762,331 results match your criteria proposed

Possible Mechanism of Human Recombinant Leptin-Induced VEGF A Synthesis via PI3K/Akt/mTOR/S6 Kinase Signaling Pathway while Inducing Angiogenesis: An Analysis Using Chicken Chorioallantoic Membrane Model.

J Vasc Res 2021 Jun 24:1-18. Epub 2021 Jun 24.

Department of Genetics, Dr. ALM PG IBMS, Taramani Campus, University of Madras, Chennai, India.

Introduction: The present study aimed to realize human recombinant leptin 's ability to synthesize VEGF A while inducing neovascularization through PI3K/Akt/mTOR/S6 kinase involved signaling pathway.

Methods: To examine the PI3K/Akt/mTOR/S6 kinase pathway involvement in leptin-induced VEGF A synthesis, the chick chorioallantoic membrane (CAM) was incubated with human recombinant leptin and specific inhibitors of the proposed signaling molecules (rapamycin and wortmannin). We analyzed the role of specified signaling molecules in human recombinant leptin-induced physiological angiogenesis via VEGF A synthesis in detail with the support of various methodologies. Read More

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3C-GAN: class-consistent CycleGAN for malaria domain adaptation model.

Biomed Phys Eng Express 2021 Jun 24. Epub 2021 Jun 24.

Electrical and Computer Engineering, North South University, Plot, 15, Block B Kuril - NSU Rd, Dhaka, Dhaka, Dhaka, 1229, BANGLADESH.

Unpaired domain translation models with distribution matching loss such as CycleGAN are now widely being used to shift domain in medical images. However, synthesizing medical images using CycleGAN can lead to misdiagnosis of a medical condition as it might hallucinate unwanted features, especially if there's a data bias. This can potentially change the original class of the input image, which is a very serious problem. Read More

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Premature beats detection based on a novel convolutional neural network.

Physiol Meas 2021 Jun 24. Epub 2021 Jun 24.

Fudan University School of Basic Medical Sciences, Shanghai, CHINA.

Objective: Automatic detection of premature beats on long electrocardiogram (ECG) recordings is of great significance for clinical diagnosis. In this paper, we propose a novel deep learning model, the ECGDet, to detect premature beats, including premature ventricular contractions (PVCs) and supraventricular premature beats (SPBs) on single-lead long-term ECGs.

Approach: The ECGDet is proposed based on a convolutional neural network and squeeze-and-excitation network. Read More

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Separation of normal and impaired dynamic cerebral autoregulation using deep embedded clustering: a proof-of-concept study.

Physiol Meas 2021 Jun 24. Epub 2021 Jun 24.

Institute of Advanced Computing and Digital Engineering, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen, Guangdong, CHINA.

A previous study has shown that a data-driven approach can significantly improve the discriminative power of transfer function analysis (TFA) used to differentiate between normal and impaired cerebral autoregulation (CA) in two groups of data. The data was collected from both healthy subjects (assumed to have normal CA) and symptomatic patients with severe stenosis (assumed to have impaired CA). However, the sample size of the labeled data was relatively small, owing to the difficulty in data collection. Read More

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Mild Cognitive Impairment Classification using Combined Structural and Diffusion Imaging Biomarkers.

Phys Med Biol 2021 Jun 24. Epub 2021 Jun 24.

Electrical Engineering, Universidad Autónoma Metropolitana Iztapalapa, Iztapalapa, 09340, MEXICO.

Alzheimer's disease is a multifactorial neurodegenerative disorder preceded by a prodromal stage called mild cognitive impairment (MCI). Early diagnosis of MCI is crucial for delaying the progression and optimizing the treatment. In this study we propose a random forest (RF) classifier to distinguish between MCI and healthy control subjects (HC), identifying the most relevant features computed from structural T1-weighted and diffusion-weighted magnetic resonance images (sMRI and DWI), combined with neuro-psychological scores. Read More

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Air side-stream ammonia stripping in a thin film evaporator coupled to high-solid anaerobic digestion of sewage sludge: Process performance and interactions.

J Environ Manage 2021 Jun 21;295:113075. Epub 2021 Jun 21.

Acqua & Sole s.r.l., Via Giulio Natta, Vellezzo Bellini, PV, Italy.

Air side-stream ammonia stripping in a thin-film evaporator (TFE) is proposed for the first time to control total ammonia nitrogen (TAN) concentration in a centralized full-scale plant performing high-solid anaerobic digestion (HSAD) of sewage sludge (SS). In this process, anaerobically digesting sludge (ADS) is continuously recirculated from the digester to the TFE unit where ammonia is stripped by an air stream. The stripped ammonia reacts with sulfuric acid in an absorption unit to produce ammonium sulfate. Read More

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Lake Michigan insights from island studies: the roles of chipmunks and coyotes in maintaining Ixodes scapularis and Borrelia burgdorferi in the absence of white-tailed deer.

Ticks Tick Borne Dis 2021 Jun 6;12(5):101761. Epub 2021 Jun 6.

Fisheries and Wildlife Department, Michigan State University, 480 Wilson Rd., East Lansing, MI, USA, 48824; Department of Large Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, 784 Wilson Rd., East Lansing, MI, USA, 48824.

Deer management (e.g., reduction) has been proposed as a tool to reduce the acarological risk of Lyme disease. Read More

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The influence of visual attention on memory-based preferential choice.

Cognition 2021 Jun 21;215:104804. Epub 2021 Jun 21.

Department of Psychology, University of Basel, Switzerland; Department of Psychology, University of Hamburg, Germany. Electronic address:

Many decisions rely on past experiences. Recent research indicates that people's choices are biased towards choosing better-remembered options, even if these options are comparatively unattractive (i.e. Read More

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An enzymatic histamine biosensor based on a screen-printed carbon electrode modified with a chitosan-gold nanoparticles composite cryogel on Prussian blue-coated multi-walled carbon nanotubes.

Food Chem 2021 Jun 17;364:130396. Epub 2021 Jun 17.

Center of Excellence for Trace Analysis and Biosensor, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand; Division of Physical Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand; Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand. Electronic address:

A histamine biosensor was developed based on a screen-printed carbon electrode modified with Prussian blue (PB) electrodeposited on multi-walled carbon nanotubes covered with a macroporous layer of chitosan-gold nanoparticles composite cryogel (CS-AuNPs Cry). With its high specific surface area and conductivity, CS-AuNPs Cry proved an excellent supporting material for diamine oxidase (DAO) immobilization. PB acted as a redox mediator to promote electron transfer between hydrogen peroxide and the electrode surface. Read More

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On a new multi-source X-ray tube concept for minimizing imaging time in digital breast tomosynthesis.

Rolf Behling

Phys Med 2021 Jun 21;88:20-22. Epub 2021 Jun 21.

XtraininX - Technical Consulting, Sanddornweg 23 c, 22846 Norderstedt, Germany. Electronic address:

Replacing moving mechanics in computed tomography (CT) and digital breast tomosynthesis (DBT) has inspired numerous projects to develop alternative X-ray sources. While less suitable for CT, DBT is a viable target application for the multi-X-ray-source array tube suggested in Becker, A.E. Read More

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Treatment-emergent central sleep apnea associated with non-positive airway pressure therapies in obstructive sleep apnea patients: A systematic review.

Sleep Med Rev 2021 Jun 5;58:101513. Epub 2021 Jun 5.

Department of Pulmonary Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.

This systematic review summarizes the prevalence of treatment-emergent central sleep apnea (TECSA) occurring with therapies other than positive airway pressure (PAP) for the management of obstructive sleep apnea (OSA). We describe its natural course as well as the proposed underlying pathophysiological mechanisms and the clinical management of affected patients. A systematic search of PubMed, Embase, Web of science, and the Cochrane Library was performed until June 2020. Read More

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Profiles, spatial distributions and inventory of brominated dioxin and furan emissions from secondary nonferrous smelting industries in China.

J Hazard Mater 2021 Jun 17;419:126415. Epub 2021 Jun 17.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China; School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310000, China. Electronic address:

Nonferrous metallurgical processes are important sources of carcinogenic polybrominated dibenzo-p-dioxin and dibenzofuran (PBDD/Fs) that transport globally. Studies on the profiles, spatial distributions and inventory of PBDD/F emissions into the atmosphere from nonferrous metallurgical plants are needed for better source control. In this study, field investigations on PBDD/F emissions from typical nonferrous metallurgical plants were conducted to characterize the PBDD/F profiles and derive their emission factors. Read More

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No-nonspecific recognition-based amplification strategy for endonuclease activity screening with dual-color DNA nano-clew.

Biosens Bioelectron 2021 Jun 18;190:113446. Epub 2021 Jun 18.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China. Electronic address:

The inevitable nonspecific recognition severely restricted widely used nucleic acid amplification strategies, which has become an urgent problem in current scientific research. Herein, we developed a novel no-nonspecific recognition-based amplification strategy to construct dual-color dye loaded nano-clew as ultrabright illuminant for screening endonuclease activity with Escherichia coliRY13 I (EcoR I) as a model, which overcame some major drawbacks such as nonspecific recognition and photobleaching. Typically, the target endonuclease induces cleavage of the customized dumbbell-shape substrate (DSS) to generate two same triggers that can initiate the rolling circle amplification (RCA) to prepare long single-strand DNA (lssDNA), which could self-assemble into irregular DNA nano-clew based on the electrostatic interactions with Mg to furtherly capture the donor and accepter fluorophore proximately, constructing the dye loaded nano-clew with dual-color fluorescence (FL) emission to resist photobleaching. Read More

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Microfabricated potentiometric sensor for personalized methacholine challenge tests during the COVID-19 pandemic.

Biosens Bioelectron 2021 Jun 12;190:113439. Epub 2021 Jun 12.

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El Aini Street, Cairo, 11562, Egypt.

The methacholine challenge test is considered to be the gold standard bronchoprovocation test used to diagnose asthma, and this test is always performed in pulmonary function labs or doctors' offices. Methacholine (MCH) acts by inducing airway tightening/bronchoconstriction, and more importantly, MCH is hydrolyzed by cholinesterase enzyme (ChE). Recently, the American Thoracic Society raised concerns about pulmonary function testing during the COVID-19 pandemic due to recently reported correlation between cholinesterase and COVID-19 pneumonia severity/mortality, and it was shown that cholinesterase levels are reduced in the acute phase of severe COVID-19 pneumonia. Read More

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Starch and protein recovery from brewer's spent grain using hydrothermal pretreatment and their conversion to edible filamentous fungi - A brewery biorefinery concept.

Bioresour Technol 2021 Jun 13;337:125409. Epub 2021 Jun 13.

Swedish Centre for Resource Recovery, University of Borås, 50190 Borås, Sweden.

This study aimed at recovering a highly concentrated starch and protein stream from the brewer's spent grain (BSG). The effect of pretreatment temperature and retention time on the solubilization of starch and protein; and the generation of fermentation inhibitors were studied. Then, the application of recovered streams for fungal cultivation was evaluated using different edible fungi Aspergillus oryzae, Neurospora intermedia, and Rhizopus delemar. Read More

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Cancer cell membrane camouflaged iridium complexes functionalized black-titanium nanoparticles for hierarchical-targeted synergistic NIR-II photothermal and sonodynamic therapy.

Biomaterials 2021 Jun 18;275:120979. Epub 2021 Jun 18.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, PR China; MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 400201, PR China. Electronic address:

The diagnosis and treatment of cancer is one of the biggest medical challenges of the century. Despite significant improvements, there remains an urgent need for novel anticancer procedures. Among the most promising approaches, increasing attention has been devoted towards photothermal and sonodynamic therapy in which sensitizers are activated upon light/ultrasound radiation to generate a cytotoxic effect. Read More

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Experimental investigation of standard effective temperature (SET*) adapted for human walking in an indoor and transitional thermal environment.

Sci Total Environ 2021 Jun 11;793:148421. Epub 2021 Jun 11.

The School of Civil Engineering, Guangzhou University, Guangzhou, 510006, China. Electronic address:

Thermal indices are widely used to predict the human body's thermal sensation indoors and outdoors, with standard effective temperature (SET*) being the most commonly used index. Although SET* has been well-proven in predicting indoor static thermal comfort, it has not yet proven its applicability in thermal comfort and dynamic condition assessments outdoors. Refers to verify the application of SET* in both an indoor and transitional space, experiments were conducted in the badminton hall of Guangzhou University (representing the indoor space) and the overhead floor of the experimental building of Guangzhou University (representing the transition space). Read More

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Exponential passivity of discrete-time switched neural networks with transmission delays via an event-triggered sliding mode control.

Neural Netw 2021 Jun 15;143:271-282. Epub 2021 Jun 15.

Department of Basic, Qinghai University, Xining 810016, China.

This paper investigates the exponential passivity of discrete-time switched neural networks (DSNNs) with transmission delays via an event-triggered sliding mode control (SMC). Firstly, a novel discrete-time switched SMC scheme is constructed on the basis of sliding mode control method and event-triggered mechanism. Next, a state observer with transmission delays is designed to estimate the system state. Read More

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A melanoma patient with macrophage-cancer cell hybrids in the primary tumor, a lymph node metastasis and a brain metastasis.

Cancer Genet 2021 May 28;256-257:162-164. Epub 2021 May 28.

Department of Dermatology and The Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, United States. Electronic address:

In 1911 it was proposed that cancer might result from fusion and hybridization between macrophages and cancer cells. Using immunohistochemistry it was determined that essentially all solid tumors expressed macrophage-like molecules on their cell surface. More recently we have used forensic (STR) genetics that allows one to detect DNA from more than one individual in the same sample. Read More

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Performance evaluation of Emergency Department patient arrivals forecasting models by including meteorological and calendar information: A comparative study.

Comput Biol Med 2021 Jun 3;135:104541. Epub 2021 Jun 3.

Maersk Mc-Kinney Moller Institute, University of Southern Denmark, Denmark.

The volume of daily patient arrivals at Emergency Departments (EDs) is unpredictable and is a significant reason of ED crowding in hospitals worldwide. Timely forecast of patients arriving at ED can help the hospital management in early planning and avoiding of overcrowding. Many different ED patient arrivals forecasting models have previously been proposed by using time series analysis methods. Read More

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Mathematical analysis of the role of pituitary-adrenal interactions in ultradian rhythms of the HPA axis.

Comput Biol Med 2021 Jun 15;135:104580. Epub 2021 Jun 15.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

The hypothalamic-pituitary-adrenal (HPA) axis is a biological system in the human body that plays an important role in controlling stress and regulating various physiological elements, including the immune system, emotions, and moods in tense situations. Over the past two decades, several ordinary or delay differential equations models of the HPA axis have been proposed. In the majority of studies presented so far, corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol are among the main variables employed to build the HPA axis models. Read More

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Unifying the Hepatopancreatobiliary Surgery Fellowship Curriculum via Delphi Consensus.

J Am Coll Surg 2021 Jun 15. Epub 2021 Jun 15.

Department of Surgery, University of California San Francisco, San Francisco, CA.

Background: HPB Fellowship training in the Americas consists of three distinctive routes with variable curricula: Surgical Oncology Fellowship via the Society of Surgical Oncology (SSO), Abdominal Transplant Surgery Fellowship via the American Society of Transplant Surgeons (ASTS), and HPB Fellowship via the Americas Hepato-Pancreato-Biliary Association (AHPBA). Our objective was to establish a pan-American consensus among hepatopancreatobiliary (HPB) surgeons, surgical oncologists, abdominal transplant surgeons, and general surgery residency program directors (GSPDs) on a core knowledge curriculum for HPB fellowship and to identify topics appropriate for general surgery residency and subspecialty beyond HPB fellowship.

Study Design: A three-round modified Delphi process was used. Read More

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World Neurosurg 2021 Jun 21. Epub 2021 Jun 21.

Médico Assistente do Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP - Ribeirão Preto (SP), Brasil.

Introduction: Among the interbody fusions, the Lateral Lumbar Interbody Fusion (LLIF) allowed access to the lumbar spine through the major psoas muscle, which offers several advantages to the spine surgeon. However, some of its drawbacks cause surgeons to avoid using it as a daily practice. Therefore, to address some of these challenges, the Prone Transpsoas technique was proposed, differing mainly from the traditional technique on patient position - moving from lateral to prone decubitus, theoretically enhancing the lordosis and impacting the psoas morphology. Read More

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In vitro evidence of propagation of superoxide dismutase-1 protein aggregation in canine degenerative myelopathy.

Vet J 2021 Jun 21:105710. Epub 2021 Jun 21.

Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan; The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan. Electronic address:

Canine degenerative myelopathy (DM) is a progressive and fatal neurodegenerative disorder that has been linked to mutations in the superoxide dismutase 1 (SOD1) gene. The accumulation of misfolded protein aggregates in spinal neurons and astrocytes is implicated as an important pathological process in DM; however, the mechanism of protein aggregate formation is largely unknown. In human neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), cell-to-cell propagation of disease-relevant proteins has been demonstrated. Read More

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An update of the molecular mechanisms underlying doxorubicin plus trastuzumab induced cardiotoxicity.

Life Sci 2021 Jun 21:119760. Epub 2021 Jun 21.

LAQV/REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal. Electronic address:

Cardiotoxicity is a major side effect of the chemotherapeutic drug doxorubicin (Dox), which is further exacerbated when it is combined with trastuzumab, a standard care approach for Human Epidermal growth factor Receptor-type 2 (HER2) positive cancer patients. However, the molecular mechanisms of the underlying cardiotoxicity of this combination are still mostly elusive. Increased oxidative stress, impaired energetic substrate uses and topoisomerase IIB inhibition are among the biological processes proposed to explain Dox-induced cardiomyocyte dysfunction. Read More

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Senotherapeutics: targeting senescent cells for the main age-related diseases.

Mech Ageing Dev 2021 Jun 21:111526. Epub 2021 Jun 21.

Santa Maria della Misericordia Hospital, Section of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Italy.

The review aims to summarize and discuss the current knowledge on targeting senescent cells to reduce the risk of age-related diseases in animal models and human studies. The role of cellular senescence in aging and the major age-related diseases -including Alzheimer's disease, atherosclerosis, and type 2 diabetes- as well as the use of senotherapeutic strategies in both experimental and preclinical studies, will be described. A large number of molecules, including synthetic agents and natural compounds, have been proposed for anti-senescence activities. Read More

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Contextual factors associated with cancer screening uptake: A systematic review of observational studies.

Prev Med 2021 Jun 21:106692. Epub 2021 Jun 21.

U1086 "ANTICIPE" INSERM-University of Caen Normandie, Centre François Baclesse: 3, Avenue du Général Harris, 14000 Caen, France.

We conducted a systematic review of a wide range of contextual factors related to cancer screening uptake that have been studied so far. Studies were identified through PubMed and Web of Science databases. An operational definition of context was proposed, considering as contextual factors: social relations directly aimed at cancer screening, health care provider and facility characteristics, geographical/accessibility measures and aggregated measures at supra-individual level. Read More

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Streptozotocin activates inflammation-associated signalling and antioxidant response in the lobster cockroach; Nauphoeta cinerea (Blattodea: Blaberidae).

Chem Biol Interact 2021 Jun 21:109563. Epub 2021 Jun 21.

Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil. Electronic address:

Streptozotocin exhibits tropism to insulin-producing beta-cells in mammals and has been used to model diabetes-like phenotypes in insects. We have previously shown increased brain glucose levels and oxidative stress in STZ-treated nymphs of Nauphoeta cinerea. Here, we validate Nauphoeta cinerea as an experimental organism for studying STZ-induced metabolic disruptions by investigating the potential changes in the expression of inflammation and antioxidant related genes. Read More

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