Acta Biomater 2020 08 1;112:262-273. Epub 2020 Jun 1.
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15219; McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15260; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15260. Electronic address:
Bone loss due to trauma and tumors remains a serious clinical concern. Due to limited availability and disease transmission risk with autografts and allografts, calcium phosphate bone fillers and growth factor-based substitute bone grafts are currently used in the clinic. However, substitute grafts lack bone regeneration potential when used without growth factors. Read More