979 results match your criteria proposed appealing

Single-breath oxygen dilution for the measurement of total lung capacity: technical description and preliminary results in healthy subjects.

Physiol Meas 2021 Jun 11. Epub 2021 Jun 11.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, ITALY.

Total lung capacity (TLC) assessment outside of a research laboratory is challenging. We describe a novel method for measuring TLC that is both simple and based only on portable equipment, and report preliminary data on healthy subjects.We developed an open circuit system to administer a known amount of oxygen to a subject in a single maximal inspiratory maneuver. Read More

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A practical response adaptive block randomization (RABR) design with analytic type I error protection.

Stat Med 2021 Jun 10. Epub 2021 Jun 10.

Global Biometrics and Data Sciences, Bristol Myers Squibb, Berkeley Heights, New Jersey, USA.

Response adaptive randomization (RAR) is appealing from methodological, ethical, and pragmatic perspectives in the sense that subjects are more likely to be randomized to better performing treatment groups based on accumulating data. However, applications of RAR in confirmatory drug clinical trials with multiple active arms are limited largely due to its complexity, and lack of control of randomization ratios to different treatment groups. To address the aforementioned issues, we propose a Response Adaptive Block Randomization (RABR) design allowing arbitrarily prespecified randomization ratios for the control and high-performing groups to meet clinical trial objectives. Read More

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Dendrite-Free Anodes Enabled by a Composite of a ZnAl Alloy with a Copper Mesh for High-Performing Aqueous Zinc-Ion Batteries.

ACS Appl Mater Interfaces 2021 Jun 10. Epub 2021 Jun 10.

Department of Materials Science and Engineering, National University of Singapore 117573, Singapore.

Aqueous zinc-ion batteries (ZIBs) have attracted considerable attention because of their low cost, high intrinsic safety, and high volumetric capacity. However, unexpected dendrite growth and side reactions that arise at the Zn anode can severely hinder the mass adoption of ZIBs in practical applications. Herein, we report a dendrite-free ZIB anode via the hybridization of a eutectic ZnAl alloy with a copper mesh (denoted as [email protected]). Read More

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CsPbX -ITO (X = Cl, Br, I) Nano-Heterojunctions: Voltage Tuned Positive to Negative Photoresponse.

Small 2021 Jun 9:e2101403. Epub 2021 Jun 9.

Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University Beijing, Beijing, 100084, P. R. China.

All-Inorganic perovskite CsPbX (X = Cl, Br, I) quantum dots (QDs) have attracted tremendous attention in the past few years for their appealing performance in optoelectronic applications. Major properties of CsPbX QDs include the positive photoconductivity (PPC) and the defect tolerance of the in-band trap states. Here it is reported that when hybridizing CsPbX QDs with indium tin oxide (ITO) nanocrystals to form CsPbX -ITO nano-heterojunctions (NHJs), a voltage tuned photoresponse-from PPC to negative photoconductivity (NPC) transform-is achieved in lateral drain-source structured ITO/CsPbX -ITO-NHJs/ITO devices. Read More

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Designing an irreversible metabolic switch for scalable induction of microbial chemical production.

Nat Commun 2021 06 8;12(1):3419. Epub 2021 Jun 8.

Warwick Integrative Synthetic Biology Centre, School of Engineering, University of Warwick, Coventry, CV4 7AL, United Kingdom.

Bacteria can be harnessed to synthesise high-value chemicals. A promising strategy for increasing productivity uses inducible control systems to switch metabolism from growth to chemical synthesis once a large population of cell factories are generated. However, use of expensive chemical inducers limits scalability of this approach for biotechnological applications. Read More

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A patent review of mTOR inhibitors for cancer therapy (2011-2020).

Expert Opin Ther Pat 2021 Jun 11:1-11. Epub 2021 Jun 11.

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, People's Republic of China.

Introduction: The mammalian target of rapamycin (mTOR) kinase is a central component in the PI3K/Akt/mTOR pathway and plays a crucial role in tumor biology, making it one appealing therapeutic target. In the past decade, the mTORi (mTOR inhibitor) development field has made great progress, with more agents entering key trials and the proposal of third-generation mTORi concept. Yet to achieve significant clinical success, combined efforts from multiple disciplines are ever needed. Read More

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Vibrational characterization of a diiron bridging hydride complex - a model for hydrogen catalysis.

Chem Sci 2020 May 6;11(21):5487-5493. Epub 2020 May 6.

SETI Institute 189 Bernardo Avenue Mountain View CA 94043 USA

A diiron complex containing a bridging hydride and a protonated terminal thiolate of the form [(μ,κ-bdtH)(μ-PPh)(μ-H)Fe(CO)] has been investigated through Fe nuclear resonance vibrational spectroscopy (NRVS) and interpreted using density functional theory (DFT) calculations. We report the Fe-μH-Fe wagging mode, and indications for Fe-μD stretching vibrations in the D-isotopologue, observed by Fe-NRVS. Our combined approach demonstrates an asymmetric sharing of the hydride between the two iron sites that yields two nondegenerate Fe-μH/D stretching vibrations. Read More

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Natural discoidal lipoproteins with tiny modification for tumor extracellular dissociation in antitumor chemoimmunotherapy.

Biomaterials 2021 May 29;275:120859. Epub 2021 May 29.

State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, China; NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Nanjing, 210009, China. Electronic address:

Appealing cancer immunotherapy requires synchronous presentation of tumor antigens and immunoadjuvant. Herein, a "one-step" modification strategy is proposed to tinily remould endogenous discoidal high density lipoprotein (dHDL) for tumor-homing and site-specific chemoimmunotherapy. For molecular targeting therapy, lipophilic immunoadjuvant CpG oligodeoxynucleotides is conjugated to facilitate HDL-surface anchoring; and GC nucleotides provide enough reservoir for completion of doxorubicin (Dox) "sandwich". Read More

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Mapping the Distribution of Potential Gradient in Bipolar Electrochemical Systems through Luminol Electrochemiluminescence Imaging.

Anal Chem 2021 Jun 3. Epub 2021 Jun 3.

Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8502, Japan.

Bipolar electrochemistry has been regarded as a powerful and sustainable electrochemical process for the synthesis of novel functional materials. The appealing features of this electrochemical technology, such as the wireless nature of the bipolar electrode (BPE) and the possibility to drive simultaneously electrochemical reactions on multiple BPEs placed in the same electrochemical cell, together with the possibility to change the shape and positioning of the driving electrodes, give significant freedom to design reaction systems. Nevertheless, the cell geometry dramatically affects the distribution and intensity of the potential gradient generated on the BPE surface and its monitoring is hampered due to the wireless nature of the BPE. Read More

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From Continuous-Time Chaotic Systems to Pseudo Random Number Generators: Analysis and Generalized Methodology.

Entropy (Basel) 2021 May 26;23(6). Epub 2021 May 26.

Instituto de Física, Universidade Federal de Alagoas (UFAL), Maceió 57072-900, Brazil.

The use of chaotic systems in electronics, such as Pseudo-Random Number Generators (PRNGs), is very appealing. Among them, continuous-time ones are used less because, in addition to having strong temporal correlations, they require further computations to obtain the discrete solutions. Here, the time step and discretization method selection are first studied by conducting a detailed analysis of their effect on the systems' statistical and chaotic behavior. Read More

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Design and Characterization of Backside Termination Structures for Thick Fully-Depleted MAPS.

Sensors (Basel) 2021 May 31;21(11). Epub 2021 May 31.

Dipartimento di Ingegneria Industriale, Università degli Studi di Trento, 38123 Trento, Italy.

Fully Depleted Monolithic Active Pixel Sensors (FD-MAPS) represent an appealing alternative to hybrid detectors for radiation imaging applications. We have recently demonstrated the feasibility of FD-MAPS based on a commercial 110 nm CMOS technology, adapted using high-resistivity substrates and backside post-processing. A p/n junction diode, fabricated on the detector backside using low-temperature processing steps after the completion of the front-side Back End of Line (BEOL), is reverse-biased to achieve the full depletion of the substrate and thus fast charge collection by drift. Read More

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Mass Transfer Study on Improved Chemistry for Electrodeposition of Copper Indium Gallium Selenide (CIGS) Compound for Photovoltaics Applications.

Nanomaterials (Basel) 2021 May 6;11(5). Epub 2021 May 6.

Department of Chemical & Biomolecular Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.

Copper indium gallium selenium (CIGS) films are attractive for photovoltaic applications due to their high optical absorption coefficient. The generation of CIGS films by electrodeposition is particularly appealing due to the relatively low capital cost and high throughput. Numerous publications address the electrodeposition of CIGS; however, very few recognize the critical significance of transport in affecting the composition and properties of the compound. Read More

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A Kalman Filter for Multilinear Forms and Its Connection with Tensorial Adaptive Filters.

Sensors (Basel) 2021 May 20;21(10). Epub 2021 May 20.

Department of Telecommunications, University Politehnica of Bucharest, 1-3, Iuliu Maniu Blvd., 061071 Bucharest, Romania.

The Kalman filter represents a very popular signal processing tool, with a wide range of applications within many fields. Following a Bayesian framework, the Kalman filter recursively provides an optimal estimate of a set of unknown variables based on a set of noisy observations. Therefore, it fits system identification problems very well. Read More

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Antidegradation Property of Alginate Materials by Riveting Functionalized Carbon Nanotubes on the Sugar Chain.

ACS Omega 2021 May 7;6(19):12813-12819. Epub 2021 May 7.

State Key Laboratory of Bio-Fibers and Eco-Textiles, Shandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological Textiles, Institute of Marine Biobased Materials, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, P. R. China.

Alginate materials with the advantages of being renewable, inexpensive, and environment-friendly have been considered promising fiber materials. However, they are prone to degrade under UV light, limiting their large-scale application in the textile field. Herein, the fracture of glycosidic bonds during the degradation process is revealed clearly by Fourier transform infrared (FT-IR) and H NMR. Read More

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Tegotae-Based Control Produces Adaptive Inter- and Intra-limb Coordination in Bipedal Walking.

Front Neurorobot 2021 12;15:629595. Epub 2021 May 12.

Research Institute of Electrical Communication, Tohoku University, Sendai, Japan.

Despite the appealing concept of central pattern generator (CPG)-based control for bipedal walking robots, there is currently no systematic methodology for designing a CPG-based controller. To remedy this oversight, we attempted to apply the Tegotae approach, a Japanese concept describing how well a perceived reaction, i.e. Read More

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The individual-level surrogate threshold effect in a causal-inference setting with normally distributed endpoints.

Pharm Stat 2021 May 21. Epub 2021 May 21.

I-BioStat, KU Leuven, Leuven, Belgium.

In the meta-analytic surrogate evaluation framework, the trial-level coefficient of determination quantifies the strength of the association between the expected causal treatment effects on the surrogate (S) and the true (T) endpoints. Burzykowski and Buyse supplemented this metric of surrogacy with the surrogate threshold effect (STE), which is defined as the minimum value of the causal treatment effect on S for which the predicted causal treatment effect on T exceeds zero. The STE supplements with a more direct clinically interpretable metric of surrogacy. Read More

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Facile Electrochemical Microbiosensor Based on Self-Assembly of Ag Nanoparticles Coated on TiCT for Measurements of Chloride Ions in the PD Mouse Brain.

Anal Chem 2021 Jun 20;93(21):7647-7656. Epub 2021 May 20.

A Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, P. R. China.

Chloride ion (Cl), one of the most important anions in the brain, has been confirmed to participate in the pathological process of Parkinson's disease (PD). As such, the development of a reliable method for measurements of Cl is extremely appealing, especially for understanding the pathogenesis of PD. We herein designed a facile electrochemical microbiosensor (ECMB), based on self-assembly of Ag nanoparticles (Ag NPs) coated on TiCT. Read More

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Strategies for research participant engagement: A synthetic review and conceptual framework.

Clin Trials 2021 May 20:17407745211011068. Epub 2021 May 20.

Duke-Margolis Center for Health Policy, Duke University, Durham, NC, USA.

Background: Research participant engagement, which we define as recruitment and retention in clinical trials, is a costly and challenging issue in clinical research. Research teams have leveraged a variety of strategies to increase research participant engagement in clinical trials, although a framework and evidence for effective participant engagement strategies are lacking. We (1) developed a novel conceptual framework for strategies used to recruit and retain participants in clinical trials based on their underlying behavioral principles and (2) categorized empirically tested recruitment and retention strategies in this novel framework. Read More

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Iterative stripe artifact correction framework for TOF-MRA.

Comput Biol Med 2021 May 11;134:104456. Epub 2021 May 11.

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China; Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China; Department of Radiation Oncology, Stanford University, Stanford, CA, 94305, USA. Electronic address:

The purpose of this study is to develop a practical stripe artifacts correction framework on three-dimensional (3-D) time-of-flight magnetic resonance angiography (TOF-MRA) obtained by multiple overlapping thin slab acquisitions (MOTSA) technology. In this work, the stripe artifacts in TOF-MRA were considered as a part of image texture. To separate the image structure and the texture, the relative total variation (RTV) was firstly employed to smooth the TOF-MRA for generating the template image with fewer image textures. Read More

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A Bayesian approach for fitting and comparing demographic growth models of radiocarbon dates: A case study on the Jomon-Yayoi transition in Kyushu (Japan).

PLoS One 2021 19;16(5):e0251695. Epub 2021 May 19.

BioArCh, University of York, Wentworth Way, Heslington, York, United Kingdom.

Large sets of radiocarbon dates are increasingly used as proxies for inferring past population dynamics and the last few years, in particular, saw an increase in the development of new statistical techniques to overcome some of the key challenges imposed by this kind of data. These include: 1) null hypothesis significance testing approaches based on Monte-Carlo simulations or mark permutations; 2) non-parametric Bayesian modelling approaches, and 3) the use of more traditional techniques such as correlation, regression, and AIC-based model comparison directly on the summed probability distribution of radiocarbon dates (SPD). While the range of opportunities offered by these solutions is unquestionably appealing, they often do not consider the uncertainty and the biases arising from calibration effects or sampling error. Read More

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Off-Policy Evaluation of the Performance of a Robot Swarm: Importance Sampling to Assess Potential Modifications to the Finite-State Machine That Controls the Robots.

Front Robot AI 2021 29;8:625125. Epub 2021 Apr 29.

IRIDIA, Université libre de Bruxelles, Brussels, Belgium.

Due to the decentralized, loosely coupled nature of a swarm and to the lack of a general design methodology, the development of control software for robot swarms is typically an iterative process. Control software is generally modified and refined repeatedly, either manually or automatically, until satisfactory results are obtained. In this paper, we propose a technique based on off-policy evaluation to estimate how the performance of an instance of control software-implemented as a probabilistic finite-state machine-would be impacted by modifying the structure and the value of the parameters. Read More

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Floating quick response code based on structural black color with the characteristic of privacy protection.

Opt Express 2021 May;29(10):15217-15227

Since the printing quick response (QR) code can be easily produced and duplicated as a potential tool for cybercriminals, QR code security has been a hotly debated issue across globe. Here we demonstrate a floating QR code device based on the moiré principle which has the advantage of displaying an appealing three-dimensional (3D) effect and privacy protection. In the imaging system, the microlens array (MLA) contributes to efficiently sampling the multiple elemental images and the metal-coated nanostructure yields patterned structural black color with a high pattern resolution (>12, 500 dpi). Read More

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Heterogeneous alkane dehydrogenation catalysts investigated a surface organometallic chemistry approach.

Chem Soc Rev 2021 May;50(9):5806-5822

Department of Chemistry and Applied Biosciences - ETH Zürich, Vladimir Prelog 2, CH8093 Zürich, Switzerland.

The selective conversion of light alkanes (C2-C6 saturated hydrocarbons) to the corresponding alkene is an appealing strategy for the petrochemical industry in view of the availability of these feedstocks, in particular with the emergence of Shale gas. Here, we present a review of model dehydrogenation catalysts of light alkanes prepared via surface organometallic chemistry (SOMC). A specific focus of this review is the use of molecular strategies for the deconvolution of complex heterogeneous materials that are proficient in enabling dehydrogenation reactions. Read More

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Power prior for borrowing the real-world data in bioequivalence test with a parallel design.

Int J Biostat 2021 May 6. Epub 2021 May 6.

Research Center of Biostatistics and Computational Pharmacy, China Pharmaceutical University, Nanjing210009, China.

Recently, real-world study has attracted wide attention for drug development. In bioequivalence study, the reference drug often has been marketed for many years and accumulated abundant real-world data. It is therefore appealing to incorporate these data in the design to improve trial efficiency. Read More

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The 20k Samples-Per-Second Real Time Detection of Acoustic Vibration Based on Displacement Estimation of One-Dimensional Laser Speckle Images.

Sensors (Basel) 2021 Apr 22;21(9). Epub 2021 Apr 22.

Graduate School of System Design and Management, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8526, Japan.

Audio signal acquisition using a laser speckle image is an appealing topic since it provides an accurate and non-contact solution for vibration measurement. However, due to the limitation of camera frame rate and image processing speed, previous research could not achieve real time reconstruction of an audio signal. In this manuscript, we use a one-dimensional laser speckle image to measure the acoustic vibration of sound source and propose a fast and sub-pixel accuracy algorithm to estimate the displacement of captured one-dimensional laser speckle images. Read More

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A Novel Method of Fault Detection and Identification in a Tightly Coupled, INS/GNSS-Integrated System.

Sensors (Basel) 2021 Apr 21;21(9). Epub 2021 Apr 21.

College of Intelligent System Science and Engineering, Harbin Engineering University, Harbin 150001, China.

Fault detection and identification are vital for guaranteeing the precision and reliability of tightly coupled inertial navigation system (INS)/global navigation satellite system (GNSS)-integrated navigation systems. A variance shift outlier model (VSOM) was employed to detect faults in the raw pseudo-range data in this paper. The measurements were partially excluded or included in the estimation process depending on the size of the associated shift in the variance. Read More

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Energy-Aware Dynamic 3D Placement of Multi-Drone Sensing Fleet.

Sensors (Basel) 2021 Apr 8;21(8). Epub 2021 Apr 8.

Department of Electrical and Computer Engineering, University of Houston, Houston, TX 77204, USA.

Unmanned Aerial Vehicles (UAVs, also known as drones) have become increasingly appealing with various applications and services over the past years. Drone-based remote sensing has shown its unique advantages in collecting ground-truth and real-time data due to their affordable costs and relative ease of operability. This paper presents a 3D placement scheme for multi-drone sensing/monitoring platforms, where a fleet of drones are sent for conducting a mission in a given area. Read More

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Context-dependent and -independent selection on synonymous mutations revealed by 1,135 genomes of Arabidopsis thaliana.

Duan Chu Lai Wei

BMC Ecol Evol 2021 04 28;21(1):68. Epub 2021 Apr 28.

College of Life Sciences, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian, Beijing, China.

Background: Synonymous mutations do not alter the amino acids and therefore are regarded as neutral for a long time. However, they do change the tRNA adaptation index (tAI) of a particular codon (independent of its context), affecting the tRNA availability during translation. They could also change the isoaccepting relationship with its neighboring synonymous codons in particular context, which again affects the local translation process. Read More

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Modulation of Src Kinase Activity by Selective Substrate Recognition with Pseudopeptidic Cages.

Chemistry 2021 Apr 27. Epub 2021 Apr 27.

Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia, IQAC-CSIC, Jordi Girona 18-26, 08034, Barcelona, Spain.

The selective recognition of tyrosine residues in peptides is an appealing approach to inhibiting their tyrosine kinase (TK)-mediated phosphorylation. Herein, we describe pseudopeptidic cages that efficiently protect substrates from the action of the Src TK enzyme, precluding the corresponding Tyr phosphorylation. Fluorescence emission titrations show that the most efficient cage inhibitors strongly bind the peptide substrates with a very good correlation between the binding constant and the inhibitory potency. Read More

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Two-dimensional Weyl points and nodal lines in pentagonal materials and their optical response.

Nanoscale 2021 Mar 22;13(12):6117-6128. Epub 2021 Mar 22.

Departamento de Física, Universidad Técnica Federico Santa María, Valparaíso, Chile.

Two-dimensional pentagonal structures based on the Cairo tiling are the basis of a family of layered materials with appealing physical properties. In this work we present a theoretical study of the symmetry-based electronic and optical properties of these pentagonal materials. We provide a complete classification of the space groups that support pentagonal structures for binary and ternary systems. Read More

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