2,676 results match your criteria propofol concentrations

Asymmetric neural dynamics characterize loss and recovery of consciousness.

Neuroimage 2021 Apr 10:118042. Epub 2021 Apr 10.

Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Anesthetics are known to disrupt neural interactions in cortical and subcortical brain circuits. While the effect of anesthetic drugs on consciousness is reversible, the neural mechanism mediating induction and recovery may be different. Insight into these distinct mechanisms can be gained from a systematic comparison of neural dynamics during slow induction of and emergence from anesthesia. Read More

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Propofol reduces the amplitude of transcranial electrical motor-evoked potential without affecting spinal motor neurons: a prospective, single-arm, interventional study.

J Anesth 2021 Apr 7. Epub 2021 Apr 7.

Department of Anesthesiology, Niigata University Medical and Dental Hospital, 1-754 Asahimachi-Dori, Chuo-ku, Niigata, 951-8520, Japan.

Purpose: Propofol inhibits the amplitudes of transcranial electrical motor-evoked potentials (TCE-MEP) in a dose-dependent manner. However, the mechanisms of this effect remain unknown. Hence, we investigated the spinal mechanisms of the inhibitory effect of propofol on TCE-MEP amplitudes by evaluating evoked electromyograms (H-reflex and F-wave) under general anesthesia. Read More

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Elevation of propofol sensitivity of cardiac I channel by KCNE1 polymorphism D85N.

Br J Pharmacol 2021 Mar 25. Epub 2021 Mar 25.

Department of Physiology, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.

Background And Purpose: The slowly activating delayed rectifier K channel (I ), composed of pore-forming KCNQ1 α-subunits and ancillary KCNE1 β-subunits, regulates ventricular repolarization in human heart. Propofol at clinically used concentrations modestly inhibits the intact (wild-type) I channels and is therefore unlikely to appreciably prolong QT interval in electrocardiogram during anesthesia. However, little information is available concerning the inhibitory effect of propofol on I channel associated with its gene variants implicated in QT prolongation. Read More

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Impact of aging on interactions between opioid and propofol concentrations during total intravenous anesthesia.

J Clin Anesth 2021 Mar 16;71:110245. Epub 2021 Mar 16.

Department of Anesthesiology and Reanimatology, University of Fukui Hospital, Fukui, Japan.

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A suitable anaesthetic protocol for metamorphic zebrafish.

PLoS One 2021 5;16(3):e0246504. Epub 2021 Mar 5.

Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom.

Zebrafish are frequently used as a means to investigate development. These studies increasingly require repeated anaesthesia of zebrafish during juvenile (i.e. Read More

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Sevoflurane But Not Propofol Provided Dual Effects of Cell Survival in Human Neuroblastoma SH-SY5Y Cells.

Curr Alzheimer Res 2020 ;17(14):1311-1319

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.

Background: We have hypothesized that the most commonly used intravenous (propofol) and inhalational (sevoflurane) general anesthetics affect cell survival concentration and duration dependently with different potency associated with their differential potency to affect intracellular Ca+2 homeostasis.

Methods: Human neuroblastoma SH-SY5Y cells stably transfected with either wild type or M146L mutant human presenilin 1 were cultured and exposed to equipotent of propofol or sevoflurane. Cell viability, cytosolic and mitochondrial calcium were measured. Read More

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January 2020

Physical Compatibility of Cefiderocol with Selected Intravenous Drugs During Simulated Y-site Administration.

Int J Pharm Compd 2021 Jan-Feb;25(1):52-61

ARL Biopharma Inc, Oklahoma City, Oklahoma.

The physical compatibility of cefiderocol for injection (prepared as a diluted 2% cefiderocol solution) with potential co-administration drug products is presented. The compatibility of cefiderocol with a selection of 91 intravenous drugs was tested at clinically relevant concentrations using the admixed volume ratio 1:1. Compatibility of the mixtures was determined by visual observations, turbidity, and particulate-matter measurements. Read More

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January 2021

A "Smart" Biosensor-Enabled Intravascular Catheter and Platform for Dynamic Delivery of Propofol to "Close the Loop" for Total Intravenous Anesthesia.

Mil Med 2021 01;186(Suppl 1):370-377

University of Memphis, Department of Biomedical Engineering, Engineering Technology Building Room 321D, Memphis, TN 38152, USA.

Background: Target-controlled infusion anesthesia is used worldwide to provide user-defined, stable, blood concentrations of propofol for sedation and anesthesia. The drug infusion is controlled by a microprocessor that uses population-based pharmacokinetic data and patient biometrics to estimate the required infusion rate to replace losses from the blood compartment due to drug distribution and metabolism. The objective of the research was to develop and validate a method to detect and quantify propofol levels in the blood, to improve the safety of propofol use, and to demonstrate a pathway for regulatory approval for its use in the USA. Read More

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January 2021

Influence of rate of administration on the mechanism behind propofol induced loss of consciousness.

Rev Esp Anestesiol Reanim 2021 Jan 18. Epub 2021 Jan 18.

Servicio de Anestesiología y Dolor, Hospital Base San José Osorno, Osorno, Chile.

Background: Propofol effect-site time course models included in TCI systems have been under discussion. We hypothesized that the rate of administration is a major contributor affecting the construction of a useful effect-site model: yielding different plasmatic concentrations, loss of consciousness may occur by different mechanisms more complex than the pharmacological effect-site.

Methodology: ASA I-II patients were randomized in two groups: rapid induction (RI) received TCI of propofol effect-site (CeCALC) 5. Read More

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January 2021

Propofol activates AMPK to inhibit the growth of HepG2 cells and hepatocarcinogenesis in xenograft mouse tumor models by inducing autophagy.

J Gastrointest Oncol 2020 Dec;11(6):1322-1332

Department of Anesthesiology, The Quanzhou First Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Background: Hepatocellular carcinoma (HCC) is a fatal malignant tumor with a poor prognosis, and is the third leading cause of cancer-related deaths worldwide. This study aimed to investigate the anti-tumor effect of propofol on the proliferation, apoptosis, and cell cycle of HCC by regulating adenosine monophosphate-activated protein kinase (AMPK) and .

Methods: The cell counting Kit-8 (CCK-8) assay was employed to screen the effect of propofol on HepG2 cell viability at various concentrations (0. Read More

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December 2020

Propofol shows less negative effects on cognitive performances than dexmedetomidine in elderly intensive care unit patients.

Neurol Sci 2021 Jan 15. Epub 2021 Jan 15.

Department of Internal Medicine, Cangzhou People's Hospital, Cangzhou, 061000, Hebei, China.

Background: Due to the improved clinical management of aging population and the consequently declined mortality among patients with critical illnesses, the number of survivors from intensive care units (ICUs) keeps rising. Studies to examine the association of cognitive impairment analgesic and sedation strategies would be beneficial to improve the quality of life of ICU survivors.

Methods: A prospective clinical trial was designed to compare the effects of two drugs, propofol, and dexmedetomidine, on short-term cognitive impairment after sedation in elderly ICU survivors by evaluating the extent of independence limited by the dementia-related activities of daily livings (ADLs). Read More

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January 2021

Do epoch lengths of hypnotic depth indicators affect estimated of blood-brain equilibration rate constants of propofol?

J Pharmacokinet Pharmacodyn 2021 Jan 7. Epub 2021 Jan 7.

Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

This study aimed to investigate the effect of epoch length of hypnotic depth indicators on the blood-brain equilibration rate constant (k) estimates of propofol. Propofol was administered by zero-order infusion (1.5, 3. Read More

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January 2021

Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability.

Eur J Clin Pharmacol 2021 Jan 7. Epub 2021 Jan 7.

Department of Psychiatric Nursing and Human Sciences, Ribeirao Preto College of Nursing, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, SP, 14040-902, Brazil.

Purpose: Propofol anesthesia is usually accompanied by hypotensive responses, which are at least in part mediated by nitric oxide (NO). Arginase I (ARG1) and arginase II (ARG2) compete with NO synthases for their common substrate L-arginine, therefore influencing the NO formation. We examined here whether ARG1 and ARG2 genotypes and haplotypes affect the changes in blood pressure and NO bioavailability in response to propofol. Read More

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January 2021

Protective effect of sevoflurane on vascular endothelial glycocalyx in patients undergoing heart valve surgery: A randomised controlled trial.

Eur J Anaesthesiol 2021 05;38(5):477-486

From the The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou (FQ-F) and The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China (JH-S, QL-W, LY-F, YX-F, JX-Y, W-G, GL-H, WJ-W).

Background: The glycocalyx plays an important physiological role and may be damaged during cardiopulmonary bypass. Sevoflurane can protect the glycocalyx; however, its relevance in a clinical setting is unknown.

Objective: Glycocalyx degradation during cardiopulmonary bypass in patients was investigated. Read More

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A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol.

Front Cell Neurosci 2020 4;14:593050. Epub 2020 Dec 4.

Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

General anesthesia has revolutionized healthcare over the past 200 years and continues to show advancements. However, many phenomena induced by general anesthetics including paradoxical excitation are still poorly understood. Voltage-gated sodium channels (Na ) were believed to be one of the proteins targeted during general anesthesia. Read More

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December 2020

Isoflurane Potentiation of GABA Receptors Is Reduced but Not Eliminated by the β3(N265M) Mutation.

Int J Mol Sci 2020 Dec 15;21(24). Epub 2020 Dec 15.

Department of Anesthesiology, University of Wisconsin, Madison, WI 53705, USA.

Mice carrying the GABA receptor β3(N265M) point mutation, which renders receptors incorporating β3-subunits insensitive to many general anesthetics, have been used experimentally to link modulation of different receptor subtypes to distinct behavioral endpoints. Remarkably, however, the effect of the mutation on the susceptibility to modulation by isoflurane (a standard reference agent for inhalational vapors) has never been tested directly. Therefore, we compared the modulation by isoflurane of expressed α5β3(N265M)γ2L receptors with their wild type counterparts. Read More

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December 2020

Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia.

Br J Anaesth 2021 02 13;126(2):386-394. Epub 2020 Dec 13.

Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.

Background: Target-controlled infusion (TCI) systems incorporating pharmacokinetic (PK) or PK-pharmacodynamic (PK-PD) models can be used to facilitate drug administration. Existing models were developed using data from select populations, the use of which is, strictly speaking, limited to these populations. Recently a propofol PK-PD model was developed for a broad population range. Read More

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February 2021

Effects of dexmedetomidine as an adjuvant in thoracic paravertebral block on EC50 of propofol for successful laryngeal mask insertion: a randomized controlled trial.

Ann Transl Med 2020 Nov;8(22):1480

Department of Anesthesiology, the Second Affiliated Hospital of Nantong University, Nantong, China.

Background: Dexmedetomidine as an adjuvant can improve the duration and the quality of thoracic paravertebral block (TPVB); however, its quantitative effect on propofol infusion is unclear. This study aimed to investigate the effect of dexmedetomidine as an adjuvant in TPVB on the medium effective concentration (EC50) of propofol for successful laryngeal mask insertion.

Methods: Sixty breast cancer patients who underwent elective modified radical mastectomy were enrolled and randomized at a 1:1 ratio into control group (Group C, n=30) or dexmedetomidine group (Group D, n=30). Read More

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November 2020

Improving Sleep in Intensive Care Unit: An Overview of Diagnostic and Therapeutic Options.

J Patient Exp 2020 Oct 17;7(5):697-702. Epub 2019 Oct 17.

Department of Intensive Care Medicine, Frankston Hospital, Frankston, Victoria, Australia.

Good quality sleep is considered to be essential for healthy living and recovering from illness. It would be logical to think that good quality sleep is most required when a patient is critically ill in an intensive care unit (ICU). Several studies have demonstrated poor quality of sleep while the patients are in ICU. Read More

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October 2020

Rapid quantitative determination of blood propofol concentration throughout perioperative period by negative photoionization ion mobility spectrometer with solvent-assisted neutral desorption.

Anal Chim Acta 2021 Jan 4;1142:118-126. Epub 2020 Nov 4.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, People's Republic of China. Electronic address:

Rapid and quantitative determination of blood propofol concentration is important for anesthesiologists to accurately control intraoperative propofol dose, timely monitor physiological statuses of patients and greatly improve the safety of surgery. Herein, a dopant-assisted negative photoionization ion mobility spectrometer with the optimized ionization region structure and the three-way inlet design was developed, increasing the generation ratio of the reactant ions O, and improving the ionization efficiency of propofol molecules. Besides, the addition of methanol-anisole solution during injection promoted the neutral desorption of propofol in blood, further improving the detection sensitivity by an order of magnitude, eliminating any sample pretreatment and effectively reducing the single analysis time to less than 1 min compared to the previous article. Read More

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January 2021

[Transcutaneous electrical acupoint stimulation relieves post-operative nausea and vomiting possibly by reducing serum motilin secretion in patients undergoing laparoscopic surgery].

Zhen Ci Yan Jiu 2020 Nov;45(11):920-3

Department of Anesthesiology, Hebei General Hospital, Shijiazhuang 050051, China.

Objective: To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) of different acupoint combinations on postoperative nausea and vomiting (PONV) and serum motilin (MTL) content in patients undergoing laparoscopic surgery, so as to provide evidence for clinical selection of suitable acupoint compatibility.

Methods: A total of 140 patients undergoing elective laparoscopic surgery were randomly divided into general anesthesia (GA) control, TG [Neiguan (PC6) + Hegu (LI4)], TG [PC6 + LI4 + Zusanli (ST36)], and TG [PC6 + LI4 + ST36 + Sanyinjiao (SP6)] groups, with 35 cases in each group. Patients of the TG, TG and TG groups received TEAS (2 Hz/100 Hz, 3-8 mA) of the above mentioned acupoint (bilateral) groups for 30 min before the induction of anesthesia until the end of the operation. Read More

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November 2020

Effect of dexmedetomidine on Nociception Level Index-guided remifentanil antinociception: A randomised controlled trial.

Eur J Anaesthesiol 2021 05;38(5):524-533

From the Department of Anaesthesiology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium (SC, SD, LP, EE, LVO, LB), Department of Anaesthesiology, Saint Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium (SC, DP, LDM, PK), EW Data Analysis, Brussels, Belgium (EE), Department of Ear-Nose-Throat Surgery, Saint Pierre University Hospital, Université Libre de Bruxelles, Brussels, Belgium (AR) and Department of Anaesthesiology, CHU Rennes, Université de Rennes, Rennes, France (JP-E).

Background: The effect of dexmedetomidine on Nociception Level Index-guided (Medasense, Israel) antinociception to reduce intra-operative opioid requirements has not been previously investigated.

Objective: We aimed to determine if low-dose dexmedetomidine would reduce remifentanil requirements during Nociception Level Index-guided antinociception without increasing complications associated with dexmedetomidine.

Design: Double-blind randomised controlled trial. Read More

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Membrane nanodomains homeostasis during propofol anesthesia as function of dosage and temperature.

Biochim Biophys Acta Biomembr 2021 02 25;1863(2):183511. Epub 2020 Nov 25.

Dept. of Physics, University at Buffalo, SUNY, Buffalo, NY 14260-1500, USA. Electronic address:

Some anesthetics bind and potentiate γ-aminobutyric-acid-type receptors, but no universal mechanism for general anesthesia is known. Furthermore, often encountered complications such as anesthesia induced amnesia are not understood. General anesthetics are hydrophobic molecules easily dissolving into lipid bilayers. Read More

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February 2021

Polyspikes and Rhythmic Polyspikes During Volatile Induction of General Anesthesia With Sevoflurane Result in Bispectral Index Variations.

Clin EEG Neurosci 2020 Nov 26:1550059420974571. Epub 2020 Nov 26.

Department of Anesthesiology and Intensive Therapy, SMDZ in Zabrze, Medical University of Silesia, Zabrze, Poland.

Background: Although electroencephalography (EEG)-based indices may show artifactual values, raw EEG signal is seldom used to monitor the depth of volatile induction of general anesthesia (VIGA). The current analysis aimed to identify whether bispectral index (BIS) variations reliably reflect the actual depth of general anesthesia during presence of different types of epileptiform patterns (EPs) in EEGs during induction of general anesthesia.

Methods: Sixty patients receiving either VIGA with sevoflurane using increasing concentrations (group VIMA) or vital capacity (group VCRII) technique or intravenous single dose of propofol (group PROP) were included. Read More

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November 2020

Nociception level-guided opioid administration in radical retropubic prostatectomy: a randomised controlled trial.

Br J Anaesth 2021 02 20;126(2):516-524. Epub 2020 Nov 20.

Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, Hamburg, Germany. Electronic address:

Background: This RCT investigated the effect of opioid titration by three different nociception monitoring devices or clinical signs during general anaesthesia.

Methods: Ninety-six patients undergoing radical retropubic prostatectomy with propofol/remifentanil anaesthesia were randomised into one of four groups to receive remifentanil guided by one of three nociception monitoring devices (surgical pleth index [SPI], pupillary pain index [PPI], or nociception level [NOL]) or by clinical judgement (control). Intraoperative remifentanil requirement was the primary endpoint, whereas recovery parameters and stress hormone levels were secondary endpoints. Read More

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February 2021

The effect of concentration, reconstitution solution and pH on the stability of a remifentanil hydrochloride and propofol admixture for simultaneous co-infusion.

BMC Anesthesiol 2020 11 12;20(1):283. Epub 2020 Nov 12.

Central Queensland University, School of Health, Medical and Applied Sciences, 554-700 Yaamba Road, Rockhampton, QLD, 4701, Australia.

Background: There are scenarios where pre-mixing and infusing analgesic and anaesthetic agents as a single intravenous (IV) solution is highly desirable; however, it is important to ensure the agents are compatible when mixed. As such, the long-term stability of a remifentanil-propofol mixture, and means of improving this, were assessed across a range of remifentanil concentrations, diluents, and time points.

Methods: Remifentanil was reconstituted with ultrapure water, 0. Read More

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November 2020

Application of a benchtop colorimetric method for quantification of blood propofol levels.

J Clin Monit Comput 2020 Nov 12. Epub 2020 Nov 12.

Department of Anesthesia, Waikato Clinical Campus, University of Auckland, Hamilton, New Zealand.

Quantification of plasma propofol (2,6-diisopropylphenol) in the context of clinical anaesthesia is challenging because of the need for offline blood sample processing using specialised laboratory equipment and techniques. In this study we sought to refine a simple procedure using solid phase extraction and colorimetric analysis into a benchtop protocol for accurate blood propofol measurement. The colorimetric method based on the reaction of phenols (e. Read More

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November 2020

Effect of Laryngeal Mask Airway Insertion on Parameters Derived From Catacrotic Phase of Photoplethysmography Under Different Concentrations of Remifentanil.

IEEE J Transl Eng Health Med 2020 17;8:2700609. Epub 2020 Aug 17.

College of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhou310027China.

Background: Some parameters have been extracted from photoplethysmography (PPG) with a good relativity with nociception, but without encouraging results in qualifying the balance of nociception-anti-nociception (NAN). The features of PPG have not been thoroughly depicted and more prospective univariate parameters deserve to be explored. The aim of this study was to investigate the ability of parameters derived from catacrotic phase of PPG to grade the level of analgesia. Read More

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Determination of propofol in human plasma with C18 pipette-tip based solid-phase extraction followed by liquid chromatography atmospheric-pressure chemical ionization tandem mass spectrometry analysis.

J Pharm Biomed Anal 2021 Jan 20;193:113714. Epub 2020 Oct 20.

Zhejiang Province Key Laboratory of Anesthesiology, Department of Anesthesiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address:

Propofol is a widely used intravenous anesthetic for sedation during the surgery and worldwide propofol abuse has been frequently reported also. As an essential procedure for sample pretreatment, solid-phase extraction (SPE) is generally time-consuming and labor-intensive, which hindered the further improvement in the analysis of propofol from biological fluids. In this study, a rapid C18 pipette-tip based SPE method was developed to pretreat human plasma samples directly, bypassing the need for protein precipitation. Read More

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January 2021