18,210 results match your criteria promotes movement

Exposure to relaxing words during sleep promotes slow-wave sleep and subjective sleep quality.

Sleep 2021 Jun 11. Epub 2021 Jun 11.

Department of Psychology, University of Fribourg, Fribourg, Switzerland.

Our thoughts alter our sleep, but the underlying mechanisms are still unknown. We propose that mental processes are active to a greater or lesser extent during sleep and that this degree of activation affects our sleep depth. We examined this notion by activating the concept of "relaxation" during sleep using relaxation-related words in 50 healthy participants. Read More

View Article and Full-Text PDF

circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis.

J Int Med Res 2021 Jun;49(6):3000605211013207

Department of Stomatology, the Wuhan Sixth Hospital, Wuhan, China.

Objective: To study the relationship between the circular RNA vesicle-associated membrane protein-associated protein A (circVAPA) and the pathogenesis of oral squamous cell carcinoma.

Methods: The expression of circVAPA was detected by RT-qPCR. loss-of-function experiments were performed in Cal-27 cells. Read More

View Article and Full-Text PDF

Consensus for experimental design in electromyography (CEDE) project: Terminology matrix.

J Electromyogr Kinesiol 2021 May 27;59:102565. Epub 2021 May 27.

School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. Electronic address:

Consensus on the definition of common terms in electromyography (EMG) research promotes consistency in the EMG literature and facilitates the integration of research across the field. This paper presents a matrix developed within the Consensus for Experimental Design in Electromyography (CEDE) project, providing definitions for terms used in the EMG literature. The definitions for physiological and technical terms that are common in EMG research are included in two tables, with key information on each definition provided in a comment section. Read More

View Article and Full-Text PDF

Tripartite motif containing 28 (TRIM28) promotes the growth and migration of endometrial carcinoma cells by regulating the AKT/mTOR signaling pathway.

Gen Physiol Biophys 2021 May;40(3):245-252

Department of Oncology, The First Affiliated Hospital of Gannan Medical College, Ganzhou City, Jiangxi Province, China.

Although the medical science has been developed for decades, the molecular mechanism of endometrial cancer (EC) is not yet completely clear. Previous studies have shown that the tripartite motif containing 28 (TRIM28) plays a crucial role in tumor development. However, TRIM28 is rarely studied in EC, and its role and mechanism need to be further determined. Read More

View Article and Full-Text PDF

Methylsulfonylmethane enhances MSC chondrogenic commitment and promotes pre-osteoblasts formation.

Stem Cell Res Ther 2021 Jun 5;12(1):326. Epub 2021 Jun 5.

Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.

Background: Methylsulfonylmethane (MSM) is a nutraceutical compound which has been indicated to counteract osteoarthritis, a cartilage degenerative disorder. In addition, MSM has also been shown to increase osteoblast differentiation. So far, few studies have investigated MSM role in the differentiation of mesenchymal stem cells (MSCs), and no study has been performed to evaluate its overall effects on both osteogenic and chondrogenic differentiation. Read More

View Article and Full-Text PDF

Co-Adaptation of Physical Attributes of the Mammalian Female Reproductive Tract and Sperm to Facilitate Fertilization.

Cells 2021 May 24;10(6). Epub 2021 May 24.

Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.

The functions of the female reproductive tract not only encompass sperm migration, storage, and fertilization, but also support the transport and development of the fertilized egg through to the birth of offspring. Further, because the tract is open to the external environment, it must also provide protection against invasive pathogens. In biophysics, sperm are considered "pusher microswimmers", because they are propelled by pushing fluid behind them. Read More

View Article and Full-Text PDF

Oral Administration of Mycelia Promotes Non-Rapid Eye Movement and Rapid Eye Movement Sleep in Rats.

J Fungi (Basel) 2021 May 10;7(5). Epub 2021 May 10.

Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 106, Taiwan.

The present study aimed to explore whether water and ethanol extracts of mycelia produce sedative and hypnotic effects in rats. Male Sprague-Dawley rats were surgically implanted with two electroencephalogram electrodes on the skull and an electromyogram electrode on neck muscle to evaluate the alterations in rapid eye movement (REM) and non-REM (NREM) sleep after oral administration of the water and ethanol extracts. Following post-surgical recovery, thirty-six rats were randomly divided into four treatment groups and two control groups. Read More

View Article and Full-Text PDF

Initiation of Pancreatic Cancer: The Interplay of Hyperglycemia and Macrophages Promotes the Acquisition of Malignancy-Associated Properties in Pancreatic Ductal Epithelial Cells.

Int J Mol Sci 2021 May 11;22(10). Epub 2021 May 11.

Institute for Experimental Cancer Research, Kiel University (CAU) and University Medical Center Schleswig-Holstein (UKSH), Campus Kiel, 24105 Kiel, Germany.

Pancreatic ductal adenocarcinoma (PDAC) is still one of the most aggressive solid malignancies with a poor prognosis. Obesity and type 2 diabetes mellitus (T2DM) are two major risk factors linked to the development and progression of PDAC, both often characterized by high blood glucose levels. Macrophages represent the main immune cell population in PDAC contributing to PDAC development. Read More

View Article and Full-Text PDF

A GIS based approach to neighbourhood physical environment and walking among adults in Colombo municipal council area, Sri Lanka.

BMC Public Health 2021 05 26;21(1):989. Epub 2021 May 26.

Postgraduate Institute of Science, University of Peradeniya, Peradeniya, Sri Lanka.

Background: Physical Activity (PA) promotes health and wellbeing and walking is one of the easiest and commonest way to incorporate activity into everyday life. This study examined the association between the objectively measured neighbourhood physical environment and walking among the adults in Colombo Municipal Council (CMC) area in Sri Lanka.

Methods: A cross sectional study was carried out and primary data collection carried out to assess walking, socio-demographic characteristics and geo location of residence. Read More

View Article and Full-Text PDF

Basal epidermis collective migration and local Sonic hedgehog signaling promote skeletal branching morphogenesis in zebrafish fins.

Dev Biol 2021 May 24;477:177-190. Epub 2021 May 24.

Institute of Molecular Biology, University of Oregon, 273 Onyx Bridge, 1318 Franklin Blvd, Eugene, OR, 97403-1229, USA; Department of Biology, University of Oregon, 77 Klamath Hall, 1370 Franklin Blvd, Eugene, OR, 97403-1210, USA. Electronic address:

Teleost fish fins, like all vertebrate limbs, comprise a series of bones laid out in characteristic pattern. Each fin's distal bony rays typically branch to elaborate skeletal networks providing form and function. Zebrafish caudal fin regeneration studies suggest basal epidermal-expressed Sonic hedgehog (Shh) promotes ray branching by partitioning pools of adjacent pre-osteoblasts. Read More

View Article and Full-Text PDF

H. pylori infection induces CXCL8 expression and promotes gastric cancer progress through downregulating KLF4.

Mol Carcinog 2021 May 26. Epub 2021 May 26.

Department of Physiopathology, Anhui Medical University, Hefei, Anhui, China.

Tumour-derived CXCL8 facilitates the movement of myeloid-derived suppressor cells, which are able to restrain antitumour immune responses to the tumour microenvironment. Kruppel-like factor 4 (KLF4) is a potential tumour suppressor in gastric cancer (GC). However, knowledge regarding correlations between KLF4 and CXCL8 in GC is limited. Read More

View Article and Full-Text PDF

Long non-coding RNA DLGAP1-AS1 promotes the progression of gastric cancer via miR-515-5p/MARK4 axis.

Braz J Med Biol Res 2021 24;54(8):e10062. Epub 2021 May 24.

Department of Medical Oncology, Dongguan People's Hospital, Dongguan, Guangdong, China.

Long non-coding RNA (lncRNA) is an essential regulator of carcinogenesis and cancer progression. In the study, we explored the role of lncRNA DLGAP1-AS1 in gastric cancer (GC). qRT-PCR was carried out to detect DLGAP1-AS1 expression in GC tissues and cell lines. Read More

View Article and Full-Text PDF

The effect of approach velocity on pelvis and kick leg angular momentum conversion strategies during football instep kicking.

J Sports Sci 2021 May 25:1-10. Epub 2021 May 25.

Chichester Institute of Sport, University of Chichester, Chichester, UK.

During football instep kicking, whole-body deceleration during the final stride has been associated with greater kick leg angular momentum and enhanced foot and ball velocities, but the influence of approach velocity on these mechanisms is unknown. This study assessed how approach velocity affects momentum conversion strategies of experienced players performing fast and accurate kicks. Eleven semi-professional footballers performed instep kicks from self-selected (3. Read More

View Article and Full-Text PDF

Biomechanics of chromosome alignment at the spindle midplane.

Curr Biol 2021 May;31(10):R574-R585

Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia. Electronic address:

During metaphase, chromosomes are aligned in a lineup at the equatorial plane of the spindle to ensure synchronous poleward movement of chromatids in anaphase and proper nuclear reformation at the end of mitosis. Chromosome alignment relies on microtubules, several types of motor protein and numerous other microtubule-associated and regulatory proteins. Because of the multitude of players involved, the mechanisms of chromosome alignment are still under debate. Read More

View Article and Full-Text PDF

The CNN Hip Accelerometer Posture (CHAP) Method for Classifying Sitting Patterns from Hip Accelerometers: A Validation Study.

Med Sci Sports Exerc 2021 May 24. Epub 2021 May 24.

Kaiser Permanente Washington Health Research Institute, Seattle, WA University of California San Diego, Department of Computer Science and Engineering, La Jolla, CA City of Hope, Beckman Research Institute, Population Sciences, Duarte, CA University of California San Diego, Herbert Wertheim School of Public Health and Human Longevity Science, La Jolla, CA Children's Mercy Kansas City, Center for Children's Healthy Lifestyles and Nutrition. Kansas City, MO University of Missouri Kansas City, Department of Pediatrics, Kansas City, MO.

Introduction: Sitting patterns predict several healthy aging outcomes. These patterns can potentially be measured using hip-worn accelerometers, but current methods are limited by an inability to detect postural transitions. To overcome these limitations, we developed the Convolutional Neural Network Hip Accelerometer Posture (CHAP) classification method. Read More

View Article and Full-Text PDF

A Murine Model for Enhancement of Pathogenicity Upon Viral Infection and Advanced Age.

Infect Immun 2021 May 24. Epub 2021 May 24.

Department of Microbiology and Immunology, University at Buffalo School of Medicine, Buffalo, New York, USA

(pneumococcus) resides asymptomatically in the nasopharynx but can progress from benign colonizer to lethal pulmonary or systemic pathogen. Both viral infection and aging are risk factors for serious pneumococcal infections. Previous work established a murine model that featured the movement of pneumococcus from the nasopharynx to the lung upon nasopharyngeal inoculation with influenza A virus (IAV) but did not fully recapitulate the severe disease associated with human co-infection. Read More

View Article and Full-Text PDF

The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells.

J Biol Chem 2021 May 21:100819. Epub 2021 May 21.

MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, UK;. Electronic address:

Collagen-derived hydroxyproline (Hyp)-containing peptides have a variety of biological effects on cells. These bioactive collagen peptides are locally generated by the degradation of endogenous collagen in response to injury. However, no comprehensive study has yet explored the functional links between Hyp-containing peptides and cellular behavior. Read More

View Article and Full-Text PDF

Mutualism promotes site selection in a large marine planktivore.

Ecol Evol 2021 May 26;11(10):5606-5623. Epub 2021 Mar 26.

School of Biomedical Sciences The University of Queensland St Lucia QLD Australia.

Mutualism is a form of symbiosis whereby both parties benefit from the relationship. An example is cleaning symbiosis, which has been observed in terrestrial and marine environments. The most recognized form of marine cleaning symbiosis is that of cleaner fishes and their clients. Read More

View Article and Full-Text PDF

Super resolution microscopy reveals DHA-dependent alterations in glioblastoma membrane remodelling and cell migration.

Nanoscale 2021 Jun;13(21):9706-9722

Cross Cancer Institute, University of Alberta, Department of Oncology, 11560 University Avenue, Edmonton, Alberta, Canada.

Brain fatty acid binding protein (FABP7; B-FABP) promotes glioblastoma (GBM) cell migration and is associated with tumor infiltration, properties associated with a poor prognosis in GBM patients. FABP7-expressing neural stem-like cells are known to drive tumor migration/infiltration and resistance to treatment. We have previously shown that FABP7's effects on cell migration can be reversed when GBM cells are cultured in medium supplemented with the omega-3 fatty acid, docosahexaenoic acid (DHA). Read More

View Article and Full-Text PDF

The phyB-dependent induction of HY5 promotes iron uptake by systemically activating FER expression.

EMBO Rep 2021 May 20:e51944. Epub 2021 May 20.

Department of Horticulture, Zhejiang University, Hangzhou, China.

Iron (Fe) deficiency affects global crop productivity and human health. However, the role of light signaling in plant Fe uptake remains uncharacterized. Here, we find that light-induced Fe uptake in tomato (Solanum lycopersicum L. Read More

View Article and Full-Text PDF

TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.

Cell Metab 2021 May 17. Epub 2021 May 17.

State Key Laboratory of Membrane Biology, Peking University, Beijing 100871, China; Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China; Center for Life Sciences, Peking University, Beijing 100871, China. Electronic address:

How amphipathic phospholipids are shuttled between the membrane bilayer remains an essential but elusive process, particularly at the endoplasmic reticulum (ER). One prominent phospholipid shuttling process concerns the biogenesis of APOB-containing lipoproteins within the ER lumen, which may require bulk trans-bilayer movement of phospholipids from the cytoplasmic leaflet of the ER bilayer. Here, we show that TMEM41B, present in the lipoprotein export machinery, encodes a previously conceptualized ER lipid scramblase mediating trans-bilayer shuttling of bulk phospholipids. Read More

View Article and Full-Text PDF

Recombinant human insulin-like growth factor-1 promotes osteoclast formation and accelerates orthodontic tooth movement in rats.

J Appl Oral Sci 2021 14;29:e20200791. Epub 2021 May 14.

Special Key Laboratory of Oral Diseases Research from Higher Education Institution of Guizhou Province & Zunyi Key Laboratory of Oral Disease Research, Zunyi, China.

Background: IGF-1 may be an important factor in bone remodeling, but its mechanism of action on osteoclasts during orthodontic tooth movement is complex and unclear.

Methodology: The closed-coil spring was placed between the left maxillary first molar and upper incisors with a force of 50 g to establish an orthodontic movement model. Eighty SD rats were randomized to receive phosphate buffer saline or 400 ng rhIGF-1 in the lateral buccal mucosa of the left maxillary first molar every two days. Read More

View Article and Full-Text PDF

Chinese stroke survivors' perceptions of participation in exercise or sitting Tai Chi.

Eur J Cardiovasc Nurs 2021 May 19. Epub 2021 May 19.

School of Nursing and Midwifery, Queen's University Belfast, Belfast, UK.

Aims: Exercise promotes functional recovery among stroke survivors and is recommended to be commenced as soon as is feasible. However, little is known about stroke survivors' perception of participation in exercise or sitting Tai Chi, a more culturally appropriate and popular movement in China. To explore Chinese stroke survivors' perceptions of participation in exercise or sitting Tai Chi. Read More

View Article and Full-Text PDF

Long non-coding RNA TP73-AS1 promotes pancreatic cancer growth and metastasis through miRNA-128-3p/GOLM1 axis.

World J Gastroenterol 2021 May;27(17):1993-2014

Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

Background: Previous studies have suggested that long non-coding RNAs (lncRNA) TP73-AS1 is significantly upregulated in several cancers. However, the biological role and clinical significance of TP73-AS1 in pancreatic cancer (PC) remain unclear.

Aim: To investigate the role of TP73-AS1 in the growth and metastasis of PC. Read More

View Article and Full-Text PDF

Benznidazole in vitro dissolution release from a pH-sensitive drug delivery system using Zif-8 as a carrier.

J Mater Sci Mater Med 2021 May 17;32(6):59. Epub 2021 May 17.

Laboratório de Tecnologia dos Medicamentos (LTM), Department of Pharmaceutical Sciences, Federal University of Pernambuco, Av. Prof. Arthur de Sá, s/n, Cidade Universitária, 50740-521, Recife, PE, Brazil.

Chagas disease is a neglected tropical disease caused by the flagellate protozoan Trypanosoma cruzi (T. cruzi). Endemic in underdeveloped and developed countries, due to the migratory movement, it is considered a serious public health problem. Read More

View Article and Full-Text PDF

Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments.

Nat Commun 2021 05 14;12(1):2815. Epub 2021 May 14.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.

Defining the principles of T cell migration in structurally and mechanically complex tumor microenvironments is critical to understanding escape from antitumor immunity and optimizing T cell-related therapeutic strategies. Here, we engineered nanotextured elastic platforms to study and enhance T cell migration through complex microenvironments and define how the balance between contractility localization-dependent T cell phenotypes influences migration in response to tumor-mimetic structural and mechanical cues. Using these platforms, we characterize a mechanical optimum for migration that can be perturbed by manipulating an axis between microtubule stability and force generation. Read More

View Article and Full-Text PDF

H Long Terminal Repeat-Associating 2 (HHLA2) is a Biomarker of Advanced Stage Hepatocellular Carcinoma and Promotes Tumor Cell Development In Vitro.

Med Sci Monit 2021 May 15;27:e930215. Epub 2021 May 15.

Department of Endoscopy, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China (mainland).

BACKGROUND Several risk factors contribute to the inflammation promoting hepatocellular carcinoma (HCC) development, but the underlying mechanisms are unknown. Human endogenous retrovirus H long terminal repeat-associating 2 (HHLA2), a B7 family member, is highly expressed in various malignant tumor tissues and is related to tumor progression and metastasis. MATERIAL AND METHODS Bioinformatics analysis was used to analyze the gene expression chip GSE33006 of HCC tissue in the GEO database, draw a heat map of differentially expressed genes, and analyze the GO pathway of gene function annotation. Read More

View Article and Full-Text PDF

Effects of resistance training at different intensities of load on cross-education of muscle strength.

Appl Physiol Nutr Metab 2021 May 13. Epub 2021 May 13.

Federal University of Triangulo Mineiro , Department of Sport Sciences, Uberaba, Brazil;

The objectives of this study were 1) to compare the extent of cross-transfer of high- versus low-load unilateral resistance training performed with external pacing of the movement (URTEP) and 2) to compare the time course of the two approaches. Fifty subjects were randomized to one of the following three groups: G80 [two sets at 80% and two sets at 40% of one maximum repetition (1RM), 1 concentric second and 3 eccentric seconds controlled by a metronome]; G40 (four sets at 40% of 1 RM, 1s and 3s controlled by a metronome); or CG (control group). At week 1, the G80 increased the elbow flexion 1RM (P<0. Read More

View Article and Full-Text PDF

Effect of Reducing Sedentary Behavior on Blood Pressure (RESET BP): Rationale, design, and methods.

Contemp Clin Trials 2021 May 7;106:106428. Epub 2021 May 7.

Department of Health and Human Development, University of Pittsburgh, Pittsburgh, PA, United States of America.

Sedentary behavior (SB) has recently been recognized as a strong risk factor for cardiovascular disease, with new guidelines encouraging adults to 'sit less, move more.' Yet, there are few randomized trials demonstrating that reducing SB improves cardiovascular health. The Effect of Reducing Sedentary Behavior on Blood Pressure (RESET BP) randomized clinical trial addresses this gap by testing the effect of a 3-month SB reduction intervention on resting systolic BP. Read More

View Article and Full-Text PDF

Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression.

Toxicol Appl Pharmacol 2021 Jul 7;423:115569. Epub 2021 May 7.

Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA. Electronic address:

Activated macrophages have been implicated in lung injury and fibrosis induced by the cytotoxic alkylating agent, nitrogen mustard (NM). Herein, we determined if macrophage activation is associated with histone modifications and altered miRNA expression. Treatment of rats with NM (0. Read More

View Article and Full-Text PDF