1,473,736 results match your criteria prophylaxis treatment

Suppression of C-C chemokine receptor 1 is a key regulation for colon cancer chemoprevention in AOM/DSS mice by fucoxanthin.

J Nutr Biochem 2021 Sep 24:108871. Epub 2021 Sep 24.

Department of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.

Fucoxanthin (Fx) has shown potential cancer chemopreventive functions in a carcinogenic murine azoxymethane/dextran sodium sulfate (AOM/DSS) model. However, the molecular mechanisms based on transcriptome profiles in vivo remain poorly understood. We investigated Fx-dependent alterations of the transcriptome with cancer-associated proteins in colorectal mucosal tissue obtained from AOM/DSS mice with or without Fx treatment. Read More

View Article and Full-Text PDF
September 2021

Single-route CNS prophylaxis for aggressive non-Hodgkin lymphomas: real-world outcomes from 21 US academic institutions.

Blood 2021 Sep 27. Epub 2021 Sep 27.

University of Virginia, United States.

Prophylaxis is commonly used to prevent central nervous system (CNS) relapse in diffuse large B cell lymphoma, with no clear standard of care. We retrospectively evaluated 1162 adult patients across 21 US academic centers with DLBCL or similar histologies who received single-route CNS prophylaxis as part of frontline therapy between 2013-2019. Prophylaxis was administered intrathecally (IT) in 894 (77%) and using systemic high-dose methotrexate (HD-MTX) in 236 (20%); 32 patients (3%) switched route due to toxicity and were assessed separately. Read More

View Article and Full-Text PDF
September 2021

Tangeretin inhibits fungal ferroptosis to suppress rice blast.

J Integr Plant Biol 2021 Sep 27. Epub 2021 Sep 27.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, 510642, China.

Flavonoids are polyphenolic secondary metabolites that function as signaling molecules, allopathic compounds, phytoalexins, detoxifying agents and antimicrobial defensive compounds in plants. Blast caused by the fungus Magnaporthe oryzae is a serious disease affecting rice cultivation. In this study, we revealed that a natural flavonoid, tangeretin, substantially delays the formation of M. Read More

View Article and Full-Text PDF
September 2021

Acceptability of Texting 4 Relapse Prevention, Text Messaging-Based Relapse Prevention Program for People With Schizophrenia and Schizoaffective Disorder.

J Nerv Ment Dis 2021 Sep 24. Epub 2021 Sep 24.

Center for Innovative Public Health Research, San Clemente, California Department of Mental Health, The Johns Hopkins Bloomberg School of Public Health Department of Psychiatry and Behavioral Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

Abstract: We report process outcomes of the pilot randomized controlled trial of Texting 4 Relapse Prevention (T4RP), a text messaging-based relapse prevention program for people with schizophrenia or schizoaffective disorder (SAD). Forty people were randomized to either the intervention or treatment as usual control group at a 2:1 ratio. Process indicators were collected at 6 months post enrollment. Read More

View Article and Full-Text PDF
September 2021

Packaging and Scaling the Stanford Pediatric Weight Control Program: A Family-Based, Group, Behavioral Weight Management Program for Children with Obesity and Their Families: Background, Rationale, and Design of the Stanford CORD 3.0 Project.

Child Obes 2021 Sep;17(S1):S86-S92

Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.

Efficacious treatments for children with obesity have not been broadly disseminated. The Stanford Pediatric Weight Control Program (SPWCP) is grounded in behavioral theory and prior observations, follows a proven treatment model, and is consistent with the US Preventive Services Task Force (USPSTF) recommendations. It has shown high levels of participation and retention and reductions in BMI and percent of median BMI for age and sex comparable to many studied programs, as well as improvements in physiological risk factors, psychological measures, and diet, activity, and screen time behaviors in children with obesity when delivered as a real-world clinical program with sociodemographically diverse families in multiple clinic and community settings. Read More

View Article and Full-Text PDF
September 2021

Effect Of A Tertiary A-level Hospital WeChat-Based Intervention On Medication Adherence And Risk Factor Control In Patients With Stable Coronary Artery Disease Compared With Traditional Community Hospital Follow-Up: A Multicenter, Prospective Study.

JMIR Mhealth Uhealth 2021 Sep 26. Epub 2021 Sep 26.

Cardiometabolic Medicine Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, No.167 North Lishi Road, Xicheng District, Beijing, China,100037, Beijing, CN.

Background: In China, the main cause of mortality is a cardiac condition known as ischemic heart disease. Having cardiac rehabilitation and a secondary prevention program in place is a class IA recommendation for individuals with coronary artery disease. WeChat-based interventions seem to be feasible and efficient for the follow-up and management of chronic diseases. Read More

View Article and Full-Text PDF
September 2021

[Clinical observation of acupoint application of Chinese herbal medicine in preventing postoperative nausea and vomiting after orthopaedic surgery under general anesthesia].

Zhongguo Gu Shang 2021 Sep;34(9):814-20

Department of Anesthesiology, Wangjing Hospital of China Academy of Chinese Medical Science, Beijing 100102, China.

Objective: To explore clinical effect of acupoint application of Chinese herbal medicine in preventing postoperative nausea and vomiting after orthopaedic surgery under general anesthesia.

Methods: From January 2018 to December 2019, 168 patients who met inclusion criteria and were underwent selective spine surgery, were double-blind divided into two groups according to central random system, 84 patients in each group. In control group, there were 39 males and 45 females aged from 30 to 65 years old with an average of (53. Read More

View Article and Full-Text PDF
September 2021

Identifying and evaluating novel treatment targets for the development of evidence-based interventions for functional neurological disorder.

Epilepsy Behav Rep 2021 2;16:100479. Epub 2021 Sep 2.

University of Alabama at Birmingham, Departments of Neurology, Neurosurgery and Neurobiology and the UAB Epilepsy Center, United States.

Historically, functional neurological disorder (FND) has been described in psychodynamic terms as the physical manifestation of psychological distress. It is often explained to patients and caregivers as the result of anxiety, stress, trauma or other psychiatric comorbidities. However, recent evidence indicates that targeting mood and stress is not equivalent to the treatment of FND and may have limited to no effect on FND symptoms. Read More

View Article and Full-Text PDF
September 2021

Epidemiology and virulence-associated genes of isolates and factors associated with toxin EIA results at a university hospital in Japan.

Access Microbiol 2020 19;2(2):acmi000086. Epub 2019 Dec 19.

Department of Infectious Diseases, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.

Introduction: is one of the most important nosocomial pathogens; however, reports regarding its clinical and molecular characteristics from Japan are scarce.

Aims: We studied the multilocus sequence typing (MLST)-based epidemiology and virulence-associated genes of isolates and the clinical backgrounds of patients from whom the isolates had been recovered.

Methods: A total of 105 stool samples tested in a toxin enzyme immune assay (EIA) were analysed at the University of Tokyo Hospital from March 2013 to July 2014. Read More

View Article and Full-Text PDF
December 2019

Significant reduction in hemarthrosis in boys with severe hemophilia A: The China hemophilia individualized low-dose secondary prophylaxis study.

Res Pract Thromb Haemost 2021 Aug 18;5(6):e12552. Epub 2021 Sep 18.

Department of Pediatrics Laboratory Medicine and Pathology Division of Hematology and Oncology University of Ottawa Children Hospital of Eastern Ontario Ottawa ON Canada.

Introduction: In countries with restricted access to clotting factor concentrates, early implementation of low-dose prophylaxis is recommended over episodic treatment.

Objective: The objective of this 1-year prospective secondary prophylaxis study was to evaluate the efficacy of a dose/frequency escalating protocol in young boys with hemophilia A in China.

Methods: Boys were started on a low-dose protocol (minimum 10-15 IU/kg of factor VIII [FVIII] twice weekly). Read More

View Article and Full-Text PDF

Outcomes after Early Anticonvulsant Discontinuation in Aneurysmal Subarachnoid Hemorrhage.

J Vasc Med Surg 2015 24;3(1). Epub 2015 Jan 24.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, USA.

Background: Empiric use of anticonvulsant (AED) for seizure prophylaxis in aneurysmal subarachnoid hemorrhage (SAH) remains controversial and may be associated with worse SAH outcome. We determined the safety and feasibility of early discontinuation of empiric AED in a select cohort of SAH patients.

Methods: In a cohort of 166 consecutive SAH patients, a subset underwent early AED discontinuation if they were awake and following commands after aneurysm treatment. Read More

View Article and Full-Text PDF
January 2015

Association Between Cardiovascular Risk Factors and the Severity of Coronavirus Disease 2019: Nationwide Epidemiological Study in Korea.

Front Cardiovasc Med 2021 9;8:732518. Epub 2021 Sep 9.

Division of Cardiology, Department of Internal Medicine, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, South Korea.

Acute respiratory viral infections can result in cardiovascular involvement, with such patients having a significantly higher mortality rate than those without cardiovascular involvement. Due to the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is important to determine whether cardiovascular risk factors are associated with the severity of COVID-19. These nationwide data were provided by the Korea Disease Control and Prevention Agency. Read More

View Article and Full-Text PDF
September 2021

Lactic Acid Bacteria Strains Differently Modulate Gut Microbiota and Metabolic and Immunological Parameters in High-Fat Diet-Fed Mice.

Front Nutr 2021 9;8:718564. Epub 2021 Sep 9.

Centro de Referencia para Lactobacilos -CONICET, Tucumán, Argentina.

Dietary strategies, including the use of probiotics as preventive agents that modulate the gut microbiota and regulate the function of adipose tissue, are suitable tools for the prevention or amelioration of obesity and its comorbidities. We aimed to evaluate the effect of lactic acid bacteria (LAB) with different adipo- and immuno-modulatory capacities on metabolic and immunological parameters and intestinal composition microbiota in high-fat-diet-induced in mice fed a high-fat diet Balb/c weaning male mice were fed a standard (SD) or high-fat diet (HFD) with or without supplementation with CRL1446 (CRL1446) CRL1434 (CRL1434), or CRL431 (CRL431) for 45 days. Biochemical and immunological parameters, white-adipose tissue histology, gut microbiota composition, and cellular functionality (adipocytes and macrophages) were evaluated in SD and HFD mice. Read More

View Article and Full-Text PDF
September 2021

Oral Microbiota Profile of Individuals Who Abuse Methamphetamine.

Front Cell Infect Microbiol 2021 10;11:706961. Epub 2021 Sep 10.

Wuhan Mental Health Center, The Ninth Clinical School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The poor oral health condition of individuals who abuse methamphetamine (MA) is well known. The roles of the oral and fecal microbiomes in addiction and nervous system diseases have been the focus of many studies. However, changes in the microbiota composition of MA users have not been reported. Read More

View Article and Full-Text PDF
September 2021

High Frequency Mutations in and of in Response to Sulfadoxine-Pyrimethamine: A Cross-Sectional Survey in Returning Chinese Migrants From Africa.

Front Cell Infect Microbiol 2021 8;11:673194. Epub 2021 Sep 8.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, China.

Background: Sulfadoxine-pyrimethamine (SP) is recommended for intermittent preventive treatment in Africa against infection. However, increasing SP resistance (SPR) of affects the therapeutic efficacy of SP, and (encoding dihydrofolate reductase) and (encoding dihydropteroate synthase) genes are widely used as molecular markers for SPR surveillance. In the present study, we analyzed single nucleotide polymorphisms (SNPs) of and in isolated from infected Chinese migrant workers returning from Africa. Read More

View Article and Full-Text PDF
September 2021

Challenges in LTBI care in the United States identified using a nationwide TB medical consultation database.

Public Health Action 2021 Sep;11(3):162-166

Global Tuberculosis Institute at Rutgers, The State University of New Jersey, Newark, NJ, USA.

Background: Identifying and treating individuals with latent TB infection (LTBI) represents a critical and challenging component of national TB elimination. Medical consultations by the Centers for Disease Control and Prevention (CDC) funded TB Centers of Excellence (COEs) are an important resource for healthcare professionals (HCPs) caring for individuals with LTBI. This study aimed to identify the most common clinical concerns regarding LTBI care and to describe epidemiologic and clinical features of patients discussed in these consultations. Read More

View Article and Full-Text PDF
September 2021

Validity, reliability, and responsiveness of daily monitoring visual analog scales in MASK-air®.

Clin Transl Allergy 2021 Aug 19;11(7):e12062. Epub 2021 Sep 19.

Medical Faculty Institute of Medical Statistics, and Computational Biology University of Cologne Cologne Germany.

Background: MASK-air® is an app that supports allergic rhinitis patients in disease control. Users register daily allergy symptoms and their impact on activities using visual analog scales (VASs). We aimed to assess the concurrent validity, reliability, and responsiveness of these daily VASs. Read More

View Article and Full-Text PDF

Wavelet Transform Artificial Intelligence Algorithm-Based Data Mining Technology for Norovirus Monitoring and Early Warning.

J Healthc Eng 2021 17;2021:6128260. Epub 2021 Sep 17.

Department of Infectious Disease Control, Urumqi Center for Disease Control and Prevention, Urumqi 830026, Xinjiang, China.

Norovirus monitoring and early warning can be used for diagnosis without etiological testing, and the treatment of this disease does not require the antibiotics. It often occurs in preschool children and affects their growth and development, so the coping measures for this disease are more prevention than treatment. In this study, the clinical data of 2133 children with diarrhea were collected. Read More

View Article and Full-Text PDF
September 2021

Neuroprotective Effects of Palmatine via the Enhancement of Antioxidant Defense and Small Heat Shock Protein Expression in A-Transgenic .

Oxid Med Cell Longev 2021 15;2021:9966223. Epub 2021 Sep 15.

School of Biosciences & Biopharmaceutics, Guangdong Province Key Laboratory for Biotechnology Drug Candidates, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Palmatine is a naturally occurring isoquinoline alkaloid that has been reported to display neuroprotective effects against amyloid-- (A-) induced neurotoxicity. However, the mechanisms underlying the neuroprotective activities of palmatine remain poorly characterized . We employed transgenic models containing human A to investigate the effects and possible mechanisms of palmatine-mediated neuroprotection. Read More

View Article and Full-Text PDF
September 2021

Using Molecular Transmission Networks to Reveal the Epidemic of Pretreatment HIV-1 Drug Resistance in Guangxi, China.

Front Genet 2021 10;12:688292. Epub 2021 Sep 10.

Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, China.

Introduction: Pretreatment drug resistance (PDR) is becoming an obstacle to the success of ART. This study investigated the prevalence of PDR and the transmission clusters (TCs) of drug resistance mutations (DRMs) in two cities where drug abuse used to be high to describe the local HIV-1 transmission dynamics.

Methods: Plasma samples were obtained from 1,027 ART-naïve patients in Guangxi. Read More

View Article and Full-Text PDF
September 2021

Archaeosomes and Gas Vesicles as Tools for Vaccine Development.

Front Immunol 2021 10;12:746235. Epub 2021 Sep 10.

Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.

Archaea are prokaryotic organisms that were classified as a new domain in 1990. Archaeal cellular components and metabolites have found various applications in the pharmaceutical industry. Some archaeal lipids can be used to produce archaeosomes, a new family of liposomes that exhibit high stability to temperatures, pH and oxidative conditions. Read More

View Article and Full-Text PDF
September 2021

Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel -Deficient Zebrafish Model.

Front Neurosci 2021 10;15:682054. Epub 2021 Sep 10.

Department of Child Health Care, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Mutations of the gene are found in some autism spectrum disorder (ASD) patients, and animal models harboring mutations exhibit a variety of ASD-like behaviors, presenting a unique opportunity to explore the underlying neuropathological mechanisms and potential pharmacological treatments. The histone deacetylase (HDAC) valproic acid (VPA) has demonstrated neuroprotective and neuroregenerative properties, suggesting possible therapeutic utility for ASD. Therefore, -associated ASD-like symptoms present a convenient model to evaluate the potential benefits, therapeutic window, and optimal dose of VPA. Read More

View Article and Full-Text PDF
September 2021

Effects of the prebiotic lactoferrin on multidrug-resistant infections in broiler chickens.

Vet World 2021 Aug 25;14(8):2197-2205. Epub 2021 Aug 25.

Department of Bacteriology, Reference Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agricultural Research Center, Nadi El-Seid Street, Dokki, Giza 12618, Egypt.

Background And Aim: Increased multidrug resistance in has created challenges for the poultry industry. Consequently, new antimicrobial agents should preferentially be utilized for the prevention and treatment of outbreaks. This study aimed to evaluate the effects of lactoferrin (LF) as a prebiotic on broiler chicks challenged with multidrug-resistant in comparison with antibiotics. Read More

View Article and Full-Text PDF

Potential beneficial effects of bariatric surgery on the prevalence of kidney cancer: a national database study.

Surg Obes Relat Dis 2021 Aug 26. Epub 2021 Aug 26.

Department of General Surgery and The Bariatric and Metabolic Institute, Cleveland Clinic Florida, Weston, Florida. Electronic address:

Background: The incidence of obesity has been steadily increasing, especially in developed countries. Also, obesity is considered one of the modifiable risk factors of kidney cancer.

Objectives: This study aims to determine the impact of bariatric surgery-induced weight loss on the prevention of kidney cancer. Read More

View Article and Full-Text PDF

Effectiveness of topical vancomycin in the prevention of spinal surgical site infections: a retrospective cohort study.

Antimicrob Resist Infect Control 2021 Sep 26;10(1):136. Epub 2021 Sep 26.

Saudi Food and Drug Authority, Riyadh, Saudi Arabia.

Background: The risk of surgical site infections (SSIs), particularly methicillin-resistant Staphylococcus aureus (MRSA) SSIs, after spinal surgeries is one of the most daunting experiences to patients and surgeons. Some authors suggest applying vancomycin powder on the wound before skin closure to minimize the risk of SSIs; however, this practice is not supported by well-established evidence. This study sought to assess the effectiveness of topical (i. Read More

View Article and Full-Text PDF
September 2021

Index event of cerebral amyloid angiopathy (CAA) determines long-term prognosis and recurrent events (retrospective analysis and clinical follow-up).

Neurol Res Pract 2021 Sep 27;3(1):51. Epub 2021 Sep 27.

Department of Neurology, University of Regensburg, Bezirksklinikum, Universitätsstraße 84, 93053, Regensburg, Germany.

Background: The modified Boston criteria (mBC) define the probability for the diagnosis of cerebral amyloid angiopathy (CAA). Its initial clinical presentation differs from asymptomatic cerebral microbleedings (cMBs), acute ischemic stroke (AIS), cortical hemosiderosis (cSS), to lobar ICH (lICH).

Methods: Retrospective analyses and clinical follow-ups of individuals with at least mBC "possible" CAA from 2005 to 2018. Read More

View Article and Full-Text PDF
September 2021

Temporal trends in pre-ART patient characteristics and outcomes before the test and treat era in Central Kenya.

BMC Infect Dis 2021 Sep 26;21(1):1007. Epub 2021 Sep 26.

Division of Global HIV & TB, Centers for Disease Control and Prevention (CDC), Nairobi, Kenya.

Background: Retention of patients who did not initiate antiretroviral therapy (ART) has been persistently low compared to those who initiated ART. Understanding the temporal trends in clinical outcomes prior to ART initiation may inform interventions targeting patients who do not initiate ART immediately after diagnosis.

Methods: A retrospective cohort analysis of known HIV-infected patients who did not initiate ART from healthcare facilities in Central Kenya was done to investigate temporal trends in characteristics, retention, and mortality outcomes. Read More

View Article and Full-Text PDF
September 2021

Identification of Important Genes Related to Ferroptosis and Hypoxia in Acute Myocardial Infarction Based on WGCNA.

Bioengineered 2021 Sep 26. Epub 2021 Sep 26.

Department of cardio-thoracis surgery, Zhejiang Hospital, Hangzhou, Zhejiang, China.

Acute myocardial infarction (AMI) tends to cause severe heart failure and the population suffering from AMI gradually become younger. This study aims to determine the key genes associated with AMI, ferroptosis and hypoxia that could serve as novel biomarkers or potential therapeutic targets for AMI. There were 522 up-regulated genes and 119 down-regulated genes in GSE4648. Read More

View Article and Full-Text PDF
September 2021

Countering the rise of syphilis: A role for doxycycline post-exposure prophylaxis?

Int J STD AIDS 2021 Sep 26:9564624211042444. Epub 2021 Sep 26.

Department of Epidemiology and Biostatistics, Dornsife School of Public Health, 582373Drexel University, Philadelphia, PA, USA.

Doxycycline post-exposure prophylaxis (PEP) holds the potential to mitigate increasing rates of syphilis among sexual minority men (SMM) in the US yet has received limited attention. Since evaluation of this intervention in actual populations is not currently feasible, we used agent-based models (ABM) to assess the population-level impact of this strategy. We adapted ABM of HIV and HPV transmission, representing a population of 10,230 SMM in Philadelphia, Pennsylvania, US. Read More

View Article and Full-Text PDF
September 2021