23,320 results match your criteria propofol


Asymmetric neural dynamics characterize loss and recovery of consciousness.

Neuroimage 2021 Apr 10:118042. Epub 2021 Apr 10.

Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

Anesthetics are known to disrupt neural interactions in cortical and subcortical brain circuits. While the effect of anesthetic drugs on consciousness is reversible, the neural mechanism mediating induction and recovery may be different. Insight into these distinct mechanisms can be gained from a systematic comparison of neural dynamics during slow induction of and emergence from anesthesia. Read More

View Article and Full-Text PDF

Analgesic comparison of dezocine plus propofol versus fentanyl plus propofol for gastrointestinal endoscopy: A meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25531

Department of Geriatrics.

Introduction: As the adjunctive anesthesia to propofol, both dezocine and fentanyl showed some potential for gastrointestinal endoscopy. This meta-analysis aimed to compare their efficacy and safety.

Methods: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Read More

View Article and Full-Text PDF

Propofol modulates the proliferation, invasion and migration of bladder cancer cells through the miR‑145‑5p/TOP2A axis.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Anesthesiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China.

Propofol‑based anesthesia has been reported to reduce the recurrence and metastasis of a number of cancer types following surgical resection. However, the effects of propofol in bladder cancer (BC) are yet to be fully elucidated. The aim of the present study was to investigate the functions of propofol in BC and their underlying mechanisms. Read More

View Article and Full-Text PDF

Comparative evaluation of the bispectral index (BIS) and BISpro during propofol anaesthesia.

J Int Med Res 2021 Apr;49(4):3000605211001705

Department of Anaesthesiology, Peking University Shenzhen Hospital, Shenzhen, China.

Objective: To compare the accuracy, correlation and agreement between the bispectral index (BIS) and BISpro during propofol anaesthesia.

Methods: The BIS, BISpro, heart rate, target-concentration of propofol and Observer's Assessment of Alertness and Sedation (OAA/S) score were recorded every 30 s in female patients scheduled for hysteroscopic surgery. Propofol anaesthesia was induced by an initial target-controlled concentration (1. Read More

View Article and Full-Text PDF

Early work activities after sedation with propofol in digestive endoscopy.

Rev Esp Enferm Dig 2021 Apr 13. Epub 2021 Apr 13.

Gastroenterología, Hospital Sierra de Segura, España.

We have long perceived that mental alertness was quite normal in patients after discharge from endoscopies sedated with propofol. This issue would support performing minor work activities earlier at the same day of the technique. Read More

View Article and Full-Text PDF

Anesthetic considerations of Joubert syndrome in patients with mitochondrial disease - A case report.

Anesth Pain Med (Seoul) 2021 Apr 12. Epub 2021 Apr 12.

Department of Anesthesiology and Pain Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

Background: Joubert syndrome and mitochondrial disease are rare congenital diseases in which a wide range of symptoms affects multiple organs. Patients with these diseases present characteristic symptoms related to the musculoskeletal, respiratory, and neurological systems, which make it difficult for anesthesiologists to manage the patient's airway and choose appropriate anesthetic drugs.

Case: A 13-year-old male patient with Joubert syndrome and mitochondrial disease underwent elective surgery to insert a continuous ambulatory peritoneal dialysis catheter. Read More

View Article and Full-Text PDF

Successful Management of Parkinson's Disease Dyskinesia During Local Anesthesia With Dexmedetomidine.

Cureus 2021 Mar 6;13(3):e13739. Epub 2021 Mar 6.

Neurology, Saiseikai Matsuyama Hospital, Matsuyama, JPN.

Dyskinesia is among the most problematic issues for local anaesthesia management in Parkinson's disease (PD) patients. We present a case of a patient with PD who underwent spinal anaesthesia while utilizing dexmedetomidine (DEX) to reduce dyskinesia during urological surgery. DEX stimulates α₂-adrenergic receptors, which works to reduce the dyskinesia in PD patients. Read More

View Article and Full-Text PDF

Influence of anesthetic induction of propofol combined with esketamine on perioperative stress and inflammatory responses and postoperative cognition of elderly surgical patients.

Am J Transl Res 2021 15;13(3):1701-1709. Epub 2021 Mar 15.

Department of Anesthesiology, Yichun People's Hospital Yichun 336000, Jiangxi Province, China.

Objective: To analyze the influence of anesthetic induction of propofol combined with esketamine on perioperative stress and inflammatory responses and postoperative cognition in elderly surgical patients.

Methods: A total of 80 elderly surgical patients were randomly divided into a control group (n=40) and a study group (n=40). The control group received anesthetic induction with propofol combined with sufentanil, while the study group received anesthetic induction with propofol combined with esketamine. Read More

View Article and Full-Text PDF

A systematic review and meta-analysis of propofol versus midazolam sedation in adult intensive care (ICU) patients.

J Crit Care 2021 Apr 6;64:91-99. Epub 2021 Apr 6.

AxiaBio Life Sciences International ltda, São Paulo, Brazil; Health Technologies Assessment Center - Department of Gynecology, Escola Paulista de Medicina - Federal University of Sao Paulo, Brazil. Electronic address:

Purpose: Compare outcomes of adult patients admitted to ICU- length of ICU stay, length of mechanical ventilation (MV), and time until extubation- according to the use of propofol versus midazolam.

Methods: We searched MEDLINE, EMBASE, LILACS, and Cochrane databases to retrieve RCTs that compared propofol and midazolam used as sedatives in adult ICU patients. We applied a random-effects, meta-analytic model in all calculations. Read More

View Article and Full-Text PDF

THORACIC SYMPATHECTOMY: SEDATION EXPERIENCE.

Rev Port Cir Cardiotorac Vasc 2021 Apr 8;28(1):31-33. Epub 2021 Apr 8.

Cardiothoracic Surgery, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.

Introduction/Study Goals: Thoracic sympathectomy is considered to be the most effective treatment for hyperhidrosis, a procedure traditionally performed under general anesthesia. Nowadays it's a minimally invasive procedure, which makes it possible to perform under sedation with local anesthesia. The goal in this study was to assess the efficacy and safety of this anesthetic technique in video-assisted thoracic sympathectomy. Read More

View Article and Full-Text PDF

Evaluation of the Development of Tolerance Following Frequent Administration of Propofol in Children Requiring Successive Sedation for Separate Procedures.

J Pediatr Pharmacol Ther 2021 31;26(3):277-283. Epub 2021 Mar 31.

Objective: Propofol is frequently used for outpatient sedation for pediatric patients, some of whom require multiple rounds of sedation for separate procedures within a short period. Anecdotal experience suggests that frequent use of propofol results in escalating doses; however, clinical evidence is unconvincing. This study was designed to evaluate if tolerance develops with frequent administration of propofol for children requiring multiple successive sedations. Read More

View Article and Full-Text PDF

Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.

Drug Des Devel Ther 2021 30;15:1409-1422. Epub 2021 Mar 30.

Department of Anesthesiology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, People's Republic of China.

Background: To investigate the neuroprotective effect of edaravone on excessive-dose propofol-induced neurotoxicity in the hippocampus of newborn rats and HT22 cells.

Methods: Cell proliferation was investigated by assessing ki67 expression in the neural stem of the hippocampus of newborn rats and by cell counting kit-8 (CCK8) assay in HT22 cells. Cell apoptosis was assessed in vivo by caspase 3 detection in Western blots and measurement of apoptosis in neurons and glial cells by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Read More

View Article and Full-Text PDF

The Effect of Vibration on Pain During Intravenous Injection of Propofol: A Randomized Controlled Trial.

Ann Plast Surg 2021 Mar 18. Epub 2021 Mar 18.

From the Division of Plastic Surgery Department of Anesthesiology, Albert Einstein College of Medicine, Bronx, New York.

Purpose: Pain is a common side effect of intravenous injection of propofol. We conducted a randomized, prospective, single-blinded controlled trial to assess the efficacy of vibration analgesia on pain during propofol infusion in ambulatory surgery.

Methods: After institutional review board approval, 100 patients undergoing elective ambulatory surgery with general anesthesia were randomized into 2 groups. Read More

View Article and Full-Text PDF