166,584 results match your criteria proportion patients

Are hypertensive patients with history of coronary artery disease at risk for silent lower extremity artery disease?

J Basic Clin Physiol Pharmacol 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Hospital, Surabaya, Indonesia.

Objectives: We aimed to investigate the association between hypertension and asymptomatic lower extremity artery disease (LEAD) in outpatients with known history of coronary artery disease (CAD).

Methods: Patients with known history of CAD who have been undergone coronary angiography and have significant coronary artery stenosis (more than 60%) were included. LEAD was defined as ankle-brachial index (ABI) < 0. Read More

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September 2021

Does reduction of the Meyerding grade correlate with outcomes in patients undergoing decompression and fusion for grade I degenerative lumbar spondylolisthesis?

J Neurosurg Spine 2021 Sep 17:1-8. Epub 2021 Sep 17.

1Department of Neurological Surgery, University of California, San Francisco, San Francisco, California.

Objective: Reduction of Meyerding grade is often performed during fusion for spondylolisthesis. Although radiographic appearance may improve, correlation with patient-reported outcomes (PROs) is rarely reported. In this study, the authors' aim was to assess the impact of spondylolisthesis reduction on 24-month PRO measures after decompression and fusion surgery for Meyerding grade I degenerative lumbar spondylolisthesis. Read More

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September 2021

The level of urbanization influences acute ischemic stroke care: A nationwide ecological study from Germany.

J Neurol Sci 2021 Sep 13;430:119983. Epub 2021 Sep 13.

Department of Neurology, St. Josef-Hospital Bochum, Ruhr University Bochum, Germany; Medical Faculty, Ruhr University Bochum, Germany. Electronic address:

Background And Purpose: Regional differences in acute ischemic stroke (AIS) care are still reported for Germany but not fully understood. We aimed to analyze the impact of the level of urbanization on the application of proved treatment procedures and the incidence of hospitalized AIS cases in Germany.

Methods: The level of urbanization of the 401 districts and district-free cities in Germany was defined according to the Federal Institute for Building, Urban Affairs and Spatial Research classification. Read More

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September 2021

To what extent are comorbidity profiles associated with referral and uptake to cardiac rehabilitation.

Int J Cardiol 2021 Sep 14. Epub 2021 Sep 14.

Department of Health Sciences, University of York, England, United Kingdom.

Introduction: Given the high proportion of comorbidities in patients with coronary heart disease (CHD) and low participation rates in cardiac rehabilitation (CR), a better understanding of how comorbidity interacts with the CR pathway is needed. We investigated associations between comorbidity profiles and referral and uptake in everyday clinical CR across UK.

Method: Patients (≥18 years) diagnosed with a CHD between 1st of January 2014 and 31st of December 2019 registered in the National Audit of Cardiac Rehabilitation (NACR) database were eligible. Read More

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September 2021

Acalabrutinib, venetoclax, and obinutuzumab as frontline treatment for chronic lymphocytic leukaemia: a single-arm, open-label, phase 2 study.

Lancet Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Background: Both continuous therapy with acalabrutinib and fixed-duration therapy with venetoclax-obinutuzumab are effective for previously untreated chronic lymphocytic leukaemia. We hypothesised that frontline time-limited, minimal residual disease (MRD)-guided triplet therapy with acalabrutinib, venetoclax, and obinutuzumab would induce deep (ie, more patients with undetectable MRD) and durable remissions.

Methods: In this open-label, single-arm, investigator-sponsored, phase 2 study, patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma were recruited from two academic hospitals in Boston, MA, USA. Read More

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September 2021

Long-Acting Injectable Antipsychotic Medication Plus Customized Adherence Enhancement in Poor Adherence Patients With Bipolar Disorder.

Prim Care Companion CNS Disord 2021 Sep 16;23(5). Epub 2021 Sep 16.

Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

People with bipolar disorder (BD) often have difficulty with medication adherence. This pilot trial combined a behavioral customized adherence enhancement (CAE) approach with long-acting injectable (LAI) antipsychotic medication and assessed effects on adherence, BD symptoms, and functional status.

This 6-month prospective, uncontrolled trial of the intervention (CAE with LAI) in 30 poorly adherent individuals with BD assessed adherence using the Tablets Routine Questionnaire (TRQ) and symptoms using the Brief Psychiatric Rating Scale (BPRS), Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HDRS), and Clinical Global Impressions (CGI). Read More

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September 2021

Diagnostic Testing in Non-Trauma Patients Presenting to the Emergency Department with Recurrent Seizures: A Systematic Review.

Acad Emerg Med 2021 Sep 17. Epub 2021 Sep 17.

National Trauma Research Institute, The Alfred Hospital, Melbourne, Victoria, Australia.

Background: There is a lack of consensus regarding the role of investigations among patients presenting to the emergency department (ED) with recurrent seizures. The aim of this systematic review was to determine the frequency and utility of commonly requested investigations for non-trauma patients presenting to the ED with recurrent seizures.

Methods: The MEDLINE, EMBASE and Cochrane Library databases were searched (March 2021) for manuscripts on this topic using search terms related to recurrent seizures, investigations and the ED. Read More

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September 2021

Methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage among patients with diabetes at the Korle Bu Teaching Hospital.

PLoS One 2021 17;16(9):e0257004. Epub 2021 Sep 17.

Department of Medical Microbiology, University of Ghana Medical School, Korle Bu, Accra, Ghana.

Aim: To investigate the epidemiology of S. aureus and MRSA nasal carriage among people with diabetes at the Korle Bu Teaching Hospital in Accra, including the prevalence, predictors of carriage, and antibiotic resistance.

Methodology: This study was cross-sectional, involving 300 diabetes patients and 106 non-diabetic individuals. Read More

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September 2021

Effect of a Multicomponent Sepsis Transition and Recovery Program on Mortality and Readmissions After Sepsis: The Improving Morbidity During Post-Acute Care Transitions for Sepsis Randomized Clinical Trial.

Crit Care Med 2021 Sep 16. Epub 2021 Sep 16.

Department of Internal Medicine, Atrium Health, Charlotte, NC. Transition Services, Department of Internal Medicine, Atrium Health, Charlotte, NC. Ambulatory Care Management, Atrium Health, Charlotte, NC. Department of Internal Medicine and Center for Outcomes Research and Evaluation, Atrium Health, Charlotte, NC. Division of Infectious Diseases, Department of Internal Medicine, Atrium Health, Charlotte, NC. Center for Outcomes Research and Evaluation, Atrium Health, Charlotte, NC. Division of Hepatology, Department of Internal Medicine, Atrium Health, Charlotte, NC. Department of Emergency Medicine, Atrium Health, Charlotte, NC.

Objectives: To evaluate whether a nurse navigator-led, multicomponent Sepsis Transition And Recovery program improves 30-day mortality and readmission outcomes after sepsis hospitalization.

Design: Multisite pragmatic randomized clinical trial.

Setting: Three hospitals in North Carolina from January 2019 to March 2020. Read More

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September 2021

Women require routine opioids to prevent painful colonoscopies: a randomised controlled trial.

Scand J Gastroenterol 2021 Sep 17:1-10. Epub 2021 Sep 17.

Department of Medical Research, Vestre Viken Hospital Trust Baerum, Gjettum, Norway.

Background: Women are at high risk for painful colonoscopy. Pain, but also sedation, are barriers to colorectal cancer (CRC) screening participation. In a randomised controlled trial, we compared on-demand with pre-colonoscopy opioid administration to control pain in women at CRC screening age. Read More

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September 2021

Impact of RBE variations on risk estimates of temporal lobe necrosis in patients treated with intensity-modulated proton therapy for head and neck cancer.

Acta Oncol 2021 Sep 17:1-8. Epub 2021 Sep 17.

Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Temporal lobe necrosis (TLN) is a potential late effect after radiotherapy for skull base head and neck cancer (HNC). Several photon-derived dose constraints and normal tissue complication probability (NTCP) models have been proposed, however variation in relative biological effectiveness (RBE) may challenge the applicability of these dose constraints and models in proton therapy. The purpose of this study was therefore to investigate the influence of RBE variations on risk estimates of TLN after Intensity-Modulated Proton Therapy for HNC. Read More

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September 2021

Spatiotemporal changes of CT manifestations in 110 patients with COVID-19 pneumonia.

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5547-5555

Jiangsu Digital Medical Key Laboratory, Nanjing University of Aeronautics and Astronautics, Nanjing, China.

Objective: The aim of the study was to analyze spatiotemporal changes of CT manifestations in patients with COVID-19 pneumonia.

Patients And Methods: In this retrospective review, 110 patients with confirmed COVID-19 by RT-PCR form February 16, 2020, to March 28, 2020 were included. A total of 449 CT scans were reviewed. Read More

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September 2021

The efficacy and safety of flow-diverting device and coil embolization for intracranial aneurysms: a meta-analysis.

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5383-5391

Xinjiang Medical University, Department of Neurosurgery 2; the First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.

Objective: To compare the clinical efficacy and safety of flow-diverting device (FDD) and coil embolization therapy (CET) in the treatment of intracranial aneurysms through a meta-analysis.

Materials And Methods: We comprehensively searched in PubMed, Embase, Cochrane Library, CNKI, Wan Fang, VIP databases, and China Biology Medicine disc (CBM) for eligible literature. Odds ratio (SMD) and 95% confidence intervals (CIs) were considered as effect measures. Read More

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September 2021

Migraine Characteristics, Comorbidities, Healthcare Resource Utilization, and Associated Costs of Early Users of Erenumab in the USA: A Retrospective Cohort Study Using Administrative Claims Data.

Pain Ther 2021 Sep 17. Epub 2021 Sep 17.

Global Health Economics, Amgen Inc., 1 Amgen Center Dr, Thousand Oaks, CA, 91320, USA.

Introduction: Erenumab is indicated for migraine preventive treatment in adults. The objective of this study was to provide descriptive information on real-world use of erenumab including patient profile and treatment patterns.

Methods: We completed a retrospective review of US data (through May 2019) from the IBM MarketScan Early View Databases, identifying adult patients newly treated with erenumab with a migraine claim in the year prior to first erenumab claim (index) and at least 1 year of continuous pre-index medical and pharmacy insurance coverage, to assess pre- and post-erenumab migraine characteristics, comorbidities, healthcare resource utilization, and associated costs. Read More

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September 2021

Moderate-Intensity Statins Plus Ezetimibe vs. High-Intensity Statins After Coronary Revascularization: A Cohort Study.

Cardiovasc Drugs Ther 2021 Sep 17. Epub 2021 Sep 17.

Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Purpose: Whether moderate-intensity statins plus ezetimibe could be an alternative to high-intensity statins in patients with atherosclerotic cardiovascular disease is unclear. We compared the risk of adverse cardiovascular events in patients receiving moderate-intensity statins plus ezetimibe vs. high-intensity statins after a coronary revascularization procedure using data from a large cohort study. Read More

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September 2021

The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases.

Cardiovasc Drugs Ther 2021 Sep 17. Epub 2021 Sep 17.

Department of Hypertension and Diabetology, Faculty of Medicine, Medical University of Gdansk, Debinki 7c, 80-952, Gdansk, Poland.

Cardiovascular disease is the leading cause of mortality worldwide, affecting a wide range of patients at different stages across the cardiovascular continuum. Hypertension is one of the earliest risk factors in this continuum and can be controlled in most patients with currently available antihypertensive agents. However, goals are often not met because treatments are not optimized in terms of tailoring therapy to individual patients based on their hypertension subclass and cardiovascular risk profile and initiating early use of adapted-dose, single-pill combinations. Read More

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September 2021

Diagnostic timelines and self-reported symptoms of patients with lung and gastrointestinal cancers undergoing radiation therapy. Retrospective case control study.

Support Care Cancer 2021 Sep 17. Epub 2021 Sep 17.

Department of Oncology, University of Calgary, 2500 University Dr NW, Calgary, AB, T2N 1N4, Canada.

Background: Previous studies have found that patients with lung cancer report worse patient experience compared to other tumour groups. Reasons that may negatively impact patient experience include delays in diagnosis as well as inadequate symptom management. The purpose of this study was to compare the diagnostic timelines and symptom reports of patients with lung and gastrointestinal (GI) cancers. Read More

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September 2021

Trends in Human Papillomavirus Vaccine Safety Concerns and Adverse Event Reporting in the United States.

JAMA Netw Open 2021 Sep 1;4(9):e2124502. Epub 2021 Sep 1.

Center for Healthcare Data, Department of Management, Policy, and Community Health, UTHealth School of Public Health, Houston, Texas.

Importance: In the US, safety concern has been identified as a primary barrier to initiating the human papillomavirus (HPV) vaccine. It is unclear if the public's sentiment concerning HPV vaccine safety aligns with postmarketing vaccine safety surveillance data.

Objective: To perform a parallel assessment of trends in HPV vaccine safety concerns and HPV vaccine adverse event (AE) reporting. Read More

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September 2021

Pre-Appointment Nurse Navigation: Patient-Centered Findings From a Survey of Patients With Breast Cancer.

Clin J Oncol Nurs 2021 Oct;25(5):E57-E62

University of California, San Francisco.

Background: Research indicates that nurse navigators can play key roles in promoting empowerment for patients with cancer through advocacy, educational support, resource navigation, and psychosocial care.

Objectives: This study attempted to elucidate the efficacy of nurse navigation in patient knowledge, care coordination, and well-being before a breast oncology appointment.

Methods: Staff provided a nine-question survey to 50 newly referred patients before their initial appointment. Read More

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October 2021

Allied health led post-operative hand clinic: Evaluation of an alternative model of care.

Aust Occup Ther J 2021 Sep 17. Epub 2021 Sep 17.

Hand Therapy Clinic, Cairns Hospital Orthopaedic Department, Cairns and Hinterland Hospital and Health Service, Cairns, Queensland, Australia.

Introduction: To assist with the increasing orthopaedic workload, an allied health led hand therapy clinic was established to manage people having routine hand surgeries. The aim of this study was to evaluate patient and doctor satisfaction and safety of this alternative service delivery model.

Methods: Prospective multimethod design evaluation was undertaken by occupational therapists and physiotherapists working in the field of hand therapy. Read More

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September 2021

A Parallel Randomized Clinical Trial for Comparison of Two Methods of Maggot Therapy, Free-Range Larvae and Larval-bag, in Diabetic Ulcer (Wagner 2).

Int J Low Extrem Wounds 2021 Sep 17:15347346211044295. Epub 2021 Sep 17.

48439Tehran University of Medical Sciences, Tehran, Iran.

In the present study, the efficiency of two formulations of maggot therapy: free-range larvae on the wounds and larvae in a special bag (larval-bag), was compared for healing diabetic ulcers with Wagner 2 diabetic ulcer. This study was conducted as a parallel randomized clinical trial. Out of 281 patients with Wagner grade 2 diabetic ulcers referred to the wound clinic, 54 patients who met the inclusion criteria were randomly assigned to intervention groups. Read More

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September 2021

What is the reality in outpatient vs inpatient groin hernia repair? An analysis from the Herniamed Registry.

Hernia 2021 Sep 16. Epub 2021 Sep 16.

Department of General and Visceral Surgery, Pius Hospital, University Hospital of Visceral Surgery, Georgstrasse 12, 26121, Oldenburg, Germany.

Introduction: Groin hernia repair is performed increasingly more often as an outpatient procedure across the world. However, the rates are extremely different and vary between below 10% and above 90%. The outpatient procedure appears to negatively impact the proportion of laparo-endoscopic repairs. Read More

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September 2021

Post-stroke palatal tremor as a clinical predictor of dysphagia and its neuroanatomical correlates in patients with midbrain and pontine lesions.

J Neural Transm (Vienna) 2021 Sep 16. Epub 2021 Sep 16.

Department of Rehabilitation Medicine, National Rehabilitation Center, Ministry of Health and Welfare, 58, Samgaksan-ro, Gangbuk-gu, Seoul, 01022, Republic of Korea.

The precise associations between dysphagia and palatal tremor (PT) remain unknown. We aimed to identify the association between PT and dysphagia among patients with midbrain/pontine stroke, compare the characteristics of dysphagia between patients with PT (PT + dysphagia) and without PT (PT- dysphagia), and verify neuroanatomical predictors of PT + dysphagia in this patient population. This retrospective observational study enrolled 40 patients (34 males, 6 females; mean age: 95% confidence interval [CI], 56. Read More

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September 2021

Classification and Treatment Strategies of Concomitant Fibular Column Injuries in Tibial Plateau Fractures.

Biomed Res Int 2021 6;2021:2698642. Epub 2021 Sep 6.

Department of Orthopaedics, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province 212000, China.

Background: About 1/3 of tibial plateau fractures are associated with proximal fibula fractures, but most proximal fibula fractures are often ignored. The aim of this study was to precisely explain the classification and treatment strategies of six injury types of the fibular column associated with tibial plateau fractures.

Methods: Patients with ipsilateral proximal fibula and tibial plateau fractures treated in our hospital were retrospectively reviewed from Aug 2007 to Mar 2020. Read More

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September 2021

Guideline-directed low-density lipoprotein management in high-risk ischemic stroke or transient ischemic attack admissions in China from 2015 to 2019.

Ann Transl Med 2021 Aug;9(15):1224

China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Lowering low-density lipoprotein cholesterol (LDL-C) is crucial for secondary stroke prevention in stroke patients with preexisting cardiovascular diseases (CVD) or cerebrovascular diseases (CeVD). However, data on attainment of guideline-recommended LDL-C levels are lacking.

Methods: We analyzed data from the Chinese Stroke Center Alliance (CSCA) program for patients with ischemic stroke and transient ischemic attack (TIA) hospitalized between August 2015 and July 2019. Read More

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Beyond the Visual Acuity: Assessing the Visual Function in mCNV Patients After Anti-VEGF Treatment.

Front Med (Lausanne) 2021 31;8:709584. Epub 2021 Aug 31.

State Key Laboratory of Ophthalmology, Retina Division, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

To investigate visual function and vision-related quality of life (VR-QoL) changes in patients with myopic choroidal neovascularization (mCNV) after ranibizumab treatment. Quantitatively evaluate the objective tests of visual function (visual acuity, microperimetry, and metamorphopsia by m-Charts) before and after 3+prn (pro re neta) ranibizumab treatment for 1 year. The National Eye Institute 25-Item Visual Function Questionnaire (VFQ-25) was performed to evaluate the VR-QoL. Read More

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Bioinformatics analysis based on immune-autophagy-related lncRNAs combined with immune infiltration in bladder cancer.

Transl Androl Urol 2021 Aug;10(8):3440-3455

Department of Urology, Maoming People's Hospital, Maoming, China.

Background: To construct a prognostic model based on immune-autophagy-related long noncoding RNA (IArlncRNAs), mainly to predict the overall survival rate (OS) of bladder cancer patients and investigate its possible mechanisms.

Methods: Transcriptome and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. We identified the IArlncRNA by co-expression analysis, differential expression analysis, and Venn analysis. Read More

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Comparison of initial tumor responses to transarterial bland embolization and drug-eluting beads-transarterial chemoembolization in the management of hepatocellular carcinoma: a propensity-score matching analysis.

J Gastrointest Oncol 2021 Aug;12(4):1838-1850

Department of Interventional Radiology, Shenzhen People's Hospital (Second Clinical Medical College of Jinan University, First Affiliated Hospital of Southern University of Science and Technology), Shenzhen, China.

Background: Transarterial bland embolization (TABE) is widely used to treat the spontaneous rupture of hepatocellular carcinoma (HCC), and can lead to ischemic necrosis of the tumor. In this study, we used the propensity-score matching (PSM) method to compare the initial responses of treatment-naïve HCC patients to TABE and drug-eluting beads-transarterial chemoembolization (DEB-TACE), and the safety of these treatments.

Methods: Patients with treatment-naïve HCC, who had been admitted to 2 medical centers from January 2016 to December 2020, were enrolled as the research subjects. Read More

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The effect of the and mutations on the survival of hepatocellular carcinoma patients with different racial backgrounds.

J Gastrointest Oncol 2021 Aug;12(4):1786-1796

Department of Hepatobiliary Surgery/Research Laboratory of Hepatobiliary Tumor, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.

Background: Racial disparities in the survival of patients with hepatocellular carcinoma (HCC) exist. Gene mutations have a profound effect on carcinogenesis, are easily affected by environment and etiology factors, and may result in survival divergences among patients with different racial backgrounds. This report explores the effects of gene mutations on the survival of American Caucasians and Asian patients. Read More

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Development of a model to predict pathologic response to chemotherapy in patients with colorectal liver metastases.

J Gastrointest Oncol 2021 Aug;12(4):1498-1508

Hepatopancreatobiliary Surgery Department I, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China.

Background: Preoperative chemotherapy has widely been used in colorectal cancer liver metastasis (CRLM). Pathological response to chemotherapy is very important in evaluating tumor biology. However, there is still a lack of a non-invasive and accurate method to evaluate pathological response before surgery. Read More

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