5,447 results match your criteria propofol infusion


THORACIC SYMPATHECTOMY: SEDATION EXPERIENCE.

Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):31-33. Epub 2021 Apr 8.

Cardiothoracic Surgery, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.

Introduction/Study Goals: Thoracic sympathectomy is considered to be the most effective treatment for hyperhidrosis, a procedure traditionally performed under general anesthesia. Nowadays it's a minimally invasive procedure, which makes it possible to perform under sedation with local anesthesia. The goal in this study was to assess the efficacy and safety of this anesthetic technique in video-assisted thoracic sympathectomy. Read More

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The Effect of Vibration on Pain During Intravenous Injection of Propofol: A Randomized Controlled Trial.

Ann Plast Surg 2021 Mar 18. Epub 2021 Mar 18.

From the Division of Plastic Surgery Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, New York.

Purpose: Pain is a common side effect of intravenous injection of propofol. We conducted a randomized, prospective, single-blinded controlled trial to assess the efficacy of vibration analgesia on pain during propofol infusion in ambulatory surgery.

Methods: After institutional review board approval, 100 patients undergoing elective ambulatory surgery with general anesthesia were randomized into 2 groups. Read More

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Neurologic Assessment of the Neurocritical Care Patient.

Front Neurol 2021 22;12:588989. Epub 2021 Mar 22.

Department of Neurosurgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States.

Sedation is a ubiquitous practice in ICUs and NCCUs. It has the benefit of reducing cerebral energy demands, but also precludes an accurate neurologic assessment. Because of this, sedation is intermittently stopped for the purposes of a neurologic assessment, which is termed a neurologic wake-up test (NWT). Read More

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Effects of Remifentanil on Cardiovascular Stimulation Caused by Local Anesthetic With Epinephrine: A Power Spectral Analysis.

Anesth Prog 2020 Mar;68(1):10-18

Professor and Chairman, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.

The objectives of this research were to investigate (a) what was the most effective infusion rate of remifentanil and (b) the degree to which sympathomimetic effects were involved with cardiovascular stimulation by using a power spectral analysis of heart rate variability (HRV). A total of 63 healthy individuals scheduled for sagittal split ramus osteotomy were enrolled and randomly allocated to 1 of 3 groups: remifentanil infusion rate of 0.1, 0. Read More

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Propofol reduces the amplitude of transcranial electrical motor-evoked potential without affecting spinal motor neurons: a prospective, single-arm, interventional study.

J Anesth 2021 Apr 7. Epub 2021 Apr 7.

Department of Anesthesiology, Niigata University Medical and Dental Hospital, 1-754 Asahimachi-Dori, Chuo-ku, Niigata, 951-8520, Japan.

Purpose: Propofol inhibits the amplitudes of transcranial electrical motor-evoked potentials (TCE-MEP) in a dose-dependent manner. However, the mechanisms of this effect remain unknown. Hence, we investigated the spinal mechanisms of the inhibitory effect of propofol on TCE-MEP amplitudes by evaluating evoked electromyograms (H-reflex and F-wave) under general anesthesia. Read More

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Comparison of Train of Four Measurements with Kinemyography NMT DATEX and Accelerography TOFscan.

Med Sci (Basel) 2021 Mar 29;9(2). Epub 2021 Mar 29.

Institut Gustave Roussy Rue Camille Desmoulins, CEDEX, 94080 Villejuif, France.

Introduction: This study was designed to compare the Datex neuromuscular transmission (NMT) kinemyography (NMTK) device with the TOFscan (TS) accelerometer during the onset and recovery of neuromuscular blockade.

Patients And Methods: This prospective study included adult patients who were scheduled to undergo elective surgery with general anesthesia and orotracheal intubation. The TS accelerometer was randomly placed at the adductor pollicis on one hand, and the NMTK was placed on the opposite arm. Read More

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Butorphanol versus Propofol in Patients Undergoing Noninvasive Ventilation: A Prospective Observational Study.

Int J Gen Med 2021 22;14:983-992. Epub 2021 Mar 22.

Intensive Care Unit, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, 310012, People's Republic of China.

Background: The present study aimed to explore sedation management in agitated patients who suffered from acute respiratory failure (ARF) and were treated with noninvasive ventilation (NIV).

Patients And Methods: We divided 118 patients undergoing NIV treatment with butorphanol or propofol into two groups: group B (n = 57, butorphanol was initiated at the rate of 0.12 µg/kg/min as a continuous intravenous infusion and then titrated by 0. Read More

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A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model.

J Nucl Med 2021 Mar 19. Epub 2021 Mar 19.

Lawson Health Research Institute, Canada.

The gold standard for imaging the cerebral metabolic rate of oxygen (CMRO) is positron emission tomography (PET); however, it is an invasive and complex procedure that also requires correction for recirculating O-HO and the blood-borne activity. We propose a noninvasive reference-based hybrid PET/magnetic resonance imaging (MRI) method that uses functional MRI techniques to calibrate O-O-PET data. Here, PET/MR imaging of oxidative metabolism (PMROx) was validated in an animal model by comparison to PET-alone measurements. Read More

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Smart Portable Pen for Continuous Monitoring of Anaesthetics in Human Serum with Machine Learning.

IEEE Trans Biomed Circuits Syst 2021 Mar 19;PP. Epub 2021 Mar 19.

Continuous monitoring of anaesthetics infusion is demanded by anaesthesiologists to help in defining personalized dose, hence reducing risks and side effects. We propose the first piece of technology tailored explicitly to close the loop between anaesthesiologist and patient with continuous drug monitoring. Direct detection of drugs is achieved with electrochemical techniques, and several options are present in literature to measure propofol (widely used anaesthetics). Read More

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Anaesthetic Management of a Patient with Brugada Syndrome in Total Knee Arthroplasty.

Turk J Anaesthesiol Reanim 2021 Feb 24;49(1):70-73. Epub 2020 Dec 24.

Department of Cardiology, Başkent University Faculty of Medicine, Ankara, Turkey.

We report the case of a 52-year-old female diagnosed with Brugada syndrome (BrS) scheduled to undergo right total knee arthroplasty. General anaesthesia was induced and maintained with thiopental intravenous sodium + remifentanil and sevoflurane + remifentanil infusion, respectively. Rocuronium bromide was used as the muscle relaxant. Read More

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February 2021

Improvement of analgesic efficacy for total hip arthroplasty by a modified ultrasound-guided supra-inguinal fascia iliaca compartment block.

BMC Anesthesiol 2021 Mar 10;21(1):75. Epub 2021 Mar 10.

The Provincial Clinical Medical College, Fujian Medical University, 134 Dong Street, Fujian, 350004, Fuzhou, China.

Background: Fascia iliaca compartment block (FICB) is an anterior approach to the lumbar plexus block and provides the effective adjunctive analgesia for total hip arthroplasty (THA).

Methods: As a case series study, 28 patients (≥ 65 years old) with THA were received a modified in-plane ultrasound-guided supra-inguinal (S-FICB) as an analgesic adjunct to evaluate the analgesic effectiveness and the local anesthetic diffusion with magnetic resonance imaging (MRI). A combination of propofol and sufentanil was administered to conduct target-controlled infusion. Read More

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Clinical validation of pharmacokinetic and pharmacodynamic models for propofol infusion. Comment on Br J Anaesth 2021; 126: 386-94.

Br J Anaesth 2021 Mar 5. Epub 2021 Mar 5.

Department of Anaesthesia, Intensive Care, Emergency and Pain Medicine, Kantonsspital, St. Gallen, Switzerland.

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The Use of Middle Latency Auditory Evoked Potentials (MLAEP) as Methodology for Evaluating Sedation Level in Propofol-Drug Induced Sleep Endoscopy (DISE) Procedure.

Int J Environ Res Public Health 2021 Feb 20;18(4). Epub 2021 Feb 20.

ENT Unit, "V.Fazzi" Hospital, 73100 ASL Lecce, Italy.

To analyze the middle latency auditory evoked potential index (MLAEPi), compared to the standard bispectral index (BIS), as a method for evaluating the sedation level in drug-induced sleep endoscopy (DISE). In this controlled clinical study on a sample of 99 obstructive sleep apnea (OSA) or snoring patients, we compared the MLAEPi with the BIS after propofol infusion during the standard DISE technique in order to define the MLAEPi values within the observational window of the procedure. The DISE procedure was divided into eight steps, and we collected both MLAEPi and BIS data values from the same patient in every step. Read More

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February 2021

Comparison of Propofol or Isoflurane Anesthesia Maintenance, Combined with a Fentanyl-Lidocaine-Ketamine Constant-Rate Infusion in Goats Undergoing Abomasotomy.

Animals (Basel) 2021 Feb 13;11(2). Epub 2021 Feb 13.

Department of Large Animal Clinical Science, School of Veterinary Medicine, Ross University, KN0111 Basseterre, Saint Kitts and Nevis.

This study aimed to compare, first, the anesthetic and cardiopulmonary effects of propofol or isoflurane anesthetic maintenance in goats receiving a fentanyl-lidocaine-ketamine infusion undergoing abomasotomy and, secondly, to compare the quality of the recovery from anesthesia. Two groups were used: propofol (TIVA) and isoflurane (PIVA). Goats were premedicated with fentanyl (10 μg/kg intravenously [IV]), lidocaine (2 mg/kg, IV), and ketamine (1. Read More

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February 2021

Outcomes of deep sedation for catheter ablation of paroxysmal supraventricular tachycardia, with adaptive servo ventilation.

J Arrhythm 2021 Feb 5;37(1):33-42. Epub 2020 Dec 5.

Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan.

Background: Catheter ablation for paroxysmal supraventricular tachycardia (PSVT) is an established treatment, but the effect of deep sedation on PSVT inducibility remains unclear.

Aim: We sought to examine PSVT inducibility and outcomes of catheter ablation under deep sedation using adaptive servo ventilation (ASV).

Methods: We retrospectively evaluated consecutive patients who underwent catheter ablation for PSVT under deep sedation (Propofol + Dexmedetomidine) with use of ASV. Read More

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February 2021

Current Anesthetic Management in a 20-Month-Old Pediatric Patient With Intestinal Transplantation Due to Microvillous Inclusion Disease.

Exp Clin Transplant 2021 Mar 3. Epub 2021 Mar 3.

From the University of Health Sciences, Izmir Tepecik Training and Research Hospital, Department of Anesthesiology and Reanimation, Izmir, Turkey.

Intestinal transplantation is a complex procedure both in terms of anesthesia and surgery. In particular, pediatric anesthesia management during intestinal transplant surgery can become even more complicated. It has been stated that propofol, remifentanil, and sevoflurane reduce patient mortality by reducing the incidence of intestinal ischemia-reperfusion injury. Read More

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Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery.

Anesthesiology 2021 04;134(4):541-551

Background: It is speculated that opioid-free anesthesia may provide adequate pain control while reducing postoperative opioid consumption. However, there is currently no evidence to support the speculation. The authors hypothesized that opioid-free balanced anesthetic with dexmedetomidine reduces postoperative opioid-related adverse events compared with balanced anesthetic with remifentanil. Read More

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Factors associated with the use of anesthetic drug infusion in patients with status epilepticus and their relation to outcome: a prospective study.

Acta Neurol Belg 2021 Feb 19. Epub 2021 Feb 19.

Department of Neurology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.

Status epilepticus (SE) is one of the most dreadful neurological emergencies; unfortunately, studies targeting SE are still inadequate. This study aims to identify factors associated with the use of CIVAD in patients presenting with status epilepticus and detect those impact the clinical outcome. A prospective study involving 144 episodes of SE in 144 patients. Read More

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February 2021

The usefulness of Smart Pilot View for fast recovery from desflurane general anesthesia.

J Anesth 2021 Apr 13;35(2):239-245. Epub 2021 Feb 13.

Department of Anesthesia, Ube Industries Central Hospital, 750 Nishikiwa, Ube, Yamaguchi, 755-0151, Japan.

Introduction: Smart Pilot View (SPV) (Dräger Medical) provide information about the estimated drug effect of anesthetic drugs. We conducted a prospective randomized trial to evaluated the recovery time in SPV-guided general anesthesia compared with usual practice in patients with desflurane general anesthesia.

Method: Thirty-four American Society of Anesthesiologist's physical status I-II patients scheduled for elective surgery under general anesthesia were enrolled in the study. Read More

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A prospective randomized double-blinded study of dexmedetomidine versus propofol infusion for orbital surgeries.

Saudi J Ophthalmol 2020 Apr-Jun;34(2):77-81. Epub 2020 Dec 28.

Department of Anesthesia, Sankara Nethralaya, Medical Research Foundation, Chennai.

Purpose: Orbital surgeries are traditionally taken up under general anesthesia. Local anesthesia combined with moderate sedation can also be considered as an alternative option. This study was performed to compare the safety and efficacy of dexmedetomidine and propofol infusion for orbital surgeries under local anesthesia. Read More

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December 2020

Intravenous infusion of rocuronium bromide prolongs emergence from propofol anesthesia in rats.

PLoS One 2021 11;16(2):e0246858. Epub 2021 Feb 11.

Department of Anesthesiology, The Jikei University School of Medicine, Tokyo, Japan.

Background: Neuromuscular blocking agents induce muscle paralysis via the prevention of synaptic transmission at the neuromuscular junction and may have additional effects at other sites of action. With regard to potential effects of neuromuscular blocking agents on the central nervous system, a definitive view has not been established. We investigated whether intravenous infusion of rocuronium bromide affects the emergence from propofol anesthesia. Read More

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February 2021

[Effect of early goal directed sedation on cerebral oxygen metabolism in patients with acute brain injury].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jan;33(1):79-83

Department of Emergency, the First Medical Center of the PLA General Hospital, Beijing 100853, China. Corresponding author: Zhu Haiyan, Email:

Objective: To observe the effect of early goal directed sedation (EGDS) on cerebral oxygen metabolism in patients with acute brain injury.

Methods: A prospective cohort study was conducted. A total of 108 patients with acute brain injury admitted to the intensive care unit (ICU) of the Third Medical Center of the PLA General Hospital from January 2015 to December 2019 were enrolled. Read More

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January 2021

The Effect of Low-Dose Intraoperative Ketamine on Closed-Loop-Controlled General Anesthesia: A Randomized Controlled Equivalence Trial.

Anesth Analg 2021 Feb 8. Epub 2021 Feb 8.

From the Department of Anesthesiology, Pharmacology and Therapeutics.

Background: Closed-loop control of propofol-remifentanil anesthesia using the processed electroencephalography depth-of-hypnosis index provided by the NeuroSENSE monitor (WAVCNS) has been previously described. The purpose of this placebo-controlled study was to evaluate the performance (percentage time within ±10 units of the setpoint during the maintenance of anesthesia) of a closed-loop propofol-remifentanil controller during induction and maintenance of anesthesia in the presence of a low dose of ketamine.

Methods: Following ethical approval and informed consent, American Society of Anesthesiologist (ASA) physical status I-II patients aged 19-54 years, scheduled for elective orthopedic surgery requiring general anesthesia for >60 minutes duration, were enrolled in a double-blind randomized, placebo-controlled, 2-group equivalence trial. Read More

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February 2021

Comparison of the target-controlled infusion and the manual infusion of propofol anesthesia during electroconvulsive therapy: an open-label randomized controlled trial.

BMC Psychiatry 2021 Feb 4;21(1):71. Epub 2021 Feb 4.

School of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Target-controlled infusion (TCI) of propofol is a well-established method of procedural sedation and has been used in Japan for anesthesia during electroconvulsive therapy (ECT). However, the usefulness of the TCI of propofol for ECT has yet to be determined. This study aimed to compare the TCI and manual infusion (MI) of propofol anesthesia during ECT. Read More

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February 2021

Bispectral index monitoring of the clinical effects of propofol closed-loop target-controlled infusion: Systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2021 Jan;100(4):e23930

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, China.

Background: To investigate whether closed-loop systems under bispectral index anesthesia depth monitoring can reduce the intraoperative propofol dosage.

Methods: All randomized controlled trials (RCTs) on reducing propofol dosage under closed-loop systems were collected, and the literature was screened out, the abstracts and full texts were carefully read, and the references were tracked, data extraction and quality evaluation were conducted on the included research, and the RevMan5.3 software was used for meta-analysis. Read More

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January 2021

Influence of hemorrhage and subsequent fluid resuscitation on transcranial motor-evoked potentials under desflurane anesthesia in a swine model.

J Clin Monit Comput 2021 Feb 1. Epub 2021 Feb 1.

Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.

Purpose: Hemorrhage increases the effect of propofol and could contribute to false-positive transcranial motor-evoked potential (TcMEP) responses under total intravenous anesthesia (TIVA). We investigated the influence of hemorrhage and subsequent fluid resuscitation on TcMEPs under desflurane anesthesia.

Methods: Sixteen swine (25. Read More

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February 2021

[Maximum dose of continuous infusion of mivacurium for thyroid surgery under total intravenous anesthesia: a sequential trial of monitoring neurological function in 30 patients].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jan;41(1):64-68

Anesthesiology Department, Peking University International Hospital, Beijing 102206, China.

Objective: To investigate the maximum dose of continuous mivacurium infusion for intraoperative neuromonitoring (IONM) and observe the adverse reactions during thyroid surgery under total intravenous anesthesia (TIVA).

Methods: Thirty patients undergoing IONM during thyroid surgery received continuous infusion of mivacurium at the initial rate of 14.97 μg · kg · min. Read More

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January 2021

Unilateral posterior reversible encephalopathy syndrome characterized with a long and gradually exacerbating course over 3 years and that presented propofol infusion syndrome - A case report.

Surg Neurol Int 2021 13;12:19. Epub 2021 Jan 13.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Miyagi, Japan.

Background: Posterior reversible encephalopathy syndrome (PRES) is characterized by acute neurological symptoms and vasogenic edema, and most patients wholly recover. We report a unilateral PRES patient characterized by a gradual onset followed by propofol infusion syndrome (PRIS) due to general anesthesia therapy.

Case Description: A 32-year-old woman had ovarian dysfunction treated by Kaufmann's treatment for 17 years. Read More

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January 2021