2,476 results match your criteria proptosis visual


Transorbital neuroendoscopic surgery as a mainstream neurosurgical corridor: a systematic review.

World Neurosurg 2021 Apr 30. Epub 2021 Apr 30.

The Loyal and Edith Davis Neurosurgical Research Laboratory, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona. Electronic address:

Background: Transorbital neuroendoscopic surgery (TONES) offers a new level of minimally invasive, minimally disfiguring skull base surgery with maximal surgical visualization.

Methods: This review systematically assesses the body of published anatomical (cadaveric) and clinical evidence for the approach. PubMed, Cochrane Library, Ovid MEDLINE, and EMBASE were systematically searched for publications where the TONES surgical technique was used in an anatomical, clinical, or combined study. Read More

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Successful repair of spontaneous indirect bilateral carotid-cavernous fistula with coil embolization.

J Surg Case Rep 2021 Apr 22;2021(4):rjab140. Epub 2021 Apr 22.

Department of Ophthalmology, Loma Linda University School of Medicine, Loma Linda, CA, USA.

Bilateral carotid-cavernous fistula (CCF) is a rare disease process, which portends poor visual outcome with delayed diagnosis and treatment. An 82-year-old woman presented with sudden onset of proptosis and decreased vision. A complete ophthalmologic examination along with magnetic resonance (MR) imaging of the brain and orbits, and MR angiography and venography of the brain confirmed the diagnosis of bilateral CCF. Read More

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Endoscopic Orbital Decompression for Graves' Orbitopathy - A Vietnam Study.

Clin Ophthalmol 2021 22;15:1685-1690. Epub 2021 Apr 22.

Department of Ophthalmology, Hanoi Medical University, Hanoi, Vietnam.

Purpose: To evaluate the efficacy and safety of endoscopic orbital decompression in patients with Graves' orbitopathy.

Patients And Methods: This is a prospective study in Hanoi Medical University and a Military Hospital from December 2017 to December 2018. Twenty-eight orbits of fifteen patients were undergoing endoscopic orbital decompression for Graves' orbitopathy. Read More

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Modified endoscopic transnasal orbital apex decompression in dysthyroid optic neuropathy.

Eye Vis (Lond) 2021 Apr 28;8(1):19. Epub 2021 Apr 28.

The Eye Hospital of Wenzhou Medical University, No. 270 Xueyuan Xi Road, Wenzhou, Zhejiang, 325027, P. R. China.

Background: To describe the surgical technique and assess the clinical efficacy and safety of modified endoscopic transnasal orbital apex decompression in the treatment of dysthyroid optic neuropathy.

Methods: In this retrospective research, forty-two subjects (74 orbits) who underwent modified endoscopic transnasal orbital apex decompression for the treatment of dysthyroid optic neuropathy were enrolled. Preoperative and postoperative best-corrected visual acuity (BCVA), visual field mean deviation (MD), Hertel exophthalmometry, and new onset diplopia were assessed before and after the intervention. Read More

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Teprotumumab for patients with active thyroid eye disease: a pooled data analysis, subgroup analyses, and off-treatment follow-up results from two randomised, double-masked, placebo-controlled, multicentre trials.

Lancet Diabetes Endocrinol 2021 Apr 15. Epub 2021 Apr 15.

Kellogg Eye Center-Michigan Medicine and University of Michigan, Ann Arbor, MI, USA.

Background: Thyroid eye disease manifests inflammation and treatment-resistant proptosis and diplopia. Teprotumumab, an insulin-like growth factor-1 receptor inhibiting monoclonal antibody, was approved in the USA on Jan 21, 2020, on the basis of two randomised trials. In this analysis we evaluated the short-term and long-term aggregate response to teprotumumab from the two trials, focusing on proptosis and diplopia. Read More

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Oral selenium improved the disease activity in patients with mild Graves' orbitopathy.

J Fr Ophtalmol 2021 Apr 13. Epub 2021 Apr 13.

Instituto de Oftalmologia Conde de Valenciana, IAP, Chimalpopoca # 14, Colonia Obrera, Delegación Cuauhtemoc, 06800, Mexico City, Mexico. Electronic address:

Background: Graves' orbitopathy (GO) is the most common extrathyroidal manifestation of Graves' disease (GD), an autoimmune disorder arising from the activity of T lymphocytes against antigens that infiltrate thyroid tissue, orbital tissue and extraocular muscles. An increase in oxidative stress has been discovered in autoimmune thyroid disease, encouraging investigation into new forms of treatment. Selenium has been described as a treatment option given its antioxidant properties. Read More

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Approach to the Superior Ophthalmic Vein for Endovascular Treatment of Cavernous Dural Fistula.

World Neurosurg 2021 Apr 14;151. Epub 2021 Apr 14.

Department of Neurosurgery, Hospital de Clinicas "Jose de San Martin," University of Buenos Aires School of Medicine, City of Buenos Aires, Buenos Aires, Argentina.

The cavernous sinus area is the second most common location for intracranial dural fistulas. Although these spontaneous dural cavernous fistulas are self-limited, a sizeable number of patients will develop progressive vision loss, diplopia, or intractable glaucoma, which warrant interventional therapy. We present the case of a 54-year-old male with hypertension and type 2 diabetes, who presented with a red right eye associated with progressive exophthalmos, ophthalmoparesis, and deterioration of visual acuity. Read More

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Surgical removal of orbital tumors by orbital approach using ultrasonic surgical system SONOPET®.

Orbit 2021 Apr 16:1-10. Epub 2021 Apr 16.

Ophthalmology Department, 12 de Octubre Hospital, Complutense University, Madrid, Spain.

: Orbital tumor surgery can be challenging when the tumor is located in a very narrow surgical field and close to important structures, such as nerves or extraocular muscles that can be damaged during surgery. Advances in technology and special surgical techniques help to avoid such damage. We describe our experience using SONOPET® ultrasonic surgical aspirator to remove 12 different orbital tumors that were difficult to treat due to their poorly defined borders, adhesions, or location. Read More

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Ocular symptoms as the initial clinical manifestations in patients with extraocular tumors.

Ann Transl Med 2021 Mar;9(6):497

Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.

Background: Due to the variety of clinical presentation, some tumors may be concealed and easily misdiagnosed, leading to delays in management. We report a series of patients who initially presented to an Ophthalmic Clinic with ocular symptoms and were subsequently diagnosed with extraocular tumors.

Methods: Patients who presented to the ophthalmic outpatient clinic at the Joint Shantou International Eye Center with ocular symptoms between April 2013 and December 2019 and were subsequently diagnosed with intracranial or systemic tumors were reviewed retrospectively. Read More

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Rhino-orbital mucormycosis during steroid therapy in COVID-19 patients: A case report.

Eur J Ophthalmol 2021 Apr 10:11206721211009450. Epub 2021 Apr 10.

Depatment of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To report two cases of COVID-19 under treatment with a corticosteroid; in one case rhino-orbitocerebral mucormycosis and in another one rhino-orbital mucormycosis developed.

Case Presentation: A 40-year old woman and a 54-year old man with severe COVID-19 underwent corticosteroid therapy for immune-related lung injuries. The first case presented with a bilateral visual loss and complete ophthalmoplegia of the right eye. Read More

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Compressive optic neuropathy (CON) in Graves' disease caused by hypertrophy of levator and superior rectus muscles: A case report.

Medicine (Baltimore) 2021 Apr;100(14):e25062

Department of Ophthalmology, Osaka Medical College, Osaka, Japan.

Rationale: Enlargemento of the medial rectus is the most predominant factor of compressive optic neuropathy (CON) in Graves' disease. This case report indicates that CON could develop only from the hypertrophic superior levator and superior rectus (SL/SR) muscle in a patient with poorly controlled Graves' disease, and described the possible risk of FT3-thyrotoxicosis with a prominent goiter to develop the current rare case with a review of the literature.

Patient Concerns: A 66-year-old woman undergoing endocrine management of hyperthyroidism with prominent goiter visited the Department of Ophthalmology due to right-eye upper-eyelid retraction. Read More

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Ophthalmic complications of Lemierre syndrome.

Acta Ophthalmol 2021 Apr 8. Epub 2021 Apr 8.

Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland.

Purpose: Lemierre syndrome is a life-threatening condition characterized by head/neck bacterial infection, local suppurative thrombophlebitis and septic embolic complications in a range of sites of distant organs. No prior study focused on the course and characteristics of ophthalmic complications of Lemierre syndrome.

Methods: We analysed data of 27 patients with ophthalmic complications from a large cohort of 712 cases with Lemierre syndrome reported globally between 2000 and 2017. Read More

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Salvage transorbital approach for the endovascular treatment of carotid cavernous fistulas.

Oral Maxillofac Surg 2021 Apr 5. Epub 2021 Apr 5.

Unit of Interventional Neuroradiology, Careggi Hospital, Largo Piero Palagi 1, 50139, Florence, Italy.

Purpose: Carotid cavernous fistulas (CCFs) are abnormal connections between the cavernous sinus (CS) and carotid arteries. In direct CCFs, a transarterial route is often the preferred vascular access; in case of indirect CCFs, the complex anatomy of the feeder vessels and their extra-intracranial anastomosis makes the transarterial embolization challenging and often ineffective. The aim of this study was to review our experience with the transorbital approach to treat patients affected by CCF who have already experienced an endovascular failure procedure, in order to assess this salvage technique feasibility, by analyzing possible risks and complications. Read More

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Wegener's granulomatosis with orbital involvement: case report and literature review.

Rom J Ophthalmol 2021 Jan-Mar;65(1):93-97

Emergency Eye Hospital, Bucharest, Romania.

To describe the chronology and the extent of orbital involvement in a case of granulomatosis with polyangiitis. Descriptive case report and literature review. A 45-year-old patient, formerly diagnosed with granulomatosis with polyangiitis due to otorhinolaryngologic manifestations, pulmonary lesions, renal impairment, left knee arthritis and high blood levels of antineutrophil cytoplasmic antibodies, addressed the Ophthalmology Department in November 2020, having the following complaints: left eye mild retro-orbital discomfort, proptosis and epiphora. Read More

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Nodular Posterior Scleritis Masquerading as a Subretinal Mass.

Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):231-234. Epub 2021 Jan 19.

Department of Neurosciences, Division of Ophthalmology, University of the Witwatersrand, Johannesburg, South Africa.

This is the case report of a 50-year-old female with no systemic comorbidities who presented to the eye clinic with a 1-month history of right-sided eye pain and visual loss. Examination revealed no signs of inflammation in the right eye, with no proptosis or conjunctival injection. A relative afferent pupillary defect was present with no inflammatory cells in the vitreous. Read More

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January 2021

[Three Cases of Orbital Metastasis from Breast Cancer Treated with Radiotherapy].

Gan To Kagaku Ryoho 2021 Mar;48(3):371-373

Dept. of Breast and Endocrine Surgery, National Hospital Organization Fukuyama Medical Center.

Orbital metastasis from breast cancer is relatively uncommon and is not the dominant prognosis. While it can reduce a patient's QOL through symptoms such as diplopia, visual impairment, and exophthalmos, evidence suggests that radiotherapy might improve these symptoms in a relatively short period. We report 3 cases of orbital metastasis from breast cancer treated with radiotherapy. Read More

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Asymmetric optic disc edema in a young patient with POEMS: A rare presentation of a rare disease.

Am J Ophthalmol Case Rep 2021 Jun 16;22:101064. Epub 2021 Mar 16.

Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, 635 West 165th Street, New York, NY, USA.

Purpose: To describe a case of asymmetric optic disc edema presenting as the initial ocular feature of POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) syndrome.

Observations: A 29-year-old female patient presented with 3 weeks history of blurred vision, proptosis, and peripheral neuropathy as well as hypothyroidism. Fundoscopy revealed optic disc edema associated with visual loss in the left eye. Read More

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Ophthalmic Presentation and Outcomes for Malignant Sinonasal Tumors.

Ophthalmic Plast Reconstr Surg 2021 Mar 24. Epub 2021 Mar 24.

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Purpose: To evaluate the ophthalmic clinical features and functional outcomes for patients with malignant sinonasal tumors who initially presented with orbital symptoms.

Patients And Methods: Retrospective chart review for patients seen at Moorfields Eye Hospital between 1997 and 2020. Patient demographics and clinical features, radiology, histology, and treatment outcomes were reviewed. Read More

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Recurrent Self-Induced Nontraumatic Orbital Emphysema Causing Orbital Compartment Syndrome with Optic Nerve Dysfunction.

Case Rep Ophthalmol Med 2021 11;2021:8884009. Epub 2021 Mar 11.

Western Sussex Hospitals NHS Trust, UK.

The majority of cases of orbital emphysema are due to trauma. Complications are rare, and therefore, the need for surgical intervention is uncommon. We present the first case of which we are aware in which nontraumatic orbital emphysema led to orbital compartment syndrome and subsequent optic nerve dysfunction. Read More

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Treatment of post-traumatic direct carotid-cavernous fistulas using flow diverting stents: Is it alone satisfactory?

J Clin Neurosci 2021 Apr 11;86:230-234. Epub 2021 Feb 11.

Division of Vascular and Endovascular Neurosurgery, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Direct carotid cavernous fistula (CCF) occurs between the internal carotid artery (ICA) and the cavernous sinus. Carotid cavernous fistulas (CCFs) frequently present with chemosis, pulsatile proptosis, ocular bruit, vision loss, and occasionally intracerebral hemorrhage or seizure. In this article, we share our experience in endovascular treatment of six patients having this pathology with intracranial flow diverting stents with review of literatures. Read More

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Trametinib for orbital plexiform neurofibromas in young children with neurofibromatosis type 1.

Childs Nerv Syst 2021 Mar 22. Epub 2021 Mar 22.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Introduction: Plexiform neurofibromas (PNF) in neurofibromatosis type 1 (NF1) are usually diagnosed in childhood and can grow rapidly during this period. In 10% of patients, PNF involve the orbital-periorbital area and may cause visual problems including glaucoma, visual loss from amblyopia (deprivational, strabismic, or refractive), optic nerve compression, or keratopathy. Ptosis, proptosis, and facial disfigurement lead to social problems and decreased self-esteem. Read More

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Clinical assessment and FGFR2 mutation analysis in a Chinese family with Crouzon syndrome: A case report.

Medicine (Baltimore) 2021 Mar;100(10):e24991

Department of Ophthalmology, Hebei Eye Hospital, Xingtai, Hebei, China.

Rationale: Crouzon syndrome is an autosomal dominant genetic disorder caused by mutations in fibroblast growth factor receptor 2 (FGFR2) and one of the most common types of craniosynostosis. Here we report the detection of FGFR2 mutation and its related clinical findings in 2 patients with Crouzon syndrome from a Chinese family.

Patient Concerns: We report a case of a 28-year-old male patient presented with the chief complaint of gradually blurring of his eyes over the last 6 months before visiting our clinics. Read More

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[Retrobulbar hematoma in endoscopic endonasal dacryocystorhinostomy].

Vestn Otorinolaringol 2021 ;86(1):112-116

Research Institute of Eye Diseases, Moscow, Russia.

Recently, an increase in the number of operations on the lacrimal ducts performed by otorhinolaryngologists has been noted throughout the world. During these operations, intra- and postoperative complications may develop, which require the intervention of an ophthalmologist. A rare complication of endoscopic dacryocystorhinostomy is the development of retrobulbar hemorrhage. Read More

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Metastatic Orbital Tumor From Breast Ductal Carcinoma With Neuroendocrine Differentiation Initially Presenting as Ocular Symptoms: A Case Report and Literature Review.

Front Endocrinol (Lausanne) 2021 22;12:625663. Epub 2021 Feb 22.

Department of Ophthalmology and Visual Sciences, Yamagata University Faculty of Medicine, Yamagata, Japan.

Background: Orbital metastases from cancers of various organs can arise the hematogenous route, and many originate from breast, prostate, and lung cancers. Such metastatic orbital tumors may be diagnosed before the primary tumor. We have encountered a case of breast ductal carcinoma with neuroendocrine differentiation that metastasized to the orbit and responded to chemotherapy, with improvement in visual function. Read More

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February 2021

Lessons Learned from Targeting IGF-I Receptor in Thyroid-Associated Ophthalmopathy.

Cells 2021 Feb 12;10(2). Epub 2021 Feb 12.

Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, MI 48105, USA.

Complex immunological mechanisms underlie the pathogenesis of thyroid-associated ophthalmopathy (TAO). Historical models of Graves' disease and TAO have focused almost entirely on autoimmune reactivity directed against the thyrotropin receptor (TSHR). The insulin-like growth factor-I receptor (IGF-IR) has been proposed as a second participating antigen in TAO by virtue of its interactions with IGFs and anti-IGF-IR antibodies generated in Graves' disease. Read More

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February 2021

Primary yolk sac tumor of pterygopalatine fossa with loss of vision: A case report.

Medicine (Baltimore) 2021 Feb;100(8):e24916

Department of Emergency Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine; Research Institute of Emergency Medicine, Zhejiang University, Hangzhou, China.

Introduction: Primary yolk sac tumor (YST) is an infrequently-diagnosed malignant extragonadal germ cell tumors. It is likely to recur locally and may present with widespread metastases once diagnosed. Primary YST of the head is uncommon but can cause severe complications, such as loss of vision once the tumor mass invades the optic nerve. Read More

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February 2021

Comparison of 2-wall versus 3-wall orbital decompression against dysthyroid optic neuropathy in visual function: A retrospective study in a Chinese population.

Medicine (Baltimore) 2021 Feb;100(8):e24513

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract: To compare visual function of 2-wall (medial and lateral) versus 3-wall (medial, lateral, and inferior) orbital decompression in patients with dysthyroid optic neuropathy (DON).A total of 52 eyes of 37 patients underwent orbital decompression for DON between 2013 and 2019 were retrospectively reviewed. Two- or 3-wall decompression was performed in 31 eyes of 23 patients and 21 eyes of 14 patients, respectively. Read More

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February 2021

Transpalpebral transorbital neuroendoscopic (TONES) repair of orbital meningoencephalocele: a technical note.

Br J Neurosurg 2021 Feb 28:1-5. Epub 2021 Feb 28.

Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

Purpose: Intraorbital encephalocele (OMEC) is a rare entity in adults, usually secondary to an orbital pathology or prior trauma, in particular orbital roof fractures. Treatment of the OMEC is warranted to alleviate the pulsating exophthalmos and prevent potential visual decline. OMEC and orbital roof fractures have been predominantly treated via a craniotomy with a reconstruction of the orbital roof using various implants. Read More

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February 2021

The changes of retinal nerve fibre layer and ganglion cell layer with different severity of thyroid eye disease.

Eye (Lond) 2021 Feb 26. Epub 2021 Feb 26.

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Objectives: To evaluate the changes of retinal nerve fibre layer (RNFL) and ganglion cell layer/inner plexiform layer (GCL/IPL) with the severity of thyroid eye disease (TED).

Methods: One hundred and forty-five eyes of 75 patients with TED and 70 eyes of 35 healthy controls were included. The eyes with TED were divided into mild group (35 eyes), moderate-to-severe group (42 eyes) and DON group (68 eyes). Read More

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February 2021

Orbital myopericytoma: an unusual tumor in an unusual location.

Orbit 2021 Feb 26:1-4. Epub 2021 Feb 26.

Ophthalmology Department, Ramon Y Cajal University Hospital, IRYCIS, Madrid, Spain.

A 71-year-old male with a 4-month history of bulging, tearing, and redness in the right eye presented with vision loss, proptosis, conjunctival hyperemia, and chemosis. Magnetic resonance imaging showed a right intraconal solid mass with extraconal extension, hyper-intense in T2 sequences with heterogeneous contrast enhancement. Complete excision of the mass was performed through a lateral orbitotomy. Read More

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February 2021