Epub 2018 Mar 9.

Department of Dermatology, Reina Sofía University Hospital, Menendez Pidal Ave, 14004, Córdoba, Spain.

Background: Epidemiology and the reporting characteristics of systematic reviews (SRs) and meta-analyses (MAs) are well known. However, no study has analyzed the influence of protocol features on the probability that a study's results will be finally reported, thereby indirectly assessing the reporting bias of International Prospective Register of Systematic Reviews (PROSPERO) registration records.

Objective: The objective of this study is to explore which factors are associated with a higher probability that results derived from a non-Cochrane PROSPERO registration record for a systematic review will be finally reported as an original article in a scientific journal. Read More

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Manual therapy for unsettled, distressed and excessively crying infants: a systematic review and meta-analyses.

BMJ Open 2018 01 24;8(1):e019040. Epub 2018 Jan 24.

Barts and The London School of Medicine and Dentistry, Centre for Primary Care and Public Health, Queen Mary University of London, London, UK.

Objective: To conduct a systematic review and meta-analyses to assess the effect of manual therapy interventions for healthy but unsettled, distressed and excessively crying infants and to provide information to help clinicians and parents inform decisions about care.

Methods: We reviewed published peer-reviewed primary research articles in the last 26 years from nine databases (Medline Ovid, Embase, Web of Science, Physiotherapy Evidence Database, Osteopathic Medicine Digital Repository , Cochrane (all databases), Index of Chiropractic Literature, Open Access Theses and Dissertations and Cumulative Index to Nursing and Allied Health Literature). Our inclusion criteria were: manual therapy (by regulated or registered professionals) of unsettled, distressed and excessively crying infants who were otherwise healthy and treated in a primary care setting. Read More

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January 2018

Effects of computerized decision support system implementations on patient outcomes in inpatient care: a systematic review.

J Am Med Inform Assoc 2018 05;25(5):593-602

Institute of Medical Informatics, University of Münster, Münster, Germany.

Objectives: To systematically classify the clinical impact of computerized clinical decision support systems (CDSSs) in inpatient care.

Materials And Methods: Medline, Cochrane Trials, and Cochrane Reviews were searched for CDSS studies that assessed patient outcomes in inpatient settings. For each study, 2 physicians independently mapped patient outcome effects to a predefined medical effect score to assess the clinical impact of reported outcome effects. Read More

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Systematic review of the effects of iodised salt and iodine supplements on prenatal and postnatal growth: study protocol.

BMJ Open 2015 Apr 23;5(4):e007238. Epub 2015 Apr 23.

Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland.

Introduction: Iodine is an essential micronutrient and component of the thyroid hormones. Sufficient ingestion of iodine is necessary for normal growth and development. If iodine requirements are not met, growth can be impaired. Read More

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