119,361 results match your criteria proportional hazards


Culture positivity may correlate with long-term mortality in critically ill patients.

BMC Infect Dis 2021 Nov 26;21(1):1188. Epub 2021 Nov 26.

Department of Critical Care Medicine, Taichung Veterans General Hospital, No, 1650, Section 4, Taiwan Boulevard, Xitun District, Taichung, 40705, Taiwan.

Background: The long-term outcome is currently a crucial issue in critical care, and we aim to address the association between culture positivity and long-term mortality in critically ill patients.

Methods: We used the 2015-2019 critical care database at Taichung Veterans General Hospital and Taiwanese nationwide death registration files. Multivariable Cox proportional hazards regression model was conducted to determine hazard ratio (HR) and 95% confidence interval (CI). Read More

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November 2021

Predicting Hospital Length of Stay at Admission Using Global and Country-Specific Competing Risk Analysis of Structural, Patient, and Nutrition-Related Data from nutritionDay 2007-2015.

Nutrients 2021 Nov 16;13(11). Epub 2021 Nov 16.

Department of Health Economics, Center for Public Health, Medical University of Vienna, 1090 Vienna, Austria.

Hospital length of stay (LOS) is an important clinical and economic outcome and knowing its predictors could lead to better planning of resources needed during hospitalization. This analysis sought to identify structure, patient, and nutrition-related predictors of LOS available at the time of admission in the global nutritionDay dataset and to analyze variations by country for countries with > 750. Data from 2006-2015 ( = 155,524) was utilized for descriptive and multivariable cause-specific Cox proportional hazards competing-risks analyses of total LOS from admission. Read More

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November 2021

Adherence to a Mediterranean-Style Dietary Pattern and Cancer Risk in a Prospective Cohort Study.

Nutrients 2021 Nov 13;13(11). Epub 2021 Nov 13.

Department of Medicine, Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA 02118, USA.

A Mediterranean-style diet is a healthy eating pattern that may benefit cancer risk, but evidence among Americans is scarce. We examined the prospective association between adherence to such a diet pattern and total cancer risk. A Mediterranean-style dietary pattern (MSDP) score was derived from a semi-quantitative food frequency questionnaire at exam 5 (1991-1995). Read More

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November 2021

Factors Associated with the Initiation of Added Sugar among Low-Income Young Children Participating in the Special Supplemental Nutrition Program for Women, Infants, and Children in the US.

Nutrients 2021 Oct 29;13(11). Epub 2021 Oct 29.

Department of Public Health Sciences, The University of North Carolina at Charlotte, University City Blvd 9201, Charlotte, NC 28223, USA.

Added sugar intake at a young age is associated with chronic diseases including cardiovascular diseases, asthma, elevated blood pressure, and overweight. The Dietary Guidelines for Americans 2020-2025 and the American Heart Association recommend delaying the introduction of added sugar until age 2. The aims of this study were to identify the timing of added sugar initiation; factors associated with added sugar initiation; and the top five added sugar foods and beverages consumed by infants and children at three age ranges (<7 months, 8-13 months, and 14-24 months). Read More

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October 2021

Association between Milk Intake and Incident Stroke among Japanese Community Dwellers: The Iwate-KENCO Study.

Nutrients 2021 Oct 25;13(11). Epub 2021 Oct 25.

The Research Institute of Strategy for Prevention, Tokyo 103-0006, Japan.

We aimed to evaluate the association between the milk consumption and incident stroke in a Japanese population, where milk consumption is lower than that of Western countries. In total, 14,121 participants (4253 men and 9868 women) aged 40-69 years, free from cardiovascular diseases (CVD) were prospectively followed for 10.7 years. Read More

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October 2021

Risk of Re-Rupture, Vasospasm, or Re-Stroke after Clipping or Coiling of Ruptured Intracranial Aneurysms: Long-Term Follow-Up with a Propensity Score-Matched, Population-Based Cohort Study.

J Pers Med 2021 Nov 16;11(11). Epub 2021 Nov 16.

Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science, Asia University, Taichung 41354, Taiwan.

Scarce evidence is available in Asia for estimating the long-term risk and prognostic factors of major complications such as re-rupture, vasospasm, or re-stroke for patients with aneurysmal subarachnoid hemorrhage (SAH) undergoing endovascular coil embolization or surgical clipping. This is the first head-to-head propensity score-matched study in an Asian population to demonstrate that endovascular coil embolization for aneurysmal SAH treatment is riskier than surgical clipping in terms of re-rupture, vasospasm, or re-stroke. In addition, the independent poor prognostic factors of vasospasm or re-stroke were endovascular coil embolization, male sex, older age (≥65 years; the risk of vasospasm increases with age), hypertension, congestive heart failure, diabetes, previous transient ischemic attack, or stroke in aneurysmal SAH treatment. Read More

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November 2021

Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer's Disease Dementia.

Int J Environ Res Public Health 2021 Nov 19;18(22). Epub 2021 Nov 19.

Premedical Science, College of Medicine, Chosun University, Gwangju 61452, Korea.

The purpose of this study was to investigate whether brain and cognitive reserves were associated with the clinical progression of AD dementia. We included participants with AD dementia from the Alzheimer's Disease Neuroimaging Initiative, provided they were followed up at least once, and candidate proxies for cognitive (education for early-life reserve and Adult Reading Test for late-life reserve) or brain reserve (intracranial volume [ICV] for early-life reserve and the composite value of [F] fluorodeoxyglucose positron emission tomography regions of interest (FDG-ROIs) for late-life reserve) were available. The final analysis included 120 participants. Read More

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November 2021

Can Videofluoroscopic Swallowing Kinematic Analysis Predict Recovery of Oral Intake in Postoperative Oral Cancer Patients Requiring Nasogastric Tube Feeding?

Int J Environ Res Public Health 2021 Nov 16;18(22). Epub 2021 Nov 16.

Department of Dysphagia Rehabilitation, Division of Gerontology and Gerodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo Ward, Tokyo 113-8549, Japan.

This retrospective study determined the significant predictive factors for the number of days required to remove nasogastric tubes (NGTs) after surgery in patients with oral cancer (OC). In this study, patients underwent a videofluoroscopic swallowing study (VFSS) approximately 2 weeks after surgery. Videofluoroscopic images were analyzed, and variables such as swallowing and swallowing kinematics were measured. Read More

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November 2021

A Polygenic Risk Score Predicts Incident Prostate Cancer Risk in Older Men but Does Not Select for Clinically Significant Disease.

Cancers (Basel) 2021 Nov 19;13(22). Epub 2021 Nov 19.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.

Despite the high prevalence of prostate cancer in older men, the predictive value of a polygenic risk score (PRS) remains uncertain in men aged ≥70 years. We used a 6.6 million-variant PRS to predict the risk of incident prostate cancer in a prospective study of 5701 men of European descent aged ≥70 years (mean age 75 years) enrolled in the ASPirin in Reducing Events in the Elderly (ASPREE) clinical trial. Read More

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November 2021

A Simple Preoperative Blood Count to Stratify Prognosis in Isocitrate Dehydrogenase-Wildtype Glioblastoma Patients Treated with Radiotherapy plus Concomitant and Adjuvant Temozolomide.

Cancers (Basel) 2021 Nov 18;13(22). Epub 2021 Nov 18.

Université d'Angers, CHU d'Angers, CRCINA, F-49000 Angers, France.

Purpose: The survival times of glioblastoma (GB) patients after the standard therapy including safe maximal resection followed by radiotherapy plus concomitant and adjuvant temozolomide are heterogeneous. In order to define a simple, reliable method for predicting whether patients with isocitrate dehydrogenase (IDH)-wildtype GB treated with the standard therapy will be short- or long-term survivors, we analyzed the correlation of preoperative blood counts and their combined forms with progression-free survival (PFS) and overall survival (OS) in these patients.

Methods: Eighty-five patients with primary IDH-wildtype GB treated with the standard therapy between 2012 and 2019 were analyzed retrospectively. Read More

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November 2021

Prognostic Effect of Preoperative Psoas Muscle Hounsfield Unit at Radical Cystectomy for Bladder Cancer.

Cancers (Basel) 2021 Nov 10;13(22). Epub 2021 Nov 10.

Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Mie, Japan.

Radical cystectomy (RC) is the standard treatment for patients with advanced bladder cancer. Since RC is a highly invasive procedure, the surgical indications in an aging society must be carefully judged. In recent years, the concept of "frailty" has been attracting attention as a term used to describe fragility due to aging. Read More

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November 2021

Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study.

J Clin Med 2021 Nov 15;10(22). Epub 2021 Nov 15.

College of Medicine, Tzu Chi University, Hualien 970, Taiwan.

Type 2 diabetes might be influenced by colonic disease; however, the association between colonic resection and type 2 diabetes has rarely been discussed. This population-based cohort study explored the association between colectomy and type 2 diabetes in patients without colorectal cancer. A total of 642 patients who underwent colectomy for noncancerous diseases at any time between 2000 and 2012 in the National Health Insurance Research Database of Taiwan were enrolled. Read More

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November 2021

Left Atrial Geometry and Phasic Function Determined by Cardiac Magnetic Resonance Are Independent Predictors for Outcome in Non-Ischaemic Dilated Cardiomyopathy.

Biomedicines 2021 Nov 10;9(11). Epub 2021 Nov 10.

Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Left atrial (LA) geometry and phasic functions are frequently impaired in non-ischaemic dilated cardiomyopathy (NIDCM). Cardiac magnetic resonance (CMR) can accurately measure LA function and geometry parameters. We sought to investigate their prognostic role in patients with NIDCM. Read More

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November 2021

Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations.

Biomedicines 2021 Oct 22;9(11). Epub 2021 Oct 22.

School of Public Health, Imperial College London, London SW7 2AZ, UK.

A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multivariable Cox proportional hazards regression among 995 CRC cases (515 deaths, 396 from CRC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Se and SELENOP serum concentrations were measured on average 46 months before CRC diagnosis. Read More

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October 2021

Pathway-Based Personalized Analysis of Pan-Cancer Transcriptomic Data.

Biomedicines 2021 Oct 20;9(11). Epub 2021 Oct 20.

Department of Mathematics, College of Science, Nanjing Agricultural University, Nanjing 210095, China.

The occurrence of cancer is closely related to the deregulation of certain pathways. Based on pathway deregulation scores (PDS) inferred by the Pathifier algorithm, we analyzed transcriptomic data of 13 different cancer types in The Cancer Genome Atlas database to identify cancer-specific deregulated pathways and prognostic pathways. The results showed that the individual-specific pathway deregulation scores can clearly distinguish different cancer types and their tumor-adjacent tissues. Read More

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October 2021

Diagnostic Methods and Risk Factors for Severe Disease and Mortality in Blastomycosis: A Retrospective Cohort Study.

J Fungi (Basel) 2021 Oct 20;7(11). Epub 2021 Oct 20.

Department of Medicine, Division of Infectious Diseases, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.

Blastomycosis can cause severe disease with progressive respiratory failure and dissemination even in immunocompetent individuals. We sought to evaluate risk factors for severe disease and mortality using clinical and laboratory data within a large health system in an endemic area. We performed a retrospective cohort study of patients diagnosed with blastomycosis at all Mayo Clinic sites from 1 January 2004 through 31 March 2020. Read More

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October 2021

A kernel- and optimal transport- based test of independence between covariates and right-censored lifetimes.

Int J Biostat 2020 Dec 2;17(2):331-348. Epub 2020 Dec 2.

Department of Statistics, University of Oxford, Oxford, UK.

We propose a nonparametric test of independence, termed optHSIC, between a covariate and a right-censored lifetime. Because the presence of censoring creates a challenge in applying the standard permutation-based testing approaches, we use optimal transport to transform the censored dataset into an uncensored one, while preserving the relevant dependencies. We then apply a permutation test using the kernel-based dependence measure as a statistic to the transformed dataset. Read More

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December 2020

Association between breast cancer's prognostic factors and 3D textural features of non-contrast-enhanced T1-weighted breast MRI.

Br J Radiol 2021 Nov 26:20210702. Epub 2021 Nov 26.

Institute of Clinical Medicine, School of Medicine, Clinical Radiology, University of Eastern Finland, Kuopio, Finland.

Objectives: The aim of this exploratory study was to evaluate whether three-dimensional texture analysis (3D-TA) features of non-contrast-enhanced T1-weighted MRI associate with traditional prognostic factors and disease-free survival (DFS) of breast cancer.

Methods: 3D-T1-weighted images from 78 patients with 81 malignant histopathologically verified breast lesions were retrospectively analysed using standard-size volumes of interest. Grey-level co-occurrence matrix (GLCM) based features were selected for statistical analysis. Read More

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November 2021

Chronic kidney disease and risk of atrial fibrillation and heart failure in general population-based cohorts: the BiomarCaRE project.

ESC Heart Fail 2021 Nov 26. Epub 2021 Nov 26.

Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr. 22, Ulm, D-89081, Germany.

Aims: Chronic kidney disease (CKD) has a complicated relationship with the heart, leading to many adverse outcomes. The aim of this study was to evaluate the relationship between CKD and the incidence of atrial fibrillation (AF) and heart failure (HF) along with mortality as a competing risk in general population cohorts. We also included an assessment of baseline biomarkers of inflammation, myocardial injury, and left ventricular dysfunction with risk of AF and HF, respectively, to shed light on the potential underlying pathophysiology. Read More

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November 2021

Relationship between the early initiation of insulin treatment and diabetic complications in patients newly diagnosed with type 2 diabetes mellitus in Korea: a nationwide cohort study.

J Diabetes Investig 2021 Nov 26. Epub 2021 Nov 26.

School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.

Aims: To evaluate the relationship between early insulin initiation within a year after type 2 diabetes mellitus (T2DM) diagnosis and the risk of diabetic complications.

Materials And Methods: We conducted a cohort study using the Korean National Health Insurance Service database. The study subjects were newly diagnosed with T2DM between 2009 and 2013. Read More

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November 2021

Characterising the relationships between physiological indicators and all-cause mortality (NHANES): a population-based cohort study.

Lancet Healthy Longev 2021 Oct 20;2(10):e651-e662. Epub 2021 Sep 20.

Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.

Background: Mortality risk stratification based on dichotomising a physiological indicator with a cutoff point might not adequately capture increased mortality risk and might not account for non-linear associations. We aimed to characterise the linear and non-linear relationships of 27 physiological indicators with all-cause mortality to evaluate whether the current clinical thresholds are suitable in distinguishing patients at high risk for mortality from those at low risk.

Methods: For this observational cohort study of the US non-institutionalised population, we used data from adults (≥18 years) included in the 1999-2014 National Health and Nutrition Examination Survey (NHANES) linked with National Death Index mortality data collected from Jan 1, 1999, up until Dec 31, 2015. Read More

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October 2021

Association of chronic musculoskeletal pain with mortality among UK adults: A population-based cohort study with mediation analysis.

EClinicalMedicine 2021 Dec 14;42:101202. Epub 2021 Nov 14.

School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Background: We aimed to quantify the association between chronic musculoskeletal pain and all-cause mortality, and to investigate the extent to which this association is mediated by physical activity, smoking status, alcohol consumption, and opioid use.

Methods: For this population-based cohort study, we used data from UK Biobank, UK between baseline visit (2006-2010) to 18th December 2020. We assessed the associations between chronic musculoskeletal pain and all-cause mortality using a Cox proportional hazards model. Read More

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December 2021

Enhanced prediction of renal function decline by replacing waist circumference with "A Body Shape Index (ABSI)" in diagnosing metabolic syndrome: a retrospective cohort study in Japan.

Int J Obes (Lond) 2021 Nov 25. Epub 2021 Nov 25.

Center of Diabetes, Endocrinology and Metabolism, Toho University, Sakura Medical Center, 564-1, Shimoshizu, Sakura-city, Chiba, 2850841, Japan.

Background: Abdominal obesity as a risk factor for diagnosing metabolic syndrome (MetS) is conventionally evaluated using waist circumference (WC), although WC does not necessarily reflect visceral adiposity.

Objective: To examine whether replacing WC with "A Body Shape Index (ABSI)", an abdominal obesity index calculated by dividing WC by an allometric regression of weight and height, in MetS diagnosis is useful for predicting renal function decline.

Subjects/methods: In total, 5438 Japanese urban residents (median age 48 years) who participated in a public health screening program for 4 consecutive years were enrolled. Read More

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November 2021

Renal outcomes of diabetic patients treated with combination therapy of ACE inhibitors plus either thiazide diuretics or calcium channel blockers: comparative retrospective cohort study in Northwestern Ethiopia.

BMJ Open 2021 Nov 25;11(11):e048442. Epub 2021 Nov 25.

Department of Clinical Pharmacy, University of Gondar, Gondar, Ethiopia.

Objective: The study determined the comparative renal functions on patients with diabetes treated with ACE inhibitors (ACEIs) plus either thiazide diuretics or calcium channel blockers (CCBs) in Northwestern Ethiopia.

Design: Retrospective cohort study design was employed to collect the data from medical records of patients with diabetes followed for 1-5 years (N=404).

Setting: The medical records of patients in chronic diabetic follow-up clinics of the hospital. Read More

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November 2021

Natural history and associated early life factors of childhood asthma: a population registry-based cohort study in Denmark.

BMJ Open 2021 Nov 25;11(11):e045728. Epub 2021 Nov 25.

Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Objective: Asthma is a common chronic disease that imposes a substantial burden on individuals and society. However, the natural history of childhood asthma in a large population remained to be studied. This study aimed to describe the natural course of childhood asthma and examine the association between early life factors and childhood asthma. Read More

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November 2021

Hypovascular Cellular Tumor in Primary Central Nervous System Lymphoma is Associated with Treatment Resistance: Tumor Habitat Analysis Using Physiologic MRI.

AJNR Am J Neuroradiol 2021 Nov 25. Epub 2021 Nov 25.

From the Department of Radiology and Research Institute of Radiology (S.Y.J., J.E.P., H.S.K.), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Background And Purpose: The microenvironment of lymphomas is known to be highly variable and closely associated with treatment resistance and survival. We tried to develop a physiologic MR imaging-based spatial habitat analysis to identify regions associated with treatment resistance to facilitate the prediction of tumor response after initial chemotherapy in patients with primary central nervous system lymphoma.

Materials And Methods: Eighty-one patients with pathologically confirmed primary central nervous system lymphoma were enrolled. Read More

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November 2021

Dexamethasone in hospitalised coronavirus-19 patients not on intensive respiratory support.

Eur Respir J 2021 Nov 25. Epub 2021 Nov 25.

VA Connecticut Health Care System and Yale University School of Medicine, New Haven, CT, USA.

Introduction: Dexamethasone decreases mortality in coronavirus disease 2019 (COVID-19) patients on intensive respiratory support (IRS) but is of uncertain benefit if less severely ill. We determined whether early (within 48 h) dexamethasone was associated with mortality in patients hospitalised with COVID-19 not on IRS.

Methods: We included patients admitted to Veterans Affairs hospitals between June 7, 2020-May 31, 2021 within 14-days after SARS-CoV-2 positive test. Read More

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November 2021

Reoperation rate and implant survivorship compared between cementless and cemented bipolar hemiarthroplasty in femoral neck fracture patients with chronic kidney disease.

Injury 2021 Nov 14. Epub 2021 Nov 14.

Division of Adult Reconstructive Surgery, Department of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand. Electronic address:

Background: Chronic kidney disease (CKD) is commonly associated with aging and disorders of mineral and bone metabolism. Femoral neck fracture (FNF) is one of the most common fractures among older adults with coexisting CKD, and bipolar hemiarthroplasty (BHA) is a preferred treatment. However, the optimal method of stem fixation has not been conclusively determined. Read More

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November 2021

Family History is Related to High Risk of Recurrent Events after Ischemic Stroke or Transient Ischemic Attack.

J Stroke Cerebrovasc Dis 2021 Nov 21;31(1):106151. Epub 2021 Nov 21.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. Electronic address:

Objective: Prior data suggest paternal or sibling stroke was associated with increased risk of offspring stroke. Whether family history of cardiovascular disease (FHc) predicts risk of stroke recurrence remains unclear, we aim to determine this issue on patients with ischemic stroke (IS) or transient ischemic attack (TIA).

Materials And Methods: This is a post hoc analysis based on the Third China National Stroke Registry III. Read More

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November 2021

Socioeconomic disparities in colorectal cancer survival: contributions of prognostic factors in a large Australian cohort.

J Cancer Res Clin Oncol 2021 Nov 25. Epub 2021 Nov 25.

The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council New South Wales, Kings Cross, P O Box 572, Sydney, NSW, 1340, Australia.

Purpose: We quantified the contributions of prognostic factors to socioeconomic disparities in colorectal cancer survival in a large Australian cohort.

Methods: The sample comprised 45 and Up Study participants (recruited 2006-2009) who were subsequently diagnosed with colorectal cancer. Both individual (education attained) and neighbourhood socioeconomic measures were used. Read More

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November 2021