1,463 results match your criteria propofol plasma


No interactive effect of lumbar epidural blockade and target-controlled infusion of propofol on mean arterial pressure, cardiac output and bispectral index: A randomised controlled and pharmacodynamic modelling study.

Eur J Anaesthesiol 2021 Apr 14. Epub 2021 Apr 14.

From the Department of Anaesthesiology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands (ES, EO, AD, JV).

Background: It is generally accepted that a neuraxial blockade strengthens the sedative effects of propofol. Deafferentation caused by neuraxial blockade is thought to play a key role.

Objectives: The objective is to determine whether epidural blockade affects the bispectral index (BIS) of propofol and two other pharmacodynamic endpoints, mean arterial pressure (MAP) and cardiac output (CO). Read More

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Propofol for Induction and Maintenance of Anesthesia in Patients With Brugada Syndrome: A Single-Center, 25-Year, Retrospective Cohort Analysis.

Anesth Analg 2021 Apr 15. Epub 2021 Apr 15.

From the Department of Anesthesiology and Perioperative Medicine.

Background: Propofol administration in patients with Brugada syndrome (BrS) is still a matter of debate. Despite lacking evidence for its feared arrhythmogenicity, up to date, expert cardiologists recommend avoiding propofol. The main aim of this study is to assess the occurrence of malignant arrhythmias or defibrillations in patients with BrS, during and 30 days after propofol administration. Read More

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Current Anesthetic Management in a 20-Month-Old Pediatric Patient With Intestinal Transplantation Due to Microvillous Inclusion Disease.

Exp Clin Transplant 2021 Mar 3. Epub 2021 Mar 3.

From the University of Health Sciences, Izmir Tepecik Training and Research Hospital, Department of Anesthesiology and Reanimation, Izmir, Turkey.

Intestinal transplantation is a complex procedure both in terms of anesthesia and surgery. In particular, pediatric anesthesia management during intestinal transplant surgery can become even more complicated. It has been stated that propofol, remifentanil, and sevoflurane reduce patient mortality by reducing the incidence of intestinal ischemia-reperfusion injury. Read More

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Comparison of anesthesia effects between closedloop and openloop target controlled infusion of propofol using the bispectral index in abdominal surgery.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Dec;45(12):1419-1424

Department of Anesthesiology, Beijing Hospital; National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

Objectives: Bispectral index (BIS) can reflect the depth of propofol sedation. This study aims to compare the anesthetic satisfaction, anesthetic dose, and hemodynamic changes between closed-loop target controlled infusion (CLTCI) and open-loop target controlled infusion (OLTCI) during abdominal surgery.

Methods: From December 2016 to December 2018, 70 patients undergoing abdominal surgery under general anesthesia were selected in Beijing Hospital, including 51 males and 19 females, at the age from 49 to 65 years old. Read More

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December 2020

Propofol shows less negative effects on cognitive performances than dexmedetomidine in elderly intensive care unit patients.

Neurol Sci 2021 Jan 15. Epub 2021 Jan 15.

Department of Internal Medicine, Cangzhou People's Hospital, Cangzhou, 061000, Hebei, China.

Background: Due to the improved clinical management of aging population and the consequently declined mortality among patients with critical illnesses, the number of survivors from intensive care units (ICUs) keeps rising. Studies to examine the association of cognitive impairment analgesic and sedation strategies would be beneficial to improve the quality of life of ICU survivors.

Methods: A prospective clinical trial was designed to compare the effects of two drugs, propofol, and dexmedetomidine, on short-term cognitive impairment after sedation in elderly ICU survivors by evaluating the extent of independence limited by the dementia-related activities of daily livings (ADLs). Read More

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January 2021

Propofol infusions using a human target controlled infusion (TCI) pump in chimpanzees (Pan troglodytes).

Sci Rep 2021 Jan 13;11(1):1214. Epub 2021 Jan 13.

Department of Anesthesiology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan.

Chimpanzees are genetically and physiologically similar to humans. Several pharmacokinetic models of propofol are available and target controlled infusion (TCI) of propofol is established in humans, but not in chimpanzees. The purpose of this study was to investigate if human pharmacokinetic models can accurately predict propofol plasma concentration (Cp) in chimpanzees and if it is feasible to perform TCI in chimpanzees. Read More

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January 2021

In vitro alteration on erythrocytes mechanical properties by propofol, remifentanil and vecuronium.

Microvasc Res 2021 05 7;135:104132. Epub 2021 Jan 7.

Facultad Cs. Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 535, 2000 Rosario, Argentina; Grupo de Física Biomédica, IFIR (CONICET-UNR), Bv. 27 de febrero 210 bis, 2000 Rosario, Argentina. Electronic address:

Several studies report flow disturbance and microcirculation disorders upon anesthesia treatment. These alterations are often related to blood rheology changes. In this work, it was attempted to make a detailed description of the alterations in erythrocyte mechanical properties by the action of propofol, remifentanil, and vecuronium. Read More

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Do epoch lengths of hypnotic depth indicators affect estimated of blood-brain equilibration rate constants of propofol?

J Pharmacokinet Pharmacodyn 2021 Jan 7. Epub 2021 Jan 7.

Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

This study aimed to investigate the effect of epoch length of hypnotic depth indicators on the blood-brain equilibration rate constant (k) estimates of propofol. Propofol was administered by zero-order infusion (1.5, 3. Read More

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January 2021

Remifentanil-based propofol-supplemented vs. balanced sevoflurane-sufentanil anesthesia regimens on bispectral index recovery after cardiac surgery: a randomized controlled study.

Anesth Pain Med (Seoul) 2020 Oct;15(4):424-433

Department of Anesthesiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Background: The present study was to compare the potential impact of remifentanil-based propofol-supplemented anesthesia regimen vs. conventional sevoflurane-sufentanil balanced anesthesia on postoperative recovery of consciousness indicated by bispectral index (BIS) values in patients undergoing cardiac surgery.

Methods: Patients undergoing cardiac surgery were randomly allocated to get the remifentanil-based propofol-supplemented anesthesia employing target-controlled infusion (TCI) of remifentanil and propofol (Group-PR, n = 15) or a balanced-anesthesia employing sevoflurane-inhalation and TCI-sufentanil (Group-C, n = 19). Read More

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October 2020

Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia.

Br J Anaesth 2021 02 13;126(2):386-394. Epub 2020 Dec 13.

Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.

Background: Target-controlled infusion (TCI) systems incorporating pharmacokinetic (PK) or PK-pharmacodynamic (PK-PD) models can be used to facilitate drug administration. Existing models were developed using data from select populations, the use of which is, strictly speaking, limited to these populations. Recently a propofol PK-PD model was developed for a broad population range. Read More

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February 2021

Linear Regression in Medical Research.

Anesth Analg 2021 01;132(1):108-109

Department of Surgery and Perioperative Care, Dell Medical School at the University of Texas at Austin, Austin, Texas.

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January 2021

Expanded Access Programs, compassionate drug use, and Emergency Use Authorizations during the COVID-19 pandemic.

Drug Discov Today 2021 02 27;26(2):593-603. Epub 2020 Nov 27.

National Coalition on Health Care, Washington, DC, USA.

The US Food and Drug Administration (FDA) Expanded Access (EA) Program, which allows for compassionate uses of unapproved therapeutics and diagnostics outside of clinical trials, has gained significant traction during the Coronavirus 2019 (COVID-19) pandemic. While development of vaccines has been the major focus, uncertainties around new vaccine safety and effectiveness have spawned interest in other pharmacological options. Experimental drugs can also be approved under the FDA Emergency Use Authorization (EUA) program, designed to combat infectious disease and other threats. Read More

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February 2021

Membrane nanodomains homeostasis during propofol anesthesia as function of dosage and temperature.

Biochim Biophys Acta Biomembr 2021 02 25;1863(2):183511. Epub 2020 Nov 25.

Dept. of Physics, University at Buffalo, SUNY, Buffalo, NY 14260-1500, USA. Electronic address:

Some anesthetics bind and potentiate γ-aminobutyric-acid-type receptors, but no universal mechanism for general anesthesia is known. Furthermore, often encountered complications such as anesthesia induced amnesia are not understood. General anesthetics are hydrophobic molecules easily dissolving into lipid bilayers. Read More

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February 2021

Intra-operative diabetes insipidus associated with cervical spine traction during staged scoliosis surgery.

Anaesth Rep 2020 Jul-Dec;8(2):123-126. Epub 2020 Oct 16.

Department of Anaesthesiology Children's Health Ireland at Crumlin Dublin Ireland.

A 15-year-old boy with cerebral palsy and epilepsy presented for a posterior spinal fusion as part of staged repair of thoracolumbar scoliosis. Total intravenous anaesthesia was induced and maintained with propofol, remifentanil and ketamine. Following prone positioning, cervical traction was applied. Read More

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October 2020

Emulsion Effect on the Measurement of Standard Laboratory Blood Parameters.

Clin Lab 2020 Nov;66(11)

Background: A number of pharmaceutical agents have limited water solubility and are therefore often prepared in a lipid emulsion. Emulsion renders plasma opaque and this could interfere with the accuracy of some standardized laboratory measurements, especially for optical or mechanical based assays. We determined the interference on some laboratory diagnostic values of blood specimens after propofol addition in vitro as well as in vivo when infused into swine. Read More

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November 2020

Application of a benchtop colorimetric method for quantification of blood propofol levels.

J Clin Monit Comput 2020 Nov 12. Epub 2020 Nov 12.

Department of Anesthesia, Waikato Clinical Campus, University of Auckland, Hamilton, New Zealand.

Quantification of plasma propofol (2,6-diisopropylphenol) in the context of clinical anaesthesia is challenging because of the need for offline blood sample processing using specialised laboratory equipment and techniques. In this study we sought to refine a simple procedure using solid phase extraction and colorimetric analysis into a benchtop protocol for accurate blood propofol measurement. The colorimetric method based on the reaction of phenols (e. Read More

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November 2020

Determination of propofol in human plasma with C18 pipette-tip based solid-phase extraction followed by liquid chromatography atmospheric-pressure chemical ionization tandem mass spectrometry analysis.

J Pharm Biomed Anal 2021 Jan 20;193:113714. Epub 2020 Oct 20.

Zhejiang Province Key Laboratory of Anesthesiology, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Propofol is a widely used intravenous anesthetic for sedation during the surgery and worldwide propofol abuse has been frequently reported also. As an essential procedure for sample pretreatment, solid-phase extraction (SPE) is generally time-consuming and labor-intensive, which hindered the further improvement in the analysis of propofol from biological fluids. In this study, a rapid C18 pipette-tip based SPE method was developed to pretreat human plasma samples directly, bypassing the need for protein precipitation. Read More

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January 2021

Randomized Trial to Compare Plasma Glucose Trends in Patients Undergoing Surgery for Supratentorial Gliomas under Maintenance of Sevoflurane, Desflurane, and Propofol.

Asian J Neurosurg 2020 Jul-Sep;15(3):579-586. Epub 2020 Aug 28.

Department of Anaesthesiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Anesthetic agents influence the glycemic response by affecting the neuroendocrine surgical response or directly modifying pancreatic insulin release. Due to chances of neuronal damage, intraoperative hyperglycemia and hypoglycemia both are detrimental for patients undergoing neurosurgeries. Inhalational (sevoflurane and desflurane) and intravenous (propofol) agents have been found to raise intraoperative glucose levels in nonneurological surgeries. Read More

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Analysis of influence factors of pharmacodynamics of propofol with target-controlled infusion during anesthetic recovery period.

Int J Clin Pharmacol Ther 2021 Feb;59(2):109-115

Objective: To explore the pharmacodynamic (PD) characteristics of propofol during anesthetic recovery period with target-controlled infusion (TCI), and to identify the clinical variables related to the PD parameters.

Materials And Methods: 20 patients scheduled for otolaryngology surgery were enrolled. After the surgery was finished, target effect site concentration was gradually decreased, blood samples were measured at 7 time points and the differences between the target and measured plasma concentration were compared. Read More

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February 2021

The Performance of an Artificial Neural Network Model in Predicting the Early Distribution Kinetics of Propofol in Morbidly Obese and Lean Subjects.

Anesth Analg 2020 11;131(5):1500-1509

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California.

Background: Induction of anesthesia is a phase characterized by rapid changes in both drug concentration and drug effect. Conventional mammillary compartmental models are limited in their ability to accurately describe the early drug distribution kinetics. Recirculatory models have been used to account for intravascular mixing after drug administration. Read More

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November 2020

De-mystifying the "Mixifusor".

Paediatr Anaesth 2020 12 4;30(12):1292-1298. Epub 2020 Nov 4.

Faculty of Health: Medicine, Dentistry and Human Sciences, University of Plymouth, Plymouth, UK.

Total intravenous anesthesia (TIVA) using a mixture of propofol and remifentanil in the same syringe has become an accepted technique in Pediatric Anesthesia. A survey by a group of respected UK anesthetists demonstrated a low incidence of serious complications, related to the pharmacology and dose of the drugs. However, a current guideline for the safe use of TIVA recommends against this practice. Read More

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December 2020

Effects of sevoflurane and propofol anesthesia on intraoperative endothelial cell function in patients undergoing laparoscopic cholecystectomy.

Authors:
Yu Fan Hao Wang Qi Ma

J Int Med Res 2020 Oct;48(10):300060520918407

Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai, China.

Objectives: To investigate the effects of sevoflurane and propofol anesthesia on inflammatory or anti-inflammatory responses in patients undergoing laparoscopic cholecystectomy (LC).

Methods: Patients undergoing LC (n = 23) were divided into sevoflurane (S) (n = 11) and propofol (P) (n = 12) anesthesia groups. A blood sample was taken before induction (T0), after induction but before pneumoperitoneum (T1), 15 minutes after pneumoperitoneum (T2), immediately after extubation (T3), and 30 minutes after extubation (T4). Read More

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October 2020

Evaluation of tumescent local anesthesia in cats undergoing unilateral mastectomy.

Vet Anaesth Analg 2021 Jan 15;48(1):134-141. Epub 2020 Sep 15.

Department of Veterinary Medicine and Surgery, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brazil.

Objective: To evaluate the analgesic efficacy and safety of tumescent local anesthesia (TLA) in cats undergoing unilateral mastectomy.

Study Design: Prospective clinical trial.

Animals: A total of 12 ovariohysterectomized female cats. Read More

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January 2021

Protracted hyperthermia and delayed rhabdomyolysis in ecstasy toxicity: A case report.

Medicine (Baltimore) 2020 Oct;99(41):e21842

University of Hawai'i at Mānoa, John A. Burns School of Medicine, Honolulu, HI.

Rationale: Despite toxicity and unpredictable adverse effects, ecstasy use has increased in the United States. Onset of hyperpyrexia, rhabdomyolysis, disseminated intravascular coagulation (DIC), among other symptoms, occurs within hours of ingestion. Moreover, patients who experience hyperpyrexia, altered mental status, DIC, and multiorgan failure, rarely survive. Read More

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October 2020

Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets (Callithrix jacchus).

J Vet Pharmacol Ther 2021 Jan 2;44(1):18-27. Epub 2020 Sep 2.

Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan.

The objectives of this study were (a) to establish a population pharmacokinetic model and (b) to investigate the clinical and physiological effects of a single bolus dose of propofol in common marmosets. In Study 1, pharmacokinetic analysis was performed in six marmosets under sevoflurane anaesthesia. 8 mg/kg of propofol was administrated at a rate of 4 mg kg  min . Read More

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January 2021

A simplified and sensitive LC-APCI-MS/MS method for the quantification of propofol: Application to a bioequivalence study in healthy Chinese subjects.

Int J Clin Pharmacol Ther 2020 Nov;58(11):664-674

Objectives: Propofol has become the preferred anesthetic in recent years due to its desirable pharmacologic properties. However, propofol possesses a very narrow therapeutic window between the favorable clinical effect and potentially lethal toxicity, therefore, a rapid, simplified, and sensitive liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS) method is presented in this study for the quantification of propofol in human plasma using the isotope-labeled internal standard (IS) of propofol-d17, and then applied in a bioequivalence study.

Materials And Methods: Sample preparation was accomplished through simple one-step precipitation of plasma protein with acetonitrile. Read More

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November 2020

Development and validation of a liquid chromatography coupled to tandem mass spectrometry method for the simultaneous quantification of five analgesics and sedatives, and six of their active metabolites in human plasma: Application to a clinical study on the determination of neurological death in the intensive care unit.

J Pharm Biomed Anal 2020 Oct 15;190:113521. Epub 2020 Aug 15.

Platform of Biopharmacy, Faculty of Pharmacy, Université de Montréal, H3T 1J4, Canada. Electronic address:

A sensitive and selective high-performance liquid chromatographic method coupled to tandem mass spectrometry was developed and validated for the quantification of morphine, hydromorphone, fentanyl, midazolam and propofol and their metabolites morphine-3-β-d-glucuronide, morphine-6-β-d-glucuronide, hydromorphone-3-β-d-glucuronide, 1'-hydroxymidazolam-β-d-glucuronide, α-hydroxymidazolam and 4-hydroxymidazolam in human plasma using potassium oxalate/sodium fluoride mixture as anticoagulant. Human plasma samples (0.4 mL) to which were added a mixture of eleven deuterated internal standards were subjected to solid phase extraction using a mixed-mode polymeric Oasis PRiME MCX in 96-well format. Read More

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October 2020

The influence of cardiac output on propofol and fentanyl pharmacokinetics and pharmacodynamics in patients undergoing abdominal aortic surgery.

J Pharmacokinet Pharmacodyn 2020 12 25;47(6):583-596. Epub 2020 Aug 25.

Department of Biopharmacy and Pharmacodynamics, Medical University of Gdansk, Hallera 107 Street, 80-416, Gdansk, Poland.

Cardiac output (CO) is expected to affect elimination and distribution of highly extracted and perfusion rate-limited drugs. This work was undertaken to quantify the effect of CO measured by the pulse pressure method on pharmacokinetics and pharmacodynamics of propofol and fentanyl administrated during total intravenous anesthesia (TIVA). The data were obtained from 22 ASA III patients undergoing abdominal aortic surgery. Read More

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December 2020

Antioxidant capacity of lipid- and water-soluble antioxidants in dogs with subclinical myxomatous mitral valve degeneration anaesthetised with propofol or sevoflurane.

BMC Vet Res 2020 Aug 24;16(1):305. Epub 2020 Aug 24.

Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000, Ljubljana, Slovenia.

Background: Antioxidants located in both the hydrophilic and lipophilic compartments of plasma act as a defence system against reactive oxygen species (ROS). Excessive production of ROS during anaesthesia affects the antioxidant capacity of plasma and may result in oxidative stress. The aim of this study was to evaluate the antioxidant capacity of lipid- (ACL) and water-soluble (ACW) antioxidants in client-owned dogs diagnosed with periodontal disease and early-stage myxomatous mitral valve degeneration (MMVD) and anaesthetised for a dental procedure with propofol and sevoflurane or with propofol only. Read More

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