515 results match your criteria prophylactic carotid

Development of Molecular Magnetic Resonance Imaging Tools for Risk Stratification of Carotid Atherosclerotic Disease Using Dual-Targeted Microparticles of Iron Oxide.

Transl Stroke Res 2021 Jul 25. Epub 2021 Jul 25.

Institute of Bioengineering and Bioimaging (IBB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Identification of patients with high-risk asymptomatic carotid plaques remains a challenging but crucial step in stroke prevention. Inflammation is the key factor that drives plaque instability. Currently, there is no imaging tool in routine clinical practice to assess the inflammatory status within atherosclerotic plaques. Read More

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A comparison of two different management plans for patients requiring both carotid endarterectomy and coronary artery bypass grafting.

Cardiovasc J Afr 2021 May-Jun 23;32(3):129-132. Epub 2021 Mar 16.

Department of Cardiovascular Surgery, Antalya Training and Research Hospital, Antalya, Turkey.

Background: Carotid endarterectomy (CEA) is a prophylactic operation that is used to mitigate the risk of stroke caused by embolism of atherosclerotic plaques in the carotid bifurcation. Previously, the large, multicentre, randomised, controlled GALA study found no significant differences in clinical outcomes between patients treated using general or local anaesthesia. While this study provided important insights into disease outcomes based on treatment modalities, it did not answer questions regarding the safety of CEA under local anaesthesia in patients at high risk for cardiovascular complications. Read More

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Superselective carotid body tumor embolization with platinum-based coils.

J Vasc Surg Cases Innov Tech 2021 Mar 27;7(1):1-5. Epub 2020 Oct 27.

Division of Vascular & Endovascular Surgery, Yale School of Medicine, New Haven, Conn.

Resection of Shamblin II and III carotid body tumors can be challenging owing to the potential for significant blood loss. Prophylactic use of liquid embolic agents poses a risk of inflammatory reactions and nontarget embolization. On the other hand, coil embolization has traditionally been limited to cases involving external carotid artery sacrifice. Read More

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Prophylactic effect of intranasal oxytocin on brain damage and neurological disorders in global cerebral ischemia in mice.

Iran J Basic Med Sci 2021 Jan;24(1):79-84

Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.

Objectives: A few experimental studies have shown the therapeutic effects of oxytocin on focal cerebral ischemia. In this study, the prophylactic effect of intranasal oxytocin on brain damage was investigated in a cerebral ischemic model.

Materials And Methods: Intranasal oxytocin (8 IU/per mouse) was prescribed daily for one week. Read More

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January 2021

Duplex ultrasound findings and clinical outcomes of carotid restenosis after carotid endarterectomy.

PLoS One 2020 29;15(12):e0244544. Epub 2020 Dec 29.

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

This study aimed to describe the duplex ultrasound (DUS) findings associated with carotid restenosis after carotid endarterectomy (CEA) and to determine whether carotid restenosis is associated with the clinical outcomes of CEA. Between January 2007 and December 2016, a total of 660 consecutive patients who underwent 717 CEAs were followed up at our hospital with DUS surveillance for at least 3 years after CEA. These patients were analyzed retrospectively for this study. Read More

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Cavernous sinus embolisation prior to removal of penetrating foreign body in a 6-year-old child.

BMJ Case Rep 2020 Dec 13;13(12). Epub 2020 Dec 13.

Department of Ophthalmology, Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Transorbital penetrating foreign bodies are extremely rare in children and may penetrate the cavernous sinus or the underlying internal carotid artery. Parent vessel sacrifice and temporary balloon occlusion are feasible options for managing arterial injury during removal of the foreign body. Even in the absence of arterial injury, the ophthalmologist may encounter significant bleeding from the cavernous sinus deep in their operative field that is difficult to control. Read More

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December 2020

Prophylactic inhibition of NF-κB expression in microglia leads to attenuation of hypoxic ischemic injury of the immature brain.

J Neuroinflammation 2020 Dec 1;17(1):365. Epub 2020 Dec 1.

Department of Pediatrics, Division of Neonatology, University of Arizona, 1501 N. Campbell Avenue, Tucson, AZ, USA.

Background: Periventricular leukomalacia (PVL), a devastating brain injury affecting premature infants, is the most common cause of cerebral palsy. PVL is caused by hypoxia ischemia (HI) and is characterized by white matter necrotic lesions, microglial activation, upregulation of NF-κB, and neuronal death. The microglia is the main cell involved in PVL pathogenesis. Read More

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December 2020

To Anticoagulate or Not: Acute Stroke in a COVID-19 Patient With Gastrointestinal Bleed.

Cureus 2020 Sep 20;12(9):e10554. Epub 2020 Sep 20.

Neurology, Sarasota Memorial Hospital, Sarasota, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the coronavirus family, which comprises enveloped positive sense ribonucleic acid (RNA) viruses responsible for pandemic outbreaks including Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), and most recently coronavirus disease 2019 (COVID-19). A 30-year-old previously healthy male diagnosed 11 days earlier with COVID-19 presented with right-sided weakness and dysarthria. The patient was found to have an acute left carotid thrombus with embolic multifocal infarcts throughout the left cerebral hemisphere. Read More

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September 2020

Support for increased cardiovascular risk in non-segmental vitiligo among Egyptians: A hospital-based, case-control study.

Pigment Cell Melanoma Res 2021 May 3;34(3):598-604. Epub 2020 Nov 3.

Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Data have been accumulating in the past few years that identify vitiligo as a disorder with systemic implications.

Results And Methods: In this hospital-based, cross-sectional, case-control study, 50 patients with non-segmental vitiligo and 50 age- and sex-matched controls underwent analysis of serum lipid profile, oxidative stress biomarkers and carotid duplex. Hydrogen peroxide (H O ) and malondialdehyde (MDA) were significantly higher in patients than controls (p-value < . Read More

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A prospective, randomized, controlled study assessing vagus nerve stimulation using the gammaCore®-Sapphire device for patients with moderate to severe CoViD-19 Respiratory Symptoms (SAVIOR): A structured summary of a study protocol for a randomised controlled trial".

Trials 2020 Jun 26;21(1):576. Epub 2020 Jun 26.

Hospital Clínico Universitario de Valencia, Anaesthesia, Critical Care and Pain Management Unit, Valencia, Spain.

Objectives: Primary Objective: The primary objective is to reduce initiation of mechanical ventilator dependency in patients with moderate to severe CoViD- 19. This will be measured as the difference between the control group and active group for subjects admitted to the hospital for CoViD-19. Secondary Objectives: • To evaluate cytokine trends / Prevent cytokine storms • To evaluate supplemental oxygen requirements • To decrease mortality of CoViD-19 patients • Delay onset of ventilation TRIAL DESIGN: The study is a single centre, 2-arm, prospective, randomized (ratio 1:1), controlled trial with parallel groups design to compare the reduction of respiratory distress in a CoViD-19 population, using the intervention of the gammaCore®-Sapphire device plus standard of care (active) vs. Read More

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Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?

Respir Physiol Neurobiol 2020 08 6;279:103476. Epub 2020 Jun 6.

Florey Institute of Neuroscience and Mental Health, Melbourne Victoria, Australia; The Florey Department of Neuroscience, University of Melbourne, Melbourne Victoria, Australia.

A very recent epidemiological study provides preliminary evidence that living in habitats located at 2500 m above sea level (masl) might protect from the development of severe respiratory symptoms following infection with the novel SARS-CoV-2 virus. This epidemiological finding raises the question of whether physiological mechanisms underlying the acclimatization to high altitude identifies therapeutic targets for the effective treatment of severe acute respiratory syndrome pivotal to the reduction of global mortality during the COVID-19 pandemic. This article compares the symptoms of acute mountain sickness (AMS) with those of SARS-CoV-2 infection and explores overlapping patho-physiological mechanisms of the respiratory system including impaired oxygen transport, pulmonary gas exchange and brainstem circuits controlling respiration. Read More

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Plaque Characteristics on CT Angiography Do Not Improve the Ability to Predict Hemodynamic Instability During and After Carotid Angioplasty and Stenting.

J Neurosurg Anesthesiol 2020 May 5. Epub 2020 May 5.

Department of Anesthesiology, Perioperative, and Pain Medicine at the Cumming School of Medicine, Calgary, AB, Canada.

Background: Hemodynamic instability is commonly seen during carotid angioplasty and stenting. Although prophylactic treatment with anticholinergics is beneficial, selected use in high-risk patients is desirable. This study examines whether plaque characteristics on computed tomography angiography in addition to demographic factors improve predictive capability. Read More

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Hemodynamic events during carotid stenting are associated with significant periprocedural stroke and adverse events.

J Vasc Surg 2020 06 19;71(6):1941-1953.e1. Epub 2020 Feb 19.

Division of Vascular Surgery, University of South Florida, Tampa, Fla.

Background: There are limited data on the impact of carotid angioplasty and stenting (CAS)-related changes in blood pressure, heart rate, and preprocedural medications on periprocedural stroke in contemporary, real-world practice. This study evaluates the risk attributable to the CAS-related hemodynamic events and the impact preprocedural medications have on mitigating this risk in a large, population-based cohort.

Methods: We studied all patients in the Vascular Quality Initiative who underwent CAS between January 2006 and December 2016. Read More

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Long-term Outcomes of Carotid Artery Stenting: A Single-center Experience.

Neurol Med Chir (Tokyo) 2020 Mar 3;60(3):121-125. Epub 2020 Jan 3.

Department of Neurosurgery, Japanese Red Cross Nagoya Daini Hospital.

The long-term prophylactic effect of carotid artery stenting (CAS) remains incompletely elucidated. We evaluated outcomes of CAS at our institution to determine the safety and efficacy of CAS in real-world settings. We retrospectively analyzed 73 patients who underwent CAS from 2006 to 2013. Read More

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[Cavernous sinus syndrome secondary to thrombophlebitis due to Streptococcus intermedius complicated with vasculitis of the internal carotid artery and brain abscesses].

Rev Neurol 2020 Jan;70(1):19-22

Hospitals Vall d'Hebron, 08035 Barcelona, España.

Introduction: Thrombophlebitis of the cavernous sinus is a severe infectious disease with high mortality and morbidity. It is usually diagnosed at a late stage and requires a number of visits to the emergency department in most cases, and the prognosis is highly dependent on prompt treatment. Despite its severity, evidence regarding treatment with corticosteroids and anticoagulation therapy is scarce and controversial. Read More

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January 2020

Prognostic factors of long-term survival to guide selection of asymptomatic patients for carotid endarterectomy.

Int Angiol 2020 Feb 5;39(1):29-36. Epub 2019 Dec 5.

Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN, USA -

Introduction: According to the current guidelines, prophylactic carotid endarterectomy (CEA) should be considered for patients with asymptomatic carotid stenosis (ACS) who are at high-risk of becoming symptomatic, provided they have a 3- to 5-year life-expectancy and perioperative stroke/death rates are ≤3%. We reviewed the literature to identify negative prognostic factors for long-term survival in ACS patients to avoid offering CEA to those not likely to benefit from the procedure.

Evidence Acquisition: PubMed/MedLine was searched until April 1, 2019, for risk prediction models to find ACS patients with poor long-term survival. Read More

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February 2020

Risk of perioperative neck hematoma in TIA and non-disabling stroke patients with symptomatic carotid artery stenosis undergoing endarterectomy within 14 days from cerebrovascular event.

J Neurol Sci 2020 Feb 22;409:116590. Epub 2019 Nov 22.

Department of Neurology, St. Josef-Hospital, Ruhr University, Bochum, Germany.

Backround & Purpose: Perioperative neck hematoma (PNH) requiring re-intervention is an important complication after carotid endarterectomy (CEA). There are limited data regarding the potential risk factors associated with PNH. The aim of this prospective, multicenter study was to document the rate of PNH in symptomatic carotid artery stenosis (sCAS) patients treated with CEA within the first 14 days of cerebrovascular symptom onset and to identify possible predictors of this complication. Read More

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February 2020

Prophylactic arterial ligation following transoral robotic surgery: A systematic review and meta-analysis.

Head Neck 2020 04 28;42(4):739-746. Epub 2019 Nov 28.

Department of Otolaryngology-HNS and Communicative Disorders, University of Louisville School of Medicine, Louisville, Kentucky.

Prophylactic arterial ligation has been proposed to reduce the severity of postoperative hemorrhage following transoral robotic surgery (TORS). Previous studies have shown a trend toward a reduction in major and severe bleeding. Search strategies were implemented in multiple databases and completed in August 2018. Read More

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Carotid to subclavian bypass and Amplatzer vascular plug subclavian endovascular occlusion before thoracic open or endovascular repair.

J Vasc Surg 2020 05 17;71(5):1480-1488.e1. Epub 2019 Oct 17.

Division of Vascular Surgery, "Vita - Salute" University, Scientific Institute H. San Raffaele, Milano, Italy.

Objective: The aim of this study was to evaluate the safety and effectiveness of endovascular occlusion of the prevertebral subclavian artery (SA) using an Amplatzer vascular plug after prophylactic revascularization with carotid-subclavian bypass (CSB) in the setting of endovascular thoracic stent grafting or open arch repair with frozen elephant trunk.

Methods: All patients who underwent SA plug embolization (SAPE) and CSB from September 2009 to December 2018 were enrolled in a registered study (SAPE study: clinicaltrials.govNCT03620006). Read More

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Medical therapy does not confer stroke prevention for all patients: identification of high-risk patients with asymptomatic carotid stenosis is still needed.

Int Angiol 2019 Oct 24;38(5):372-380. Epub 2019 Jul 24.

Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Case Western Reserve University, Cleveland, OH, USA -

Background: Recent advances in best medical therapy (BMT) has been associated with reduced risk of stroke similar to that observed following surgical carotid revascularization (CR). Thus, it remains uncertain which subset(s) of patients would benefit from prophylactic CR+BMT for asymptomatic carotid stenosis (ACS) over BMT alone. The purpose of this study was to analyze the contemporary experience in the management of >70% ACS in an academic institution, to compare the short- and long-term outcomes of BMT alone against CR+BMT, and to identify risk factors for the development of future cerebrovascular events. Read More

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October 2019

Quantitative evaluation using single-photon emission computed tomography with acetazolamide is reliable for preoperative evaluation before cardiac surgery in severe carotid intracranial artery stenotic and/or occlusive disease: a case report.

J Cardiothorac Surg 2019 Jul 23;14(1):141. Epub 2019 Jul 23.

Department of Cardiovascular Surgery, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, 1-8-1 Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan.

Background: Severe carotid and intracranial artery stenosis disease (CIAD) is major risk for perioperative stroke in coronary artery bypass grafting. Then, preoperative risk assessment is quite important.

Case Presentation: A 58-years old Japanese woman with bilateral carotid stenosis and bilateral middle cerebral artery occlusion was suffered from worsening effort angina due to severe three coronary vessel disease. Read More

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Probiotic supplementation attenuates hippocampus injury and spatial learning and memory impairments in a cerebral hypoperfusion mouse model.

Mol Biol Rep 2019 Oct 8;46(5):4985-4995. Epub 2019 Jul 8.

Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.

Probiotics are referred to species of living microscopic organisms may help conserve the normal balance of the digestive system and/or manage diseases. A number of autoimmune, psychiatric, cardiovascular and cerebrovascular disorders may be associated with the imbalance of gut microbiota. This study examines the effect of 21 days consumption of multistrain probiotics on hippocampus injury, spatial and learning memory and some potential molecular mechanisms in a mouse model with cerebral hypoperfusion. Read More

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October 2019

A Staged Therapy for Internal Carotid Artery Dissection Caused by Vascular Eagle Syndrome.

World Neurosurg 2019 Sep 30;129:133-139. Epub 2019 May 30.

Department of Neurosurgery, Koseikai Takeda Hospital, Kyoto, Japan; Department of Neurosurgery, National Cerebral and Cardiovascular Center, Osaka, Japan. Electronic address:

Background: Eagle syndrome with stroke onset is a rare condition. Carotid stenting of dissected arteries and/or surgical resection of the elongated styloid process are frequently performed; however, there are no definitive criteria for selecting these treatments.

Case Description: A 46-year-old man presented with left hemiplegia. Read More

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September 2019

Common carotid artery ligation at the proximal side before rupture in patients with ligation or occlusion of the external carotid artery at risk of carotid blowout syndrome.

Jpn J Clin Oncol 2019 Sep;49(9):839-844

Department of Head and Neck Oncology, National Cancer Center Hospital, Tokyo, Japan.

Background: Carotid blowout syndrome (CBS) is among the fatal complications in head and neck cancer treatment. However, the optimal treatment for CBS has not been established yet. This study aimed to describe our experience with two patients at high risk of CBS who underwent common carotid artery (CCA) ligation at the proximal side of the bleeding point under local anesthesia and before CCA rupture, and to review and compare the medical records of these two patients against 10 CBS cases treated in our department. Read More

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September 2019

Strain-selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains.

Br J Pharmacol 2019 08 24;176(15):2795-2807. Epub 2019 Jun 24.

Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, New York.

Background And Purpose: Sacubitril/valsartan (Sac/val) is more effective than valsartan in lowering BP and mortality in patients with heart failure. Here, we proposed that Sac/val treatment would be more effective in preventing pathological vascular remodelling in 129X1/SvJ (129X1), than in C57BL/6J (B6) inbred mice.

Experimental Approach: Sac/val (60 mg·kg ·day ) and valsartan (27 mg·kg ·day ) were given as prophylactic or therapeutic treatments, to 129X1 or B6 mice with carotid artery ligation for 14 days. Read More

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Tribulusterine Containing Tribulus terrestris Extract Exhibited Neuroprotection Through Attenuating Stress Kinases Mediated Inflammatory Mechanism: In Vitro and In Vivo Studies.

Neurochem Res 2019 May 12;44(5):1228-1242. Epub 2019 Mar 12.

Department of Pharmacology, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamil Nadu, 641004, India.

The present study has been aimed to explore the different secondary messengers of the inflammatory pathway NF-κB, kinases (JNK, P38MAPK, GSK3β/βcatenin), apoptosis pathway (Caspase-3 and AIF), and neuronal survival pathway (BDNF) in order to understand the neuroprotective mechanism of aqueous extract of Tribulus terrestris (AQTT). In primary cortical neurons, the ischemic condition was induced through oxygen-glucose deprivation (OGD). Anti-inflammatory activity of AQTT was evaluated in formalin induced inflammation model and carrageenan-induced paw edema test. Read More

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Revascularization surgery for symptomatic non-moyamoya intracranial arterial stenosis or occlusion.

J Neurosurg 2019 02;132(2):415-420

2Department of Clinical Medicine, Macquarie University; and.

Objective: Previous trials rejected a role of extracranial-to-intracranial bypass surgery for managing symptomatic atheromatous disease. However, hemodynamic insufficiency may still be a rationale for surgery, provided the bypass can be performed with low morbidity and patency is robust.

Methods: Consecutive patients undergoing bypass surgery for symptomatic non-moyamoya intracranial arterial stenosis or occlusion were retrospectively identified. Read More

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February 2019

The Prophylactic and Therapeutic Effects of Fermented Powder, Cs-C-Q80, on Subcortical Ischemic Vascular Dementia in Mice.

Evid Based Complement Alternat Med 2018 18;2018:4362715. Epub 2018 Dec 18.

Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Corbrin Capsule, a preparation of analogue, is a pleiotropic traditional Chinese patent medicine with the main component of fermentative cordyceps fungus powder (Cs-C-Q80). The neuroprotective effects of Cs-C-Q80, as a substitution of , have not been fully identified. The objectives of this study were to explore the prophylactic and therapeutic effects of Cs-C-Q80 in vascular dementia mice model. Read More

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December 2018

3D aortic morphology and stiffness in MRI using semi-automated cylindrical active surface provides optimized description of the vascular effects of aging and hypertension.

Comput Biol Med 2018 12 11;103:101-108. Epub 2018 Oct 11.

Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), F-75006, Paris, France.

Background: Clinically, aortic geometry assessment is mainly based on the measurement of maximal diameters at different anatomic locations, which are subsequently used to indicate prophylactic aortic surgery. However, 3D evaluation of aortic morphology could provide volumetric quantification, which integrates both aortic dilatation and elongation and might thus be more sensitive to early geometric changes than diameters. Precise aortic morphology is also required for the calculation of pulse wave velocity (PWV), an established marker of aortic stiffness. Read More

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December 2018

Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors.

Nat Commun 2018 10 2;9(1):4030. Epub 2018 Oct 2.

Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary Alberta, T2N 4N1, Canada.

Asthma accounts for 380,000 deaths a year. Carotid body denervation has been shown to have a profound effect on airway hyper-responsiveness in animal models but a mechanistic explanation is lacking. Here we demonstrate, using a rat model of asthma (OVA-sensitized), that carotid body activation during airborne allergic provocation is caused by systemic release of lysophosphatidic acid (LPA). Read More

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October 2018