11,714 results match your criteria proportional liver


Comparing the Clinicopathological Characteristics of Combined Hepatocellular-Cholangiocarcinoma with Other Primary Liver Cancers Using the Updated WHO Classification.

Histopathology 2021 Apr 10. Epub 2021 Apr 10.

Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is an uncommon hepatic malignancy with a poor outcome. The 2019 WHO classification modified the definition and discarded the subtypes harboring stem cell features. However, the differences among cHCC-CCA, hepatocellular carcinoma (HCC), HCC with stem cell features (HCCscf) and intrahepatic cholangiocarcinoma (iCCA) remain undetermined. Read More

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Transarterial radioembolization versus systemic treatment for hepatocellular carcinoma with macrovascular invasion: Analysis of the US National Cancer Database.

J Nucl Med 2021 Apr 9. Epub 2021 Apr 9.

Cedars-Sinai Medical Center, United States.

Systemic therapy remains the recommended first-line treatment for hepatocellular carcinoma (HCC) with macrovascular invasion (MVI). Transarterial radioembolization (TARE) is a promising alternative treatment given superior quality of life. The aims of this study were to 1) characterize trends and correlates for TARE as first-line treatment of HCC patients with MVI in the US and 2) compare survival after TARE versus systemic therapy. Read More

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Pathologic upstaging in resected pancreatic adenocarcinoma: Risk factors and impact on survival.

J Surg Oncol 2021 Apr 9. Epub 2021 Apr 9.

Section of Surgical Oncology, Division of Surgery, Baptist MD Anderson Cancer Center, Jacksonville, Florida, USA.

Background: Clinical and pathologic staging determine treatment of pancreatic cancer. Clinical stage has been shown to underestimate final pathologic stage in pancreatic cancer, resulting in upstaging.

Methods: National Cancer Database was used to identify clinical stage I pancreatic adenocarcinoma. Read More

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Lu-DOTATATE in older patients with metastatic neuroendocrine tumours: safety, efficacy and health-related quality of life.

Eur J Nucl Med Mol Imaging 2021 Apr 9. Epub 2021 Apr 9.

Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, London, NW3 2QG, UK.

Purpose: The safety and efficacy of Lu-DOTATATE in older patients with advanced neuroendocrine tumours (NET) are not well understood.

Methods: Patients ≥70 years of age and treated with Lu-DOTATATE were included. Toxicity, health-related quality of life (HRQoL), objective response, progression-free survival (PFS) and overall survival (OS) were assessed. Read More

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Contour prognostic model for predicting survival after resection of colorectal liver metastases: development and multicentre validation study using largest diameter and number of metastases with RAS mutation status.

Br J Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Background: Most current models for predicting survival after resection of colorectal liver metastasis include largest diameter and number of colorectal liver metastases as dichotomous variables, resulting in underestimation of the extent of risk variation and substantial loss of statistical power. The aim of this study was to develop and validate a new prognostic model for patients undergoing liver resection including largest diameter and number of colorectal liver metastases as continuous variables.

Methods: A prognostic model was developed using data from patients who underwent liver resection for colorectal liver metastases at MD Anderson Cancer Center and had RAS mutational data. Read More

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Prevalence and consequences of non-proportional hazards in surgical randomized controlled trials.

Br J Surg 2021 Apr 8. Epub 2021 Apr 8.

Department of Vascular Surgery, University Hospital Zurich, Zurich, Switzerland.

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Post-operative heparin reduces early venous thrombotic complications after orthotopic paediatric liver transplantation.

Blood Transfus 2021 Mar 12. Epub 2021 Mar 12.

Department of Immunohaematology and Transfusion Medicine, "Papa Giovanni XXIII" Hospital, Bergamo, Italy.

Background: Despite significant improvements in surgical techniques and medical care, thrombotic complications still represent the primary cause of early graft failure and re-transplantation following paediatric liver transplantation. There is still no standardized approach for thrombosis prevention.

Materials And Methods: The study aimed to evaluate the effectiveness of early intravenous unfractionated heparin started 12 hours postoperatively at 10 UI/kg per hour and used a retrospective "before and after" design to compare the incidence of early thrombotic complications prior to (2002-2010) and after (2011-2016) the introduction of heparin in our institute. Read More

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Risk factors for systemic and venous thromboembolism, mortality and bleeding risks in 1125 patients with COVID-19: relationship with anticoagulation status.

Aging (Albany NY) 2021 Mar 26;13. Epub 2021 Mar 26.

Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Aim: Coronavirus disease 2019 (COVID-19) has been associated with increased mortality and morbidity from thromboembolism, especially venous thromboembolism. There are more limited data for systemic thromboembolism. The present study aimed to investigate the prevalence of systemic and venous thromboembolism as well as major bleeding and mortality in relation to underlying risk factors and the impact of anticoagulation use in hospitalized patients with COVID-19. Read More

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Relationship between hemodynamic parameters and portal venous pressure in cirrhosis patients with portal hypertension.

Open Life Sci 2020 31;15(1):981-987. Epub 2020 Dec 31.

Gerontological Surgery Department, Xi'an International Medical Center, Xi'an, 710100, China.

Cirrhosis caused by viral and alcoholic hepatitis is an essential cause of portal hypertension (PHT). The incidence of PHT complication is directly proportional to portal venous pressure (PVP), and the clinical research of PVP and its hemodynamic indexes is of great significance for deciding the treatment strategy of PHT. Various techniques are currently being developed to decrease portal pressure but hemodynamic side effects may occur. Read More

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December 2020

RATIO OF MAIN PHYLOTYPES OF GUT MICROBIOTA IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE DEPENDING ON THE BODY MASS INDEX.

Wiad Lek 2021 ;74(3 cz 1):523-528

GOVERNMENT INSTITUTION "L.T.MALAYA THERAPY NATIONAL INSTITUTE OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE", KHARKIV, UKRAINE.

Objective: The aim: To analyze the status of Gut microbiota (GM) at the level of the main phylotypes in patients with NAFLD, depending on the body mass index (BMI) and gender in comparison with a group of practically healthy individuals.

Patients And Methods: Materials and methods: The study involved 120 patients with NAFLD, who were divided into two groups depending on BMI and the control group containing 20 practically healthy individuals.

Results: Results: In patients with NAFLD with comorbid obesity, a statistically significant increase in the relative amount of Firmicutes (52. Read More

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Multi-Center Evaluation of Survival and Toxicities following Radioembolization: analysis of the RESiN Registry.

J Vasc Interv Radiol 2021 Apr 1. Epub 2021 Apr 1.

Interventional Radiology, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

Purpose: To determine overall survival (OS), progression-free survival (PFS) and toxicity in a multicenter, real-world data collection using transarterial radioembolization (TARE) with resin microspheres.

Materials And Methods: 448 patents were treated at 36 centers between 2015-2019. Treatment history, baseline laboratory and imaging, and treatment goal were assessed. Read More

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Cancer Risk in Patients With Biopsy-Confirmed Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study.

Hepatology 2021 Apr 3. Epub 2021 Apr 3.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Recent studies link nonalcoholic fatty liver disease (NAFLD) to an increased incidence of hepatocellular carcinoma (HCC) and extrahepatic cancers. However, prior studies were small or lacked liver histology, which remains the gold standard for staging NAFLD severity. We conducted a population-based cohort study of all adults with histologically defined NAFLD in Sweden from 1966 to 2016 (N=8,892). Read More

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Deep Neck Infection Risk in Patients with Sleep Apnea: Real-World Evidence.

Int J Environ Res Public Health 2021 Mar 19;18(6). Epub 2021 Mar 19.

Department of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan.

(1) Background: Sleep apnea may be a risk factor for deep neck infection (DNI). The objective of this study was to investigate the effects of sleep apnea on DNI. (2) Methods: In this first nationwide retrospective cohort study on the sleep apnea-DNI correlation, we obtained data from the Longitudinal Health Insurance Database 2005, a subset of the Taiwan National Health Insurance Research Database. Read More

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Rupture Risk of Intracranial Aneurysm and Prediction of Hemorrhagic Stroke after Liver Transplant.

Brain Sci 2021 Mar 31;11(4). Epub 2021 Mar 31.

Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Postoperative hemorrhagic stroke (HS) is a rare yet devastating complication after liver transplantation (LT). Unruptured intracranial aneurysm (UIA) may contribute to HS; however, related data are limited. We investigated UIA prevalence and aneurysmal subarachnoid hemorrhage (SAH) and HS incidence post-LT. Read More

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Pharmacokinetic Characterization of Supinoxin and Its Physiologically Based Pharmacokinetic Modeling in Rats.

Pharmaceutics 2021 Mar 11;13(3). Epub 2021 Mar 11.

Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Korea.

Supinoxin is a novel anticancer drug candidate targeting the Y593 phospho-p68 RNA helicase, by exhibiting antiproliferative activity and/or suppression of tumor growth. This study aimed to characterize the in vitro and in vivo pharmacokinetics of supinoxin and attempt physiologically based pharmacokinetic (PBPK) modeling in rats. Supinoxin has good permeability, comparable to that of metoprolol (high permeability compound) in Caco-2 cells, with negligible net absorptive or secretory transport observed. Read More

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Obesity in Saudi Arabia in 2020: Prevalence, Distribution, and Its Current Association with Various Health Conditions.

Healthcare (Basel) 2021 Mar 11;9(3). Epub 2021 Mar 11.

Liver Transplant Unit, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia.

The global prevalence of obesity is increasing. Obesity is associated with many chronic diseases and health conditions. This study aims to estimate the current prevalence of obesity in Saudi Arabia and described the current national-level status of the association between obesity and various health conditions. Read More

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Association between use of Qingfei Paidu Tang and mortality in hospitalized patients with COVID-19: A national retrospective registry study.

Phytomedicine 2021 Feb 28;85:153531. Epub 2021 Feb 28.

National Clinical Research Center for Cardiovascular Diseases, State Key, Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for, Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union, Medical College, Beijing, People's Republic of China; Central China Subcenter of the National Center for Cardiovascular Diseases, Zhengzhou, People's Republic of China; Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, People's Republic of China. Electronic address:

Background: Qingfei Paidu Tang (QPT), a formula of traditional Chinese medicine, which was suggested to be able to ease symptoms in patients with Coronavirus Disease 2019 (COVID-19), has been recommended by clinical guidelines and widely used to treat COVID-19 in China. However, whether it decreases mortality remains unknown.

Purpose: We aimed to explore the association between QPT use and in-hospital mortality among patients hospitalized for COVID-19. Read More

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February 2021

Prevalence and Long-Term Outcomes of Solid Organ Transplant in Children with Intellectual Disability.

J Pediatr 2021 Mar 29. Epub 2021 Mar 29.

Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington.

Objectives: To describe the prevalence and long-term outcomes of kidney, liver, and heart transplant for children with intellectual disability.

Study Design: We performed a retrospective cohort analysis of children receiving a first kidney, liver, or heart-alone transplant in the United Network for Organ Sharing dataset from 2008-2017. Recipients with definite intellectual disability were compared with those Possible/no ID. Read More

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Donation After Circulatory Death Liver Transplantation: An in Depth Analysis and Propensity-Score Matched Comparison.

Clin Transplant 2021 Apr 1:e14304. Epub 2021 Apr 1.

Department of Surgery, J.C. Walter, Jr. Transplant Center, Sherrie and Alan Conover Center for Liver Disease and Transplantation, Houston Methodist, Houston, USA.

Background: Careful donor-recipient matching and reduced ischemia times have improved outcomes following donation after circulatory death (DCD) liver transplantation (LT). This study examines a single center experience with DCD LT including high-acuity and hospitalized recipients.

Methods: DCD LT outcomes were compared to a propensity-score matched (PSM) donation after brain death (DBD) LT cohort (1:4); 32 DCD LT patients and 128 PSM DBD LT patients transplanted from 2008-2018 were included. Read More

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Real-World Incidence of Suboptimal Response to Anti-Tumor Necrosis Factor Therapy for Ulcerative Colitis: A Nationwide Population-Based Study.

Gut Liver 2021 Apr 2. Epub 2021 Apr 2.

Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background/aims: Although anti-tumor necrosis factor (TNF) agents have been widely used to treat ulcerative colitis (UC), the real-world incidence of suboptimal response to anti-TNF agents has not been thoroughly investigated, especially among Asians.

Methods: Using the Korean National Health Insurance database, we collected data on UC patients who initiated anti-TNF agents between July 1, 2014, and June 30, 2017. We assessed suboptimal responses, including anti-TNF discontinuation or dose escalation, switching to other biologics, augmentation with a non-biologic therapy, and the requirement for colectomy. Read More

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Evaluation of the prognosis for N2 status in patients with small bowel neuroendocrine tumors.

Am J Surg 2021 Mar 24. Epub 2021 Mar 24.

Division of Surgical Oncology, Department of Surgery, Oregon Health & Science University, United States. Electronic address:

Background: The 8th edition AJCC Staging for small bowel neuroendocrine tumors created a novel N2 classification. This study investigates if it is independently prognostic.

Methods: Records of patients from 2008 to 2019 were reviewed. Read More

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Obesity and incident gastrointestinal cancers: overall body size or central obesity measures, which factor matters?

Eur J Cancer Prev 2021 May;30(3):267-274

Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

BMI does not reflect the location or amount of body fat. We aimed to investigate the role of general and central obesity measures in the prediction of incident gastrointestinal cancers. In this analysis of the Golestan Cohort Study, we included 47 586 cancer-free individuals followed for 12. Read More

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Clinical outcomes and prognostic factors following the surgical resection of renal cell carcinoma spinal metastases.

Cancer Sci 2021 Mar 29. Epub 2021 Mar 29.

Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

The efficacy of surgical resection in metastatic renal cell carcinoma is an active and important research field in the post-cytokine era. Bone metastases, especially in the spine, compromise patient performance status. Metastasectomy is indicated, if feasible, since it helps to achieve the best clinical outcomes possible compared to other treatments. Read More

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Roux-en-Y Gastric Bypass Is Associated With Increased Hazard for De Novo Alcohol-related Complications and Liver Disease.

J Clin Gastroenterol 2021 Mar 12. Epub 2021 Mar 12.

*Department of Medicine, Division of Gastroenterology and Hepatology ‡Department of Surgery, Division of Gastrointestinal Surgery §Department of Psychiatry, University of North Carolina, Chapel Hill †Department of Statistical Science, Duke University, Durham, NC.

Goal: The goal of this study was to determine if bariatric surgeries are associated with de novo alcohol-related complications.

Background: Bariatric surgery is associated with an increased risk of alcohol use disorders. The effect of bariatric surgeries on other alcohol-related outcomes, including liver disease, is understudied. Read More

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Low Rates of Hepatitis B Virus Treatment Among Treatment-Eligible Patients in Safety-Net Health Systems.

J Clin Gastroenterol 2021 Mar 17. Epub 2021 Mar 17.

*Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Healthcare System, Palo Alto †Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford ‡Division of Gastroenterology and Hepatology, Alameda Health System-Highland Hospital, Oakland, CA §Division of Infectious Diseases, University of Texas Southwestern Medical Center ∥Parkland Health and Hospital System, Dallas, TX ¶Multi-Organ Transplant Institute, Ochsner Health System, New Orleans, LA #Division of Gastroenterology and Hepatology, MetroHealth System, Cleveland, OH **Medical Technology and Practice Patterns Institute, Bethesda, MD.

Background: Timely initiation of antiviral therapy in chronic hepatitis B virus (CHB) reduces risk of disease progression. We evaluate overall treatment rates and predictors of treatment among treatment-eligible safety-net CHB patients.

Methods: We retrospectively evaluated adults with CHB from 2010 to 2018 across 4 large safety-net health systems in the United States. Read More

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Colorectal cancer liver metastases: management and five-year survival in a South African patient cohort.

S Afr J Surg 2021 Mar;59(1):2-6

WITS Donald Gordon Medical Centre; University of the Witwatersrand, South Africa.

Background: Approximately 25% of patients with colorectal cancer (CRC) will be diagnosed with CRC liver metastases (CRCLM) during the course of their disease. No data regarding CRCLM presentation, management and survival outcomes has been published from either the private or public health care sectors in South Africa. This study aimed to address this deficit, reporting on a private sector cohort. Read More

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Performance of initial LI-RADS 2018 treatment response in predicting survival of patients with hepatocellular carcinoma following TACE: a retrospective, single-center cohort study.

J Cancer Res Clin Oncol 2021 Mar 28. Epub 2021 Mar 28.

Second Department of Radiology, Medical University of Warsaw, Ul. Banacha 1a, 02-097, Warsaw, Poland.

Purpose: Treatment response following transarterial chemoembolization (TACE) is frequently evaluated with Liver Imaging Reporting and Data System Treatment Response (LR-TR) algorithm, but its association with patients' outcomes is not supported in the literature. The purpose of this study was to provide such data.

Methods: A retrospective analysis of 99 TACE patients with stage A/B hepatocellular carcinoma according to Barcelona-Clinic Liver Cancer staging system was performed. Read More

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Blood Cell Salvage and Autotransfusion Does Not Worsen Oncologic Outcomes Following Liver Transplantation with Incidental Hepatocellular Carcinoma: A Propensity Score-Matched Analysis.

Ann Surg Oncol 2021 Mar 28. Epub 2021 Mar 28.

HBP and Multi Organ Transplant Program, Division of General Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.

Background: Intraoperative blood cell salvage and autotransfusion (IBSA) during liver transplantation (LT) for hepatocellular carcinoma (HCC) is controversial for concern regarding adversely impacting oncologic outcomes.

Objective: We aimed to evaluate the long-term oncologic outcomes of patients who underwent LT with incidentally discovered HCC who received IBSA compared with those who did not receive IBSA.

Methods: Patients undergoing LT (January 2001-October 2018) with incidental HCC on explant pathology were retrospectively identified. Read More

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Two-stage Cox-nnet: biologically interpretable neural-network model for prognosis prediction and its application in liver cancer survival using histopathology and transcriptomic data.

NAR Genom Bioinform 2021 Mar 22;3(1):lqab015. Epub 2021 Mar 22.

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48104, USA.

Pathological images are easily accessible data with the potential of prognostic biomarkers. Moreover, integration of heterogeneous data types from multi-modality, such as pathological image and gene expression data, is invaluable to help predicting cancer patient survival. However, the analytical challenges are significant. Read More

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[F]FDG PET radiomics to predict disease-free survival in cervical cancer: a multi-scanner/center study with external validation.

Eur J Nucl Med Mol Imaging 2021 Mar 26. Epub 2021 Mar 26.

GIGA-CRC in vivo Imaging, University of Liège, GIGA, Avenue de l'Hôpital 11, 4000, Liege, Belgium.

Purpose: To test the performances of native and tumour to liver ratio (TLR) radiomic features extracted from pre-treatment 2-[F] fluoro-2-deoxy-D-glucose ([F]FDG) PET/CT and combined with machine learning (ML) for predicting cancer recurrence in patients with locally advanced cervical cancer (LACC).

Methods: One hundred fifty-eight patients with LACC from multiple centers were retrospectively included in the study. Tumours were segmented using the Fuzzy Local Adaptive Bayesian (FLAB) algorithm. Read More

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