85,154 results match your criteria prone


Defining the microbiome of the head and neck: A contemporary review.

Am J Otolaryngol 2021 Sep 11;43(1):103224. Epub 2021 Sep 11.

University of Connecticut Health Center Department of Otolaryngology-Head and Neck Surgery, United States of America. Electronic address:

Objective: The purpose of this paper is to define the microbiome of the head and neck by characterizing and distinguishing the commensal bacteria from pathogenic species.

Study Design: Literature review.

Methods: Pubmed and Google scholar databases were queried for relevant articles. Read More

View Article and Full-Text PDF
September 2021

Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis.

Int Immunopharmacol 2021 Sep 15;100:108131. Epub 2021 Sep 15.

The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an 710004, Shaanxi, China. Electronic address:

Background: Vitamin D receptor (VDR) and NLRP3 inflammasome play critical roles in lupus nephritis (LN) pathogenesis.

Aim Of The Study: This study explored the therapeutic effect of VDR agonist on LN and its molecular mechanism to inhibit NLRP3 signalling.

Methods: C57BL/6 mice, lupus-prone MRL/lpr mice, and VDR agonist paricacitol-treated MRL/lpr mice (300 ng/kg/mouse per dose, 5 times/week for 8 weeks from 8 weeks old) were used to assess kidney histopathology and measure proteinuria, serum anti-ds-DNA antibody and expression of NF-κB/NLRP3/caspase-1/IL-1β/IL-18 axis. Read More

View Article and Full-Text PDF
September 2021

A rational reinterpretation of dual-process theories.

Cognition 2021 Sep 15;217:104881. Epub 2021 Sep 15.

Department of Psychology, Princeton University, Princeton, NJ 08544, USA; Department of Computer Science, Princeton University, Princeton, NJ 08544, USA. Electronic address:

Highly influential "dual-process" accounts of human cognition postulate the coexistence of a slow accurate system with a fast error-prone system. But why would there be just two systems rather than, say, one or 93? Here, we argue that a dual-process architecture might reflect a rational tradeoff between the cognitive flexibility afforded by multiple systems and the time and effort required to choose between them. We investigate what the optimal set and number of cognitive systems would be depending on the structure of the environment. Read More

View Article and Full-Text PDF
September 2021

Early versus late awake prone positioning in non-intubated patients with COVID-19.

Crit Care 2021 09 17;25(1):340. Epub 2021 Sep 17.

Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University Medical Center, 600 S Paulina St, Suite 765, Chicago, IL, USA.

Background: Awake prone positioning (APP) is widely used in the management of patients with coronavirus disease (COVID-19). The primary objective of this study was to compare the outcome of COVID-19 patients who received early versus late APP.

Methods: Post hoc analysis of data collected for a randomized controlled trial (ClinicalTrials. Read More

View Article and Full-Text PDF
September 2021

Plötzlicher Kindstod von zwei Säuglingen in Babytragehilfen.

Klin Padiatr 2021 Sep 17. Epub 2021 Sep 17.

Charité Universitätsmedizin Berlin, Neonatology, Berlin, Germany.

Sudden unexpected death in infancy (SUDI), previously termed sudden infant death syndrome (SIDS), is the second leading cause of death in infants beyond the neonatal period in Germany, and a major cause of infant mortality in economically well developed countries (OECD Health Statistics, 2019). The risk of SUDI peaks at the age of 2-4 months and then decreases continuously till the end of the first year. A complex multifactorial cause, rather than a single characteristic factor, may cause SUDI within a critical period of infant development (Guntheroth WG et al. Read More

View Article and Full-Text PDF
September 2021

Drugs for patients with epilepsy and excessive daytime sleepiness.

Epilepsy Behav 2021 Sep 14;124:108311. Epub 2021 Sep 14.

Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.

Excessive daytime sleepiness (EDS) and attentional deficits are often observed in people with epilepsy. They may be the consequence of seizures and subclinical discharges as well as of comorbid conditions as obstructive sleep apnea/hypopnea syndrome (OSAS), attention deficit hyperactivity disorder (ADHD), or other less frequent disorders. Excessive daytime sleepiness may also be caused or worsened by antiseizure medications (ASMs). Read More

View Article and Full-Text PDF
September 2021

Pharmacological approaches for bone health in persons with spinal cord injury.

Authors:
William A Bauman

Curr Opin Pharmacol 2021 Sep 14;60:346-359. Epub 2021 Sep 14.

Department of Veterans Affairs Rehabilitation Research & Development Service National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA; Internal Medical Service, James J. Peters VA Medical Center, Bronx, NY, USA; Departments of Medicine & Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Spinal cord injury (SCI) results in rapid, marked skeletal deterioration below the level of neurological lesion. Ideally, the most effective therapeutic approach would prevent loss of bone mass and architecture shortly after paralysis. Bisphosphonates preserve bone mineral density at the hip but not at the knee, which is the anatomical site most prone to fracture in the SCI population. Read More

View Article and Full-Text PDF
September 2021

Measuring the effects of postmortem time and age on mouse lens elasticity using atomic force microscopy.

Exp Eye Res 2021 Sep 14:108768. Epub 2021 Sep 14.

Biomedical Atomic Force Microscopy Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Miami, FL, USA. Electronic address:

The mouse lens is frequently used both in vivo and ex vivo in ophthalmic research to model conditions affecting the human lens, such as presbyopia. The mouse lens has a delicate structure which is prone to damage and biomechanical changes both before and after extraction from the whole globe. When not properly controlled for, these changes can confound the biomechanical analysis of mouse lenses. Read More

View Article and Full-Text PDF
September 2021

Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture.

J Neuropathol Exp Neurol 2021 Sep 17. Epub 2021 Sep 17.

Neurosurgery Research Group, Biomedicum, Helsinki, Finland.

Saccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage. Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative remodeling that precedes its rupture. A better understanding of the pathobiological process is essential for improved future treatment of patients carrying sIAs. Read More

View Article and Full-Text PDF
September 2021

An implantable restorative-neurostimulator for refractory mechanical chronic low back pain: a randomized sham-controlled clinical trial.

Pain 2021 Oct;162(10):2486-2498

Division of Pain Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA, United States.

Abstract: Chronic low back pain can be caused by impaired control and degeneration of the multifidus muscles and consequent functional instability of the lumbar spine. Available treatment options have limited effectiveness and prognosis is unfavorable. We conducted an international randomized, double-blind, sham-controlled trial at 26 multidisciplinary centers to determine safety and efficacy of an implantable, restorative neurostimulator designed to restore multifidus neuromuscular control and facilitate relief of symptoms (clinicaltrials. Read More

View Article and Full-Text PDF
October 2021

Median Nerve Mononeuropathy and Meralgia Paresthetica After Prone Positioning in a Patient with COVID-19 ARDS: A Case Report.

JBJS Case Connect 2021 09 17;11(3). Epub 2021 Sep 17.

Department of Orthopaedic Surgery, University of Illinois Medical Center at Chicago, Chicago, Illinois.

Case: Throughout the COVID-19 pandemic, prone positioning has decreased mortality in patients with severe acute respiratory distress syndrome. We present the unique case of a patient who developed left median nerve mononeuropathy and bilateral meralgia paresthetica after prone positioning while afflicted with COVID-19. These nerve injuries have been rarely reported in the literature and never before in the same patient. Read More

View Article and Full-Text PDF
September 2021

Pulmonary vasculitis in Hughes-Stovin syndrome (HSS): a reference atlas and computed tomography pulmonary angiography guide-a report by the HSS International Study Group.

Clin Rheumatol 2021 Sep 17. Epub 2021 Sep 17.

Serviço de Reumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Introduction: Hughes-Stovin syndrome (HSS) is a systemic vasculitis characterized by widespread venous/arterial thrombosis and pulmonary artery aneurysms (PAAs), which is associated with serious morbidity and mortality. All fatalities reported in HSS resulted from unpredictable fatal suffocating hemoptysis. Therefore, it is necessary to recognize pulmonary complications at an early stage of the disease. Read More

View Article and Full-Text PDF
September 2021

Cyclophilin A: a possible host modulator in Chandipura virus infection.

Arch Virol 2021 Sep 17. Epub 2021 Sep 17.

ICMR-National Institute of Virology, 130/1 Sus Road, Pashan, Pune, 411021, India.

Chandipura virus (CHPV), belonging to the genus Vesiculovirus of the family Rhabdoviridae, has been identified as one of the causes of pediatric encephalitis in India. Currently, neither vaccines nor therapeutic drugs are available against this agent. Considering that the disease progresses very fast with a high mortality rate, working towards the development of potential therapeutics against it will have a public health impact. Read More

View Article and Full-Text PDF
September 2021

The development of autoverification system of lymphocyte subset assays on the flow cytometry platform.

Clin Chem Lab Med 2021 Sep 15. Epub 2021 Sep 15.

NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, P. R. China.

Objectives: Peripheral blood lymphocyte subsets are important parameters for monitoring immune status; however, lymphocyte subset detection is time-consuming and error-prone. This study aimed to explore a highly efficient and clinically useful autoverification system for lymphocyte subset assays performed on the flow cytometry platform.

Methods: A total of 94,402 lymphocyte subset test results were collected. Read More

View Article and Full-Text PDF
September 2021

Electropolymerized 1D Growth Coordination Polymer for Hybrid Electrochromic Aqueous Zinc Battery.

Adv Sci (Weinh) 2021 Sep 17:e2101944. Epub 2021 Sep 17.

School of Materials Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore.

Organic materials are always viewed as promising electrochromic (EC) materials due to their synthetic versatility, color tunability, ready processability, and derivability from sustainable feedstocks. Most organic materials, however, are prone to undesirable redox side reactions in the presence of oxygen and water. As such, redox-active organic layers are often used in tandem with organic electrolytes to preserve their electrochemical stability. Read More

View Article and Full-Text PDF
September 2021

Clinicopathological characteristics and prognostic risk factors of breast cancer patients with bone metastasis.

Ann Transl Med 2021 Aug;9(16):1340

Department of Orthopedics, Peking University First Hospital, Beijing, China.

Background: A retrospective study was performed to summarize the clinicopathological characteristics of breast cancer patients with bone metastasis, to clarify the metastasis sites, and to explore the risk factors affecting prognosis.

Methods: Breast cancer patients with bone metastasis diagnosed in our hospital from January 2008 to January 2019 were included. Through follow-up by telephone call or return visit, the metastasis sites and clinicopathological characteristics were summarized. Read More

View Article and Full-Text PDF

Animal models of diabetic retinopathy.

Ann Transl Med 2021 Aug;9(15):1272

Department of Ophthalmology and Visual Sciences, State University of New York (SUNY), Upstate Medical University, Syracuse, NY, USA.

The retina is the posterior neuro-integrated layer of the eye that conducts impulses induced by light to the optic nerve for human vision. Diseases of the retina often leads to diminished vision and in some cases blindness. Diabetes mellitus (DM) is a worldwide public health issue and globally, there is an estimated 463 million people that are affected by DM and its consequences. Read More

View Article and Full-Text PDF

High BTBD7 expression positive is correlated with SLUG-predicted poor prognosis in hormone receptor-negative breast cancer.

Ann Transl Med 2021 Aug;9(15):1252

Department of Rheumatology, The First Affiliated Hospital, Shantou University Medical College, Shantou, China.

Background: Hormone receptor-negative breast cancer (HRNBC), which includes triple-negative breast cancer (TNBC) and human epidermal growth factor receptor 2 (HER-2) overexpressing breast cancer, is prone to metastasis and has a poor prognosis. BTB/POZ domain-containing protein 7 (Btbd7) is thought to regulate SLUG and the epithelial-mesenchymal transition (EMT) process. However, the role of Btbd7 in HRNBC is unclear. Read More

View Article and Full-Text PDF

Cambodia malaria indicator survey 2020: Implications for malaria elimination.

Malariaworld J 2021 1;12. Epub 2021 Jul 1.

Health and Social Development (HSD), Cambodia.

Background: Cambodia has made significant progress in controlling malaria in the past decade. It now aims to eliminate malaria from the country by 2025. It launched the Malaria Elimination Action Framework (MEAF 2016-2020) in 2015 with strong political commitment targeting appropriate interventions on high-risk populations, particularly mobile and migrant groups. Read More

View Article and Full-Text PDF

Construction and evaluation of prognostic models for esophageal cancer patients with distant and non-distant metastases: providing a reference process for clinical diagnosis and treatment.

J Gastrointest Oncol 2021 Aug;12(4):1241-1254

Department of Anesthesiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Although the current treatment for esophageal cancer has great technological progress, the 5-year survival rate of patients is not optimistic. About 70% of patients with esophageal cancer are at an advanced stage at first diagnosis. These patients are prone to distant metastasis, and the prognosis is poor. Read More

View Article and Full-Text PDF

L-citrulline inhibits body weight gain and hepatic fat accumulation by improving lipid metabolism in a rat nonalcoholic fatty liver disease model.

Food Sci Nutr 2021 Sep 16;9(9):4893-4904. Epub 2021 Jul 16.

School of Pharmaceutical Science Mukogawa Women's University Nishinomiya Japan.

Background: Body weight gain is a social issue all over the world. When body weight increased, hepatic fat accumulation also increased and it causes fatty liver disease. Therefore, developing a new treatment method and elucidating its mechanism is necessary. Read More

View Article and Full-Text PDF
September 2021

Partially Hydrolysed Whey Has Superior Allergy Preventive Capacity Compared to Intact Whey Regardless of Amoxicillin Administration in Brown Norway Rats.

Front Immunol 2021 31;12:705543. Epub 2021 Aug 31.

National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark.

Background: It remains largely unknown how physicochemical properties of hydrolysed infant formulas influence their allergy preventive capacity, and results from clinical and animal studies comparing the preventive capacity of hydrolysed infant formula with conventional infant formula are inconclusive. Thus, the use of hydrolysed infant formula for allergy prevention in atopy-prone infants is highly debated. Furthermore, knowledge on how gut microbiota influences allergy prevention remains scarce. Read More

View Article and Full-Text PDF

The effects of ecological rehabilitation projects on the resilience of an extremely drought-prone desert riparian forest ecosystem in the Tarim River Basin, Xinjiang, China.

Sci Rep 2021 Sep 16;11(1):18485. Epub 2021 Sep 16.

State Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, 830011, Xinjiang, China.

The Tarim River Basin in Xinjiang, China, has a typical desert riparian forest ecosystem. Analysis of the resilience of this type of ecosystem under extreme drought conditions and ecological rehabilitation projects could provide a theoretical basis for understanding ecosystem stability and resistance, and provide new ecological rehabilitation measures to improve ecosystem resilience. We employed a quantitative framework to assess net primary productivity (NPP) resilience, emphasizing four aspects of NPP dynamics: NPP, NPP stability, NPP resistance, and maximum NPP potential. Read More

View Article and Full-Text PDF
September 2021

Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3.

J Am Coll Cardiol 2021 Sep;78(12):1257-1265

Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; Kyung Hee University, Seoul, South Korea. Electronic address:

Plaque rupture is the most common cause of acute coronary syndromes and sudden cardiac death. Characteristics and pathobiology of vulnerable plaques prone to plaque rupture have been studied extensively over 2 decades in humans using optical coherence tomography (OCT), an intravascular imaging technique with micron scale resolution. OCT studies have identified key features of plaque vulnerability and described the in vivo characteristics and spatial distribution of thin cap fibroatheromas as major precursors to plaque rupture. Read More

View Article and Full-Text PDF
September 2021

SARS-CoV-2 Seroprevalence among the Health Care Staff of an Ophthalmological Reference Centre, a Cross Sectional Study.

Ophthalmic Epidemiol 2021 Sep 16:1-8. Epub 2021 Sep 16.

Research Unit, Institute of Ophthalmology, Conde De Valenciana Foundation. Chimalpopoca, Mexico City, Mexico.

Purpose: During the COVID-19 pandemic, healthcare workers (HCWs) are at a considerable risk of being infected with SARS-CoV-2; among them, HCWs from ophthalmology departments are more prone to develop severe symptoms. In Mexico City, the prevalence of SARS-CoV-2 infection among HCWs is 30%. The present work aims to describe the seroprevalence among HCWs at an Ophthalmological Reference Centre in Mexico City. Read More

View Article and Full-Text PDF
September 2021

Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen .

Gut Microbes 2021 Jan-Dec;13(1):1966263

Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.

The change of dietary habits in Western societies, including reduced consumption of fiber, is linked to alterations in gut microbial ecology. Nevertheless, mechanistic connections between diet-induced microbiota changes that affect colonization resistance and enteric pathogen susceptibility are still emerging. We sought to investigate how a diet devoid of soluble plant fibers impacts the structure and function of a conventional gut microbiota in specific-pathogen-free (SPF) mice and how such changes alter susceptibility to a rodent enteric pathogen. Read More

View Article and Full-Text PDF
September 2021

Serological Screening of Suspected COVID-19 Patients in Pakistan.

J Coll Physicians Surg Pak 2021 01;31(1):S71-S74

Department of Pathology, Mardan Medical Complex, Mardan, Pakistan.

Objective: To determine the antibody levels (IgM and IgG), using ELISA in suspected patients of COVID-19.

Study Design: Descriptive cross-sectional study. Place & Duration of Study: Real Time PCR Diagnostic and Research Laboratory, Peshawar, Khyber Pakhtunkhwa, Pakistan, from May to July 2020. Read More

View Article and Full-Text PDF
January 2021

Resilient planning optimization through spatially explicit, Bi-directional sociohydrological modeling.

J Environ Manage 2021 Sep 13;300:113742. Epub 2021 Sep 13.

Department of Landscape Architecture, University of Illinois at Urbana-Champaign, USA. Electronic address:

Stormwater runoff is one critical urban issue that exemplifies the complexity in coupling human and natural systems. Innumerable studies have described and assessed the hydrological responses that result from land-use changes through a 'post land use change' hydrological analysis. Complex systems theory, however, suggests that the urban and ecological systems operate as an intertwined whole. Read More

View Article and Full-Text PDF
September 2021

An approach to quantifying the potential importance of residual confounding in systematic reviews of observational studies: A GRADE concept paper.

Environ Int 2021 Sep 13;157:106868. Epub 2021 Sep 13.

McMaster University, Hamilton, Canada.

Small relative effect sizes are common in observational studies of exposure in environmental and public health. However, such effects can still have considerable policy importance when the baseline rate of the health outcome is high, and many persons are exposed. Assessing the certainty of the evidence based on these effect sizes is challenging because they can be prone to residual confounding due to the non-randomized nature of the evidence. Read More

View Article and Full-Text PDF
September 2021

Decreasing hyaluronic acid combined with drug-loaded nanoprobes improve the delivery and efficacy of chemotherapeutic drugs for pancreatic cancer.

Cancer Lett 2021 Sep 13. Epub 2021 Sep 13.

CAS Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Beijing, 100190, China; Beihang University, Beijing, 100083, China. Electronic address:

Pancreatic cancer is one of the common malignant tumors of the digestive system, and its clinical treatment is still very challenging. Most of the pancreatic cancer chemotherapeutic drugs have poor plasma stability, low cell uptake efficiency, and are prone to developing drug resistance and toxic side effects. Besides, pancreatic cancer often has a dense extracellular matrix, which consists of collagens, hyaluronic acid, and other proteoglycans. Read More

View Article and Full-Text PDF
September 2021