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Intracerebroventricular injection of propranolol blocked analgesic and neuroprotective effects of resveratrol following L spinal nerve ligation in rat.

J Complement Integr Med 2021 May 7. Epub 2021 May 7.

Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Objectives: Resveratrol as a natural polyphenolic agent can alleviate neuropathic pain symptoms. The mechanism of analgesic activity of resveratrol is far from clear. The current study examine whether analgesic activity of resveratrol is mediated by its neuroprotective and anti-oxidant activity in the neuropathic pain. Read More

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Acute hemolytic transfusion reaction caused by anti-Yt.

Immunohematology 2021 Mar;37(1):13-17

Department of Transfusion Medicine and Transplantation Biology, University Clinical Hospital Zagreb , Zagreb , Croatia .

Many patients with anti-Yt receive multiple transfusions of Yt(a+) red blood cells (RBCs) with no ill effects. However, anti-Yt has been implicated in hemolytic transfusion reactions. Antibody identification typically determines specificity of antibodies and their clinical significance to justify blood requirements for antigen-negative blood when clinically significant antibodies are involved. Read More

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COVID-19, Diabetes, and Associated Health Outcomes in China: Results from a Nationwide Survey of 10 545 Adults.

Horm Metab Res 2021 May 7;53(5):301-310. Epub 2021 May 7.

Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.

This study examined the associations between diabetes and self-reported/familial COVID-19 infection and investigated health-related outcomes among those with diabetes during China's nationwide quarantine. The 2020 China COVID-19 Survey was administered anonymously via social media (WeChat). It was completed by 10 545 adults in all of mainland China's 31 provinces. Read More

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Microvesicles and Exosomes Released by Amnion Epithelial Cells Under Oxidative Stress Cause Inflammatory Changes in Uterine Cells.

Biol Reprod 2021 May 7. Epub 2021 May 7.

Division of Maternal-Fetal Medicine and Perinatal Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.

Extracellular vesicles (EVs) play a crucial role in feto-maternal communication and provide an important paracrine signaling mechanism in pregnancy. We hypothesize that fetal cells-derived exosomes and microvesicles (MVs) under oxidative stress carry unique cargo and traffic through feto-maternal interface, which cause inflammation in uterine cells associated with parturition. Exosomes and MVs, from primary amnion epithelial cell (AEC) culture media under normal or oxidative stress (OS)-induced conditions, were isolated by optimized differential centrifugation method followed by characterization for size (nanoparticle tracking analyzer), shape (transmission electron microscopy), and protein markers (western blot and immunofluorescence). Read More

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Influence of estradiol on bovine trophectoderm and uterine gene transcripts around maternal recognition of pregnancy.

Biol Reprod 2021 May 7. Epub 2021 May 7.

Department of Animal Science, South Dakota State University, Brookings SD; USA.

Embryo survival and pregnancy success is increased among animals that exhibit estrus prior to fixed time artificial insemination (AI), but there are no differences in conceptus survival to d16. The objective of this study was to determine effects of preovulatory estradiol on uterine transcriptomes, select trophectoderm transcripts, and uterine luminal fluid (ULF) proteins. Beef cows/heifers were synchronized, artificially inseminated (d0), and grouped into either high (highE2) or low (lowE2) preovulatory estradiol. Read More

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Low plasma angiotensin-converting enzyme 2 level in diabetics increases the risk of severe COVID-19 infection.

Aging (Albany NY) 2021 May 6;13. Epub 2021 May 6.

Department of Cardiology, The Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing, China.

Patients with pre-existing chronic diseases are more susceptible to coronavirus disease 2019 (COVID-19), yet the underlying causes of increased risk are of infection remain unclear. Angiotensin-converting- enzyme 2 (ACE2), the cell surface receptor that recognizes the coronavirus spike protein has protective effects against inflammation and chronic hyperglycemia in animal models. The roles of ACE2 in severe SARS-CoV-2 infections remains ambiguous due to contradictory findings. Read More

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Circular RNA circitga7 accelerates glioma progression via miR-34a-5p/VEGFA axis.

Aging (Albany NY) 2021 May 7;13. Epub 2021 May 7.

Department of Oncological Neurosurgery, First Hospital of Jilin University, Changchun 130021, China.

Circular RNAs (circRNAs) are a group of noncoding RNAs derived from back-splicing events. CircRNA is reported to be involved in various tumor progressions, including glioma. Although there are a few reports of circular RNAs participating in gliomas, it is still unclear whether circular RNAs regulate the occurrence of gliomas. Read More

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Increased hypospadias risk by rs3743104[G] in the southern Han Chinese population.

Aging (Albany NY) 2021 May 7;13. Epub 2021 May 7.

Department of Pediatric Urology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.

Hypospadias is a common congenital genitourinary malformation characterized by ventral opening of the urethral meatus. As a member of the bone morphogenic protein antagonist family, has been identified as associated with susceptibility to hypospadias in the European population. The present study was designed to elaborate on the mutual relationship between replicated single-nucleotide polymorphisms (SNPs) and hypospadias in Asia's largest case-control study in the Southern Han Chinese population involving 577 patients and 654 controls. Read More

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The utility of supine radiographs in the assessment of thoracic flexibility and risk of proximal junctional kyphosis.

J Neurosurg Spine 2021 May 7:1-7. Epub 2021 May 7.

Objective: Supine radiographs have successfully been used for preoperative planning of lumbar deformity corrections. However, they have not been used to assess thoracic flexibility, which has recently garnered attention as a potential contributor to proximal junctional kyphosis (PJK). The purpose of this study was to compare supine to standing radiographs to assess thoracic flexibility and to determine whether thoracic flexibility is associated with PJK. Read More

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Incidence of concussion and recovery of neurocognitive dysfunction on ImPACT assessment among youth athletes with premorbid depression or anxiety taking antidepressants.

J Neurosurg Pediatr 2021 May 7:1-7. Epub 2021 May 7.

1Neurosurgery Department, Icahn School of Medicine at Mount Sinai, New York.

Objective: Concussions in youth sports comprise an estimated 1.6-3.8 million annual injuries in the US. Read More

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Silent corticotroph pituitary adenomas: clinical characteristics, long-term outcomes, and management of disease recurrence.

J Neurosurg 2021 May 7:1-8. Epub 2021 May 7.

Departments of1Neurological Surgery.

Objective: Silent corticotroph adenomas (SCAs) are a distinct subtype of nonfunctioning pituitary adenomas (NFAs) that demonstrate positive immunohistochemistry for adrenocorticotropic hormone (ACTH) without causing Cushing's disease. SCAs are hypothesized to exhibit more aggressive behavior than standard NFAs. The authors analyzed their institution's surgical experience with SCAs in an effort to characterize rates of invasion, postoperative clinical outcomes, and patterns of disease recurrence and progression. Read More

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The predictive value of intraoperative visual evoked potential for visual outcome after extended endoscopic endonasal surgery for adult craniopharyngioma.

J Neurosurg 2021 May 7:1-11. Epub 2021 May 7.

1Department of Neurosurgery, Beijing Tiantan Hospital, and.

Objective: Due to the proximity of craniopharyngioma to the optic apparatus, one of the most common complications after surgery is visual deterioration. Intraoperative visual evoked potential (VEP), as a means of real-time visual function monitoring, has been integrated into transsphenoidal surgery for pituitary adenoma to predict postoperative visual outcome. Compared with pituitary tumor, craniopharyngioma often adheres to optic nerves, with increased risk of postoperative visual impairment. Read More

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Functionalization of TiO sol-gel derived films for cell confinement.

Colloids Surf B Biointerfaces 2021 Apr 25;204:111787. Epub 2021 Apr 25.

Department of Industrial Engineering, University of Trento, Via Sommarive 9, 38123 Trento, Italy.

The neuroscience field has increased enormously over the last decades, achieving the possible real application of neuronal cultures not only for reproducing neural architectures resembling in vivo tissues, but also for the development of functional devices. In this context, surface patterning for cell confinement is crucial, and new active materials together with new protocols for preparing substrates suitable for confining cells, guiding their processes in the desired configuration are extremely appreciated. Here, TiO sol-gel derived films were selected as proof-of-concept materials to grow neurons in suitable confined configurations, taking advantage of the biocompatible properties of modified TiO substrates. Read More

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Pulse wave velocity is decreased in acromegaly compared to non-acromegaly study participants with similar cardiovascular risk profile.

Growth Horm IGF Res 2021 Apr 29;57-58:101395. Epub 2021 Apr 29.

Almazov National Medical Research Centre, Ulica Akkuratova 2, St. Petersburg 197341, Russia.

Objective: Acromegaly patients were reported to have an increased arterial stiffness that could contribute to the frequent cardiovascular complications in this population. The chronic excess of GH and IGF-1 may lead to arterial stiffening via different mechanisms, including hypertension, impaired glucose tolerance and dyslipidemia, however, it is not known whether the activation of GH/IGF-1 axis might influence arterial stiffening independently of cardiovascular risk factors. The objective of this prospective case-control study was to compare arterial stiffness assessed with pulse-wave velocity (PWV) in acromegaly versus non-acromegaly group with similar cardiovascular risk profile. Read More

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Loneliness, social relationships, and mental health in adolescents during the COVID-19 pandemic.

J Affect Disord 2021 Apr 24;289:98-104. Epub 2021 Apr 24.

Department of Psychology, University of Bath, UK; Bristol Medical School, University of Bristol, UK.

Loneliness is a common experience in adolescence and is related to a range of mental health problems. Such feelings may have been increased by social distancing measures introduced during the COVID-19 pandemic. We aimed to investigate the effect of loneliness, social contact, and parent relationships on adolescent mental health during lockdown in the UK. Read More

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Trends in depression & anxiety symptom severity among mental health service attendees during the COVID-19 pandemic.

J Affect Disord 2021 Apr 24;289:105-109. Epub 2021 Apr 24.

Centre for Outcomes and Research Effectiveness, Research Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London, UK; Camden & Islington NHS Foundation Trust, St Pancras Hospital, 4 St Pancras Way, London, UK.

Background: General population surveys have shown that some groups, particularly young women, experienced increased distress during nationally mandated restrictions to control the spread of COVID-19. However, there has been limited research on such trends among people with pre-existing mental health conditions, leaving mental health services ill equipped to plan for current and future lockdowns.

Methods: Mean weekly scores on the GAD-7 and PHQ-9 between 01/01/2020-22/06/2020 (n=9,538 individuals) for all patients of two psychological treatment services (Improving Access to Psychological Therapies) in London, were compared to mean weekly scores from the same time periods in 2017-2019 (n=37,849). Read More

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Time-of-day effects of consumption of fish oil-enriched sausages on serum lipid parameters and fatty acid composition in normolipidemic adults: A randomized, double-blind, placebo-controlled, and parallel-group pilot study.

Nutrition 2021 Mar 24;90:111247. Epub 2021 Mar 24.

Healthy Food Science Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan; Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan; School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address:

Objectives: The body clock controls diurnal rhythms of nutrient digestion, absorption, and metabolism. Fish oil (FO) contains abundant ω-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), that are thought to lower triglyceride (TG) levels. This randomized, placebo-controlled, double-blind, parallel-group trial aimed to confirm the effects of the time of FO intake on TG in healthy Japanese adults. Read More

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Gestational folic acid deficiency alters embryonic eye development: Possible role of basement membrane proteins in eye malformations.

Nutrition 2021 Mar 26;90:111250. Epub 2021 Mar 26.

Universidad Complutense de Madrid, Faculty of Optics and Optometry, Anatomy and Embryology Department, Madrid, Spain; Universidad Complutense de Madrid, Faculty of Medicine, Anatomy and Embryology Department, Madrid, Spain.

Objectives: Folic acid (FA) is crucial before and during early pregnancy. FA deficiency can occur because dietary FA intake is low in mothers at the time of conception. Likewise, various ocular pathologies are related to the alteration of extracellular matrices. Read More

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The use of bioelectrical impedance analysis to predict post-operative complications in adult patients having surgery for cancer: A systematic review.

Clin Nutr 2021 Mar 17;40(5):2914-2922. Epub 2021 Mar 17.

Department of Perioperative Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK; University of Southampton, Southampton, UK.

Background: Patients undergoing surgery for cancer are at particular risk of post-operative complications. The pre-operative period is an opportunity to identify and mitigate risk factors and improve outcome. Bioelectrical impedance analysis (BIA) may offer an additional means of identifying patients at risk of post-operative morbidity. Read More

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Pre-clinical evaluation of immunoPET imaging using agonist CD40 monoclonal antibody in pancreatic tumor-bearing mice.

Nucl Med Biol 2021 Apr 21;98-99:8-17. Epub 2021 Apr 21.

Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University, Stanford, CA, USA. Electronic address:

Background: A novel [Cu]Cu-NOTA-aCD40 immunoPET tracer was developed to image a CD40 pancreatic tumor model in C57BL/6 mice and to study the biodistribution profile of the agonist CD40 (aCD40) monoclonal antibody (mAb) alone or combined with other mAbs.

Procedures: Copper-64 ([Cu]Cu) labeled NOTA-aCD40 and NOTA-IgG (10 μg; 7 MBq) were injected intravenously into C57BL/6 mice with subcutaneous mT4 tumors to assess specificity 48 h post injection (p.i. Read More

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Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume.

Neurobiol Aging 2021 Mar 6;104:24-31. Epub 2021 Mar 6.

Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain; Present address: H. Lundbeck A/S, Denmark. Electronic address:

Neurofilament light chain (NfL) is an axonal protein that when measured in cerebrospinal fluid (CSF) serves as a biomarker of neurodegeneration. We aimed at investigating the association among CSF NfL, presence of Subjective Cognitive Decline (SCD) and hippocampal volume, and how CSF amyloid-β (Aβ) modifies these associations. We included 278 cognitively unimpaired participants from the Alfa+ cohort (78 SCD and 200 Controls). Read More

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Influence of bisphosphonates on oral implantology: Sodium alendronate and zoledronic acid enhance the synthesis and activity of matrix metalloproteinases by gingival fibroblasts seeded on titanium.

Arch Oral Biol 2021 Apr 24;127:105134. Epub 2021 Apr 24.

Department of Physiology and Pathology, São Paulo State University (UNESP), School of Dentistry, Araraquara, SP, Brazil.

Objective: This study aimed to assess the influence of the bisphosphonates zoledronic acid and sodium alendronate on MMP-2 and MMP-9 synthesis and activity by gingival fibroblasts seeded onto titanium substrate.

Design: Titanium discs were placed in 24-well cell culture plates and gingival fibroblasts were seeded (1 × 10 cells/discs) on them using Dulbecco's Modified Eagle's Medium (DMEM) + 10 % fetal bovine serum (FBS) for 24 h. After this period, a fresh serum-free DMEM containing zoledronic acid or sodium alendronate at 0. Read More

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The influence of cognitive load on balance control during steady-state walking.

J Biomech 2021 Apr 23;122:110466. Epub 2021 Apr 23.

Walker Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX, USA. Electronic address:

For an individual to successfully walk, they must maintain control of their dynamic balance. However, situations that require increased cognitive attention may impair an individual's ability to actively control their balance. While dual-task studies have analyzed walking-while-talking conditions, few studies have focused specifically on the influence of cognitive load on balance control. Read More

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Mathematical model of modified hybrid pump mechanism for cardiopulmonary resuscitation.

Comput Methods Programs Biomed 2021 Apr 18;206:106106. Epub 2021 Apr 18.

Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea; Institute of BioEngineering, Bio-MAX Institute, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

Background And Objective: The "Cardiac pump theory" and "Thoracic pump theory" are representative theories of cardiopulmonary resuscitation (CPR) mechanisms. Based on these theories, many studies on mathematical modeling have been performed to help understand hemodynamics during CPR. However, there are parts that do not yet properly reflect the physiology of CPR. Read More

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Effect of cortisol on the immune-like response of rainbow trout (Oncorhynchus mykiss) myotubes challenged with Piscirickettsia salmonis.

Vet Immunol Immunopathol 2021 Apr 6;237:110240. Epub 2021 Apr 6.

Universidad Andres Bello, Laboratorio de Biotecnología Molecular, Facultad de Ciencias de la Vida, 8370146, Santiago, Chile; Interdisciplinary Center for Aquaculture Research (INCAR), 4030000, Concepción, Chile; Universidad Andres Bello, Centro de Investigación Marina Quintay (CIMARQ), 2340000, Valparaíso, Chile. Electronic address:

Salmonids are a species of high commercial value in Chilean aquaculture, where muscle is the final product of the industry. Fish can be affected by stress during intensive cultures, increasing susceptibility to infections. Recently, we reported that muscle is an important focus of immune reactions. Read More

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Anthropogenic underwater vibrations are sensed and stressful for the shore crab Carcinus maenas.

Environ Pollut 2021 Apr 16;285:117148. Epub 2021 Apr 16.

Biosciences, College of Life and Environmental Sciences, Hatherly Laboratories, University of Exeter, Stocker Road, Exeter, EX4 4PS, UK; Departamento de Zoología, Facultad de Ciencias Naturales y Oceanográficas, Universidad de Concepción, Casilla 160-C, Concepción, Chile; Instituto Milenio de Oceanografía (IMO), Universidad de Concepción, Chile. Electronic address:

Acoustic pollution in aquatic environments has increased with adverse effects on many aquatic organisms. However, little work has been done considering the effects of the vibratory component of acoustic stimuli, which can be transmitted in the substrate and propagated into the aquatic medium. Benthic marine organisms, including many invertebrates, are capable of sensing seabed vibration, yet the responses they trigger on organism have received little attention. Read More

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Excretion from long glandular trichomes contributes to alleviation of cadmium toxicity in Nicotiana tabacum.

Environ Pollut 2021 Apr 29;285:117184. Epub 2021 Apr 29.

Key Laboratory for Cultivation of Tobacco Industry, College of Tobacco Science, Henan Agricultural University, Zhengzhou, 450002, China. Electronic address:

The B-type cyclin gene, CycB2, serves as a negative regulator of glandular trichome initiation. Through targeted knockout of NtCycB2 in Nicotiana tabacum cv. K326 using the CRISPR/Cas9 system, we created a variety, HK326, which exhibits significantly increased density and larger glandular heads of long glandular trichomes. Read More

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Enhanced proteins and amino acids production based on ammonia nitrogen assimilation and sludge increment by the integration of bioadsorption with anaerobic-anoxic-oxic (AAO) process.

Chemosphere 2021 Apr 30;280:130721. Epub 2021 Apr 30.

Jiangsu Key Laboratory of Anaerobic Biotechnology, School of Environment and Civil Engineering, Jiangnan University, Wuxi, 214122, China; Jiangsu College of Water Treatment Technology and Material Collaborative Innovation Center, Suzhou, 215009, China. Electronic address:

Poor effect of contaminants removal efficiency and low organic matter content of activated sludge are common in wastewater treatment plants (WWTPs) in China due to the low-strength wastewater. An anaerobic-anoxic-oxic (AAO) and an adsorption/AAO (A/AAO) combined system were established simultaneously to conduct a comparative study for realizing the conversion of carbon source in influent and the enrichment and recovery of proteins and amino acids through the assimilation of ammonia nitrogen. The experimental results showed that 63. Read More

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Unraveling the mechanism of efficient adsorption of riboflavin onto activated biochar derived from algal blooms.

J Environ Manage 2021 May 4;291:112725. Epub 2021 May 4.

School of Geographic Sciences, Nantong University, Nantong, 226007, China. Electronic address:

Riboflavin is commercially produced primarily by bio-fermentation. Nonetheless, purification and separation are particularly complex and costly. Adsorption from the fermentation liquor is an alternative riboflavin separation technology during which a cost-efficient adsorbent is highly desired. Read More

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Greater increases in China's dryland ecosystem vulnerability in drier conditions than in wetter conditions.

J Environ Manage 2021 May 4;291:112689. Epub 2021 May 4.

State Key Laboratory of Earth Surface Processes and Resource Ecology, Faculty of Geographical Science, Beijing Normal University, Beijing, 100875, China; State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.

Dryland ecosystems are experiencing dramatic climate change, either drier or wetter. However, the differences in response amplitudes of dryland ecosystems to drier and wetter climates have not been frequently discussed, especially when using composite indicators at large scales. This study explores the changing patterns of ecosystem vulnerability in China's drylands by comprehensively considering exposure, sensitivity and resilience indicators using leaf area index (LAI) datasets and meteorological data within two periods from 1982 to 1999 (P1) and from 2000 to 2016 (P2). Read More

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