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A secondary approach with conventional medicines and supplements to recuperate current COVID-19 status.

Biomed Pharmacother 2021 Jul 27;142:111956. Epub 2021 Jul 27.

School of Pharmacy, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address:

Novel coronavirus 2019 (COVID-19) is a zoonosis that revised the global economic and societal progress since early 2020. The SARS-CoV-2 has been recognized as the responsible pathogen for COVID-19 with high infection and mortality rate potential. It has spread in 192 countries and infected about 1. Read More

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Application of QSAR for the identification of key molecular fragments and reliable predictions of effects of textile dyes on growth rate and biomass values of Raphidocelis subcapitata.

Aquat Toxicol 2021 Jul 23;238:105925. Epub 2021 Jul 23.

Drug Theoretics and Cheminformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, 188 Raja S C Mullick Road, 700032, Kolkata, India. Electronic address:

The current quantitative structure-activity relationship (QSAR) study seeks to explore the underlying causes of fluctuations in growth rate and biomass of microalgae mainly due to textile dyes. The derived QSAR models cover two endpoints: EC (growth rate) and EC (biomass) of Raphidocelis subcapitata. In order to extract the structural features involved, multiple PLS (partial least squares) models have been developed with easy to interpret and uncomplicated 2D descriptors having proper physico-chemical meaning. Read More

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Restoring lost nigrostriatal fibers in Parkinson's disease based on clinically-inspired design criteria.

Brain Res Bull 2021 Jul 28. Epub 2021 Jul 28.

Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States; Center for Brain Injury & Repair, Department of Neurosurgery, United States; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States. Electronic address:

Parkinson's disease is a neurodegenerative disease affecting around 10 million people worldwide. The death of dopaminergic neurons in the substantia nigra and the axonal fibers that constitute the nigrostriatal pathway leads to a loss of dopamine in the striatum that causes the motor symptoms of this disease. Traditional treatments have focused on reducing symptoms, while therapies with human fetal or stem cell-derived neurons have centered on implanting these cells in the striatum to restore its innervation. Read More

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The crux of C1-INH testing in everyday lab work.

J Immunol Methods 2021 Jul 28:113109. Epub 2021 Jul 28.

Department of Dermatology and Venereology, Medical University of Graz, Austria.

Background: The determination of functional C1-INH is complex and depends on methodology, sample transport, and storage conditions. In clinical practice, we encounter individuals with pathological values which then cannot be proved true, and HAE patients in whom the values were wrongly found to be normal under non-optimum conditions. We aimed to test realistic real-life sample processing conditions for accurate C1-INH determination. Read More

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Regulation of male fertility and accessory gland gene expression by the Drosophila HR39 nuclear receptor.

Dev Biol 2021 Jul 28. Epub 2021 Jul 28.

Department of Human Genetics, University of Utah School of Medicine, 15 North 2030 East, Rm 5100, Salt Lake City, UT, 84112, USA. Electronic address:

Successful reproduction is dependent on the transfer of male seminal proteins to females upon mating. These proteins arise from secretory tissues in the male reproductive tract, including the prostate and seminal vesicles in mammals and the accessory gland in insects. Although detailed functional studies have provided important insights into the mechanisms by which accessory gland proteins support reproduction, much less is known about the molecular mechanisms that regulate their expression within this tissue. Read More

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The presence of Toxoplasma gondii in the terrestrial and marine environments and its importance for public health.

Ann Parasitol 2021 ;67(2):137-149

Institute of Health Sciences, Pomeranian University in Słupsk, ul. Bohaterów Westerplatte 64, Słupsk 76-200, Poland.

Toxoplasma gondii occurred in terrestrial and marine environments. Many people still do not realize that how important are the role of prevention, especially hygiene and proper food processing as well as diagnostics for pregnant women. Humans become infected with T. Read More

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January 2021

COVID-19 transmission: a positive perspective.

Horm Mol Biol Clin Investig 2021 Jul 30. Epub 2021 Jul 30.

Department of Community Medicine, AIIMS Nagpur, Nagpur, Maharashtra, India.

Objectives: To understand the dynamics of infectivity of COVID-19 and allay the fear and anxiety associated with it in healthcare workers and the society.

Case Presentation: Three individuals accompanied their pediatric patients in the COVID ward but did not develop infection. Information about their knowledge and perspective about the disease and the protective measures undertaken by them during their stay in the hospital was gathered by administering a questionnaire 14 days after discharge. Read More

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Factors related to anxiety among resident doctors assigned to emergency room during the COVID-19 pandemic: a multivariate study at Sumatera Utara Affiliated Teaching Hospital.

Med Glas (Zenica) 2021 Aug 1;18(2). Epub 2021 Aug 1.

Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.

Aim To evaluate and assess knowledge and perception, as well as factors related to the occurrence of anxiety among frontliners, especially resident doctors working in emergency room (ER). Methods This multivariate study was conducted with cross-sectional approach involving 80 eligible subjects (based on inclusion and exclusion criteria) that are consecutively assigned and assessed with GAD-7 questionnaire. The study was held in ER of Universitas Sumatera Utara affiliated teaching hospital from May to August 2020. Read More

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An Overview of the Ethical Issues in Assisted Reproductive Technology Practices in Nigeria.

Authors:
O M Loto

West Afr J Med 2021 Jul;38(7):679-683

Department of Obstetrics, Gynaecology & Perinatology, Obafemi Awolowo University, Ile- Ife, Osun State, Nigeria.

Assisted reproductive technology (ART) is becoming a popular method of treating infertility in Nigeria however the practice still remains largely unregulated leaving room for unethical practices and/or with possible financial exploitation of the infertile couple thereby compounding their misery. There is an urgent need for widespread adoption of proper ethical guidelines and regulation in the provision of ART services in the country for the protection of both the providers and the clients. Read More

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Unsatisfactory Upper Blepharoplasty Revision Technique: Reconstruction of the Upper Orbital Septum and its Fusion Point.

Aesthetic Plast Surg 2021 Jul 30. Epub 2021 Jul 30.

Department of Burns and Plastic Surgery, Tianjin First Central Hospital, Tianjin, People's Republic of China.

Background: The orbital septum prevents both superficial eyelid infection and the spread of bleeding into the orbit. The fusion point between the upper eyelid orbital septum and the levator aponeurosis or the tarsal plate plays an important role in determining the width of the natural double eyelid. We observed a number of unsatisfactory upper eyelid blepharoplasty outcomes resulting from improper handling of the orbital septum-such as excessive destruction of orbital septum tissue and failure to form a firm attachment point between the orbital septum and the levator aponeurosis or palpebrae plate-during primary surgery. Read More

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New Donor Excision Design for Better Hair Alignment in Hair Restoration Surgery.

Aesthetic Plast Surg 2021 Jul 30. Epub 2021 Jul 30.

DHT Clinic, 408/138 Paholyothin Place Bldg., Floor 32, Paholyothin Road, Phayathai, Bangkok, 10400, Thailand.

Background: The linear scar and misalignment of hair follicles are disadvantages of the follicular unit transplantation (FUT) or strip technique. The most common misalignment is at the end of the strip. Although most surgeons try to match hair direction to achieve optimal hair alignment, their attempts are often unsuccessful. Read More

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Physiological and interactomic analysis reveals versatile functions of Arabidopsis 14-3-3 quadruple mutants in response to Fe deficiency.

Sci Rep 2021 Jul 30;11(1):15551. Epub 2021 Jul 30.

Department of Structural Biology, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, the Netherlands.

To date, few phenotypes have been described for Arabidopsis 14-3-3 mutants or the phenotypes showing the role of 14-3-3 in plant responding to abiotic stress. Although one member of the 14-3-3 protein family (14-3-3 omicron) was shown to be involved in the proper operation of Fe acquisition mechanisms at physiological and gene expression levels in Arabidopsis thaliana, it remains to be explored whether other members play a role in regulating iron acquisition. To more directly and effectively observe whether members of 14-3-3 non-epsilon group have a function in Fe-deficiency adaptation, three higher order quadruple KOs, kappa/lambda/phi/chi (klpc), kappa/lambda/upsilon/nu(klun), and upsilon/nu/phi/chi (unpc) were generated and studied for physiological analysis in this study. Read More

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Cell-free reconstitution reveals the molecular mechanisms for the initiation of secondary siRNA biogenesis in plants.

Proc Natl Acad Sci U S A 2021 Aug;118(31)

Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan;

Secondary small interfering RNA (siRNA) production, triggered by primary small RNA targeting, is critical for proper development and antiviral defense in many organisms. RNA-dependent RNA polymerase (RDR) is a key factor in this pathway. However, how RDR specifically converts the targets of primary small RNAs into double-stranded RNA (dsRNA) intermediates remains unclear. Read More

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[Prioritization by patients of a series of common components in the standard comprehensive geriatric assessment in Primary Care].

Rev Esp Geriatr Gerontol 2021 Jul 27. Epub 2021 Jul 27.

OSI Bilbao-Basurto, Bizkaia, España.

Objective: To know the prioritization by people aged ≥70 of a series of common components in the comprehensive geriatric assessment (CGA) in primary care (PC), according to the influence on health.

Method: Cross-sectional descriptive study through questionnaire to 109 people, have been excluded those at the end of life or with cognitive, sensory or mental/psychiatric impairment that made collaboration difficult. The main variable was a selection of 23 items of the physical/clinical, functional, mental and social/family, common components on a CGA in PC. Read More

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The aiming device for cervical distractor pin insertion: a proof-of-concept, feasibility study.

BMC Musculoskelet Disord 2021 Jul 30;22(1):648. Epub 2021 Jul 30.

Department of Neurological Surgery, Weill Cornell Medicine, New York, NY, USA.

Background: Restoration of cervical lordosis after anterior discectomy and fusion is a desirable goal. Proper insertion of the vertebral distraction or Caspar pin can assist lordotic restoration by either putting the tips divergently or parallel to the index vertebral endplates. With inexperienced surgeons, the traditional free-hand technique for Caspar pin insertion may require multiple insertion attempts that may compromise the vertebral body and increase radiation exposure during pin localization. Read More

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Effect of Nutrition Education on Diet Quality, Sustainable Nutrition and Eating Behaviors among University Students.

J Am Coll Nutr 2021 Jul 30:1-7. Epub 2021 Jul 30.

Department of Nutrition and Dietetics, Baskent University - Baglica Campus, Ankara, Turkey.

Nutrition information is provided by proper nutrition education and nutrition education programs have a direct impact on nutrition knowledge and behavior. This study aims to determine the effect of nutrition education on diet quality, sustainable nutrition and eating behavior.

Cross-sectional survey. Read More

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Are We Underestimating the Morbidity of Single Rib Fractures?

J Surg Res 2021 Jul 27;268:174-180. Epub 2021 Jul 27.

Department of Surgery, Division of Thoracic and Esophageal Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio 44106; Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106.

Purpose: Previous studies suggest that patients with multiple rib fractures have poor outcomes, but it is unknown how isolated single rib fractures (SRF) are associated with morbidity or mortality. We hypothesized that patients with poor outcomes after SRF can be identified by demographics and comorbidities. The purpose of this study was to model adverse outcome after single rib fractures. Read More

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Implementation of a text-based postpartum blood pressure monitoring program at three different academic sites.

Am J Obstet Gynecol MFM 2021 Jul 27:100446. Epub 2021 Jul 27.

Division of Maternal Fetal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

Background: Up to 30% of patients with hypertensive disorders of pregnancy continue to have elevated blood pressures after delivery, often necessitating medication titration or hospital evaluation in the weeks following hospital discharge. A previous randomized controlled trial demonstrated that remote blood pressure monitoring program resulted in more blood pressures and increased compliance with clinical guidelines in monitoring patients for persistent or worsening postpartum hypertension.

Objective: To measure program participant response rate during the first 10 days after hospital discharge, to assess replicability and scalability of the program, and to evaluate patient satisfaction at 3 distinct sites. Read More

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Assessment reliability of cervical spine parameters on full-body radiographs apply to asymptomatic and spinal deformities subjects.

Orthop Traumatol Surg Res 2021 Jul 27:103026. Epub 2021 Jul 27.

Faculty of Medicine, University of Saint-Joseph in Beirut, Lebanon. Electronic address:

Background: Cervical spinal alignment is usually assessed on full-body radiographs allowing for the concomitant evaluation of possible compensatory mechanisms that may occur at any level in the setting of postural malalignment.

Hypothesis: Cervical parameters measured on full-body radiographs are reliable.

Patients & Methods: A total of 70 subjects were included and divided in 3 groups: asymptomatic adults (N=21), adolescents with idiopathic scoliosis (N=20), and adults with spinal deformity (N=29), for whom full-body low-dose biplanar radiographs were obtained. Read More

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Evaluation of Anterior Segment Parameters in Pseudoexfoliation Disease Using Anterior Segment Optical Coherence Tomography.

Am J Ophthalmol 2021 Jul 27. Epub 2021 Jul 27.

Purpose: To compare anterior segment and angle parameters between pseudoexfoliation syndrome(PEX) and pseudoexfoliation glaucoma (PEXG) and normal control subjects by using anterior segment optical coherence tomography (AS-OCT) imaging.

Design: cross- sectional study METHODS: One hundred and two subjects with PEXG, PEX and normal eyes as the control group were recruited from academic referral institution. All subjects underwent complete ophthamologic examination, axial length measurement, AS-OCT imaging (CASIA SS-1000, Tomey). Read More

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Ceftaroline Dosage Optimized for Pediatric Patients with Renal Impairment Using Physiologically Based Pharmacokinetic Modeling.

J Clin Pharmacol 2021 Jul 30. Epub 2021 Jul 30.

Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, 20 Cha Zhong M. Rd, Fuzhou, 350005, People's Republic of China.

Ceftaroline fosamil is a fifth-generation cephalosporin approved as a treatment for adults and children with community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI). However, its pharmacokinetics has not been fully evaluated in children with renal impairment. This study aimed to propose proper ceftaroline dosages optimized for the renally impaired pediatric population using physiologically based pharmacokinetic (PBPK) modeling. Read More

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Predictors of Follow-Up Compliance in Pediatric Burn Patients During the Time of COVID.

J Burn Care Res 2021 Jul 30. Epub 2021 Jul 30.

Division of Pediatric Surgery, Johns Hopkins University School of Medicine; Baltimore, MD.

The effect of the COVID-19 pandemic has led to increased isolation and potentially decreased access to healthcare. We therefore evaluated the effect of COVID-19 on rates of compliance with recommended post-injury follow-up. We hypothesized that this isolation may lead to detrimental effects on adherence to proper follow-up for children with burn injuries. Read More

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Cortical Motor Planning and Biomechanical Stability During Unplanned Jump-Landings in Males With ACL-Reconstruction.

J Athl Train 2021 Jul 30. Epub 2021 Jul 30.

*Goethe University, Frankfurt am Main, Germany.

Context: Athletes with anterior cruciate ligament (ACL) reconstruction exhibit increased cortical motor planning during simple sensorimotor tasks compared to healthy controls. This may interfere with proper decision-making during time-constrained movements elevating the re-injury risk.

Objective: To compare cortical motor planning and biomechanical stability during jump-landings between participants with ACL-reconstruction and healthy individuals. Read More

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Structure and dynamics of the quaternary hunchback mRNA translation repression complex.

Nucleic Acids Res 2021 Jul 30. Epub 2021 Jul 30.

Structural and Computational Biology Unit, European Molecular Biology Laboratory Heidelberg, Heidelberg 69117, Germany.

A key regulatory process during Drosophila development is the localized suppression of the hunchback mRNA translation at the posterior, which gives rise to a hunchback gradient governing the formation of the anterior-posterior body axis. This suppression is achieved by a concerted action of Brain Tumour (Brat), Pumilio (Pum) and Nanos. Each protein is necessary for proper Drosophila development. Read More

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The Small GTPase OsRac1 Forms Two Distinct Immune Receptor Complexes Containing the PRR OsCERK1 and the NLR Pit.

Plant Cell Physiol 2021 Jul 31. Epub 2021 Jul 31.

Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630-0192, Japan.

Plants employ two different types of immune receptors, cell surface pattern recognition receptors (PRRs) and intracellular nucleotide-binding and leucine-rich repeat-containing proteins (NLRs), to cope with pathogen invasion. Both immune receptors often share similar downstream components and responses but it remains unknown whether a PRR and an NLR assemble into the same protein complex or two distinct receptor complexes. We have previously found that the small GTPase OsRac1 plays key roles in the signaling of OsCERK1, a PRR for fungal chitin, and of Pit, an NLR for rice blast fungus, and associates directly and indirectly with both of these immune receptors. Read More

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Knowledge of Triad and RED-S in Female Cross-Country Athletes and Support Staff.

J Athl Train 2021 Jul 30. Epub 2021 Jul 30.

*Syracuse University, NY.

Context: Female endurance athletes exhibit an increased risk of Female Athlete Triad (Triad) and Relative Energy Deficiency in Sport (RED-S). Triad and RED-S are conditions that explore the health and performance consequences of low energy availability (LEA). Few studies to date have assessed the knowledge that athletes, coaches, and athletic trainers (ATs) have regarding Triad/RED-S. Read More

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Using financial diaries to understand the economic lives of HIV-positive pregnant women and new mothers in PMTCT in Zomba, Malawi.

PLoS One 2021 30;16(7):e0252083. Epub 2021 Jul 30.

Global Health and Population Research, Durham, North Carolina, United States of America.

Background: Economic strengthening (ES) interventions can address economic barriers to retention and adherence (R&A) to antiretroviral therapy in prevention of mother-to-child transmission (PMTCT) services. To inform tailoring of ES activities for PMTCT, we used financial diaries to understand the economic lives of women in PMTCT and examine associations between participants' finances and their R&A.

Methods: We collected financial data from a stratified sample (n = 241) of HIV-positive pregnant women and new mothers enrolled in PMTCT from three clinics in Zomba, Malawi. Read More

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Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.

PLoS Genet 2021 Jul 30;17(7):e1009715. Epub 2021 Jul 30.

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.

Histone methylation is dynamically regulated to shape the epigenome and adjust central nuclear processes including transcription, cell cycle control and DNA repair. Lysine-specific histone demethylase 2 (LSD2) has been implicated in multiple types of human cancers. However, its functions remain poorly understood. Read More

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W-type normal dispersion thulium-doped fiber-based high-energy all-fiber femtosecond laser at 1.7  µm.

Opt Lett 2021 Aug;46(15):3637-3640

We propose a parabolic W-type thulium-doped fiber for the 1.7 µm high-energy femtosecond pulsed laser. Despite its attractive normal dispersion, the fiber offers high gain in 1. Read More

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Facile construction of dual heterojunction [email protected]/MXene hybrid with efficient and stable catalytic activity for phenol degradation with peroxymonosulfate under visible light irradiation.

J Hazard Mater 2021 Jul 18;420:126686. Epub 2021 Jul 18.

CSIRO Manufacturing, Private Bag 10, Clayton South, VIC 3169, Australia. Electronic address:

Photocatalysis and peroxymonosulfate (PMS) based advanced oxidation processes (AOP) are emerging technology for the degradation of refractory organic pollutant in the field of water treatment. Here we report a novel [email protected]/MXene (CTM) hybrid through a facile sonication-hydrothermal method for efficient degradation of phenol via an integrated PMS activation-photocatalysis process. Benefiting from the proper position and superior suitability of the band structure, a dual interfacial charge transport channel was constructed, boosting the separation of photo-generated charge carriers and generating sufficient potential difference for redox reaction. Read More

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