Pathol Res Pract 2021 Apr 5;222:153429. Epub 2021 Apr 5.
Department of Laboratory Medicine, University of Pecs, School of Medicine, Pecs, Hungary; Szentagothai Research Center, University of Pecs, Pecs, Hungary. Electronic address:
Background: Wnt signaling plays important roles in tumorigenesis, invasiveness and therapeutic resistance of glioblastoma (GBM).
Methods: We simultaneously investigated six Wnt pathway markers (Wnt5a, Fzd-2, beta-catenin, Wnt3a, Wnt7b, Fzd-10) at epigenetic and protein levels in 21 sequential formalin-fixed paraffin-embedded GBM pairs and controls.
Results: Expression levels of Wnt5a, beta-catenin and Wnt3a proteins either moderately or significantly increased, while those of Fzd-2, Wnt7b and Fzd-10 decreased in the primary (GBM-P) and recurrent (GBM-R) tumors compared to the controls. Read More