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Hydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma.

Sci Rep 2021 Jul 30;11(1):15553. Epub 2021 Jul 30.

Ultrasound Research Laboratory, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA, 19104, USA.

This study investigates the use of hydralazine to enhance ultrasound hyperthermia for the treatment of hepatocellular carcinoma (HCC) by minimizing flow-mediated heat loss from the tumor. Murine HCC tumors were treated with a continuous mode ultrasound with or without an intravenous administration of hydralazine (5 mg/kg). Tumor blood flow and blood vessels were evaluated by contrast-enhanced ultrasound (CEUS) imaging and histology, respectively. Read More

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Bird neurocranial and body mass evolution across the end-Cretaceous mass extinction: The avian brain shape left other dinosaurs behind.

Sci Adv 2021 Jul 30;7(31). Epub 2021 Jul 30.

Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA.

Birds today are the most diverse clade of terrestrial vertebrates, and understanding why extant birds (Aves) alone among dinosaurs survived the Cretaceous-Paleogene mass extinction is crucial to reconstructing the history of life. Hypotheses proposed to explain this pattern demand identification of traits unique to Aves. However, this identification is complicated by a lack of data from non-avian birds. Read More

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Amorphous NiS and FeOOH as bifunctional co-catalysts for oxygen reduction and phenol (water) oxidation over BiVO under visible light.

J Hazard Mater 2021 Jul 21;421:126650. Epub 2021 Jul 21.

State Key Laboratory of Silicon Materials and Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China. Electronic address:

Monoclinic BiVO (BiV) has been widely used as a photoanode for water oxidation, but rarely as a photocatalyst for organic oxidation due to slow reaction of O. In this work, BiV has been modified with poorly crystallized sFe and sNi, where sFe is FeOOH, and sNi is a mixture of Ni(OH) and polysulfide. Under light, sFe/BiV and sNi/BiV in aqueous solution were more active than BiV, respectively, not only for phenol oxidation but also for O reduction. Read More

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Large-scale true-time-delay remote beamforming with EO frequency combs and multicore fiber.

Opt Lett 2021 Aug;46(15):3793-3796

Optical true-time-delay (OTTD) beamforming is a promising solution to support the ultra-broadband radio access network. However, large-scale antenna arrays set at remote radio units require the OTTD counterpart to have corresponding larger-scale channel numbers. Here, we demonstrate an OTTD remote beamforming network with a record 287 channel number using electro-optic frequency combs and multicore fiber. Read More

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A novel γ-like MnO catalyst for ozone decomposition in high humidity conditions.

J Hazard Mater 2021 Jul 19;420:126641. Epub 2021 Jul 19.

State Key Joint Laboratory of Environment Simulation and Pollution Control, National Engineering Laboratory for Multi Flue Gas Pollution Control Technology and Equipment, School of Environment, Tsinghua University, Beijing 100084, PR China.

MnO catalysts have been widely studied for catalytic gaseous ozone decomposition. However, their poor moisture resistance often leads to undesirable catalytic effects in the presence of high humidity. In this study, a novel catalyst with γ-like MnO was synthesized using the selective dissolution method on LaMnO perovskites. Read More

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Classifying and Predicting Surgical Complications After Laryngectomy: A Novel Approach to Diagnosing and Treating Patients.

Ear Nose Throat J 2021 Jul 30:1455613211029749. Epub 2021 Jul 30.

Department of Otolaryngology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Objectives: The total laryngectomy is one of the most standardized major surgical procedures in otolaryngology. Several studies have proposed the Clavien-Dindo classification (CDC) as a solution to classifying postoperative complications into 5 grades from less severe to severe. Yet more data on classifying larger patient populations undergoing major otolaryngologic surgery according to the CDC are needed. Read More

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Analyzing Patient Secure Messages Using a Fast Health Care Interoperability Resources (FIHR)-Based Data Model: Development and Topic Modeling Study.

J Med Internet Res 2021 Jul 30;23(7):e26770. Epub 2021 Jul 30.

Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN, United States.

Background: Patient portals tethered to electronic health records systems have become attractive web platforms since the enacting of the Medicare Access and Children's Health Insurance Program Reauthorization Act and the introduction of the Meaningful Use program in the United States. Patients can conveniently access their health records and seek consultation from providers through secure web portals. With increasing adoption and patient engagement, the volume of patient secure messages has risen substantially, which opens up new research and development opportunities for patient-centered care. Read More

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Predicting Biologic Therapy Outcome of Patients With Spondyloarthritis: Joint Models for Longitudinal and Survival Analysis.

JMIR Med Inform 2021 Jul 30;9(7):e26823. Epub 2021 Jul 30.

Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

Background: Rheumatic diseases are one of the most common chronic diseases worldwide. Among them, spondyloarthritis (SpA) is a group of highly debilitating diseases, with an early onset age, which significantly impacts patients' quality of life, health care systems, and society in general. Recent treatment options consist of using biologic therapies, and establishing the most beneficial option according to the patients' characteristics is a challenge that needs to be overcome. Read More

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Myopic loss aversion or equate-to-differentiate heuristic? A heuristic decision making model for both single and aggregated plays.

J Gen Psychol 2021 Jul 30:1-18. Epub 2021 Jul 30.

Zhejiang University of Technology.

Myopic loss aversion (MLA)-a combination of myopic loss and a greater sensitivity to losses than gains-has been proposed to explain the equity premium puzzle and then extended to myopic prospect theory (MPT). However, such an expected-value/utility-based theory has been challenged and the underlying mechanism remains debatable. In the current study, we applied the modified equate-to-differentiate model to address this phenomenon. Read More

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Intraoral scanners for capturing the palate and its relation to the dentition.

Sci Rep 2021 Jul 29;11(1):15489. Epub 2021 Jul 29.

Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Freiburgstrasse 7, CH-3010, Bern, Switzerland.

Proper superimposition of intraoral scan generated 3D models enables detailed assessment of soft and hard tissue surface changes. This requires accurate 3D models and stable structures as superimposition references. In the maxilla, different reference areas have been proposed, mostly located at the palatal region. Read More

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Thymoma Staging: An Analysis of the Different Schemas.

Authors:
Cesar A Moran

Adv Anat Pathol 2021 Jul 29. Epub 2021 Jul 29.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Over the last years, a number of changes has taken place in the evaluation of thymomas. More recently, the introduction of a TNM staging system in the assessment of thymic epithelial tumors, in general, has been put forward. Important to highlight is that this TNM system is not based on tumor size, and because of that shortcoming, it was in need to borrow most if not all of the information from the experience derived from other schemas that over the years have been tested with larger series of cases. Read More

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Montmorillonite promoted photodegradation of amlodipine in natural water via formation of surface complexes.

Chemosphere 2021 Jul 24;286(Pt 1):131641. Epub 2021 Jul 24.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, China. Electronic address:

The photolysis of amlodipine (AML) as a ubiquitous pollutant in natural water has been extensively studied. Montmorillonite (MMT), a major component of suspended particles in surface aquifers, plays key roles in the natural transportation and transformation of organic contaminants in the environment. However, literature has scarcely focused on whether and how suspended particles affect the phototransformation of AML. Read More

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Semi-supervised learning with progressive unlabeled data excavation for label-efficient surgical workflow recognition.

Med Image Anal 2021 Jul 8;73:102158. Epub 2021 Jul 8.

Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong; T Stone Robotics Institute, The Chinese University of Hong Kong, Hong Kong.

Surgical workflow recognition is a fundamental task in computer-assisted surgery and a key component of various applications in operating rooms. Existing deep learning models have achieved promising results for surgical workflow recognition, heavily relying on a large amount of annotated videos. However, obtaining annotation is time-consuming and requires the domain knowledge of surgeons. Read More

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Does mobile payment change consumers' perception during payment process? -an ERP study.

Neurosci Lett 2021 Jul 26:136138. Epub 2021 Jul 26.

School of Business Administration, Guizhou University of Finance and Economics, Guiyang, P.R. China.

Innovative payment methods have been getting worldwide attention. Exploring the mechanisms behind consumers' purchase behaviors modulated by different payment methods was critical but challenging. In this paper, we proposed a 2 (payment methods: cash payment vs mobile payment) × 2 (price levels of products: high vs low) Event-Related Potentials (ERPs) experiment to study the difference of cash payment and mobile payment on consumers' purchase intention of products in different price level from a neuroscience perspective. Read More

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Hybrid Atomic Orbital Basis from First Principles: Bottom-Up Mapping of Self-Energy Correction to Large Covalent Systems.

J Phys Chem A 2021 Jul 29. Epub 2021 Jul 29.

National Institute of Science Education and Research, Homi Bhaba National Institute, Jatni, Khurda, Bhubaneswar, 752050, Odisha, India.

Construction of hybrid atomic orbitals is proposed as the approximate common eigenstates of finite first moment matrices. Their hybridization and orientation can be a priori tuned as per their anticipated neighborhood. Their Wannier function counterparts constructed from the Kohn-Sham (KS) single particle states constitute an orthonormal multiorbital tight binding (TB) basis resembling hybrid atomic orbitals locked to their immediate atomic neighborhood, while spanning the subspace of KS states. Read More

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Can Deep Learning Replace Gadolinium in Neuro-Oncology?: A Reader Study.

Invest Radiol 2021 Jul 28. Epub 2021 Jul 28.

From the Imaging Department, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif BioMaps (UMR1281), Université Paris-Saclay, CNRS, Inserm, CEA, Villejuif Guerbet Research, Villepinte Center for Visual Computing, CentraleSupélec, Inria, Université Paris-Saclay, Gif-sur-Yvette, France.

This study proposes and evaluates a deep learning method that predicts surrogate images for contrast-enhanced T1 from multiparametric magnetic resonance imaging (MRI) acquired using only a quarter of the standard 0.1 mmol/kg dose of gadolinium-based contrast agent. In particular, the predicted images are quantitatively evaluated in terms of lesion detection performance. Read More

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CuCoOx/BiVO multifunctional catalyst for organics degradation, water oxidation, and O reduction under visible light.

J Hazard Mater 2021 Jun 29;419:126515. Epub 2021 Jun 29.

State Key Laboratory of Silicon Materials and Department of Chemistry, Zhejiang University, Hangzhou 310027, China. Electronic address:

Monoclinic BiVO (BiV) is an excellent photoanode for water oxidation, but it is a poor photocatalyst for organic oxidation due to slow O reduction. Herein we report a 94-fold increased photocatalytic activity of BiV through a surface deposited CuCoOx. The model reaction was phenol degradation in aqueous solution under visible light. Read More

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Significant Improvement in CO Absorption by Deep Eutectic Solvents as Immobilized Sorbents: Computational Analysis.

J Phys Chem B 2021 Jul 29. Epub 2021 Jul 29.

Department of Chemistry, Shiraz University, Shiraz 71946-84795, Iran.

To find an alternative way for improving the efficacy of deep eutectic solvents (DESs) to dissolve carbon dioxide, a computational study of DES systems comprising choline chloride and different hydrogen-bond donors (ethylene glycol and glycerol) immobilized on hydrophobic (graphite) and hydrophilic (titanium dioxide) solid surfaces was performed. This research provides quantitative molecular understanding of the role of the DES thickness and also the type of solid support in CO sorption and diffusion using molecular dynamics simulations. In general, the proposed model based on supported DESs immobilized on different supports was developed to correlate the solubility of CO in DESs based on choline chloride. Read More

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Immunomodulation as a Potent COVID-19 Pharmacotherapy: Past, Present and Future.

J Inflamm Res 2021 20;14:3419-3428. Epub 2021 Jul 20.

Department of Physiology and Medical Biochemistry, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.

In the first year of its appearance, the 2019 coronavirus disease (COVID-19) has affected more than 150 million individuals and killed 3 million people worldwide. The pandemic has also triggered numerous global initiatives to tackle the newly emerging disease, including the development of SARS-CoV-2 vaccines and the attempt to discover potential pharmacological therapies. Nonetheless, despite the success of SARS-CoV-2 vaccine development, COVID-19 therapy remains challenging. Read More

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Combination of wet fixation and drying treatments to improve dye fixation onto spray-dyed cotton fabric.

Sci Rep 2021 Jul 28;11(1):15403. Epub 2021 Jul 28.

Sanitary Environmental Engineering Division (SEED), Department of Civil Engineering, University of Salerno, via Giovanni Paolo II 132, 84084, Fisciano, SA, Italy.

The conventional dyeing process requires a substantial amount of auxiliaries and water, which leaches hazardous colored effluents to the environment. Herein, a newly developed sustainable spray dyeing system has been proposed for cotton fabric in the presence of reactive dyes, which has the potential to minimize the textile dyeing industries environmental impact in terms of water consumption and save significant energy. The results suggest that fresh dye solution can be mixed with an alkali solution before spray dyeing to avoid the reactive dye hydrolysis phenomenon. Read More

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Thrombospondin-2 as a diagnostic biomarker for distal cholangiocarcinoma and pancreatic ductal adenocarcinoma.

Clin Transl Oncol 2021 Jul 28. Epub 2021 Jul 28.

Department of Surgery, Clinical Sciences Lund, Surgery, Lund University and Skåne University Hospital, 221 85, Lund, Sweden.

Purpose: Distal cholangiocarcinoma and pancreatic ductal adenocarcinoma are malignancies with poor prognoses that can be difficult to distinguish preoperatively. Thrombospondin-2 has been proposed as a novel diagnostic biomarker for early pancreatic ductal adenocarcinoma. The aim of the present study was to evaluate thrombospondin-2 as a diagnostic and prognostic biomarker in combination with current biomarker CA 19-9 for distal cholangiocarcinoma and pancreatic ductal adenocarcinoma. Read More

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Case study meta-analysis in the social sciences. Insights on data quality and reliability from a large-N case survey.

Res Synth Methods 2021 Jul 27. Epub 2021 Jul 27.

Faculty of Sustainability, Leuphana University Lüneburg, Germany.

Meta-analytical methods face particular challenges in research fields such as social and political research, where studies often rest primarily on qualitative and case study research. In such contexts, where research findings are less standardized and amenable to structured synthesis, the case survey method has been proposed as a means of data generation and analysis. The method offers a meta-analytical tool to synthesize larger numbers of qualitative case studies, yielding data amenable to large-N analysis. Read More

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Taxonomic and phylogenetic characterizations reveal four new species of Simplicillium (Cordycipitaceae, Hypocreales) from Guizhou, China.

Sci Rep 2021 Jul 27;11(1):15300. Epub 2021 Jul 27.

Department of Ecology, Institute of Fungus Resources, College of Life Sciences, Guizhou University, Guiyang, 550025, Guizhou, People's Republic of China.

Simplicillium species are commonly found from soil, seawater, rock surface, decayed wood, air and as symbiotic, endophytic, entomopathogenic and mycoparasitic fungi. Minority insect-associated species was reported. Simplicillium coccinellidae, S. Read More

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Challenging the Established Order: Innovating Clinical Trials for Amyotrophic Lateral Sclerosis.

Neurology 2021 Jul 27. Epub 2021 Jul 27.

Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.

Development of effective treatment for amyotrophic lateral sclerosis (ALS) has been hampered by disease heterogeneity, a limited understanding of underlying pathophysiology and methodological design challenges. Here we have evaluated two major themes in the design of pivotal, phase 3 clinical trials for ALS: (1) patient selection and (2) analytical strategy, and discussed potential solutions with the European Medicines Agency (EMA). Several design considerations were assessed using data from five placebo-controlled clinical trials (N = 988), four population-based cohorts (N = 5,100), and 2,436 placebo-allocated patients from the PRO-ACT database. Read More

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A wearable ring-shaped inertial system to identify action planning impairments during reach-to-grasp sequences: a pilot study.

J Neuroeng Rehabil 2021 Jul 27;18(1):118. Epub 2021 Jul 27.

Department of Industrial Engineering, University of Florence, Florence, Italy.

Background: The progressive ageing of the population is leading to an increasing number of people affected by cognitive decline, including disorders in executive functions (EFs), such as action planning. Current procedures to evaluate cognitive decline are based on neuropsychological tests, but novel methods and approaches start to be investigated. Reach-to-grasp (RG) protocols have shown that intentions can influence the EFs of action planning. Read More

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An experimental method to correct low-frequency concentric artifacts in photon counting CT.

Phys Med Biol 2021 Jul 27. Epub 2021 Jul 27.

Department of Medical Physics and Department of Radiology, University of Wisconsin-Madison, 1111 Highland Ave. Rm 1005, Madison, Wisconsin, 53705, UNITED STATES.

Large-area photon counting detectors (PCDs) are usually built by tiling multiple semiconductor panels that often have slightly different spectral responses to input x-rays. As a result of this spectral inconsistency, experimental PCD-CT images of large, human-sized objects may show high-frequency ring artifacts and low-frequency band artifacts. Due to the much larger width of the bands compared with the rings, the concentric artifact problem in PCD-CT images of human-sized objects cannot be adequately addressed by conventional CT ring correction methods. Read More

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Urban road greenbelt configuration: The perspective of PM removal and air quality regulation.

Environ Int 2021 Jul 24;157:106786. Epub 2021 Jul 24.

Key Laboratory for Urban Habitat Environmental Science and Technology, School of Urban Planning and Design, Peking University, Shenzhen 518055, PR China. Electronic address:

The establishment of the road green belt (RGB) is an effective means to reduce particle matter (PM) emissions from road traffic. This study tested the ability of 23 common tree species in Shenzhen to reduce PM concentrations using field investigations and wind tunnel tests. The association between leaf microstructure and individual reduction ability was also analyzed. Read More

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Quasi-phase-matched laser wakefield acceleration of electrons in an axially density-modulated plasma channel.

Sci Rep 2021 Jul 26;11(1):15207. Epub 2021 Jul 26.

Laser and Plasma Research Institute, Shahid Beheshti University, 1983969411, Tehran, Iran.

Quasi-phase matching in corrugated plasma channels has been proposed as a way to overcome the dephasing limitation in laser wakefield accelerators. In this study, the phase-lock dynamics of a relatively long electron bunch injected in an axially-modulated plasma waveguide is investigated by performing particle simulations. The main objective here is to obtain a better understanding of how the transverse and longitudinal components of the wakefield as well as the initial properties of the beam affect its evolution and qualities. Read More

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Construction of Z-scheme CuFeO/MnO photocatalyst and activating peroxymonosulfate for phenol degradation: Synergistic effect, degradation pathways, and mechanism.

Environ Res 2021 Jul 24;200:111736. Epub 2021 Jul 24.

School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu, 610500, China.

Photocatalysis coupled with sulfate radical-based advanced oxidation process (SR-AOPs) is an efficient strategy to enhance the degradation efficiency of organic pollution. Herein, a Z-scheme CuFeO/MnO composite catalyst was successfully fabricated by the hydrothermal method. A series of characterizations demonstrated that the higher CuFeO particle dispersion and larger BET surface area of CuFeO/MnO catalyst contributed to a high catalytic activity toward the phenol removal compared with pure CuFeO. Read More

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3D-Printed Architected Materials Inspired by Cubic Bravais Lattices.

ACS Biomater Sci Eng 2021 Jul 26. Epub 2021 Jul 26.

Department of Mechanical Engineering, Politecnico di Milano via La Masa 1, Milano 20156, Italy.

Learning from Nature and leveraging 3D printing, mechanical testing, and numerical modeling, this study aims to provide a deeper understanding of the structure-property relationship of crystal-lattice-inspired materials, starting from the study of single unit cells inspired by the cubic Bravais crystal lattices. In particular, here we study the simple cubic (SC), body-centered cubic (BCC), and face-centered cubic (FCC) lattices. Mechanical testing of 3D-printed structures is used to investigate the influence of different printing parameters. Read More

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